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Understanding Nanog's Role During Cell Differentiation, Oluwatobiloba Samuel Aminu Jan 2023

Understanding Nanog's Role During Cell Differentiation, Oluwatobiloba Samuel Aminu

Theses and Dissertations

Pluripotency is characterized by the capacity to self-renew and differentiate into all cell types. This state relies on both extrinsic factors, such as leukemia inhibitory factor and bone morphogenetic protein, and intrinsic factors, including pluripotent transcription factors.While the role of pluripotent transcription factors in stem cell maintenance is well understood, their functions beyond pluripotency remain unclear. In this study, we focused on NANOG, a core member of the pluripotency network, and investigated its roles in two different models of differentiation: the transition from the naive to the primed pluripotent state and neuroectodermal differentiation. Our findings demonstrate that NANOG plays a …

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A Deep Review Of Sustainable Approaches For Hydrogen Production For Energy Generation, Patrick Bernard Ferron Jan 2023

A Deep Review Of Sustainable Approaches For Hydrogen Production For Energy Generation, Patrick Bernard Ferron

Theses and Dissertations

Fossil fuel energy sources such as coal, oil, and natural gas produce greenhouse gases upon combustion. Over time the greenhouse gases trap heat in the atmosphere and cause global temperatures to continually increase. This continued rise in global temperatures has led to severe climate conditions that have resulted in increasing environmental, financial, social, and medical issues. To mitigate the rise in global temperatures, and the negative effects associated with it, the carbon intensity of our energy sources must be substantially reduced or eliminated where possible. In addition, alternate sources of carbon-free energy sources must be pursued and implemented. Hydrogen is …

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Computational Framework For Neuro-Optics Simulation And Deep Learning Denoising, Cecilia Ling Jan 2023

Computational Framework For Neuro-Optics Simulation And Deep Learning Denoising, Cecilia Ling

Theses and Dissertations

The application of machine learning techniques in microscopic image restoration has shown superior performance. However, the development of such techniques has been hindered by the demand for large datasets and the lack of ground truth. To address these challenges, this study introduces a computer simulation model that accurately captures the neural anatomic volume, fluorescence light transportation within the tissue volume, and the photon collection process of microscopic imaging sensors. The primary goal of this simulation is to generate realistic image data for training and validating machine learning models. One notable aspect of this study is the incorporation of a machine …

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Intergenerational Continuity Of Sexual Violence Victimization: A Socio-Ecological Examination Of Risk, Angela Hunter Minnich Jan 2023

Intergenerational Continuity Of Sexual Violence Victimization: A Socio-Ecological Examination Of Risk, Angela Hunter Minnich

Theses and Dissertations

The present study examined intergenerational continuity of sexual violence victimization across the lifespan within mother-daughter dyads. Because increased risk for sexual violence in daughters is not the fault of the mother, this study examined risk factors across socio-ecological levels (i.e., individual, familial, and community risk factors) and the interplay across risk levels. Undergraduate and community dwelling mother-daughter dyads (N=202) completed self-report measures of Childhood Sexual Abuse (CSA), adolescent/adult sexual violence victimization (ASV), demographics, psychopathology, parenting, abuse and abuser characteristics, intimate partner violence (IPV), rape culture, and sexual education characteristics. Multiple mediation, moderation, and DYADIC analyses were implemented to test study …

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Teaching Professionalism To Undergraduate Medical Laboratory Science Students Using Virtually Simulated Case Studies, Samantha Peterson Jan 2023

Teaching Professionalism To Undergraduate Medical Laboratory Science Students Using Virtually Simulated Case Studies, Samantha Peterson

Theses and Dissertations

Professionalism is a required curricular component in accredited medical laboratory science (MLS) programs in the United States and is a critical element for career success and optimal patient care. A standardized definition of professionalism in MLS, however, has yet to be established. This poses a challenge to MLS programs when pertaining to teaching professionalism to MLS students. To explore a novel method for teaching professionalism in MLS, interactive and virtually simulated case studies were designed and built to cover three professional behaviors required of MLS professionals. Before and after case study completion, students (n= 49) responded to a survey designed …

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Application Of Artificial Intelligence And Multi-Omics To Understand The Effect Of Heavy Metals Exposure On Human Health, Sonalika Singhal Jan 2023

Application Of Artificial Intelligence And Multi-Omics To Understand The Effect Of Heavy Metals Exposure On Human Health, Sonalika Singhal

Theses and Dissertations

IARC classified arsenic (iAs) as “carcinogenic to humans”, but despite the health consequences, there is no molecular signature available yet to predict when exposure may lead to the disease development. In this study, a three-step analysis was employed: (1) the gene expression profiles obtained from diverse arsenic-exposed populations were utilized to identify differentially expressed genes associated with arsenic exposure in human subjects, (2) the gene expression profiles induced by arsenic exposure in different myeloma cancer cell lines were used to define common genes and pathways altered by arsenic exposure,(3) the genetic profiles of human bladder cancer studies were used to …

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Plant Composition And Turnover In Great Plains Conservation Reserve Program Grasslands, Lydia M. Westberg Jan 2023

Plant Composition And Turnover In Great Plains Conservation Reserve Program Grasslands, Lydia M. Westberg

Theses and Dissertations

The Conservation Reserve Program supports grassland reconstruction practices that vary in the number (richness) and identity of species added to enrolled sites. Although the program is administered at the federal level, the methods and species pools used to reconstruct these grasslands have changed over time and vary across the United States. Additionally, while the goal is to augment site species pools with desired species, there is some question as to what extent the prescribed practices result in a diverse species pool over the long term given the immense non-native propagule pressure that can exist on these sites. Unfortunately, no large-scale …

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Thematic Content Analysis Exploring American Indian Suicidality, Todd E. Phelps Jan 2023

Thematic Content Analysis Exploring American Indian Suicidality, Todd E. Phelps

Theses and Dissertations

This research project aimed to explore the trajectory of suicide within one tribal nation, the Sioux. The researcher attempted to identify risk factor significance, create new factors current research may be lacking, and gain saturated context for suicide from Siouan-affiliated individuals. Suicidality was explored in two phases. Phase one required individual participants to classify and rank potential life stressors (PLS). Phase two included another round of classification in addition to thematic content analysis within an expert panelist setting. Phases were completed by three different panel groups. Panel one included individuals who have attempted suicide, panel two included a group of …

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Staphylococcal Enterotoxin I Immunotherapy Combined With Hla-Dq8 Induces Tumoricidal Activity, With Low Superantigen Toxicity, Leading To Long-Term Survival And Tumor-Specific Memory Against Established B16-F10 Melanoma In Humanized Hla-Dq8 Transgenic Mice, Nathan Velaris Jan 2023

Staphylococcal Enterotoxin I Immunotherapy Combined With Hla-Dq8 Induces Tumoricidal Activity, With Low Superantigen Toxicity, Leading To Long-Term Survival And Tumor-Specific Memory Against Established B16-F10 Melanoma In Humanized Hla-Dq8 Transgenic Mice, Nathan Velaris

Theses and Dissertations

Immunotherapies now stand at the forefront of cancer treatment as a versatile arsenal of cutting-edge tools wielded by medical professionals to combat and conquer a spectrum of formidable diseases. Most notably, immunotherapies such as immune checkpoint inhibitors, have revolutionized the field of oncology offering a promising alternative to conventional treatments like chemo and radiation therapy with significant improvements for patients in terms of quality of life and survival. Immunotherapies can be uniquely personalized to a patient's genetic and immune system profile leading to more effective treatments and durable long-lasting responses. Our research group has identified Staphylococcal enterotoxin I as a …

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A Molecular Phylogeny Of Ctenuchina Kirby, 1837 (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina), Sydney Winterton Jan 2023

A Molecular Phylogeny Of Ctenuchina Kirby, 1837 (Lepidoptera: Erebidae: Arctiinae: Arctiini: Ctenuchina), Sydney Winterton

Theses and Dissertations

Ctenuchina are a subtribe of tiger moths in the subfamily Arctiinae and are known for their aposematism and mimicry of noxious insects. Their overall appearance signals predators of their unpalatability due to larval sequestration of plant secondary chemicals. The taxonomic history of Ctenuchina is complicated because of convergent phenotypes within the lineage and with other tiger moth groups such as the Euchromiina. Independent evolutionary events that converge on mimetic phenotypes obscure evolutionary relationships and render classifications based on morphology to be suspect. Although morphological phylogenies have since been used less often in favor of quantifiable, molecular-based phylogenies, these studies provide …

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Integrating Technology Into Wildlife Surveys, Sally E. Yannuzzi Jan 2023

Integrating Technology Into Wildlife Surveys, Sally E. Yannuzzi

Theses and Dissertations

Technology is rapidly improving and being incorporated into field biology, with survey methods such as machine learning and uncrewed aircraft systems (UAS) headlining efforts. UAS paired with machine learning algorithms have been used to detect caribou, nesting waterfowl and seabirds, marine mammals, white-tailed deer, and more in over 19 studies within the last decade alone. Simultaneously, UAS and machine learning have also been implemented for infrastructure monitoring at wind energy facilities as wind energy construction and use has skyrocketed globally. As part of both pre-construction and regulatory compliance of newly constructed wind energy facilities, monitoring of impacts to wildlife is …

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Synthesis And Characterization Of Soybean Feedstock-Based Composite Systems For Sustainable Material Application., Temofeh Nathaniel Esenamunjor Jan 2023

Synthesis And Characterization Of Soybean Feedstock-Based Composite Systems For Sustainable Material Application., Temofeh Nathaniel Esenamunjor

Theses and Dissertations

This study explores the synthesis and characterization of soybean-based composites with a focus on their potential for sustainable material applications. Soybean meal (SBM), known for its high protein content, is blended with the biopolymer polylactic acid (PLA) using eco-friendly manufacturing processes. The solvent casting and hot-pressing methods are employed to fabricate composites, and their mechanical and thermal properties are investigated. Tensile strength of the composites decreases with higher concentrations of soybean meal, while thermal properties remain comparable to PLA. The hot press method, optimized at 250°C and 235 MPa, shows promising results in enhancing compressive strength with increased SBM concentration …

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Trauma Education In Social Work Curricula: An Innovative Approach To The Teaching Of Trauma-Informed Care, Jennifer M. Schlinger Jan 2023

Trauma Education In Social Work Curricula: An Innovative Approach To The Teaching Of Trauma-Informed Care, Jennifer M. Schlinger

Theses and Dissertations

Many professionals, especially social workers, work with individuals who have a history of or are experiencing trauma. If students understand the trauma their clients have experienced, they are better suited to meet the individual where they are and help them work towards their goals. Social work professors must prepare their students by instructing them about different types of traumatic experiences, the impacts, assessment tools, and various intervention strategies. I used a qualitative research approach and document analysis to understand how social work programs incorporate education related to trauma and trauma-informed practice into their curricula. This method allowed me to gain …

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Stroke Survivors’ And Informal Caregivers’ Perceptions Of Depressive Symptoms After Stroke: A Mixed-Methods Sequential Explanatory Study, Tanya Leigh Breckenridge-Trotter Jan 2023

Stroke Survivors’ And Informal Caregivers’ Perceptions Of Depressive Symptoms After Stroke: A Mixed-Methods Sequential Explanatory Study, Tanya Leigh Breckenridge-Trotter

Theses and Dissertations

Background: Poststroke depression (PSD) is a frequently occurring complication of stroke that affects up to 30% of all stroke survivors in the first 24 months after stroke. PSD has been correlated with increases in hospital length of stay and hospital costs, increased physical morbidity and mortality, the risk for recurrent stroke at one year, decreased functional outcome, decreased cognitive function, and decreased quality of life post stroke. Estimates are >50% stroke survivors with depressive symptoms are left untreated due to lack of recognition. Moreover, depression in family caregivers of stroke survivors may negatively influence stroke recovery and stroke survivor quality …

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Enhancing Resin Composite Using Nanoparticle Embedded Jute Fiber And Exploring Plant Polymer For Biomedical Applications, Md Sultan Mahmud Jan 2023

Enhancing Resin Composite Using Nanoparticle Embedded Jute Fiber And Exploring Plant Polymer For Biomedical Applications, Md Sultan Mahmud

Theses and Dissertations

The severe detrimental effect of nondegradable and toxic synthetic materials on the environment in the last couple of decades has led researchers to focus more on eco-friendly products such as building materials, medical instruments, sports, textile, and automobile industries. Lignocellulosic plants and their fibers are the first choices for both material and biological science researchers due to their chemical structure, abundance, low cost, and nontoxic nature. These plants are composed of three major biopolymers such as cellulose, hemicellulose, and lignin. Cellulose is the most abundant polymer. In the recent past natural fibers have attracted substantial importance as potential structural materials …

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Evaluating The Potential Of Wrought And Additively Manufactured Co-Cr Alloy For Prosthodontic Applications, Sudip Saha Jan 2023

Evaluating The Potential Of Wrought And Additively Manufactured Co-Cr Alloy For Prosthodontic Applications, Sudip Saha

Theses and Dissertations

Tribological analysis of metallic implants for orthodontics applications is a long-studied topic of research. The study covers human mouth anatomy, implant types, and major wear mechanisms, materials, and manufacturing techniques commonly used for dental implant materials. Common contributing factors to evaluate the mechanical performance of metal implants includes tribological behavior analysis in varying physiological conditions, material properties, corrosive responsiveness and manufacturing techniques. By conducting systematic experiments to cover these areas, this study aims to evaluate the performance of wrought and additively manufactured Co-Cr alloy for metallic implants for orthodontics applications.For the tribological test and corrosion experiments laboratory prepared artificial saliva …

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Continuous Decomposition Of Corn Stover-Derived Lignin To Valuable Products And Vanillin, Wyatt Larson Jan 2023

Continuous Decomposition Of Corn Stover-Derived Lignin To Valuable Products And Vanillin, Wyatt Larson

Theses and Dissertations

As the world moves away from fossil fuels, it is important to find new feedstock sources not only for fuels but also for chemicals and materials used every day that are also derived from fossil fuels. One potential source is lignin. Lignin is a large complex polymer with an abundance of cyclic groups making it a good candidate to produce chemicals that typically come from crude oil. However, the transformation of lignin into these compounds is a challenge, and processes to use lignin as a crude oil substitute have yet to be commercialized. Lignin is present in woods, grasses, and …

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Community College Faculty Perceptions Of Open Educational Resources, Heather Ann Leavitt Jan 2023

Community College Faculty Perceptions Of Open Educational Resources, Heather Ann Leavitt

Theses and Dissertations

This study examined Open Educational Resources (OER) through a community college faculty perspective. Specifically, this study aimed to gain a deeper understanding of faculty motivations surrounding OER, faculty perceptions of OER’s influences on students, and pedagogical changes that faculty have made in response to OER. A qualitative research methodology was chosen, including semi-structured phenomenological interviews conducted with community college faculty members. The methodology was guided by activity theory. Faculty discussed their use of the 5 Rs (retain, reuse, revise, remix, redistribute) in practice, with revise being the most commonly used of the 5 Rs. Notably, the eight participants had mixed …

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Cognitive Decay And Memory Recall During Long Duration Spaceflight, Terry E. Rector Jan 2023

Cognitive Decay And Memory Recall During Long Duration Spaceflight, Terry E. Rector

Theses and Dissertations

This dissertation aims to advance the efficacy of Long-Duration Space Flight (LDSF) pre-flight and in-flight training programs, acknowledging existing knowledge gaps in NASA's methodologies. The research's objective is to optimize the cognitive workload of LDSF crew members, enhance their neurocognitive functionality, and provide more meaningful work experiences, particularly for Mars missions.The study addresses identified shortcomings in current training and learning strategies and simulation-based training systems, focusing on areas requiring quantitative measures for astronaut proficiency and training effectiveness assessment. The project centers on understanding cognitive decay and memory loss under LDSF-related stressors, seeking to establish when such cognitive decline exceeds acceptable …

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The Effects Of Demographic And Nutritional Variables On Anxiety And Depression Symptoms In Usa And Non-Usa Adults, Jonathan Santiago Jan 2023

The Effects Of Demographic And Nutritional Variables On Anxiety And Depression Symptoms In Usa And Non-Usa Adults, Jonathan Santiago

Theses and Dissertations

The present study investigated the effects of demographic variables (e.g. country of residence and socioeconomic status) and nutritional variables (e.g. dietary diversity and micronutrient content) on anxiety and depression symptoms, as well as subjective health self-rating. Prior research suggests that a variety of demographic and nutritional factors influence chronic stress, which can cause systemic inflammation and lead to various cardiovascular-related diseases. Participants (USA=41; Non-USA= 58) were recruited via an online platform and completed demographic questionnaires and a 24-hour dietary recall. Results indicated that food accessibility emerged as the strongest predictor, and was associated with anxiety, depression, and combined mood symptoms. …

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Und Leads: A Strategic Vision For The University Of North Dakota, University Of North Dakota Jan 2023

Und Leads: A Strategic Vision For The University Of North Dakota, University Of North Dakota

LEADS Development Documents

Official UND LEADS strategic plan for the University of North Dakota. The plan presents UND’s mission and vision, introduces the five LEADS pillars of Learning, Equity, Affinity, Discovery, and Service, and outlines strategic priorities developed through campus and community input.

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Addressing Interoceptive Awareness In Elementary School Students Affected By Childhood Trauma To Improve Emotional Regulation, Alison O’Sadnick Jan 2023

Addressing Interoceptive Awareness In Elementary School Students Affected By Childhood Trauma To Improve Emotional Regulation, Alison O’Sadnick

Occupational Therapy Capstones

Childhood trauma can affect students’ interoceptive awareness affecting their ability to emotionally regulate within the classroom environment (Neal, 2021). Evidence demonstrates that for students to emotionally regulate, they must have interoceptive awareness (Mahler, 2020). Interoceptive awareness is described as the ability to detect the physiological state of the body such as recognizing signals of respiratory effort, temperature, fatigue, hunger, thirst, satiety, pain, muscle aches, and heart rate (Mahler et al., 2022). Children who have experienced trauma commonly have difficulty identifying and describing internal arousal states, labeling, and expressing emotions and making their needs and wants to be known (Scaffa, 2019).

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Volume Vi, Spring 2023, International Anchoritic Society Jan 2023

Volume Vi, Spring 2023, International Anchoritic Society

International Anchoritic Society Newsletter

No abstract provided.

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Fostering A Loving Connection: A Foster Parent’S Toolkit For Understanding And Addressing Behaviors For Children Placed In Out-Of-Home Care, Emily A. Knust Jan 2023

Fostering A Loving Connection: A Foster Parent’S Toolkit For Understanding And Addressing Behaviors For Children Placed In Out-Of-Home Care, Emily A. Knust

Occupational Therapy Capstones

Children placed in out-of-home care have an 80% chance of having a mental health diagnosis or experiencing negative behaviors related to trauma experiences (Armstrong-Hiemsoth et al., 2020). Children in foster care have been exposed to trauma by being removed from their biological parents and the abuse, neglect, or unsafe conditions that occurred leading up to the removal and placement in out-of-home care (Bartlett, 2021). From this trauma, a child is more likely to experience difficulty with basic self-care skills, executive functioning, emotional regulation, attachment disorders, or positive interactions and relationships within the foster home and their environment (Pervis et al., …

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The Impact Of Trauma On Occupational Performance For People Experiencing Homelessness, Isabella Jeanette Johannes Jan 2023

The Impact Of Trauma On Occupational Performance For People Experiencing Homelessness, Isabella Jeanette Johannes

Occupational Therapy Capstones

People transitioning from homelessness experience trauma at three times the risk than the general population (McCurry, 2021). Occupational therapy can provide trauma-informed services that helps people that have experienced homelessness transition to supported housing by addressing occupational competence and identity formation through meaningful activity (McCurry, 2021). Occupational therapy can address this area by educating staff and students that work with this population to be more trauma- informed. It is important to utilize a trauma-informed approach to avoid retraumatization to people that have experienced homelessness (AOTA, 2021). There were two purposes of this project: a) develop advanced knowledge in trauma-informed care, …

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Examining The Unique Experiences Of Underrepresented Minority Stem Faculty: How Discrimination, Microaggression, And Allyship Relate To Sense Of Relatedness, Motivation, And Perceived Success, Mojdeh J. Mardani Jan 2023

Examining The Unique Experiences Of Underrepresented Minority Stem Faculty: How Discrimination, Microaggression, And Allyship Relate To Sense Of Relatedness, Motivation, And Perceived Success, Mojdeh J. Mardani

Theses and Dissertations

Results from empirical studies reveal underrepresented minority, URM, university faculty experience biases, discrimination, and affiliated stress that can impact multiple aspects of their work such as research performance (Fisher et al., 2019; O’Meara et al., 2020; Stolzenberg et al., 2019; Stupnisky et al., 2015), isolation, and lessened relatedness to colleagues (Zambrana et al., 2017; 2021), which may affect their motivation to conduct research. This dissertation is a collection of three separate but complementary research studies examining the effects of various forms of discrimination and the role of allyship in shaping the motivation of URM faculty members to engage in research, …

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Application Of Artificial Treatment Wetland Systems In The English Coulee, Michael Anthony Rosati Jan 2023

Application Of Artificial Treatment Wetland Systems In The English Coulee, Michael Anthony Rosati

Theses and Dissertations

Artificial treatment wetlands are commonly used for treating urban stormwater runoffand surface waters affected by agricultural runoff. While this method is well-established, its effectiveness can vary based on environmental, design, and hydraulic factors. In Grand Forks, ND, the English Coulee, a hydraulically altered class III stream, is currently experiencing elevated nutrient pollution, specifically nitrates and phosphates. Implementing a floating treatment wetland (FTW) system in the English Coulee is a potential solution. This paper analyzes the feasibility and requirements for a 4.64 ha FTW to achieve a minimum of 50% nutrient removal, utilizing comprehensive modeling approaches. Through HEC-HMS and HECRAS simulations, …

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Quantification Of Rigidity And Synthesis Of Cyclobutane Bisimide Building Blocks, Joseph Earl Mcgilligan Robertson Jan 2023

Quantification Of Rigidity And Synthesis Of Cyclobutane Bisimide Building Blocks, Joseph Earl Mcgilligan Robertson

Theses and Dissertations

The quantification of a molecule’s conformational rigidity was achieved via development of a new measure called the Rigidity Factor, Rgf. This value is a unit interval wherein molecules with corresponding Rgf values closer to 1 are rigid and values closer to 0 are more flexible. The value is determined as a ratio between the molecule’s Van der Waals volume, VW, and it’s Van der Waals potential volume, VWpot. The VWpot was defined as the minimum total volume occupied by a rotamer ensemble of the molecule which has been aligned according to the RMSD for …

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Machine Learning And Data Mining To Validate The Prognostics And Predictive Breast Cancer Biomarkers On A Large Racially Diverse Population, Kalli Scheafer Jan 2023

Machine Learning And Data Mining To Validate The Prognostics And Predictive Breast Cancer Biomarkers On A Large Racially Diverse Population, Kalli Scheafer

Theses and Dissertations

Breast cancer biomarkers have great potential in providing clinicians more individualized information about the composition and outcomes of a patient’s breast cancer. However, many breast cancer biomarkers have not been evaluated on a large scale or in groups of patients with diverse characteristics, leading to difficulty in their translation to having an impact on patients. In this study, we compile a large, pooled breast cancer patient data cohort and evaluate breast cancer biomarkers on patients with diverse characteristics. Biomarkers are found to have varying expression patterns within the different breast cancer subtypes, validating the need to evaluate biomarkers on patient …

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Exploring Zinc Amido-Oxazolinate Complexes As Catalysts For Ring Opening Polymerization (Rop) And Ring Opening Co-Polymerization (Rocop), Muneer Shaik Jan 2023

Exploring Zinc Amido-Oxazolinate Complexes As Catalysts For Ring Opening Polymerization (Rop) And Ring Opening Co-Polymerization (Rocop), Muneer Shaik

Theses and Dissertations

This research aims to explore the potential of zinc amido-oxazolinate complexes as catalysts for ring opening polymerization (ROP) and ring opening copolymerization (ROCOP). ROP is a method for synthesizing polymers by opening cyclic monomers, while ROCOP involves using two different monomers to create a copolymer. The ROP of lactones is a well-established method for the synthesis of polyesters, whereas the ROCOP of epoxides and cyclic anhydrides is a more recent development. Zinc amido-oxazolinate complexes are a promising class of catalysts due to their tunable electronic properties and high reactivity. The catalytic activity of these complexes can be tuned by modifying …

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