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Leads Data Insights: Affinity — May 2025, University Of North Dakota

LEADS Development Documents

Data insights presentation file labeled for AFFINITY in May 2025. The file includes planning notes for Affinity metrics and materials related to campus environments, shared governance, first-year retention, study abroad, and other measures connected to belonging and campus engagement.

Leads Data Insights: Affinity — May 2025, University Of North Dakota

LEADS Implementation Documents

Data insights presentation file labeled for AFFINITY in May 2025. The file includes planning notes for Affinity metrics and materials related to campus environments, shared governance, first-year retention, study abroad, and other measures connected to belonging and campus engagement.

Monoclonal Antibody Therapy Versus Oral Immunotherapy In Food Allergies, Kendra Bohm

Physician Assistant Scholarly Project Papers

Food allergies are classified as an immune hyperreaction that leads to various symptoms that can range from mild to severe and even result in death. Often, management of food allergies includes avoidance of triggering substances or rescue treatment after exposure has occurred. This literature review aims to examine preventative management options for food allergies, including oral immunotherapy, and recent medications, including monoclonal antibodies. The databases searched for this literature review include PubMed, Embase, and Google Scholar. Additional references were also selected from reference lists in those studies as they pertained. This review explores the success in reaching desensitization following treatment …

Efficacy Of Menstrual Cycle Awareness In The Identification Of Premenstrual Dysphoric Disorder, Rachel Brothers

Physician Assistant Scholarly Project Papers

Premenstrual Dysphoric Disorder (PMDD) is characterized by identifiable psychological and physical symptoms that are present in the week before menses and is estimated to affect 3-8% of women of reproductive age globally. The identification of women who meet criteria for PMDD is important both clinically, to provide proper support and treatment, and for advancing research by identifying appropriate study participants. This literature review aims to investigate the efficacy of current and prospective tools to screen for symptoms of PMDD by comparing a common depression screening tool, the PHQ-9, to tools that enhance menstrual cycle awareness. A literature review was conducted …

Treatment Of Adult Adhd, Megan Bryn

Physician Assistant Scholarly Project Papers

Attention-deficit/hyperactivity disorder (ADHD) is commonly considered a childhood disorder diagnosed and treated in adolescents. Options for management of adverse symptoms associated with ADHD are primarily pharmaceutical therapy, most commonly stimulant therapy. There has been significantly less research regarding the management of adult ADHD in contrast with children diagnosed with ADHD. The purpose of this systematic literature review is to determine in adults with ADHD if nonpharmaceutical therapies including cognitive behavioral therapy, psychoeducation, and mindfulness behavioral therapy are effective alternatives to pharmaceutical therapy. Current research provides significant data supporting the use of pharmaceutical therapy for the management of adult ADHD, as …

Cannabidiol: Anxiety Relief Or Fool’S Gold?, Jase Bakker

Physician Assistant Scholarly Project Papers

Anxiety disorders affect millions of Americans each year and the interest in alternative therapies is growing. The purpose of this literature review is to evaluate the efficacy of cannabidiol (CBD) as a therapeutic intervention for anxiety in adults and adolescents. In this review, three databases including PubMed, PsychInfo, and EMBASE were searched using key terms. Out of 775 articles initially identified, 11 met the inclusion criteria, focusing exclusively on randomized controlled trials (RCTs) investigating CBD's effects compared to placebo in human subjects. Trials prior to 2011 were excluded, along with subjects who had psychiatric comorbidities or adjunctive therapies, were less …

Efficacy Of Low-Dose Naltrexone Compared To Gabapentinoids In Fibromyalgia, Dillon Boen

Physician Assistant Scholarly Project Papers

Fibromyalgia is a chronic pain disorder and often a diagnosis of exclusion characterized by widespread non-specific pain, fatigue, and cognitive dysfunction. Despite fibromyalgia’s significant prevalence, optimal clinical management remains uncertain because of its uncertain pathophysiology. This literature review evaluates the efficacy, safety, and tolerability of low-dose naltrexone (LDN) compared to gabapentinoids, including gabapentin and pregabalin, in the management of fibromyalgia symptoms. A literature review of studies published between 2005 and 2024 was conducted using PubMed's electronic search base. Specific keywords included LDN, low-dose-naltrexone, fibromyalgia, pregabalin, and gabapentin. Specific criteria were set to include all clinical trials and randomized controlled trials …

Efficacy Of Parent-Child Interaction Therapy For The Treatment Of Children With Generalized Anxiety Disorder, Sarah Herman

Physician Assistant Scholarly Project Papers

Generalized Anxiety Disorder (GAD) is a prevalent mental health condition in children, characterized by persistent and excessive worry that interferes with daily functioning and overall quality of life. Anxiety disorders are considered the most common psychiatric disorders among children. The trajectory of untreated anxiety in early life can result in more resistant and chronic presentations in the future, complicating both therapeutic engagement and outcomes. Parent- Child Interaction Therapy (PCIT) has emerged as a potential alternative treatment for children displaying anxiety symptoms, particularly those diagnosed with GAD. This literature review endeavors to assess the effectiveness of Parent-Child Interaction Therapy as an …

Efficacy And Safety Of Angiopoietin-Like 3 Inhibitors In Decreasing Low-Density Lipoprotein Cholesterol, Paige Fritz

Physician Assistant Scholarly Project Papers

Hypercholesterolemia is estimated to effect 31.7% of the United States population according to the Center for Disease Control and Prevention. The mainstay of treatment for this condition is currently statin therapy. While these medications are often effective in decreasing low-density lipoprotein cholesterol (LDL-C) to patient’s goal range, there are populations in which they are not sufficient. These populations include those who have genetic predispositions, such as familial hypercholesterolemia, or those who experience refractory hypercholesterolemia to statin medications. To combat this issue, a class of medications named Angiopoietin-like 3 (ANGPTL3) inhibitors have been created to use as an adjunct to statin …

Impact Of Altering Gut Microbiota With Multinutrient Supplementation On Neuropsychiatric Symptoms In Attention Deficit/Hyperactivity Disorder, Benjamin Hinkle

Physician Assistant Scholarly Project Papers

Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent neuropsychiatric condition affecting children, often characterized by inattention, hyperactivity, and impulsivity. Recent evidence suggests a potential link between gut microbiota composition and neuropsychiatric disorders, including ADHD, through the gut-brain axis (GBA). A literature review of studies published between 2017 and 2024 explores the efficacy of multinutrient interventions on influencing gut microbiota to treat the core symptoms of ADHD in children ages 6-12 years old. Findings indicate that multinutrient supplementation may modulate gut microbiota and subsequently impact neuropsychiatric symptoms, offering a promising adjunctive treatment for ADHD. However, variability in study methodologies and small sample sizes …

Telemedicine Vs. Clinic Monitoring: Adherence In Hypertension Management, Kimberly Hinkle

Physician Assistant Scholarly Project Papers

Hypertension affects over a billion adults worldwide and remains a major contributor to cardiovascular disease and mortality. Effective management requires consistent medication adherence and lifestyle changes, but barriers such as limited healthcare access often hinder follow-up. This literature review evaluates the efficacy of home blood pressure (BP) monitoring combined with telemedicine follow-up in improving medication adherence among adults with hypertension compared to traditional clinic-based follow-ups. A literature review was conducted, resulting in the inclusion of six studies that examined interventions such as telepharmacy, remote BP monitoring, bidirectional text support, and mobile health applications. Results demonstrated that telemedicine significantly enhances BP …

Effectiveness Of Epinephrine In Cardiac Arrest On Survivability With A Favorable Neurologic Outcome, Nathan Young

Physician Assistant Scholarly Project Papers

Cardiac arrest represents a critical medical emergency characterized by the cessation of effective cardiac function resulting in loss of blood flow to vital organs. The management of cardiac arrest often involves pharmacological interventions, primarily the administration of epinephrine. Historically, epinephrine has been the first-line agent in resuscitation protocols due to its sympathomimetic properties that can enhance cardiac contractility and blood circulation. However, the efficacy of epinephrine in yielding favorable long-term survival outcomes with maintained neurological function remains in question. This literature review examines the effectiveness of epinephrine in adult cardiac arrest, comparing outcomes to scenarios of no drug use and …

Pharmacological Treatment Options For Nonalcoholic Steatohepatitis: Resmetirom Vs Glp- 1 Receptor Agonists, Debbie Zabel

Physician Assistant Scholarly Project Papers

The incidence of nonalcoholic steatohepatitis (NASH) is continually rising and has now emerged as one of the leading causes of cirrhosis requiring liver transplantation (Maurice et al., 2018). Until recently, the management of this disease has been limited to lifestyle modification and treatment of comorbid risk factors. In March 2024, the FDA approved resmetirom, the first and only medication for the treatment of this condition. The purpose of this literature review is to investigate the efficacy of GLP-1 and dual GLP/GIP or GLP/GCGR receptor agonist medications for the reduction of liver fat content in comparison to resmetirom. A literature review …

Efficacy Of Probiotic Use In Allergic Rhinitis And Asthma In Children And Adolescents, Mary Janke

Physician Assistant Scholarly Project Papers

Allergic rhinitis and asthma are chronic conditions affecting children and adults, often impairing quality of life. Conventional treatments, including allergen avoidance, antihistamines, corticosteroids, and bronchodilators, manage symptoms but may also have limitations and side effects. Recent studies have explored the efficacy of probiotics as a potential adjunct therapy to alleviate AR symptoms, decrease asthma severity, and reduce the dependence on these conventional treatments. This literature review aims to determine the efficacy of probiotics in treating asthma and allergic rhinitis. It includes studies using probiotics to treat asthma and/or allergic rhinitis, as found using Embase and PubMed. Only studies involving pediatric …

Disparities In Guideline-Directed Medical Therapies In Rural And Underserved Heart Failure Patients, Shawn Mcclaughry

Physician Assistant Scholarly Project Papers

Heart failure with reduced ejection fraction (HFrEF) continues to be a substantial public health challenge, thus optimal management through guideline-directed medical therapy (GDMT) continues to be vital. Evolving GDMT has established four pillars of first-line optimal treatment with expeditious and maximized titration of established target dosing of pillar medications. GDMT has been shown to decrease mortality among HF patients. Although continuing advancements in treatment efficacy prevail, studies demonstrate that vulnerable populations, particularly rural, Black and Hispanic individuals, exhibit significantly lower rates of GDMT optimization, leading to increased hospitalization and mortality. This literature review evaluates disparities in GDMT implementation among urban, …

Improving Fertility In Women With Endometriosis, Todd Marchant

Physician Assistant Scholarly Project Papers

Endometriosis is a common condition in women and has a strong association with infertility. The purpose of this literature review is to determine the efficacy of hormonal therapy as compared to surgical therapy before assisted reproductive therapy (ART) on endometriosis-related infertility. The electronic databases PubMed and Embase were searched from June 23, 2024, to January 4, 2025. Keywords used were associated with fertility, IVF, and endometriosis. Article selection was limited to research published after the year 2000 with a preference for randomized control trials (RCTs), although one pilot study and one clinical cohort study were also included. The search yielded …

Efficacy Of Prediabetes Management Options For Lowering Cardiovascular Risk, Cassidy Mindeman

Physician Assistant Scholarly Project Papers

Around 86 million people in the United States are diagnosed with prediabetes, a metabolic syndrome characterized by insulin resistance and inflammation. The inflammatory nature of the disease increases a patient's cardiovascular risk. Common treatment options include metformin and lifestyle intervention – primarily exercise and diet plans. However, there is no standard medical recommendation for lowering cardiovascular risk. The purpose of this literature review is to determine which treatment options, including the combination of lifestyle and intervention, best lower cardiovascular risk and better detail the effect of prediabetes on cardiovascular risk. Electronic databases PubMed and Embase were utilized and 12 studies …

Impact Of Medication Opioid Use Disorder (Moud) Programs In Emergency Departments, Mechelle A. Zima

Nursing Capstones

The purpose of this paper is to provide a discussion of how a medication opioid use disorder (MOUD) programs integrated into the emergency department (ED) can improve patient’s outcomes compared to standard ED discharges. This study utilized a systematic literature review using PubMed, CINAHL and Google Scholar. The initial literature search identified 594 articles. After applying the predefined inclusion and exclusion criteria, 18 articles were selected. Inclusion criteria included peer reviewed articles that focused on opioid use disorder (OUD) patients treated in the ED with OUD medications while exclusion criteria involved articles with OUD patients treated in ED without OUD …

Effects Of Exercise On Adhd Symptoms In Children And Adolescents, Morgan Mozinski

Nursing Capstones

The purpose of this study was to assess the impact of exercise compared to traditional treatment methods on symptoms of ADHD in children, such as improved executive function. A systematic literature review utilizing PubMed, CINAHL, and UND Medical Library resulted in a total of 113 articles, with 15 articles meeting inclusion and exclusion criteria. Results were filtered to studies within the past 5 years. Studies suggest that physical activity could be used as an adjunct to current treatment. Results of various studies support this concept as children showed an improvement in attention, a decrease in impulsivity and hyperactivity, and an …

Evaluating The Effectiveness Of Telehealth Interventions In Managing Type 2 Diabetes Among Adults In Underserved Rural Areas, Taylor Lemke

Nursing Capstones

Managing Type 2 diabetes (T2D) in underserved rural areas presents ongoing challenges due to limited healthcare access and provider shortages. Telehealth interventions, such as remote monitoring, mobile health applications, and virtual consultations, have emerged as promising strategies to enhance care delivery. This systematic review evaluated the effectiveness of telehealth in improving glycemic control and patient satisfaction among adults with T2D in rural settings. Recent studies, including randomized controlled trials, cohort studies, and systematic reviews published between 2019 and 2025, were analyzed. Overall, telehealth was associated with reductions in hemoglobin A1c (HbA1c), improved medication adherence, and increased patient engagement. High levels …

Juvenile Treatment: A Systematic Review Of Methadone On Juveniles After Incarceration, Joshua Bortieh

Criminal Justice Scholarly Projects

Methadone Maintenance Treatment (MMT) has emerged as a harm-reduction strategy for addressing opioid use disorder (OUD) among justice-involved juveniles. Despite its growing implementation, there remains limited consensus regarding its effectiveness in reducing recidivism, its ethical and legal implications, and the systemic barriers surrounding its administration. This study employed a systematic literature review (SLR) to examine the therapeutic, ethical, and criminological dimensions of MMT in juvenile justice populations. The review followed PRISMA 2020 guidelines and synthesized 15 peer-reviewed empirical studies published between 2010 and 2023. Data were sourced from four major electronic databases PubMed, PsycINFO, Scopus, and Web of Science using …

Moderate Exercise And Tirzepatide Versus Tirzepatide Alone For Long-Term Weight Loss Maintenance, Edward Amoah Acheampong

Nursing Capstones

Background: Glucagon-like peptide-1 (GLP-1) receptor agonist (RA) drugs have been transformative when managing obesity in the clinical setting. Though these medications are effective for weight loss, questions regarding their efficacy for long-term weight loss or maintenance remain unanswered.

Purpose: The purpose of this scoping review was to answer the following clinical question: Can overweight or obese patients (P) who use tirzepatide without exercise (I) as compared to those incorporating 150 minutes a week of moderate aerobic exercise (C) sustain a ≥5% weight loss (O) one-year post-treatment (T)?

Methods: Five electronic article databases were searched to locate articles …

Nature's Relief: Efficacy Of Plant-Based Therapies Vs. Placebo In Easing Vasomotor Menopausal Symptoms, Megan N. Schneider

Nursing Capstones

Background: Vasomotor symptoms (VMS) impact the lives of menopausal women. Plant-based therapies are frequently used as alternatives to hormonal therapy, warranting evaluation of their effectiveness.

Purpose: This literature review evaluates the efficacy of plant-based therapies in alleviating VMS during menopause and compares their effectiveness to placebo treatment.

Methods: A literature review was conducted utilizing PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL).

Results: The review includes a synthesis of 16 primary studies, highlighting five therapies: black cohosh, soy, red clover, evening primrose, and combination therapy in managing VMS. Soy consistently reduces VMS. Black cohosh, red clover, evening …

The Effect Of Breastfeeding On Maternal Mental Health, Quinn Packineau

Nursing Capstones

Postpartum depression (PPD) is a significant public health issue impacting maternal and infant well-being, and though breastfeeding benefits both mother and baby, its effect on PPD is uncertain. This scoping literature review explores whether breastfeeding versus bottle feeding reduces PPD risk within six months postpartum using CINAHL and PubMed search of studies from the last five years on breastfeeding, bottle feeding, and PPD correlations. From 17 qualifying studies, results display exclusive and prolonged breastfeeding linked to lower PPD rates. However, the relationship is bidirectional because PPD can also prompt early breastfeeding cessation. Maternal self-efficacy, lactation support, and socioeconomic- demographic factors …

Evaluating The Effectiveness Of Selective Serotonin Reuptake Inhibitors In Reducing Migraine Frequency In Adults: A Literature Review, Samantha Tully

Nursing Capstones

This scoping review aims to evaluate current literature on selective serotonin reuptake inhibitors (SSRIs) for migraine prevention and prophylaxis in adults. Key themes and gaps in the research are identified. A systematic review was completed across two databases including PubMed and Cochrane. Fifteen studies have been examined in this review with a range of publication dates from 1999 to 2022. Based on this literature review, the author concludes that SSRIs may reduce migraine frequency and severity in the adult population through their action to increase serotonin availability and stabilize serotonin levels. Further research is needed in this area.

The Impact Of Sensory Sensitivity On Nutritional Outcomes In Children With Neurodevelopmental Disorders, Rachel M. Qualley

Theses and Dissertations

Background/Objective: Children with neurodevelopmental disorders (NDDs) are at increased risk of malnutrition due to restrictive dietary patterns and behavioral difficulties at mealtimes. Research suggests that heightened sensory sensitivity, a characteristic accompanying several of these disorders, may be a contributing factor. However, the effects of sensory sensitivity on nutritional outcomes across distinct NDDs have not been fully explored. This review aims to examine the relationship between sensory sensitivity and nutritional status, food preferences, and eating behaviors in children with NDDs, specifically investigating how atypical sensory processing might influence dietary intake.

Methods: A literature search was conducted using Google Scholar, PubMed, …

The Effects Of Excessive Screen Time On Children, Emma Bock

Psychology Student Publications

This paper examines the effects of excessive screen time in children. Screen time is considered “excessive” in children when it is over an hour or two per day. Too much screen time can heavily impact a child’s life physically, psychologically, developmentally, and socially. This paper focuses specifically on how screen time affects attention, language development, eating habits, and sleep.

Dietary Patterns And Their Effects On C-Reactive Protein Regarding Female Reproductive Disorders, Mckenzie Moe

Theses and Dissertations

Objectives: Chronic inflammation, as indicated by elevated C-reactive protein (CRP), plays a critical role in women’s reproductive health disorders. CRP is one of the most common biomarkers of inflammation. Dietary components, lifestyle factors, and women’s reproductive health disorders are major components that influence the levels of CRP within the body. Other influential factors include injury, infection, and illness. The purpose of this review is to explore the findings of literature available on nutrition interventions for CRP levels in consideration of women's reproductive disorders.

Methods: This narrative review examines the works of 15 articles, including 10 cross-sectional and five longitudinal designs. …

The Role Of Almonds In Exercise Recovery And Athletic Performance, Kathryn M. Trochman

Theses and Dissertations

Objectives: During exercise, many trained athletes and physically active adults experience symptoms of exercise-induced muscle damage (EIMD). The effects of EIMD can cause limitations in athletic performance and increased duration of exercise recovery. Nutritional interventions have shown results in improving the duration of recovery. However, there are few studies completed on common food items. This review aims to examine the role of almonds in exercise recovery and athletic performance. Methods: A literature search was conducted utilizing Google Scholar, PubMed, CINAHL Ultimate, and reference hand searching. The search parameters included the dietary intervention of almonds for trained athletes and physically active …

Examining Multiple Layers Of Course Materials Cost: Experiences Of Private College Students, Virginia Clinton-Lisell, Lindsey Gwozdz

Education, Health & Behavior Studies Faculty Publications

Students in private, nonprofit (independent) higher education institutions, particularly those who are economically disadvantaged, often struggle with the costs of course materials like textbooks. However, much less is known about these students and how to assist them with these cost barriers compared to their peers at public institutions. It is also not well known how students perceive institutional course marking in which filters are available to identify courses based on the cost of their materials during registration. To address this lack of knowledge, students at four independent, private colleges (N = 316) were surveyed about their experiences with the cost …