Digital Commons Network^™

Oral Immunotherapy In Ige-Mediated Cow’S Milk Protein Allergy, Jody Bauer

Physician Assistant Scholarly Project Posters

Cow’s milk allergy prevalence in children has been increasing significantly over the last several decades. The diagnosis of a cow’s milk allergy (CMA) can occur through several methods such as signs and symptoms, double blind oral food challenge, skin prick testing, IgE and IgG4 serum levels. Currently, there are no treatments beyond strict allergen avoidance. The patient’s quality of life is impacted with the fear of inadvertent exposure resulting in allergic reactions that may be life threatening. Recent studies have explored desensitization to CM using oral immunotherapy (OIT), subcutaneous immunotherapy, and sublingual immunotherapy (SLIT). Research has found that desensitization will …

Alpha Lipoic Acid: A Potential Therapeutic Option For Painful Peripheral Neuropathies, Jessica Curcio

Physician Assistant Scholarly Project Posters

• Peripheral neuropathy (PN) is a major public health concern.

• There are many etiologies for PN including injury, infection, toxicity, genetics, metabolic disease and nutritional deficiencies.

• Alpha lipoic acid (ALA), also known as thioctic acid, is a potent antioxidant and cofactor in many cellular metabolic processes.

• Oxidative damage plays a significant role in the pathogenesis of both diabetic peripheral neuropathy (DPN) and chemotherapy induced peripheral neuropathy (CIPN).

• Because of the antioxidant capability ALA has been studied for its potential benefit in preventing and treating PN

Pfapa: A Periodic Febrile Syndrome Afflicting Children, Jessica Lahti

Physician Assistant Scholarly Project Posters

• Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).

• Auto-inflammatory disorder occurring in affected children every 3-8 weeks.

• Onset around age 2; lasting into second decade of life.

• A current pathophysiologic theory is PFAPA is a disorder of the innate immune system involving interleukins, chemoattractants, and cytokines that stimulating the inflammatory response causing symptoms associated with PFAPA.

• Early diagnosis of PFAPA may help prevent the unnecessary use of antibiotics.

• Biomarker CD64, galectin-3 and the MPV may be useful in the diagnosis of PFAPA along with other laboratory values during the febrile attack period …

Adolescent Idiopathic Scoliosis: Comparing And Contrasting Operative Versus Non-Operative Treatment Abstract, Ethan Morris

Physician Assistant Scholarly Project Posters

• Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis. It affects 2-4 percent of adolescents aged 10-16 years. Although most adolescents diagnosed with scoliosis will not develop clinical symptoms, ten percent will progress and require medical intervention due to the potential for rib deformity and respiratory compromise as well as significant emotional distress due to aesthetic changes in appearance. Primary care providers should be prepared to evaluate and recommend treatment when idiopathic scoliosis is discovered or addressed by the patient. Three major factors that determine whether scoliosis will progress are patient gender, magnitude of curve on presentation, …

Implementing Animal Therapy Into Current Medicinal Practices, Jenna Schiefelbein

Physician Assistant Scholarly Project Posters

• The purpose of this study was to explore an unconventional intervention of medicine; specifically the integration of animals into current healthcare practices.

• The review of literature evaluated the implementation of animal therapy in medicine, both in the past and present.

• It was demonstrated that incorporating animal-assistance therapy into modern day medicine had a positive correlation with overall patient health, pain control, and disposition.

Does Pharmacogenetics Play A Role In The Treatment Of Type Ii Diabetes Mellitus?, Lucas N. Vanemelen

Physician Assistant Scholarly Project Posters

• Type 2 diabetes mellitus (T2DM) is a disease commonly presented in the family practice setting. Current therapies include one or multiple medications. Until recently, providers have used algorithms and medical expertise to control T2DM.

• Pharmacogenomics is a branch of pharmacology dealing with genetic variation on a medication response in an individual patient to discover medication compatibility, efficacy or toxicity.

• Analysis of genetic factors are still being discovered; however, this growing field may change the way medications are being prescribed for diabetes. This analysis investigated if pharmacogenetics is a useful tool for prescribing diabetic medications to T2DM patients. …

Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection Antibiotic Prophylaxis Treatment Compared With Alternative Treatment Options, Heather Watkins

Physician Assistant Scholarly Project Posters

• Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal Infection, known as PANDAS, is a clinical diagnosis made after a child develops Obsessive Compulsive Disorder and/or ticks after a Streptococcal Pharyngitis. Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal Infection is diagnosed in children 3 years of age until 14 years of age. The purpose of this study is to determine if antibiotics versus selective serotonin reuptake inhibitor with cognitive behavior therapy versus prophylaxis with antibiotics should be used in the treatment of children who develops PANDAS. The review of literature will explore studies that compare current treatment options with new research …

The Da Vinci Robotic Surgical Systems In Atrial Septal Defect Repair, Coronary Artery Bypass Graft And Mitral Valve Repair, Randy Yergenson

Physician Assistant Scholarly Project Posters

Historically, these cardiac interventions have been performed using partial or complete open sternotomy.
1. Coronary artery bypass grafting (CABG)
2. Atrial septal defect (ASD) repair,
3. Mitral valve repair and/or replacement

In 2000, the Federal Food and Drug Administration approved the use of the da Vinci Robotic Surgical System. Less invasive surgical option.

Avoiding Extinction, Preserving Culture: Sustainable, Sovereignty-Centered Tribal Citizenship Requirements, Michael D. Oeser

North Dakota Law Review

No abstract provided.

Twenty Years Later: Was It A Success? Revisiting The Unification Of Trial Courts In North Dakota, Kathleen M. Johnson, Jared Wall

North Dakota Law Review

No abstract provided.

Artificial Magnetic Conductor Integrated Textile Monopole Antenna, Ala Alemaryeen

Theses and Dissertations

Wearable antenna is a fast growing field in application-oriented research, which introduced a new generation of garments capable of monitoring wear health, as well as environmental states. This thesis is concerned with the design and fabrication of a compact textile wearable antenna at operating frequency within the Industrial, Scientific and Medical (ISM) band, intended for integration into a flight jacket of the astronaut inside the habitat. The antenna is integrated with artificial material known as High Impedance Surface (HIS) for performance enhancement. The purpose of the system is to constantly monitor vital signals of the astronauts.

The entire design cycle …

The Effects Of Income Inequality On Society, Jessica Lee Clark

Theses and Dissertations

This study is an examination of the relationship between income inequality and numerous indicators that capture the physical health of the citizens, additionally controlling for numerous other confounding factors. The analysis contributes to the literature by examining this relationship at a more disaggregated level within the Unites States than previous studies. This approach may help us to explore any impacts of income inequality on health that are lost in aggregation. The analysis also includes the most recent recession and adds to the literature the impact of inequality on health during a period of economic crisis. Results suggest that there is …

Alpha1a Adrenergic Receptor Influences On Adult Neurogenesis, Cell Fate, Mood, Learning, Memory, Lifespan, And Cancer Incidence, Katie Collette

Theses and Dissertations

Norepinephrine is a catecholamine neurotransmitter that signals through the adrenergic receptors (ARs), α1, α2, and β, each with three subtypes. There is little research on the function of α1AR subtypes, α1A- and α1BARs, in the brain. By using α1AR agonists, antagonists, and transgenic activation there appears to be a role for the subtypes in learning, memory, mood, adult neurogenesis, and cancer.

α1AAR activation enhances learning and memory in the adult mouse. In the current study, we used α1A- or α1BAR knockout mice (α1AAR or α1BAR-KO mice) and behavioral testing to examine learning, memory, depression, and anxiety. We found that KO …

Ixodes Scapularis In North Dakota: Phenology, Population Genetics, And Local Host Reservoir Competency In An Emerging Vector Population, Michael Dougherty

Theses and Dissertations

Tick surveillance in eastern North Dakota has revealed the presence of established I. scapularis populations in fragmented forest habitats previously regarded as unsuitable for this species. Understanding I. scapularis phenology, the reservoir competency of local vertebrate hosts, and population structure of blacklegged ticks in this region is essential to determining potential human risk of Lyme disease. Tick surveys were conducted throughout North Dakota by flagging and small mammal trapping. 1,701 ticks were collected, including 297 I. scapularis exhibiting a relatively low Borrelia burgdorferi infection rate (ca. 3-5%). Seasonal abundance varied greatly among life stages, with adult I. scapularis being most …

Digital Games For 21st Century Learning: Teacher Librarians' Beliefs And Practices, Amanda Hovious

Theses and Dissertations

Digital games as tools for learning in K–12 have been a topic of intense discussion over the last 15 years. One area of focus has been on the integration of commercial off-the-shelf games in lesson plans. A predictive factor for the adoption and integration of digital games is the attitudes or readiness of teachers. Yet, while many studies have examined this with teachers themselves, teacher librarians (TLs) have largely been ignored, despite the key role they play in education and technology adoption in schools. This study attempted to determine TLs’ beliefs and practices about digital games as 21st century learning …

Teacher Performance Assessments: Exploring Student Perspectives Of The Edtpa, Teri Jo Langlie

Theses and Dissertations

At least 34 states require teacher candidates to complete a comprehensive teacher performance assessment (edTPA) during their student teaching experience. Teacher candidates are assigned the edTPA during this critical time in their preparation. One state--Minnesota--uses the edTPA portfolio exclusively for teacher preparation program approval. Teacher candidates in Minnesota thus devote considerable effort, during a critical time in their teacher preparation program, in the completion of an assessment where the results do not affect their ability to obtain a teaching license. This study explored the impact of the edTPA's timing and perception of personal benefit on the level of effort teacher …

Secondary Social Studies Teachers’ Perceptions Of Special Education, Kelli Ann Odden

Theses and Dissertations

Through educational reform and federal mandates, general and special education teachers’ responsibilities are designed to intersect. Focusing on secondary social studies teachers, the purpose of this qualitative study was to understand the teachers’ perceptions of special education and how this influences the implementation of special education services in the classroom. From data collected through interviews and analyzed through Moustakas’ phenomenological design, two textural themes emerged (expertise and communication) in addition to three structural themes (placement, Individual Education Plan (IEP)-Reader’s Digest Version, and time). Findings indicate that social studies teachers appreciated the role of special education, but their perception was focused …

The N-Terminus Of Type Iii Secretion Needle Protein Yscf From Yersinia Pestis Functions To Modulate Innate Immune Responses, Patrick Osei-Owusu

Theses and Dissertations

The type III secretion system is employed by many pathogens, including the genera Yersinia, Shigella, Pseudomonas, and Salmonella, to deliver effector proteins into eukaryotic cells. The injectisome needle is formed by the polymerization of a single protein, e.g., YscF (Yersinia pestis), PscF (Pseudomonas aeruginosa), PrgI (Salmonella enterica SPI-1), SsaG (Salmonella enterica SPI-2), or MxiH (Shigella flexneri). In this study, we demonstrated that the N termini of some needle proteins, particularly the N terminus of YscF from Yersinia pestis, influences host immune responses. The N termini of several needle proteins were truncated and tested for the ability to induce inflammatory responses …

Changing Bike Mode Share Between Time Periods For Suffolk County, Ma, David Wiosna

Theses and Dissertations

This thesis looks at the impact of new bikeways on the rate of bicycle commuting among census tracts in the city of Boston, MA. Data from 2000 and averages from 2009-2013 are compared. Bikeways are negligible in the year 2000, but many were built after implementation of new policy in 2007. Data for 2009-2013 is interpolated into a common zonal scheme using 2000 census tract boundaries. Regression analysis is performed on socio-demographic and new bikeway variables. Results indicate that new bikeways are likely not cause of greater bike mode share in city of Boston.

Marine Boundary Layer Cloud And Drizzle Properties Over Arm Azores Site, Peng Wu

Theses and Dissertations

In this study, a new method has been developed to retrieve the marine boundary layer (MBL) cloud microphysical properties, which provides a complete diurnal variation of MBL cloud properties for 19-month dataset at the Azores. All nighttime monthly means of cloud liquid water path (LWP) exceed their daytime counterparts with an annual mean LWP of 140 g m-2, which is ~30.9 g m-2 larger than the daytime mean. The seasonal and diurnal variations of cloud LWC and optical depth basically follow the variation of LWP. There are, however, no significant day-night differences and diurnal variations in cloud-droplet effective radius (re) …

Development Of Molecular Biosensors And Multifunctional Graphene-Based Nanomaterials, Xu Wu

Theses and Dissertations

In the first project, a simple, rapid, and reversible fluorescent DNA INHIBIT logic gate has been developed for sensing mercury (Hg2+) and iodide (I-) ions based on a molecular beacon (MB). In this logic gate, a mercury ion was introduced as the first input into the MB logic gate system to assist in the hybridization of the MB with an assistant DNA probe through the thymine–Hg2+–thymine interaction, which eventually restored the fluorescence of MB as the output. With this signal-on process, mercury ions can be detected with a limit of detection as low as 7.9 nM. Furthermore, when iodide ions …

The Role Of Atg7 In The Host Defense Against Bacterial Infection, Yan Ye

Theses and Dissertations

Klebsiella pneumoniae (Kp) is a Gram-negative bacterium that can cause serious infections in humans. Autophagy-related gene 7 (Atg7) has been involved in certain bacterial infections; however, the role of Atg7 in macrophage-mediated immunity against Kp infection has not been elucidated. To gain a better understanding of Kp-host interaction which may provide insight into the design of novel and effective therapeutics for this infection, we set out to investigate the potential immune role for autophagy in Kp infection in vitro and in vivo. We found that Atg7 was significantly induced in murine alveolar macrophages (MH-S) upon Kp infection, indicating that Atg7 …

The Evolution Of Outer Space Law: An Economic Analysis Of Rule Formation, Christopher Michael Hearsey

Theses and Dissertations

This thesis comprises a study of those socio-economic dynamics that establish and influence the existence, distribution, and evolution of rules for the outer space environment. In particular, this thesis analyzes how the initial State practice of launching objects into outer space led to the genesis of rules for the outer space environment. The presentation of this thesis includes an introduction, a methodology section, three studies, and a conclusion. The first study considers the formation of initial rules for the outer space environment as a consequence of State practice using historical analysis and game theory. The second study considers how States …

Prevalence, Statistical Trends And Phylogenetics Of Blood Parasites (Haemosporidia: Haemoproteus, Plasmodium And Leucocytozoon) In Songbird Passerines From Grasslands Of Northwest Minnesota, Danielle Kvasager

Theses and Dissertations

Passerine birds that primarily use grassland habitats are rarely the focus of a parasite study. With many rapidly declining bird populations that breed at even faster decreasing grassland habitat, it is important to know the potential risks to the birds posed by blood parasites. During the breeding seasons of 2009-2011, 150 samples from 148 individual birds (fourteen species) were collected from five grassland sites in northwest Minnesota, USA and surveyed for blood parasites using microscopy and molecular methods. Eighty-five (56.67%) of the 150 samples were infected with at least one of three haemosporidian genera: Haemoproteus, Plasmodium and Leucocytozoon. Seventy (46.67%) …

Empire, Tradition, And Ideologies: The Anti-Imperialist League Of The United States 1898-1920, Andrew Faber Larson

Theses and Dissertations

The American Anti-Imperialist League began in Boston in 1898 and shortly thereafter worked to consolidate other anti-imperialist organizations in an attempt to prevent the United States from creating its first overseas empire. The League was united in its opposition to empire yet its organizational structure prevented it from becoming a truly national, and thus unified, special interest group. Early on in 1898, the League’s unity came from its appeals to preserve the traditional American foreign policies of George Washington, ideas surrounding isolation from the affairs of Europe and its focus upon the Americas in particular. The League also advocated for …

Regulation Of Vectorial Active Transport In Human Proximal Tubule Cells By Mt-3: The Role Of The C-Terminal Domain On E-And N-Cadherin Expression And The Confirmation Of Protein-Protein Interactions, Andrea Marie Nore

Theses and Dissertations

The proximal tubule of the kidney is particularly susceptible to toxicant-induced damage and cell cultures of human proximal tubule cells are widely utilized to study the role of epithelial-mesenchymal transition (EMT) in renal disease. Cadmium is a toxic metal ion that is known to produce renal tubular necrosis and accumulate in the proximal tubule. This metal binds to a family of cysteine rich metal binding proteins known as metallothioneins (MT) that are found in abundance in the kidney. Previous studies from our laboratory have shown that the third isoform of metallothionein (MT-3) is expressed in the epithelial cells of the …

The Relationship Between A Series Of Vitamin D Levels And A Blood Glucose Level In Pregnant Women In The Upper Midwest, Jeanine Louise Senti

Theses and Dissertations

Hyperglycemia during pregnancy is associated with adverse outcomes for both mother and offspring. In order to facilitate glucose delivery to the fetus, insulin resistance increases as gestation progresses which results in hyperglycemia if the mother’s body is unable to compensate by producing adequate insulin in response to these changes in glucose metabolism. Evidence suggests that calcidiol (vitamin D) influences insulin sensitivity and glucose metabolism in the non-pregnant population yet there are inconsistent findings on the effects of calcidiol on maternal glucose levels during pregnancy. A secondary analysis was completed on a de-identified data set. The original prospective study included a …

New Employment In Post-1990s Algeria: Are Rapidly Added Jobs Positively Affecting Economic Recovery?, Adrian Troyer

Theses and Dissertations

An apparent labor recovery success story since the turn of the century has been the reduction of Algeria’s post-war high unemployment rate. However, there are reasons to doubt the effectiveness of government programs that induced the adding of large totals of short-term, low-paying jobs, particularly following new labor legislation in December 2004. By nature, this added employment has not been genuine permanent work for the educated that might be associated with labor productivity and economic growth. We use dynamic panel models with Arellano-Bond estimators by the generalized method of moments to suggest that Algeria has not exhibited the expected positive …

Development And Validation Of The Scale Of Atheist Microaggressions (Sam), Louis Anthony Pagano

Theses and Dissertations

Atheists in the United States are a gradually growing population representing an increasingly important percentage of the population (Pew Research Survey, 2012). The United States, a largely religious country, and its citizens cultivate many negative positions and principles towards Atheists that progress into discriminatory actions of varying degrees. To date there have been limited attempts to assess how Atheists experience and perceive discrimination in a generally religious country that does not trust Atheists or feel that they fit with the paradigms of what it means to be an American. The purpose of this dissertation project was to create an instrument …

Electromyographic Analysis Of Hip Muscle Activity During Stair Climbing: A Pilot Study, Alexander Barney, Mary Loken, Paige Torgerson, Lyndsey Wunderlich

Physical Therapy Scholarly Projects

Introduction: Prior to this study, little evidence exists for a quality predictive tool correlating maximum velocity contraction (MVC) strength of the hip abductor muscles to walking and stair climbing (ascending/descending, side-stepping) ability. Stair climbing is an important functional activity of daily living and as physical therapists we are involved in training clients to ascend/descend stairs safely, which can be difficult for clients with hip abductor muscle weakness. Subjects: Eleven females voluntarily agreed to participate in this study. All participants were under the age of 30 years old, nonpregnant, physical therapy students without a current musculoskeletal injury. Methods: …