Digital Commons Network^™

Analysis Of Pre-Procedural Intranasal Anxiolytic Use In The Emergency Treatment Of Pediatric Laceration Repair, Mackenzie Weis

Physician Assistant Scholarly Project Papers

Pediatric laceration repair is a common, yet anxiety-inducing procedure for patients who must undergo them, with limited research analyzing the different types of pre-procedural anxiolytic medications. The purpose of this research and literature review was to analyze two different, but commonly used intranasal anxiolytics, dexmedetomidine and midazolam, and to compare the efficacy, adverse effects, and overall pediatric anxiety and parental satisfaction. Only articles including clinical trials and pediatric participants were included. A combination of keywords and MeSH phrases included, but were not limited to “pediatric”, “laceration repair”, “anxiolytic”, “administration intranasal”, “intranasal midazolam”, “intranasal dexmedetomidine”, and “parent satisfaction” were used to …

Efficacy Of Probiotic Use In Allergic Rhinitis And Asthma In Children And Adolescents, Mary Janke

Physician Assistant Scholarly Project Posters

• Allergic rhinitis and asthma are chronic conditions affecting children and adults, often impairing quality of life. • Recent studies have explored the efficacy of probiotics as a potential adjunct therapy to alleviate AR symptoms, decrease asthma severity, and reduce the dependence on these conventional treatments. • Studies discovered using Embase and PubMed with key terms including probiotics, asthma, allergic rhinitis, seasonal allergic rhinitis, children, child, and adolescent were used for this review. • These studies suggest probiotics may improve pulmonary function and AR symptoms in children with allergic rhinitis and asthma. • Further research is needed to refine dosage, …

Safety And Efficacy Of Combined Glucosamine And Chondroitin Supplementation In Osteoarthritis, Klayton Johnson

Physician Assistant Scholarly Project Papers

According to the CDC, over 30 million adults in the United States have osteoarthritis, many of whom experience pain, stiffness, and swelling that hinder daily activities. Typical treatment consists of nonsteroidal anti-inflammatory drugs, which are associated with gastrointestinal, renal, and cardiovascular risks. This literature review examines key research on glucosamine and chondroitin supplementation to provide a comprehensive understanding of its impact on adults with osteoarthritis. A literature search was conducted using the electronic databases PubMed, Embase, and Google Scholar. Keywords and MeSH terms were used to identify studies discussing the combination of glucosamine and chondroitin as a potential alternative, effective, …

Disparities In Guideline-Directed Medical Therapies In Rural And Underserved Heart Failure Patients, Shawn Mcclaughry

Physician Assistant Scholarly Project Papers

Heart failure with reduced ejection fraction (HFrEF) continues to be a substantial public health challenge, thus optimal management through guideline-directed medical therapy (GDMT) continues to be vital. Evolving GDMT has established four pillars of first-line optimal treatment with expeditious and maximized titration of established target dosing of pillar medications. GDMT has been shown to decrease mortality among HF patients. Although continuing advancements in treatment efficacy prevail, studies demonstrate that vulnerable populations, particularly rural, Black and Hispanic individuals, exhibit significantly lower rates of GDMT optimization, leading to increased hospitalization and mortality. This literature review evaluates disparities in GDMT implementation among urban, …

Improving Fertility In Women With Endometriosis, Todd Marchant

Physician Assistant Scholarly Project Posters

• Endometriosis is a common condition in women and has a strong association with infertility. The purpose of this systematic literature review is to determine the efficacy of hormonal therapy as compared to surgical therapy before assisted reproductive therapy (ART) on endometriosis-related infertility. • The electronic databases PubMed and Embase were searched from June 23, 2024, to January 4, 2025. Keywords used were associated with fertility, IVF, and endometriosis. Article selection was limited to research published after the year 2000 with a preference for randomized control trials (RCTs), although one pilot study and one clinical cohort study were also included. …

High Dose Intravenous Vitamin C In Breast Cancer Therapy, Brianna Solis

Physician Assistant Scholarly Project Posters

• Breast cancer remains one of the most prevalent malignancies globally, emphasizing the need for adjunct therapies to enhance treatment outcomes and improve patient care. Current breast cancer treatments, including radiation, chemotherapy, and surgery, are often effective but are frequently associated with significant side effects that can impact treatment tolerance and quality of life. This review examines the effectiveness of high-dose intravenous (IV) vitamin C as an adjunct therapy in breast cancer treatment, specifically its potential to reduce tumor size and alleviate chemotherapy-associated side effects. A literature review was performed using electronic databases PubMed and Google Scholar from April to …

The Utility Of Pharmacogenetic Testing In Pain Reduction, Jacqueline Mattson

Physician Assistant Scholarly Project Posters

Chronic pain is one of the most common reasons patients seek care from primary care providers. Individualized responses to pain medications make pain difficult to treat effectively. The purpose of this literature review is to examine the utility of pharmacogenetic-guided opioid therapy across chronic, postoperative, and cancer-related pain. A structured search of PubMed and Embase yielded 151 articles, of which nine met the inclusion criteria. Findings suggest that pharmacogenetic-guided therapy may reduce opioid dosages and enhance pain control, particularly in chronic pain settings. Evidence for postoperative pain outcomes was mixed, and studies on cancer-related pain emphasized the role of genetic …

Efficacy Of Stem Cell Therapy Versus Standard Drug Therapy In Adults With Heart Failure, Evie Reynolds

Physician Assistant Scholarly Project Papers

Myocardial infarction (MI) or other damage to the heart tissue may result in ischemia, and because cardiomyocytes have limited regenerative capacity, this often leads to the development of heart failure (HF). Typical symptoms of HF include dyspnea, edema, cough, fatigue, and chest pain, which arises from fluid overload and congestion. Current medical treatments focus on alleviating these symptoms through loop diuretics, which reduce fluid accumulation but do not treat the underlying ischemic damage. Recent studies have shifted focus towards stem cell therapy, which have shown potential to differentiate into cardiomyocytes and regenerate ischemic heart tissue. A comprehensive search of databases …

Efficacy Of Prediabetes Management Options For Lowering Cardiovascular Risk, Cassidy Mindeman

Physician Assistant Scholarly Project Papers

Around 86 million people in the United States are diagnosed with prediabetes, a metabolic syndrome characterized by insulin resistance and inflammation. The inflammatory nature of the disease increases a patient's cardiovascular risk. Common treatment options include metformin and lifestyle intervention – primarily exercise and diet plans. However, there is no standard medical recommendation for lowering cardiovascular risk. The purpose of this literature review is to determine which treatment options, including the combination of lifestyle and intervention, best lower cardiovascular risk and better detail the effect of prediabetes on cardiovascular risk. Electronic databases PubMed and Embase were utilized and 12 studies …

Cannabidiol: Anxiety Relief Or Fool’S Gold?, Jase Bakker

Physician Assistant Scholarly Project Posters

This literature review evaluates the efficacy of cannabidiol (CBD) as a treatment for anxiety in adults and adolescents. A systematic search of three databases (PubMed, PsychInfo, EMBASE) yielded 775 articles, with 11 randomized controlled trials meeting inclusion criteria. These studies utilized diverse methodologies, including public speaking tests, neuroimaging, and physiological measures, to assess CBD's effects compared to placebo. • Findings indicate mixed results: moderate doses (300 mg) show promise in social anxiety, while other trials report inconsistent outcomes due to dosing and bioavailability challenges. Limitations such as small sample sizes and variable methodologies hinder definitive conclusions. Further research is needed …

The Impact Of Structured Feedback And Evaluation Systems On Clinical Preceptor Performance And Student Satisfaction In Medical Laboratory Science Programs, Kyleen Newman, Mary Coleman, Heather Langerud

Medical Laboratory Science Independent Study Projects

Medical Laboratory Science (MLS) students' education heavily relies on clinical practicum experiences to bridge the gap between theory and practice. Knowledgeable clinical preceptors are vital for engaging and inspiring learning and enabling students to interact within authentic clinical environments involving laboratory peers, patients, and healthcare providers. This literature review explores the impact of implementing a structured feedback and evaluation system for clinical preceptors in medical laboratory science (MLS) programs, highlighting its influence on student satisfaction and preceptor performance. The databases utilized for this literature review include PubMed and CINAHL. Due to a profound lack of published literature available additional healthcare …

Benefits Of Succession Planning In Medical Laboratories, Christina Jones, Samantha Peterson, Robert Porter

Medical Laboratory Science Independent Study Projects

This discussion examines the potential impact of implementing a succession plan in the laboratory to reduce survey deficiencies. It highlights the importance of understanding the determinants of quality in the lab, addressing staffing shortages and turnover, and the role of succession plans in improving workplace quality. Quality encompasses various aspects from quality control to quality management. Accreditation and inspection processes, such as those required by the Clinical Laboratory Improvement Amendments of 1988 (CLIA ‘88), play a crucial role in ensuring quality laboratories.

However, frequent turnover, including leadership changes, poses challenges to maintaining quality. The laboratory workforce faces high turnover rates …

Quality Improvement Of Technical Training Program For Mls/Mlt Hires, Bethany E. Johnson, Allison Waswick, Heather Langerud

Medical Laboratory Science Independent Study Projects

As a pinnacle of clinical support services, the laboratory department plays a crucial role in diagnostic medicine. Given the highly technical and regulated nature of clinical laboratories, training, education and competency are important. Meta analysis was conducted to review several important aspects of a quality training program. These aspects include barriers to effective training and competency programs, laboratory regulatory requirements, current processes for clinical training, continuing education and good laboratory practices. Research into these aspects will help learn how to improve the overall initial training and competency for new laboratory professionals. There is a need to reduce patient safety errors …

The Impact Of Structured Feedback And Evaluation Systems On Clinical Preceptor Performance And Student Satisfaction In Medical Laboratory Science Programs, Kyleen Newman, Mary Coleman, Heather Langerud

Medical Laboratory Science Independent Study Projects

Medical Laboratory Science (MLS) students' education heavily relies on clinical practicum experiences to bridge the gap between theory and practice. Knowledgeable clinical preceptors are vital for engaging and inspiring learning and enabling students to interact within authentic clinical environments involving laboratory peers, patients, and healthcare providers. This literature review explores the impact of implementing a structured feedback and evaluation system for clinical preceptors in medical laboratory science (MLS) programs, highlighting its influence on student satisfaction and preceptor performance. The databases utilized for this literature review include PubMed and CINAHL. Due to a profound lack of published literature available additional healthcare …

Treatment Of Adult Adhd, Megan Bryn

Physician Assistant Scholarly Project Papers

Attention-deficit/hyperactivity disorder (ADHD) is commonly considered a childhood disorder diagnosed and treated in adolescents. Options for management of adverse symptoms associated with ADHD are primarily pharmaceutical therapy, most commonly stimulant therapy. There has been significantly less research regarding the management of adult ADHD in contrast with children diagnosed with ADHD. The purpose of this systematic literature review is to determine in adults with ADHD if nonpharmaceutical therapies including cognitive behavioral therapy, psychoeducation, and mindfulness behavioral therapy are effective alternatives to pharmaceutical therapy. Current research provides significant data supporting the use of pharmaceutical therapy for the management of adult ADHD, as …

Cannabidiol: Anxiety Relief Or Fool’S Gold?, Jase Bakker

Physician Assistant Scholarly Project Papers

Anxiety disorders affect millions of Americans each year and the interest in alternative therapies is growing. The purpose of this literature review is to evaluate the efficacy of cannabidiol (CBD) as a therapeutic intervention for anxiety in adults and adolescents. In this review, three databases including PubMed, PsychInfo, and EMBASE were searched using key terms. Out of 775 articles initially identified, 11 met the inclusion criteria, focusing exclusively on randomized controlled trials (RCTs) investigating CBD's effects compared to placebo in human subjects. Trials prior to 2011 were excluded, along with subjects who had psychiatric comorbidities or adjunctive therapies, were less …

Efficacy Of Parent-Child Interaction Therapy For The Treatment Of Children With Generalized Anxiety Disorder, Sarah Herman

Physician Assistant Scholarly Project Papers

Generalized Anxiety Disorder (GAD) is a prevalent mental health condition in children, characterized by persistent and excessive worry that interferes with daily functioning and overall quality of life. Anxiety disorders are considered the most common psychiatric disorders among children. The trajectory of untreated anxiety in early life can result in more resistant and chronic presentations in the future, complicating both therapeutic engagement and outcomes. Parent- Child Interaction Therapy (PCIT) has emerged as a potential alternative treatment for children displaying anxiety symptoms, particularly those diagnosed with GAD. This literature review endeavors to assess the effectiveness of Parent-Child Interaction Therapy as an …

Telemedicine Vs. Clinic Monitoring: Adherence In Hypertension Management, Kimberly Hinkle

Physician Assistant Scholarly Project Papers

Hypertension affects over a billion adults worldwide and remains a major contributor to cardiovascular disease and mortality. Effective management requires consistent medication adherence and lifestyle changes, but barriers such as limited healthcare access often hinder follow-up. This literature review evaluates the efficacy of home blood pressure (BP) monitoring combined with telemedicine follow-up in improving medication adherence among adults with hypertension compared to traditional clinic-based follow-ups. A literature review was conducted, resulting in the inclusion of six studies that examined interventions such as telepharmacy, remote BP monitoring, bidirectional text support, and mobile health applications. Results demonstrated that telemedicine significantly enhances BP …

Efficacy And Safety Of P2y12 Inhibitor Monotherapy Versus Dual Antiplatelet Therapy In Patients Who Have Received Drug Eluting Stents Post-Acute Coronary Syndrome, Jordan Saxerud

Physician Assistant Scholarly Project Papers

According to the American Heart Association, there are approximately 1.4 million people who are hospitalized and 700,000 deaths attributed to acute coronary syndrome on a yearly basis in the United States. It is standard therapy for patients to receive a drug eluting stent and dual antiplatelet therapy to prevent occlusion of the stent and other coronary arteries. Dual antiplatelet therapy typically consists of aspirin and a P2Y12 inhibitor. Dual antiplatelet leads to an increased risk of bleeding. This literature review aims to investigate if earlier initiation of P2Y12 inhibitor monotherapy decreases the risk of bleeding while maintaining adequate protection against …

Pharmacological Treatment Options For Nonalcoholic Steatohepatitis: Resmetirom Vs Glp- 1 Receptor Agonists, Debbie Zabel

Physician Assistant Scholarly Project Papers

The incidence of nonalcoholic steatohepatitis (NASH) is continually rising and has now emerged as one of the leading causes of cirrhosis requiring liver transplantation (Maurice et al., 2018). Until recently, the management of this disease has been limited to lifestyle modification and treatment of comorbid risk factors. In March 2024, the FDA approved resmetirom, the first and only medication for the treatment of this condition. The purpose of this literature review is to investigate the efficacy of GLP-1 and dual GLP/GIP or GLP/GCGR receptor agonist medications for the reduction of liver fat content in comparison to resmetirom. A literature review …

Oral Nsaids Vs. Topical Anesthetics For Pain Management During Iud Insertion: A More Effective Standard Of Care, Hannah Ulven

Physician Assistant Scholarly Project Papers

An intrauterine device (IUD) is a highly effective, long-acting reversible contraceptive (LARC) option for patients from menarche until menopause. Despite its effectiveness, pain associated with IUD insertion remains a significant barrier to IUD insertion use. Unrelieved pain during the procedure may lead to serious complications, such as vasovagal shock and cardiac arrhythmias, which may negatively impact patient experience and adherence to contraceptive methods. To this day, there is no standard, effective recommendation for pain management during IUD insertion. This literature review aims to compare the efficacy of oral NSAIDs, which are commonly used due to their nonspecific analgesic property, and …

Benefits Of Succession Planning In Medical Laboratories, Christina Jones, Samantha Peterson, Robert Porter

Medical Laboratory Science Independent Study Projects

This discussion examines the potential impact of implementing a succession plan in the laboratory to reduce survey deficiencies. It highlights the importance of understanding the determinants of quality in the lab, addressing staffing shortages and turnover, and the role of succession plans in improving workplace quality. Quality encompasses various aspects from quality control to quality management. Accreditation and inspection processes, such as those required by the Clinical Laboratory Improvement Amendments of 1988 (CLIA ‘88), play a crucial role in ensuring quality laboratories.

However, frequent turnover, including leadership changes, poses challenges to maintaining quality. The laboratory workforce faces high turnover rates …

Efficacy Of Menstrual Cycle Awareness In The Identification Of Premenstrual Dysphoric Disorder, Rachel Brothers

Physician Assistant Scholarly Project Posters

Premenstrual Dysphoric Disorder (PMDD) impacts 3-8% of women of reproductive age globally. • PMDD is characterized by psychological and physical symptoms that occur in the week before menses. • This literature review aims to investigate the efficacy of menstrual awareness in the identification of women who meet criteria for PMDD versus the commonly used PHQ-9 depression screening tool. • Studies were all peer-reviewed and included randomized control trials and cross-sectional studies. • Findings of this review suggest that while the PHQ-9 may be a sufficient screening tool for identifying severe symptoms of PMDD, it would need to be administered in …

Effects Of Nsaids On Bone Healing Time In Orthopedic Patients, Alayne Brekke

Physician Assistant Scholarly Project Posters

Use of NSAIDs in adults recovering from orthopedic injury or surgery has been found to be largely inconclusive when it comes to determining significance in delay of bone healing. The purpose of this review is to determine whether use of NSAIDs is detrimental to bone healing after orthopedic injury or surgery. A literature review was performed using electronic databases PubMed and SportsDiscus from May to July of 2024. There were fifteen studies that met final inclusion criteria. Research overwhelmingly acknowledged that selective COX-2 inhibitors are not recommended in a post injury or post operative state. However, when it comes to …

Efficacy Of Low-Dose Naltrexone Compared To Gabapentinoids In Fibromyalgia, Dillon Boen

Physician Assistant Scholarly Project Posters

• . This literature review evaluates the efficacy, safety, and tolerability of low-dose naltrexone (LDN) compared to gabapentinoids, including gabapentin and pregabalin, in the management of fibromyalgia symptoms. • Pilot studies on LDN highlighted its potential anti-inflammatory benefits and its ability to reduce pain severity and improve quality of life, with minimal side effects. Gabapentinoids demonstrated dose-dependent efficacy in pain reduction and sleep quality improvement but had adverse effects, including dizziness and sedation, which may limit their tolerability. • The findings underscore the need for more extensive, long-term research to confirm the therapeutic potential of LDN and refine the clinical …

Efficacy Of Once Weekly Insulin And Lowering Hba1ccarly, Carly Gilbertson

Physician Assistant Scholarly Project Posters

• The purpose of this literature review is to determine if patients with diabetes mellitus taking once weekly insulin injections compared to once daily insulin injections offer the same, or better, effectiveness at lowering their HbA1c. This is critical in the management and progression of the disease. • The electronic databases PubMed, Clinical Key and Embase were searched and there was 92 articles found. Inclusion criteria included articles published within the past 5 years, randomized clinical trials and meta-analysis. Seven studies met final criteria for inclusion. Current research provides data supporting the use of once weekly insulin is just as …

Outcomes Of Blood Flow Restriction Training In Comparison To Traditional Strength Training In Patients Undergoing Acl Reconstruction, Alex Lange

Physician Assistant Scholarly Project Posters

• ACL injuries are common in athletes and active individuals with a significant impact on knee stability, function and strength. The ACL is crucial in activities involving jumping, cutting, and pivoting which places the ligament under increased stress, increasing the risk of rupture. ACLR surgery is often necessary, especially in younger, active individuals, to restore knee stability, function and strength • The purpose of this literature review is to explore the effectiveness of BFR-RT as an alternative or adjuvant to traditional rehabilitation techniques following ACLR surgery. The electronic databases PubMed and Embase were searched, and the seven studies chosen for …

Disparities In Gdmt In Rural And Underserved Hfref Patients, Shawn Mcclaughry

Physician Assistant Scholarly Project Posters

Heart failure with reduced ejection fraction (HFrEF) continues to be a substantial public health challenge, thus optimal management through guideline-directed medical therapy (GDMT) continues to be vital. Evolving GDMT has established four pillars of first-line optimal treatment with expeditious and maximized titration of established target dosing of pillar medications. GDMT has been shown to decrease mortality among HF patients. Although continuing advancements in treatment efficacy prevail, studies demonstrate that vulnerable populations, particularly rural, Black and Hispanic individuals, exhibit significantly lower rates of GDMT optimization, leading to increased hospitalization and mortality. This literature review evaluates disparities in GDMT implementation among urban, …

Glp-1 Vs Gastric Bypass In Treating Obesity And Type 2 Diabetes, Abir Oliver

Physician Assistant Scholarly Project Posters

Obesity and type 2 diabetes are interconnected global health challenges, contributing significantly to morbidity, mortality, and healthcare costs. This literature review compares the efficacy, safety, and applicability of glucagon-like peptide-1 (GLP-1) receptor agonists and bariatric surgery as treatment options. A literature search with defined inclusion and exclusion criteria was conducted using PubMed and EBSCOhost from May to July 2024, resulting in 14 randomized controlled trials for evaluation. This literature review supports the efficacy of both GLP-1 receptor agonists, particularly semaglutide, and bariatric surgery as effective interventions for weight loss and glycemic control in patients with obesity and type 2 diabetes. …

Efficacy Of Stem Cell Therapy Versus Standard Drug Therapy In Adults With Heart Failure, Evie Reynolds

Physician Assistant Scholarly Project Posters

Myocardial infarction (MI) or other damage to the heart tissue may result in ischemia, and because cardiomyocytes have limited regenerative capacity, this often leads to the development of heart failure (HF). Typical symptoms of HF include dyspnea, edema, cough, fatigue, and chest pain, which arises from fluid overload and congestion. Current medical treatments focus on alleviating these symptoms through loop diuretics, which reduce fluid accumulation but do not treat the underlying ischemic damage. Recent studies have shifted focus towards stem cell therapy, which have shown potential to differentiate into cardiomyocytes and regenerate ischemic heart tissue. A comprehensive search of databases …