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Managing For Radical Ecosystem Change: Applying The Resist-Accept-Direct (Rad) Framework, Abigail J. Lynch, Laura M. Thompson, Erik A. Beever, David N. Cole, Augustin C. Engman, Cat Hawkins Hoffman, Stephen T. Jackson, Trevor J. Krabbenhoft, David J. Lawrence, Douglas Limpinsel, Robert T. Magill, Tracy A. Melvin, John M. Morton, Robert Newman, Jay O. Peterson, Mark T. Porath, Frank J. Rahel, Gregor W. Schuurman, Suresh A. Sethi, Jennifer L. Wilkening Jul 2021

Managing For Radical Ecosystem Change: Applying The Resist-Accept-Direct (Rad) Framework, Abigail J. Lynch, Laura M. Thompson, Erik A. Beever, David N. Cole, Augustin C. Engman, Cat Hawkins Hoffman, Stephen T. Jackson, Trevor J. Krabbenhoft, David J. Lawrence, Douglas Limpinsel, Robert T. Magill, Tracy A. Melvin, John M. Morton, Robert Newman, Jay O. Peterson, Mark T. Porath, Frank J. Rahel, Gregor W. Schuurman, Suresh A. Sethi, Jennifer L. Wilkening

Biology Faculty Publications

Ecosystem transformation involves the emergence of persistent ecological or social–ecological systems that diverge, dramatically and irreversibly, from prior ecosystem structure and function. Such transformations are occurring at increasing rates across the planet in response to changes in climate, land use, and other factors. Consequently, a dynamic view of ecosystem processes that accommodates rapid, irreversible change will be critical for effectively conserving fish, wildlife, and other natural resources, and maintaining ecosystem services. However, managing ecosystems toward states with novel structure and function is an inherently unpredictable and difficult task. Managers navigating ecosystem transformation can benefit from considering broader objectives, beyond a …


Nanozymes—Hitting The Biosensing “Target”, Yingfen Wu, Diane Darland, Julia Zhao Jul 2021

Nanozymes—Hitting The Biosensing “Target”, Yingfen Wu, Diane Darland, Julia Zhao

Biology Faculty Publications

Nanozymes are a class of artificial enzymes that have dimensions in the nanometer range and can be composed of simple metal and metal oxide nanoparticles, metal nanoclusters, dots (both quantum and carbon), nanotubes, nanowires, or multiple metal-organic frameworks (MOFs). They exhibit excellent catalytic activities with low cost, high operational robustness, and a stable shelf-life. More importantly, they are amenable to modifications that can change their surface structures and increase the range of their applications. There are three main classes of nanozymes including the peroxidase-like, the oxidase-like, and the antioxidant nanozymes. Each of these classes catalyzes a specific group of reactions. …


Completion Design Evolution For Saltwater Disposal Injection Wells In The Bakken Play, Darren D. Schmidt, Jeffrey W. Bader, Ashleigh Day, Mark Bohrer Jul 2021

Completion Design Evolution For Saltwater Disposal Injection Wells In The Bakken Play, Darren D. Schmidt, Jeffrey W. Bader, Ashleigh Day, Mark Bohrer

EERC Publications, Papers, & Presentations

Disposal of produced water is a critical component of unconventional oil development. The significant increase in Bakken production over the past decade in concert with the expansion of saltwater disposal wells geographically, places new demands on the storage reservoir. Development has spurred investigations of the reservoir and well performance.


Stress And Coping During Simulated Evas And Habitat Living, Gloria R. Leon, Travis Nelson, Pablo De Leon Jul 2021

Stress And Coping During Simulated Evas And Habitat Living, Gloria R. Leon, Travis Nelson, Pablo De Leon

Space Studies Faculty Publications

Planning for long duration exploration missions (LDEM) involves both the effectiveness of the extravehicular operations, in particular as it is related to the functioning and comfort of the space suits, and how the crew functions together in accomplishing the objectives of the mission. The University of North Dakota Department of Space Studies has developed a multi-modular Inflatable Lunar/Mars Analog Habitat (ILMAH) and is testing iterations of their NDX-2AT space suit. Five 12-14 day missions, each consisting of 3-4 individuals (Total 13; 11 men, two women) were carried out. Team members independently completed a Daily Rating Form (DRF) each day of …


A Classical Approach To The Traditional Sound Of Serbia As Captured During The Time Of Former Yugoslavia, Galina Dordevic Jul 2021

A Classical Approach To The Traditional Sound Of Serbia As Captured During The Time Of Former Yugoslavia, Galina Dordevic

Theses and Dissertations

This independent study serves as an introduction of the Serbian folk music from the time of former Yugoslavia to classical musicians unfamiliar with its style. It provides research about its characteristics, heritage, and development, as well as the introduction to a few of many folk songs popular to this day. Furthermore, it offers arrangements and an explanation of the arranging process from the perspective of a classical music performer, which can serve as an inspiration and guide to other musicians interested in arranging music, as well as different styles of music.


Interactive Features Of E-Texts’ Effects On Learning: A Systematic Review And Meta-Analysis, Virginia Clinton-Lisell, Ben Seipel, Staci Gilpin, Christine Litzinger Jun 2021

Interactive Features Of E-Texts’ Effects On Learning: A Systematic Review And Meta-Analysis, Virginia Clinton-Lisell, Ben Seipel, Staci Gilpin, Christine Litzinger

Education, Health & Behavior Studies Faculty Publications

E-texts afford interactive features that are not feasible with paper texts. Several studies have been conducted examining interactive features of E-texts, but it is uncertain what the overall effect is or what features may be most useful. The purpose of this study is to systematically review and meta-analysis of the findings comparing reading performance and/or reading times between E-texts with interactive features and control texts (paper or static E-texts). The systematic search of the literature identified 26 independent studies on reading performance. Based on the meta-analysis, interactive features benefited reading performance (g = .66, p < .001). Individual studies with positive effects involved multiple interactive features; however, potential contributions of three types of features (questions with feedback, digital glossaries, and collaborative tools) are discussed. Future directions for examining interactive features experimentally to better understand what features are most helpful for whom are described.


Sdnet2021: Annotated Nde Dataset For Structural Defects, Eberichi Ichi, Sattar Dorafshan Jun 2021

Sdnet2021: Annotated Nde Dataset For Structural Defects, Eberichi Ichi, Sattar Dorafshan

Datasets

SDNET2021 is a uniquely validated annotated dataset for evaluating the condition of concrete bridge decks and benchmarking advanced deep learning models for defects (delamination, cracks, rebar corrosion) detection and bridge deck evaluation. Common structural defects, such as cracks, delamination, spalling, rebar corrosion, etc. are commonly detected using traditional hands-on inspections (visual, destructive, chain dragging, and sounding). These methods are accompanied with limitations such as disruption and closure of traffic, laborious, costly, time consuming and possible inconsistencies and likelihood of errors in field data collection and interpretation. Usually there exists dataset for surface defects from laboratory specimens, but rare validated datasets …


Autonomy In Nurse Education On Advance Health Care Directives, Rachel Wolden May 2021

Autonomy In Nurse Education On Advance Health Care Directives, Rachel Wolden

Nursing Capstones

Advance Health Care Directives (AHCD) are important documents in place as a way for nurses to respect a patient's autonomy in all aspects of their care. When critical ailments or accidents happen, AHCDs can be an important tool to carry out patient wishes. An in-depth literary search was performed to determine the extent of nurse education received on advance directives. Analysis of a plethora of different scholarly articles from nursing students to veteran staff was reviewed. Beliefs, attitudes, and education were researched on AHCDs and comfortability in nursing. Discussion of the importance of advance directive education given to nurses will …


Treatment Of Trichotillomania, Kelsey Schwehr May 2021

Treatment Of Trichotillomania, Kelsey Schwehr

Nursing Capstones

No abstract provided.


Study Title-Based Framing Effects On Reports Of Sexual Violence Factors In College Students, Raeann E. Anderson, Emily M. Carstens Namie, Paige K. Michael, Douglas L. Delahanty May 2021

Study Title-Based Framing Effects On Reports Of Sexual Violence Factors In College Students, Raeann E. Anderson, Emily M. Carstens Namie, Paige K. Michael, Douglas L. Delahanty

Psychology Faculty Publications

Objective: There are many methodological issues in studying sexual violence, including potential framing effects. Framing effects refer to how researchers communicate the purpose of a study to participants, such as, how the study is advertised or explained. The aim of the current study was to investigate if framing effects were associated with differences in participants’ self-reported experiences of sexual violence and related correlates.

Methods: College students (N = 782) were recruited to participate in one of four identical studies that differed in the title: “Questionnaires about Alcohol,” “Questionnaires about Crime,” “Questionnaires about Health,” or “Questionnaires about Sexual Assault.” Participants chose …


Partner Trust Level In Collaborative Demand Forecast Sharing And Its Impact On Supply Chain Profitability, Seong-Hyun Nam May 2021

Partner Trust Level In Collaborative Demand Forecast Sharing And Its Impact On Supply Chain Profitability, Seong-Hyun Nam

School of Entrepreneurship Faculty Publications

Considering trust as a critical factor for successful collaborative demand forecast sharing, this paper studies the dynamic relationship between trust level-based forecasting capability and supply chain profitability. We develop a forecasting coordination model to examine how the enhanced partner trust level can influence the forecasting evolution to improve demand forecasts’ accuracy. We estimate costs and profits from demand forecast sharing under varying trust levels between a buyer and a partner supplier and then determine the optimal level of trust for both parties to create the maximum economic value through collaborative demand forecast sharing. To assess the opportunity costs associated with …


A 70 Year Old Male With Left-Sided Flaccidity Following Right Hemorrhagic Cerebrovascular Accident: A Case Study, Hannah Dekrey May 2021

A 70 Year Old Male With Left-Sided Flaccidity Following Right Hemorrhagic Cerebrovascular Accident: A Case Study, Hannah Dekrey

Physical Therapy Scholarly Projects

Background and Purpose: Cerebrovascular accidents (CVAs) are a common medical issue addressed by physical therapists. This case study examines the effectiveness of one rehabilitation plan in an inpatient rehabilitation setting, and explores potential improvements in the method of intervention for patients following a CVA.

Case Description: This patient was a 70-year-old male admitted to an inpatient rehabilitation facility following a right CVA resulting in left-sided flaccidity of upper and lower extremities. He underwent therapy in this facility for five weeks.

Interventions: Conventional therapy interventions were used with this patient. The interventions consisted of a combination of strengthening, …


Hospital Acquired Deconditioning In A 78-Yeaar Old Individual: A Case Study, Brooke Rehm May 2021

Hospital Acquired Deconditioning In A 78-Yeaar Old Individual: A Case Study, Brooke Rehm

Physical Therapy Scholarly Projects

Background and Purpose: Physical therapy management of older adults following hospitalization is common. Patients tend to show impairments such as generalized weakness, decreased endurance, impaired mobility and gait, and an increase in dependence on others to complete activities of daily living. The purpose of this case study is to examine the physical therapy implications of treating patients with hospital acquired disability. This paper outlines the management of a patient who was newly admitted to skilled nursing facility, following a proximal humeral fracture.

Description: Following her stay at the hospital, the patient was discharged to the skilled nursing facility for …


Bankart Labral Repair Rehabilitation Using Fascial Counterstrain, Proprioceptive Neuromuscular Facilitation, And Range Of Motion: A Case Report, Lauren Mcintosh May 2021

Bankart Labral Repair Rehabilitation Using Fascial Counterstrain, Proprioceptive Neuromuscular Facilitation, And Range Of Motion: A Case Report, Lauren Mcintosh

Physical Therapy Scholarly Projects

Background and Purpose: This case study will address the use of fascial counterstrain, proprioceptive neuromuscular facilitation (PNF), and range of motion (ROM) to rehabilitate an arthroscopic anterior Bankart labrum repair in a pediatric patient. Bankart labral tears are defined as an anteroinferior tear of the labrum, frequently caused by multiple anterior shoulder dislocations. Fascial counterstrain can be used in post-surgical patients to reduce swelling, decrease healing time, and reduce pain. PNF and ROM allow the patient to return to a functional lifestyle and are included in most protocols provided by the surgeon. The purpose of this study is to demonstrate …


Bilateral Patellofemoral Pain Syndrome And The Effects Of Physical Therapy In The Outpatient Setting: A Case Study, Paige Mriden May 2021

Bilateral Patellofemoral Pain Syndrome And The Effects Of Physical Therapy In The Outpatient Setting: A Case Study, Paige Mriden

Physical Therapy Scholarly Projects

Background and Purpose: Patellofemoral pain syndrome (PFPS) is characterized by musculoskeletal-related knee pain localized to the anterior retropatellar and/or peripatellar area of the knee. This case study describes the physical therapy management of bilateral PFPS. The results can be used to understand examination, evaluation, and interventions to treat PFPS.

Case Description: The patient was a 76-year-old female that reported progressive pain in both knees. She demonstrated weak hip abductors and extensors, tenderness upon palpation to bilateral pes anserine, bilateral ITB, and bilateral medial joint line with increased lateral tibial torsion on the left and a positive Hamstring 90-90 test. …


Chronic Low Back Pain With Possible Si Involvement And Weak Abdominals: A Case Study, Stacy Remer May 2021

Chronic Low Back Pain With Possible Si Involvement And Weak Abdominals: A Case Study, Stacy Remer

Physical Therapy Scholarly Projects

Background and Purpose: Chronic, non-specific low back pain is highly prevalent and is a cause for a large proportion of medical expenses along with many people’s pain and disability. This case report presents a variety of interventions implemented for a patient with low back pain and her reaction to therapy.

Case Description: The case study presents a 42 y/o mother to three children. Her pain began about two years ago and has been persistent throughout that time. She has tried many different forms of treatment through medical physicians, physical therapy, and massage therapy but nothing has had long-term relief of …


Effects Of Physical Therapy Following A Right Shoulder Arthroscopy In The Outpatient Orthopedic Setting: A Case Study, Hannah Riveland May 2021

Effects Of Physical Therapy Following A Right Shoulder Arthroscopy In The Outpatient Orthopedic Setting: A Case Study, Hannah Riveland

Physical Therapy Scholarly Projects

Background and Purpose. Shoulder pain is the third most common complaint in the musculoskeletal system. Subacromial impingement syndrome consists of 44-65% of those complaints. This case study examines the effectiveness of physical therapy treatment following a right shoulder arthroscopy including a subacromial decompression, extensive intraarticular debridement, and subpectoral proximal biceps tenodesis in an outpatient orthopedic setting.

Case Description. This patient was a 57-year old male with past medical history of chronic shoulder and back pain. He presented to outpatient physical therapy post-operatively with right upper extremity guarding, pain, weakness, tenderness, and impaired functional mobility.

Intervention. Treatment addressed …


Simultaneous Bilateral Total Knee Arthroplasty And The Effects Of Physical Therapy In The Outpatient Setting: A Case Study., Erin Syverson May 2021

Simultaneous Bilateral Total Knee Arthroplasty And The Effects Of Physical Therapy In The Outpatient Setting: A Case Study., Erin Syverson

Physical Therapy Scholarly Projects

Background and Purpose: A bilateral total knee arthroplasty (TKA) is a surgical procedure that has seen success in managing end-stage osteoarthritis of the knee joint. This case study evaluates the usefulness of physical therapy following bilateral TKA and deliberates the outcomes the patient experienced.

Case Description: The patient was a 62-year-old male who received postoperative physical therapy in an outpatient orthopedic clinic for a total of 8 weeks. The patient demonstrated decreased bilateral knee range of motion (ROM), decreased bilateral gross lower extremity (LE) strength, increased pain and swelling in both knees, and decreased endurance for ambulation.

Intervention …


The Effectiveness Of Physical Therapy Intervention Modeled After The Scroth Method And Fits Concept For Treatment Of Radicular Symptoms Secondary To Mild Scoliosis In A 16-Year Old Female., Mary T. Gray May 2021

The Effectiveness Of Physical Therapy Intervention Modeled After The Scroth Method And Fits Concept For Treatment Of Radicular Symptoms Secondary To Mild Scoliosis In A 16-Year Old Female., Mary T. Gray

Physical Therapy Scholarly Projects

Background and Purpose. Physical therapy as an intervention for scoliosis typically involves a method-based scoliosis specific approach to treatment that requires extensive training such as the Schroth method or FITS concept. The purpose of this study is to determine if physical therapy treatment alone, when modeled after the Schroth method and FITS concept can be an effective treatment method for lumbar radiculopathy and pain secondary to mild scoliosis.

Case Description. The patient featured in this case report is a 16-year-old female with a medical diagnosis of scoliosis and fibro-lipoma on her filum terminal. The patient had a Cobb …


Thoracic Outlet Syndrome Decompression And The Effect Of Physical Therapy In The Outpatient Setting: A Case Study, Kaiann Arellano May 2021

Thoracic Outlet Syndrome Decompression And The Effect Of Physical Therapy In The Outpatient Setting: A Case Study, Kaiann Arellano

Physical Therapy Scholarly Projects

Background and Purpose: Thoracic outlet syndrome (TOS) includes the signs and symptoms in the upper extremity caused by a compression of the brachial plexus, subclavian vein and/or subclavian artery at the thoracic outlet. The thoracic outlet symptoms may present as pain, weakness, numbness, tingling, and early fatigue or heaviness of the arm. Severe and unrelenting symptoms may lead to individuals considering surgical treatment. The purpose of this case report is to present an evidence based strengthening and stretching program for the post-operative care of TOS.

Case Description: This article describes the 10 - week outpatient physical therapy treatment …


Outpatient Physical Therapy Management Of A Patient With Left Hip Femoroacetabular Impingement: A Case Study, Mark Geerdes May 2021

Outpatient Physical Therapy Management Of A Patient With Left Hip Femoroacetabular Impingement: A Case Study, Mark Geerdes

Physical Therapy Scholarly Projects

Background and Purpose: Femoroacetabular impingement (FAI) syndrome is a motion related clinical disorder of the hip in which there is premature contact between the acetabulum and the proximal femur. This case study evaluates the effectiveness of physical therapy as a first line treatment for FAI and discusses the patient outcomes based on the chosen interventions. The results can be used to better understand the most appropriate interventions for conservative FAI treatment.

Case Description: The patient was a 15-year-old male student athlete who presented to physical therapy with left anterior and lateral hip pain.

Interventions: The rehabilitation program …


Outpatient Management Of Low Back And Neck Pain With Radicular Symptoms, Riley Ryan May 2021

Outpatient Management Of Low Back And Neck Pain With Radicular Symptoms, Riley Ryan

Physical Therapy Scholarly Projects

Background and Purpose. Neck and back pain are very prevalent in the world today. This pain can range mild to debilitating. The purpose of this case study is to examine the use of physical therapy for patients with neck and back pain.

Case Description. A 49 year old female with neck and back pain with radiculopathy. The patient presented with decreased cervical range of motion, kyphotic posture with rounded shoulders and forward head and was seen for a total of six weeks. (20 visits).

Intervention. The treatment of the patient involved education on posture/body mechanics/exercises, manual therapy techniques, modalities …


Analyzing The Accelerated Physical Rehabilitation Of A Patient Status Post Periacetabular Osteotomy And Femoral Derotation Osteotomy, Zachary Burtsfield May 2021

Analyzing The Accelerated Physical Rehabilitation Of A Patient Status Post Periacetabular Osteotomy And Femoral Derotation Osteotomy, Zachary Burtsfield

Physical Therapy Scholarly Projects

Background and Purpose: The purpose of this case is to analyze the accelerated treatment of a periacetabular osteotomy in a patient who requires up to six surgical corrections to his femoracetabular joint compared to a standard treatment protocol.

Case Description: The patient was a 20 year old martial artist presenting with bilateral hip dysplasia seeking physical therapy following a periacetabular osteotomy with a femoral derotation osteotomy.

Intervention. Therapeutic exercise and neuromuscular reeducation techniques were included in treatment to improve range of motion, strength, balance, and gait.

Outcomes: The patient was able to increase range of motion and strength …


Comparative Research Of Effective Treatment Measures For Postpartum Depression, Aunica Novacek May 2021

Comparative Research Of Effective Treatment Measures For Postpartum Depression, Aunica Novacek

Physician Assistant Scholarly Project Papers

Postpartum depression is a mood disorder that includes depressive symptoms during the time period following childbirth. There are various possibilities for what may cause this disorder, but the drastic change in hormones after delivery can play a role. With the chance this disorder may be fatal to both the mother and child, an appropriate, effective, and safe treatment is necessary to control depressive symptoms. The standard, first-line pharmacotherapeutic option is a selective serotonin reuptake inhibitor (SSRI) antidepressant. SSRI antidepressants are well understood, but these medications may take time to become effective. Knowing this, medical professionals can find a more rapid …


Active Therapies In The Management Of Concussion And Post-Concussion Syndrome, Breanna Raquel Krueger May 2021

Active Therapies In The Management Of Concussion And Post-Concussion Syndrome, Breanna Raquel Krueger

Physician Assistant Scholarly Project Papers

The purpose of this research and literature review is to evaluate the recently completed literature to provide guidance to medical providers of the safest and most efficacious treatment options for adolescent patients with concussion and post-concussion syndrome. The literature was searched for studies directly related to adolescents and active therapies such as physical therapy, vestibular rehabilitation, exertional therapy, and cognitive behavioral therapy. The search time frame implemented was studies completed within the last ten years. Ten studies met the final criteria. The research shows a substantial benefit for immediate cognitive and physical rest following a mTBI. The research suggests that …


The Role Of The Gut Microbiome In Autoimmune Disorders, Sierra Baxter May 2021

The Role Of The Gut Microbiome In Autoimmune Disorders, Sierra Baxter

Physician Assistant Scholarly Project Papers

According to the National Institute of Health (NIH), it is estimated that over 24 million Americans are diagnosed with autoimmune disorders, and the cases are increasing (2005). A significant risk factor that has been linked to the formation of these diseases is the gut microbiome. The gut microbiome of the adult plays a vital role in the efficacy of the immune system. The purpose of this research and systematic literature review is to determine how the gut microbiome can influence autoimmune disorders. In this review, five databases were searched including PubMed, DynaMed, Cochrane Library, Embase, and Clinical Key. A variety …


Buprenorphine Versus Methadone For Treatment Of Opioid Use Disorder, Ben Devries May 2021

Buprenorphine Versus Methadone For Treatment Of Opioid Use Disorder, Ben Devries

Physician Assistant Scholarly Project Papers

The purpose of this literature review is to analyze the use of buprenorphine and methadone for the treatment of opioid use disorder. Comparison of overall safety, efficacy, morbidity and mortality between the two treatment options is accomplished throughout this literature review. The literature review was performed using databases: PubMed, Clinical Key, Cochrane and Upto- date. Results were limited to studies completed within the past seven years. Methadone has been the treatment mainstay of opioid use disorder for decades. buprenorphine has increased in popularity and prevalence for treatment of opioid use disorder, especially after receiving FDA approval for such use in …


Invasive Needling Therapy For Myofascial Pain Syndrome, Katelyn Corine Krueger May 2021

Invasive Needling Therapy For Myofascial Pain Syndrome, Katelyn Corine Krueger

Physician Assistant Scholarly Project Papers

Myofascial pain syndrome (MPS) is one of the most common musculoskeletal conditions characterized by tight bands of fascia and muscle fibers known as myofascial trigger points (MTrP). Empirical evidence suggests that deactivation of MTrP’s is best accomplished with invasive needling therapy such as dry needling, trigger point injections, and Botulinum toxin-A (BTX-A) injections. The objective of this systemic review is to compare the effectiveness of various needling therapies on pain intensity and determine if ultrasound guidance and obtaining a local twitch response (LTR) improves clinical outcomes. A comprehensive search of five databases including PubMed, Science Direct, Google Scholar, Cochran, and …


Comparison Of Oral Glucose Tolerance And Hemoglobin A1c As An Initial Indicator Of Type 2 Diabetes, Shelby L. Knox May 2021

Comparison Of Oral Glucose Tolerance And Hemoglobin A1c As An Initial Indicator Of Type 2 Diabetes, Shelby L. Knox

Physician Assistant Scholarly Project Papers

The purpose of this literature review was to evaluate the diagnostic utility of hemoglobin A1c (HbA1c) compared to oral glucose tolerance testing (OGTT) for diagnosis of type 2 diabetes. Databases ClinicalKey, PubMed, Dynamed, and CINAHL withdrew a total of 17 peer-reviewed cross-sectional and retrospective studies, secondary data and pooled data analyses, and meta-analyses. Inclusion criteria included human studies, black, white, Hispanic, and Asian populations, studies < 10 years old, individuals > 15 years of age, fasting plasma glucose in conjunction with OGTT, and subjects without known type 2 diabetes. Exclusion criteria included alternative forms of diabetes, screening and diagnosis of prediabetes, comparisons in relation to specific …


Effect Of Cftr Modulators On Respiratory Function In Adults With Cystic Fibrosis, Melissa Severson May 2021

Effect Of Cftr Modulators On Respiratory Function In Adults With Cystic Fibrosis, Melissa Severson

Physician Assistant Scholarly Project Papers

Cystic Fibrosis (CF) is an autosomal recessive disorder that shortens one’s life due to its effect on the cystic fibrosis transmembrane regulator (CFTR) gene. CFTR modulator medications can correct the CFTR gene and consist of a potentiator (ivacaftor), and corrector (lumacaftor, tezacaftor and elexacaftor). This research and literature review sought to evaluate if lung function improved in an individual with genetically confirmed CF after being started on CFTR modulator medications. To complete the review, six databases were searched which included: CINAHL, PubMed, Clinical Key, Cochrane Library, Embase and Dynamed Plus. Both keyword and mesh terms were used to define a …