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Volume 39, Number 12: November 16, 2001, University Of North Dakota

University Letter Archive

No abstract provided.

Cross-Channel And Diel Variation In The Distribution Of Ichthyoplankton In The Red River Of The North, Ryan Duffield

Undergraduate Theses and Senior Projects

No abstract provided.

Volume 37, Number 14: November 26, 1999, University Of North Dakota

University Letter Archive

No abstract provided.

Reaction Of Arylsulfenyl Chloride Adducts Of Glycals With Vinyl Ethers., Mingming Han

Theses and Dissertations

This Ph.D. dissertation is focused on the stereoselective synthesis of β- C-glycosides. Such carbohydrate derivatives have been found to possess a wide spectrum of physiological activities. They can serve as non-hydrolizable enzyme inhibitors. C-Glycosides have been used as chiral precursors for synthesis of other compounds. The synthesis of β-C-glycosides is based on the fact that, in the presence of Lewis acids, ArSCl adducts of glycals can be converted to active intermediates, episulfonium ions. These intermediates are known to react with a number of C-nucleophiles. In this study, the reaction of ArSCl adducts of glycals with vinyl ethers was investigated. To …

Volume 36, Number 10: October 30, 1998, University Of North Dakota

University Letter Archive

No abstract provided.

Environmental Radon Decay Products In Neurological Diseased And Non-Diseased Brains, And Brains Of Cigarette Smokers., Hassaan Ahmad Alkhatib

Theses and Dissertations

The focus of this study was to measure alpha and beta emissions of $\sp{210}$Po (alpha emissions), $\sp{210}$Pb and $\sp{210}$Bi (beta emissions) from brain samples which were obtained at autopsy from persons who were clinically diagnosed with Alzheimer's Disease (AD), Parkinson's Disease (PD), or Controls (no known neurological diseases) and cigarette smokers (SMK). The samples were digested, processed and analyzed for alpha and beta emissions.Measurement of alpha and beta radiation activity in tissues can be used to demonstrate prior exposure of tissues to environmental radioisotopes and/or their decay products. In the present study alpha emissions from brain tissues were measured with …

Studies On The 13-Carbaartemisinin Antimalarials: Total Synthesis And Iron(Ii) Bromide-Promoted Rearrangement Of 13-Carba-10-Deoxoartemisinin And Analogs, And, Samarium(Ii) Iodide-Promoted Reductive Cyclization Of Ketones Tethered To Nonactivated Olefins., Pingchen Fan

Theses and Dissertations

Part one is the study of 13-carbaartemisinin analogs as potential antimalarial drugs. Based on knowledge of the artemisinin's chemistry, mode of action, and structure-activity relationship, we proposed 13-carba-10-deoxoartemisinin 6 as an orally active antimalarial. Thus, the total synthesis of 6 was carried out and completed in 12 steps with a yield of 2% starting with ($-$)isopulegol. More analogs were produced from an intermediate in the total synthesis sequence: two stereoisomers of 6, 13-carbaartemisinin, and five tricyclic analogs. In general, the 13-carba analogs showed lower in vitro biological activity than artemisinin 1, only a stereoisomer of 6 displayed comparable activity to …

Genetic Analyses Of Captive And Wild Populations Of Hawaiian Geese., Elizabeth H. Rave

Theses and Dissertations

Preserving genetic diversity is important for maintaining the evolutionary potential and fitness of endangered species such as the Hawaiian goose (Branta sandvicensis), or nene. I used DNA fingerprinting to assess genetic diversity in captive nene from Hawaii and England and in wild nene from Hawaii. I used pedigrees and DNA fingerprinting to assess the effects of inbreeding on reproductive success in captive nene. I determined (1) differences in mean similarity coefficients between unrelated and related nene within and between captive colonies and the relationship between coancestry and similarity coefficients in captive nene from Hawaii, (2) differences in mean similarity coefficients …

Land-Use Change In The Fringe Regions Of Montana's Bob Marshall Wilderness, Brian W. Savage

Theses and Dissertations

No abstract provided.

Use Of Chlorine Dioxide To Remove Fish Pathogens From Garrison Diversion Water, Wayne C. Hustoft

Theses and Dissertations

This report considers the use of chlorine dioxide as an alternate disinfectant for the removal of biota from Garrison Diversion water. Laboratory testing has shown that chlorine may not be an acceptable disinfectant because it can produce carcinogens from side reactions with constituents found in natural surface waters.

This study used Lake Sakakawea water collected at the Snake Creek Pumping Station located on the eastern shore. Water samples were of direct filtration effluent from a laboratory scale filter column. samples were gathered at several different turbidity levels. The "DPD" method, as published in "Standard Methods for the Analysis of Water …

The Use Of Transition Metal Complexes For The Construction Of Unusual Metal-Modified Phosphorus Linkages Between Nucleosides., Theresa Jo Schmaltz

Theses and Dissertations

Oligonucleotides based on methyl phosphonate linkages between nucleoside units have been of particular interest as anti-sense molecules for inhibiting mRNA function. The focus of our research has been on the development of new construction techniques for anti-sense oligonucleotides. Specifically we have been investigating new methods for generating iron and cobalt-modified linkages in oligonucleotides during the course of automated synthesis.We have found that (dicarbonyl)($\eta\sp5$-cyclopentadienyl)($\eta\sp2$-ethylene)iron reacts with 5$\sp\prime$-O-dimethoxytritylnucleoside 3$\sp\prime$-phosphite esters to yield (dicarbonyl)($\eta\sp5$-cyclopentadienyl)iron(ethyl)phosphonates. These phosphonates appear to be stable to the conditions commonly used to construct oligonucleotides by phosphoramidite methodology. This chemistry has been extended to the formation of a dimer on …

The Synthesis Of Fluorinated Analogs Of Nucleic Acid Components., Daniel Joseph Swartling

Theses and Dissertations

The overall objective of this research was to find methods for incorporating CF$\sb2$ groups into nucleosides in order to obtain biologically active molecules. The nucleoside analogs were designed to be inhibitors of DNA synthesis and to block viral replication. Particular emphasis was directed toward analogs with the potential to inhibit HTLV-III encoded reverse transcriptase. The specific objectives were, (a) to find ways to replace each of the deoxyribose oxygens by the isosteric-isopolar CF$\sb2$ group, and (b) to replace the 2$\sp\prime$-CH$\sb2$ and 3$\sp\prime$-CHOH groups by a CF$\sb2$ group. Emphasis was placed on a detailed investigation of the introduction of the CF$\sb2$ …

October 1985, University Of North Dakota Alumni Association

ALL: UND Alumni Review Master List

October 1985 issue of "The University of North Dakota Alumni Review." 12 pages

Volume 68, Number 2

The Effect Of Dietary Vanadium On Vanadium-48 Metabolism And Proximal Tibial Growth Plate Morphology In The Chick., Curtiss Dean Hunt

Theses and Dissertations

No abstract provided.

Distribution Of S-Adenosylhomocysteine Hydrolase, S-Adenosylhomocysteine Nucleosidase, S-Ribosylhomocysteine Cleavage Enzyme And Homoserine Dehydratase In Various Species, Robert D. Walker

Theses and Dissertations

Microorganisms, plants and the major organs from cold and warm blooded vertebrates ware assayed for the presence of S-adenosylhomocysteine hydrolase, S-adenosylhomocysteine nucleosidase, S-ribosylhomocysteine cleavage enzyme and homoserine dehydratase.

S-Adenosylhomocysteine hydrolase was found in all yeasts and plants assayed and in the livers of all cold blooded vertebrates assayed except the Polyodon spathula (Paddlefish). Liver extracts from all warm blooded vertebrates except the Odocoileus hemionus (Mule deer), Odocoileus virginianus (Whitetail deer) and Homo sapiens (human) were also found to possess S-adenosylhomocysteine hydrolase. This enzyme was also found in the spleens of the Ictalurus punctatus (Channel cat), Perca flavescens (Yellow perch) and …

Ddt-Induced Chromosomal Aberrations In Mice, Gregg A. Johnson

Theses and Dissertations

No abstract provided.

Assay Of Murine Sarcoma Virus (Moloney) Viremia Using Tissue Culture Methods, Timothy M. Dolan

Theses and Dissertations

No abstract provided.

Triatoma Infestans As An Experimental And Natural Vector Of Rauscher Murine Leukemia, Mary Frances Bobo

Theses and Dissertations

The reduviid bug, Triatoma infestans, was Investigated as a possible vector of Rauscher murine leukemia, since these insects are closely associated in nature as inhabitants of rodent burrows.

The effect of triatomid ingestion of leukemic blood was tested by maintaining insects fed on leukemic mice for various periods, and then injecting whole-insect homogenates into test mice. The viremic period for mice injected with Rauscher virus was determined by inoculating a large group of mice and sacrificing them over an 18-day period. Blood and spleen preparations were assayed for presence of virus by inoculating test mice. Biological and mechanical transmission was …

November 1966, University Of North Dakota Alumni Association

ALL: UND Alumni Review Master List

November 1966 issue of "The University of North Dakota Alumni Review." 8 pages

Volume 49, Number 3

An Analysis Of The Opinion Of The Values Of High School Biology As Held By Selected Groups, John L. Rhoades

Theses and Dissertations

No abstract provided.

The Development Of An Experience Program For Use In Teaching High School Biology, James G. Lade

Theses and Dissertations

No abstract provided.

The Relation Of Law And Social Evolution, M A. Brannon

North Dakota Law Review

No abstract provided.

Effects Of Immigration, Iver Andrew Acker

Theses and Dissertations

No abstract provided.