Digital Commons Network^™

The Effect Of Including Pressure Within Cracks On Failure Times Of Cylinders Subjected To Internal Air Blast Loading, Molly M. Bailey

Mechanical Engineering ETDs

The importance of internal crack pressure on the extent of crack propagation is studied using both numerical and experimental results. Experimental data were obtained from shock tube testing of internally pressurized quasi-brittle hollow cylinders loaded to failure. Half of the samples were tested with an inserted membrane that transferred the shocked fluid load but prevented the fluid from entering the developing cracks. In the other cases, the membrane was removed allowing the fluid to enter the crack and assist development of fracture. A novel approach to modeling this complex structural response involving dynamic failure and fluid structure interaction is presented, …

Pkcδ Causes Sepsis-Induced Cardimyopathy By Inducing Mitochondrial Dysfunction, Leroy C. Joseph, Michael V. Reyes, Kundanika R. Lakkadi, Blake H. Gowen, Gyorgy Hasko, Konstantinos Drosatos, John P. Morrow

Pathology Research and Scholarship

Sepsis-induced cardiomyopathy (SIC) is associated with increased patient mortality. At present, there are no specific therapies for SIC. Previous studies have reported increased reactive oxygen species (ROS) and mitochondrial dysfunction during SIC. However, a unifying mechanism remains to be defined. We hypothesized that PKCδ is required for abnormal calcium handling and cardiac mitochondrial dysfunction during sepsis and that genetic deletion of PKCδ would be protective. Polymicrobial sepsis induced by cecal ligation and puncture (CLP) surgery decreased the ejection fraction of wild-type (WT) mice but not PKCδ knockout (KO) mice. Similarly, WT cardiomyocytes exposed to lipopolysaccharide (LPS) demonstrated decreases in contractility …

Book Reviews Spring 2020

New Mexico Historical Review

No abstract provided.

Who Decides: Is Water Life Or Capital? Contesting Visions Of Western Water Management In The 21st Century, Ceorl

Water Resources Professional Project Reports

There is an ideological divide between the goal of universal access to clean water and the outcomes of how water regulations are implemented. John Fleck, author of Water is for Fighting Over: and Other Myths about Water in the West and Sivas, et al. in California Water Governance in the 21st Century present contesting prescriptions for Western water management. The ideologies advocated by Fleck and Sivas, et al. differ as to who enacts and profits from each and exemplify the divide between the goals of water regulations and how they are implemented. Fleck regards water as property and an economic …

Give Me Liberty, Or Give Me Breath: A Call For Economic Justice, Verónica C. Gonzales

Faculty Scholarship

In Part I of this essay I interpret this unique moment in history through a retelling of the folk story La Llorona in order to identify the monsters and ghosts of the past and the present. Domino Renee Perez describes her own critical reflection of La Llorona as reinforcing 'a valuable lesson about power and authority' because her family’s 'storytelling circle was more than simply an arbitrary setting; it was a safe place for them to create, however problematically, a world of words, where they faced the dangers and challenges of life, embodied by a woman, and survived.' The lore …

20200331_Free Resources During Covid19 For Education, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

2020-03-30 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200327_Student Resources, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

2020-03-27 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-03-26 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Association Of Immunophenotype With Expression Of Topoisomerase Ii Α And Β In Adult Acute Myeloid Leukemia, Andrew P. Michelson, Shannon Mcdonough, Cheryl L. Willman, Eric R. Koegle, John E. Godwin, Stephen H. Petersdorf, Alan F. List, Megan Othus, Frederick R. Appelbaum, Jerald P. Radich, Mahrukh K. Ganapathi, Anjali S. Advani, Ram N. Ganapathi

Pathology Research and Scholarship

Anthracyclines used in the treatment of acute myelogenous leukemia (AML) inhibit the activity of the mammalian topoisomerase II (topo II) isoforms, topo II α and topo IIβ. In 230 patients with non-M3 AML who received frontline ara-C/daunorubicin we determined expression of topo IIα and topo IIβ by RT-PCR and its relationship to immunophenotype (IP) and outcomes. Treatment outcomes were analyzed by logistic or Cox regression. In 211 patients, available for analysis, topo IIα expression was significantly lower than topo IIβ (P < 0.0001). In contrast to topo IIα, topo IIβ was significantly associated with blast percentage in marrow or blood (P = 0.0001), CD7 (P = 0.01), CD14 (P < 0.0001) and CD54 (P < 0.0001). Event free survival was worse for CD56-negative compared to CD56-high (HR = 1.9, 95% CI [1.0-3.5], p = 0.04), and overall survival was worse for CD-15 low as compared to CD15-high (HR = 2.2, 95% CI [1.1-4.2], p = 0.02). Ingenuity pathway analysis indicated topo IIβ and immunophenotype markers in a network associated with cell-to-cell signaling, hematological system development/function and inflammatory response. Topo IIβ expression reflects disease biology of highly proliferative disease and distinct IP but does not appear to be an independent variable influencing outcome in adult AML patients treated with anthracycline-based therapy.

The Mk2 Pathway Is Linked To G-Csf, Cytokine Production And Metastasis In Gastric Cancer: A Novel Intercorrelation Analysis Approach, Fares Qeadan, Pranshu Bansal, Joshua A. Hanson, Ellen J. Beswick

Pathology Research and Scholarship

BACKGROUND: Gastric cancer is associated with chronic inflammation, but there is still much to understand about the tumor microenvironment and the underlying tumor-promoting mechanisms. The Map kinase-activated protein kinase 2 (MK2) pathway is a regulator of inflammatory cytokine production that we have been studying in gastrointestinal cancers. Here, we set out to determine the significance of this gene in gastric cancer along with its downstream mediators and if there were differences in the primary tumors with and without metastasis.

METHODS: Human gastric cancer tissues with and without metastasis were examined for MK2 expression and cytokine profile in organ culture supernatants. …

2020-03-25 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Clinical Performance Of The Novel Genmark Dx Eplex Blood Culture Id Gram-Positive Panel, Karen C. Carroll, Jennifer L. Reid, Adam Thornberg, Natalie N. Whitfield, Deirdre Trainor, Shawna Lewis, Teresa Wakefield, Thomas E. Davis, Keisha G. Church, Linoj Samuel, Ray Mills, Patricia Jim, Stephen Young, Frederick S. Nolte

Pathology Research and Scholarship

Rapid identification from positive blood cultures is standard of care (SOC) in many clinical microbiology laboratories. The GenMark Dx ePlex Blood Culture Identification Gram-Positive (BCID-GP) Panel is a multiplex nucleic acid amplification assay based on competitive DNA hybridization and electrochemical detection using eSensor technology. This multicenter study compared the investigational-use-only (IUO) BCID-GP Panel to other methods of identification of 20 Gram-positive bacteria, four antimicrobial resistance genes, and both Pan

20200324_Coronavirus Disease 2019 (Covid-19) Guide, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

2020-03-24 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-03-23 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200323_Supporting Our Hsc Faculty Transitioning To Virtual Instruction, Jonathan M. Pringle

HSLIC Blog Post

No abstract provided.

Neutrosophic N-Soft Sets With Topsis Method For Multiple Attribute Decision Making, Muhammad Riaz, Khalid Naeem, Iqra Zareef, Deeba Afzal

Neutrosophic Sets and Systems

No abstract provided.

Arithmetic And Geometric Operators Of Pentagonal Neutrosophic Number And Its Application In Mobile Communication Service Based Mcgdm Problem, Avishek Chakraborty, Baisakhi Banik, Sankar Prasad Mondal, Shariful Alam

Neutrosophic Sets and Systems

No abstract provided.

A Novel Of Neutrosophic T-Structure Ring Extb And Extv Spaces, R. Narmada Devi

Neutrosophic Sets and Systems

No abstract provided.

Single And Multi-Valued Neutrosophic Hypersoft Set And Tangent Similarity Measure Of Single Valued Neutrosophic Hypersoft Sets, Muhammad Saqlain, Naveed Jafar, Sana Moin, Muhammad Saeed, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Fuzzy Matrices And Some Algebraic Operations, Rakhal Das, Florentin Smarandache, Binod Chandra Tripathy

Neutrosophic Sets and Systems

No abstract provided.

A Contemporary Approach On Neutrosophic Nano Topological Spaces,, D. Sasikala, K. C. Radhamani

Neutrosophic Sets and Systems

No abstract provided.

On Optimizing Neutrosophic Complex Programming Using Lexicographic Order, Hamiden Abd El- Wahed Khalifa, Pavan Kumar, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.

Parameter Reduction Of Neutrosophic Soft Sets And Their Applications, Abhijit Saha, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Geometric Programming (Ngp) Problems Subject To (\/, .) Operator; The Minimum Solution, Huda E. Khalid

Neutrosophic Sets and Systems

No abstract provided.

Ngpr Homeomorphism In Neutrosophic Topological Spaces, K. Ramesh

Neutrosophic Sets and Systems

No abstract provided.

Generalized Neutrosophic Separation Axioms In Neutrosophic Soft Topological Spaces, A. Mehmood, F. Nadeem, G. Nordo, M. Zamir, C. Park, H. Kalsoom, S. Jabeen, M. I. Khan

Neutrosophic Sets and Systems

No abstract provided.

Interval Valued Neutrosophic Topological Spaces, T. Nanthini, A. Pushpalatha

Neutrosophic Sets and Systems

No abstract provided.