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No “Box To Be Checked”: Environmental Justice In Modern Legal Practice, Clifford J. Villa Jan 2022

No “Box To Be Checked”: Environmental Justice In Modern Legal Practice, Clifford J. Villa

Faculty Scholarship

For nearly thirty years, environmental justice has been part of our civic conversation and included in the mission of federal agencies. But while public attention to environmental justice has waxed and waned over time, environmental justice principles have endured and developed into rules of law. This development may be expected to continue and accelerate with recent events such as the nationwide outcry after the police killing of George Floyd in 2020, the disparate impacts of COVID-19 on people of color, and the express priorities of the Biden administration. This paper seeks to help legal practitioners and other interested parties comprehend …


A Unifying Doctrine Of Subsurface Property Rights, Joseph A. Schremmer Jan 2022

A Unifying Doctrine Of Subsurface Property Rights, Joseph A. Schremmer

Faculty Scholarship

This Article advances the “fair opportunity doctrine,” a theory of subsurface property rights that systematizes the case law in this confused area using formal legal reasoning. This theory offers a jurisprudential approach to analyzing private law that can then be applied to the field of subsurface property. This approach emphasizes the law’s role in providing ex ante guidance to members of a community in ordering their affairs and interactions with others and the importance of coherence in that function. On this basis, the “fair opportunity doctrine” improves substantially on the current state of subsurface property law and demonstrates the potential …


The Holder And The Holdings: Identity Dynamics And Tobacco Consumption In Juan Rodríguez Juárez’S Dama Con Rebozo (Ca. 1720), María Carrillo Marquina Jan 2022

The Holder And The Holdings: Identity Dynamics And Tobacco Consumption In Juan Rodríguez Juárez’S Dama Con Rebozo (Ca. 1720), María Carrillo Marquina

Hemisphere: Visual Cultures of the Americas

No abstract provided.


Ecofeminism(S): A Closer Look At Ana Mendieta’S Bacayu (Light Of Day), Catriona Reid Jan 2022

Ecofeminism(S): A Closer Look At Ana Mendieta’S Bacayu (Light Of Day), Catriona Reid

Hemisphere: Visual Cultures of the Americas

No abstract provided.


Digital Humanities, Women Artists, And Chicanx Graphics: An Interview With Claudia Zapata, Ph.D., Eleanor Kane Jan 2022

Digital Humanities, Women Artists, And Chicanx Graphics: An Interview With Claudia Zapata, Ph.D., Eleanor Kane

Hemisphere: Visual Cultures of the Americas

No abstract provided.


Affirmed Or Delegated? Finding Inherent Tribal Civil Power To Issue Protection Orders Against All Persons In Light Of Spurr V. Pope, Kelly Gaines Stoner, Cherokee Ancestry, Lauren Van Schilfgaarde, Cochiti Pueblo Jan 2022

Affirmed Or Delegated? Finding Inherent Tribal Civil Power To Issue Protection Orders Against All Persons In Light Of Spurr V. Pope, Kelly Gaines Stoner, Cherokee Ancestry, Lauren Van Schilfgaarde, Cochiti Pueblo

Tribal Law Journal

Federal courts have wreaked havoc on tribal jurisdiction by injecting incertitude over their most basic authority, including the authority to issue and enforce civil protection orders. This jurisdictional incertitude causes not just legal disruption, but also further compromises the safety of Native people who are disproportionately victimized, especially by gender-based forms of violence. While Congress has been slow to remedy the onslaught of judicial limitations on tribal jurisdiction, Congress has at least remedied tribal authority to issue and enforce protection orders in 18 U.S.C. § 2265(e). However, even in this remedy, jurisdictional incertitude remains.


Multiple Shallow Crustal Origins For Spinel-Bearing Lithologies On The Moon: A Perspective From The Luna 20 Mission, Steven B. Simon, Charles K. Shearer, Stephen E. Haggerty, Daniel P. Moriarty Iii, Noah Petro, James J. Papike, Zoltan Vaci Jan 2022

Multiple Shallow Crustal Origins For Spinel-Bearing Lithologies On The Moon: A Perspective From The Luna 20 Mission, Steven B. Simon, Charles K. Shearer, Stephen E. Haggerty, Daniel P. Moriarty Iii, Noah Petro, James J. Papike, Zoltan Vaci

Earth and Planetary Sciences Faculty and Staff Publications

No abstract provided.


Spatially Distributed Infection Increases Viral Load In A Computational Model Of Sars-Cov-2 Lung Infection, Melanie E. Moses, Steven Hofmeyr, Judy L. Cannon, Akil Andrews, Rebekah Gridley, Monica Hinga, Kirtus Leyba, Abigail Pribisova, Vanessa Surjadidjaja, Humayra Tasnim, Stephanie Forrest Dec 2021

Spatially Distributed Infection Increases Viral Load In A Computational Model Of Sars-Cov-2 Lung Infection, Melanie E. Moses, Steven Hofmeyr, Judy L. Cannon, Akil Andrews, Rebekah Gridley, Monica Hinga, Kirtus Leyba, Abigail Pribisova, Vanessa Surjadidjaja, Humayra Tasnim, Stephanie Forrest

Pathology Research and Scholarship

A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary dramatically across individuals. Because spatial-temporal dynamics of viral spread and immune response are challenging to study in vivo, we developed Spatial Immune Model of Coronavirus (SIMCoV), a scalable computational model that simulates hundreds of millions of lung cells, including respiratory epithelial cells and T cells. SIMCoV replicates viral growth dynamics observed in patients and shows how spatially dispersed infections can lead to increased viral loads. The model also shows how the timing and strength of the T cell response can affect viral persistence, oscillations, and control. …


Randomized Controlled Trial Of Early Outpatient Covid-19 Treatment With High-Titer Convalescent Plasma, David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Bryan Lau, Aarthi G G Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley, Evan M. Bloch, Valerie C. Cluzet Dec 2021

Randomized Controlled Trial Of Early Outpatient Covid-19 Treatment With High-Titer Convalescent Plasma, David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Bryan Lau, Aarthi G G Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley, Evan M. Bloch, Valerie C. Cluzet

Pathology Research and Scholarship

BACKGROUND: The efficacy of polyclonal high titer convalescent plasma to prevent serious complications of COVID-19 in outpatients with recent onset of illness is uncertain.

METHODS: This multicenter, double-blind randomized controlled trial compared the efficacy and safety of SARS-CoV-2 high titer convalescent plasma to placebo control plasma in symptomatic adults ≥18 years positive for SARS-CoV-2 regardless of risk factors for disease progression or vaccine status. Participants with symptom onset within 8 days were enrolled, then transfused within the subsequent day. The measured primary outcome was COVID-19-related hospitalization within 28 days of plasma transfusion. The enrollment period was June 3, 2020 to …


Geochemical And Sensor-Based Monitoring Of Fault-Associated Carbonic Springs In Grand Canyon And Northern New Mexico: Identifying Hydrologic Pathways And Establishing Baselines, Chris Mcgibbon Dec 2021

Geochemical And Sensor-Based Monitoring Of Fault-Associated Carbonic Springs In Grand Canyon And Northern New Mexico: Identifying Hydrologic Pathways And Establishing Baselines, Chris Mcgibbon

Earth and Planetary Sciences ETDs

This dissertation examines the interaction of spring systems and faulting. When springs discharge within a fault zone the interaction is often complex, and multiple methods are required to understand the flow, mixing and evolution of groundwater. In karst aquifer systems fracture networks can range from sub-millimeter to meters and only adds to the complexities involved in examining spring hydrology. The Interest in springs and faulting is not only driven by science, but also has applied applications. Faulting and fluid flow are of interest to the oil and gas industry, and potential CO2 sequestration. In the southwestern US, water quantity …


The Power Of Outdoor Learning Experiences: A Narrative Inquiry, Vincent M. Case Dec 2021

The Power Of Outdoor Learning Experiences: A Narrative Inquiry, Vincent M. Case

Language, Literacy, and Sociocultural Studies ETDs

Outdoor learning experiences offer schools an initial avenue to address global community issues, including climate change, natural resource depletion, disconnection from nature, and the current global coronavirus pandemic. This narrative inquiry study, grounded in the theoretical work of Vygotsky, Cajete, Brody, and Kahn, seeks to understand how children’s perceptions of their outdoor learning experiences provide insights into their learning processes. This study’s findings suggest that regardless of the location (mountains, home, school campuses, local natural areas), students say that they: experience positive affect and enjoyment; observe through their senses to explore, discover, inquire, change their behavior, and build deeper relationships …


Arginine-Rich Polypeptides Are Potent Inhibitors Of Human Papillomavirus Infection And Powerful Tools To Investigate Viral Attachment And Entry, Jesse Mckay Young Dec 2021

Arginine-Rich Polypeptides Are Potent Inhibitors Of Human Papillomavirus Infection And Powerful Tools To Investigate Viral Attachment And Entry, Jesse Mckay Young

Biomedical Sciences ETDs

HPV is the most common sexually transmitted infection. It is estimated that 80% of sexually active adults will contract an HPV infection. Thus, there is a significant need for low-cost and easily distributable HPV antivirals that can be used alongside vaccines to combat infection. Herein I have identified protamine sulfate (PS) as a potent microbicide against HPV infection. PS was agnostic to genotype and efficacious pre and post HPV exposure. PS application topically reduced HPV internalization by altering epidermal growth factor receptor (EGFR) signaling and suppressed EGFR-stimulated HPV entry. Our preliminary data also suggest that heparin binding epidermal growth factor …


The Effect Of Ph On Organic Carbon Uptake And Biological Phosphorus Removal By Tetrasphaera Polyphosphate Accumulating Organisms, Derek Belka Dec 2021

The Effect Of Ph On Organic Carbon Uptake And Biological Phosphorus Removal By Tetrasphaera Polyphosphate Accumulating Organisms, Derek Belka

Civil Engineering ETDs

Tetrasphaera polyphosphate accumulating organisms (PAOs) have been found in greater abundance and may remove more P in full-scale enhanced biological phosphorus removal (EBPR) water resource recovery facilities (WRRF) worldwide than the more extensively studied Accumulibacter PAO. Understanding the effect that environmental conditions, such as pH, have on Tetrasphaera metabolisms is critical to understanding EBPR WRRF process upsets, achieving consistent low effluent P concentrations, and formulating optimization strategies. The objective of this study was to determine pH effects over the range from 5.5 to 8.5 on anaerobic amino acid uptake, P release, and cation release in a Tetrasphaera-enriched culture from …


Soil Moisture Dependent Runoff In A Dryland Region: An Investigation Of The Role Of Antecedent Conditions, Monitoring, And Modeling Strategies, Gerhard Schoener Dec 2021

Soil Moisture Dependent Runoff In A Dryland Region: An Investigation Of The Role Of Antecedent Conditions, Monitoring, And Modeling Strategies, Gerhard Schoener

Civil Engineering ETDs

Approximately 30% of the Earth’s land surface is characterized as arid or semiarid, including much of the western United States. Accurate runoff predictions are important for informed watershed management, particularly in rapidly urbanizing areas. Infiltration excess overland flow is the dominant mechanism for runoff generation in many dryland basins, and event-based infiltration or loss models are commonly used to estimate runoff. However, predictions are associated with considerable uncertainty due to the role antecedent soil moisture, an initial condition that must be set by the modeler. The objectives of my research were to (1) evaluate the impact of antecedent soil moisture …


20211217_Hslic Door Window Decorating Contest, Tamara Wheeler Dec 2021

20211217_Hslic Door Window Decorating Contest, Tamara Wheeler

HSLIC Blog Post

No abstract provided.


Characterization Of Phase Behavior In Idp Solutions By Uv-Vis Spectrophotometry And Phase Volume Fraction Measurements In Capillaries, Qing Sun Dec 2021

Characterization Of Phase Behavior In Idp Solutions By Uv-Vis Spectrophotometry And Phase Volume Fraction Measurements In Capillaries, Qing Sun

Biomedical Engineering ETDs

Intrinsically disordered proteins (IDPs) play vital roles in cell signaling and regulation by changing conformation dynamically under various stimulus. Thus, it is crucial to understand their physical properties in vitro especially liquid-liquid phase separation (LLPS). Here, we first used UV-vis spectrophotometry to investigate two of IDPs' physical properties – transition temperature (Tt) and coacervate size. This deeper insight allows us to further understand the dynamics of phase growth. We then constructed a binodal curve in the phase diagram by measurement of volume ratios in phase separated IDP solution in glass capillaries.


Systems And Methods For Scalable Retinal Screening Programs, Jeremy Richard Benson Dec 2021

Systems And Methods For Scalable Retinal Screening Programs, Jeremy Richard Benson

Computer Science ETDs

This dissertation addresses gaps in artificial intelligence-based computer vision tasks in the medical image processing field. We demonstrate effective methods for standardizing and augmenting digital fundus photographs so that robust convolutional neural network-based systems can perform high-throughput disease classification and generalize to never-before-seen data from novel camera technologies, scaling with the changing hardware landscape, as well as keeping up with vast amount of incoming data from the ever-increasing population. We also tackle the problem of discovering relevant samples in an unlabeled cohort of image data, thus widening the bottleneck to all downstream supervised machine learning tasks.


Subject Disintegration: Identity And Alterity In The Age Of The Hyperreal, Sophie Ell Dec 2021

Subject Disintegration: Identity And Alterity In The Age Of The Hyperreal, Sophie Ell

American Studies ETDs

What do the signs “identity” and “alterity” point to within the economy of representation and the logic of simulation that govern the present era? How does the visual saturation of a screen-mediated life affect the study of identity? Where does the information overload within which we operate leave the production of knowledge about otherness? My goal in this project is not to resolve these questions, but rather to linger in them. Focusing on various portrayals of categorical identities in film, photography, and digital media, I utilize a semiotic analysis to examine the formulaic, repetitive maneuvers of signification practices that reproduce …


Rapid Source To Sink Transition In A Mixed-Conifer Forest Following Stand-Replacing Fire, Ryan Matthew Schulze Dec 2021

Rapid Source To Sink Transition In A Mixed-Conifer Forest Following Stand-Replacing Fire, Ryan Matthew Schulze

Biology ETDs

Mixed-conifer forests play an important role in the Southwestern USA’s regional carbon cycle by sequestering and storing large amounts of atmospheric carbon onto the landscape. Despite this, little is known about how large, stand-replacing fire alters ecosystem carbon sink-source dynamics. In this study, we used eddy covariance to quantify how stand-replacing fire altered forest sink strength, and the sensitivity of carbon uptake to soil and atmospheric drought in a mixed-conifer forest located in The Valles Caldera National Preserve, NM. We found that the post-burn ecosystem returned to an annual net sink of carbon in the year immediately following the fire, …


Energetic Tradeoffs, Infection, And Immunity In Wild Chimpanzees Of Uganda And Tanzania, Sarah Renee Phillips Dec 2021

Energetic Tradeoffs, Infection, And Immunity In Wild Chimpanzees Of Uganda And Tanzania, Sarah Renee Phillips

Anthropology ETDs

Infectious disease is a primary source of mortality for most mammal species, but scientists have little understanding of factors driving variation in infection and immunity between individuals, populations, and species in the wild. Life history theory provides an evolutionary framework for delineating distribution of available energy to competing physiological demands, including growth, reproduction, and maintenance. Early life reproduction should be favored over late life survival, but, in long-lived species, reproductive success is strongly tied to survival to old age. Slower pace of reproduction could allow investment in immunity, reducing risk of morbidity and mortality to infectious disease. Additionally, several host …


Paleoindian Response To Climate Change In The Northern Jornada Del Muerto, Christopher Wayne Merriman Dec 2021

Paleoindian Response To Climate Change In The Northern Jornada Del Muerto, Christopher Wayne Merriman

Anthropology ETDs

Human-environment interaction is a long-standing and productive line of inquiry that includes the study of cultural responses to climate change. However, demonstrating a causal relationship between climate change and the consequent culture change is rarely straightforward for numerous reasons. In this dissertation I develop an optimality model to predict how Paleoindians should have responded to changes in precipitation across the Late Pleistocene-Early Holocene. The water supply model (WSM) ranks water supplies much like the diet breadth model ranks food resources. To adjust the WSM for climate change, paleoclimate records from playas in the northern Jornada del Muerto were used in …


An Examination Of Leadership Needs, Preparation, And Expectations In Rural Indigenous Communities, Roselyn Carroll-Trujillo Dec 2021

An Examination Of Leadership Needs, Preparation, And Expectations In Rural Indigenous Communities, Roselyn Carroll-Trujillo

Teacher Education, Educational Leadership & Policy ETDs

ABSTRACT Every single person has leadership ability. Some step up and take them. Some don't. My answer was to step up and lead. ̴Wilma Mankiller ̴ How well prepared are New Mexico school leaders to serve in leadership positions in rural communities with high ratios of Indigenous populations? In this study, I utilized an Indigenous research paradigm to explore policy, reciprocal relationships, licensure requirements in one state, and perceptions from a variety of individuals in rural communities to develop an understanding of what is necessary to create and sustain successful school leadership in an Indigenous community. An Indigenous paradigm of …


Intracavity Phase Interferometry Based Fiber Sensors, Luke Jameson Horstman Dec 2021

Intracavity Phase Interferometry Based Fiber Sensors, Luke Jameson Horstman

Optical Science and Engineering ETDs

Intracavity Phase Interferometry (IPI) is a detection technique that exploits the inherent sensitivity of a laser's frequency to the parameters of its cavity. Intracavity interferometry is orders of magnitude more sensitive than its extracavity alternatives. This dissertation improves on previous free-space proof-of-concept designs. By implementing the technique in fiber optics, using optical parametric oscillation, and investigating non-Hermitian quantum mechanics and dispersion tailoring enhancement techniques, IPI has become more applicable and sensitive. Ring and linear IPI configurations were realized in this work, both operating as bidirectional fiber optical parametric oscillators. The benefit of using externally pumped synchronous optical parametric oscillation is …


Synthetic Aperture Optical Imaging Interferometric Microscopy With Improved Image Quality, Preyom K. Dey Dec 2021

Synthetic Aperture Optical Imaging Interferometric Microscopy With Improved Image Quality, Preyom K. Dey

Electrical and Computer Engineering ETDs

The resolution limit of optical microscopy can be extended by using Imaging Interferometric Microscopy (IIM), which uses a low numerical aperture (NA) objective lens to achieve resolution equivalent to that of a high-NA objective lens with multiple sub-images. Along with the resolution enhancement challenge, IIM often suffers from poor image quality. In this dissertation, several image quality improvement methods are proposed and verified with simulation and experimental results. Next, techniques to extend the resolution limit of IIM to ≤ 100nm using a low-NA objective lens are demonstrated. An experimental technique of using a grating coupler on …


Moderate Prenatal Ethanol Exposure, Sex, And Housing Modify Spatial Navigation Behavior And Hippocampal Cell Firing In Adult Rodents, Christy Magcalas Dec 2021

Moderate Prenatal Ethanol Exposure, Sex, And Housing Modify Spatial Navigation Behavior And Hippocampal Cell Firing In Adult Rodents, Christy Magcalas

Psychology ETDs

Prenatal alcohol exposure (PAE) is associated with structural and physiological changes that impact the central nervous system and can result in persistent negative consequences in a broad spectrum of cognitive and behavioral domains including deficits in spatial learning and memory and behavioral flexibility. The current study focuses on examining the behavioral and mechanistic consequences of PAE, sex and housing. Rats were tested in the Morris Water Task where they were trained to navigate to a goal location and tested in a pool shift manipulation. There were no significant differences between PAE treatment, sex, or housing groups during training, but there …


Lwd Belize: A Case Study For A Rapid Growth Community During The Terminal Classic Period In The Maya Lowlands, Rafael Alfredo Guerra Dec 2021

Lwd Belize: A Case Study For A Rapid Growth Community During The Terminal Classic Period In The Maya Lowlands, Rafael Alfredo Guerra

Anthropology ETDs

This dissertation examines the rise of Lower Dover (LWD) a Late Classic Polity in the middle Belize River Valley (BRV)in the Central Maya Lowlands, Belize. LWD was advantageously situated at the confluence of three important waters ways in the middle BRV to control riverine trade from the coast to the interior Maya heartland. Most large Maya centers developed over many centuries from Preclassic (ca. 400 BC) farming villages to polity capitals. LWD emerged in the Late Classic (ca. 600 AD) as many polities in the BRV were in decline. LWD was rapidly built by local elites and filled a power …


Ultrafast Spectroscopy Of Air Lasing In Filaments, Brian Robert Kamer Dec 2021

Ultrafast Spectroscopy Of Air Lasing In Filaments, Brian Robert Kamer

Optical Science and Engineering ETDs

Filamentation in air is a phenomenon that has been extensively investigated for the last two decades. At sufficiently high intensity, even air is a nonlinear medium. These intensities are reached with ultrashort pulses (50 to 100 fs) of more than 1 J energy, which self-focus in air, reach ionizing intensities of oxygen and nitrogen, creating a plasma that defocuses the beam. The air filament is a self-induced waveguide resulting from a balance of focusing and defocusing. In this work new techniques were developed to visualize and analyze this phenomenon through its emission, in particu- lar the UV emission of the …


20211215_Dr. Eldredge Receives Hsc Faculty Research Excellence Award, Tamara Wheeler Dec 2021

20211215_Dr. Eldredge Receives Hsc Faculty Research Excellence Award, Tamara Wheeler

HSLIC Blog Post

No abstract provided.


Comparison Of The Transcriptomic Signatures In Pediatric And Adult Cml, Minyoung Youn, Stephanie M. Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara Murphy Jones, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman Lacayo, Gary Dahl, Catherine Aftandilian, Kara L. Davis, Jairo A. Matthews, Steven M. Kornblau, Min Huang, Nathan Sumarsono, Michele S. Redell, Cecilia H. Fu, I-Ming Chen, Todd A. Alonzo, Elizabeth Eklund, Jason Gotlib, Purvesh Khatri, E Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M. Sakamoto Dec 2021

Comparison Of The Transcriptomic Signatures In Pediatric And Adult Cml, Minyoung Youn, Stephanie M. Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara Murphy Jones, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman Lacayo, Gary Dahl, Catherine Aftandilian, Kara L. Davis, Jairo A. Matthews, Steven M. Kornblau, Min Huang, Nathan Sumarsono, Michele S. Redell, Cecilia H. Fu, I-Ming Chen, Todd A. Alonzo, Elizabeth Eklund, Jason Gotlib, Purvesh Khatri, E Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M. Sakamoto

Pathology Research and Scholarship

Children with chronic myeloid leukemia (CML) tend to present with higher white blood counts and larger spleens than adults with CML, suggesting that the biology of pediatric and adult CML may differ. To investigate whether pediatric and adult CML have unique molecular characteristics, we studied the transcriptomic signature of pediatric and adult CML CD34+ cells and healthy pediatric and adult CD34+ control cells. Using high-throughput RNA sequencing, we found 567 genes (207 up- and 360 downregulated) differentially expressed in pediatric CML CD34+ cells compared to pediatric healthy CD34+ cells. Directly comparing pediatric and adult CML CD34+ cells, 398 genes (258 …


Wagon Tracks Volume 36, Issue 1 (November 2021) Dec 2021

Wagon Tracks Volume 36, Issue 1 (November 2021)

Wagon Tracks

Contents

2 On the Cover: East Meets West, by Cally Krallman

4 Insights from your President

5 Joanne’s Jottings

2, 6-9, 13, 19 Trail News

10-12 Remembering Faye Gaines

14 Faces at the Symposium By Dotti Russell

15-20 A Million Ways to Die in the West: Three Pandemics by John F. Steinle

21-28 Santa Fe Trail Association Hall of Fame Inductees

29-35 Chapter Reports

33 Membership Form

36 Calendar