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Heterogeneity Of Treatment Effects Of Hydrocortisone By Risk Of Bronchopulmonary Dysplasia Or Death Among Extremely Preterm Infants In The National Institute Of Child Health And Human Development Neonatal Research Network Trial: A Secondary Analysis Of A Randomized Clinical Trial, Samuel J. Gentle, Matthew A. Rysavy, Lei Li, Matthew M. Laughon, Ravi M. Patel, Erik A. Jensen, Susan Hintz, Namasivayam Ambalavanan, Waldemar A. Carlo, Kristi Watterberg, National Institute Of Child Health And Human Development Neonatal Research Network

Pediatrics Research and Scholarship

IMPORTANCE: Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health and Human Development Neonatal Research Network (NICHD NRN) Hydrocortisone Trial, hydrocortisone neither reduced rates of BPD or death nor increased rates of neurodevelopmental impairment (NDI) or death.

OBJECTIVE: To determine whether estimated risk for grades 2 to 3 BPD or death is associated with the effect of hydrocortisone on the composite outcomes of (1) grades 2 to 3 BPD or death and (2) moderate or severe NDI or death.

DESIGN, SETTING, AND PARTICIPANTS: …

Assessment Of Corticosteroid Therapy And Death Or Disability According To Pretreatment Risk Of Death Or Bronchopulmonary Dysplasia In Extremely Preterm Infants, Erik A. Jensen, Laura Elizabeth Wiener, Matthew A. Rysavy, Kevin C. Dysart, Marie G. Gantz, Eric C. Eichenwald, Rachel G. Greenberg, Heidi M. Harmon, Matthew M. Laughon, Kristi L. Watterberg, Michele C. Walsh, Bradley A. Yoder, Scott A. Lorch, Sara B. Demauro, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network

Pediatrics Research and Scholarship

IMPORTANCE: Meta-analyses suggest that corticosteroids may be associated with increased survival without cerebral palsy in infants at high risk of bronchopulmonary dysplasia (BPD) but are associated with adverse neurologic outcomes in low-risk infants. Whether this association exists in contemporary practice is uncertain because most randomized clinical trials administered corticosteroids earlier and at higher doses than currently recommended.

OBJECTIVE: To evaluate whether the pretreatment risk of death or grade 2 or 3 BPD at 36 weeks' postmenstrual age modified the association between postnatal corticosteroid therapy and death or disability at 2 years' corrected age in extremely preterm infants.

DESIGN, SETTING, AND …

Alveolar Rhabdomyosarcoma Has Superior Response Rates To Vinorelbine Compared To Embryonal Rhabdomyosarcoma In Patients With Relapsed/Refractory Disease: A Meta-Analysis, Wendy Allen-Rhoades, Philip J. Lupo, Michael E. Scheurer, Yueh-Yun Chi, John F. Kuttesch, Rajkumar Venkatramani, William H. Meyer, Leo Mascarenhas

Pediatrics Research and Scholarship

BACKGROUND: Patients with alveolar rhabdomyosarcoma (ARMS) have inferior outcomes compared to patients with embryonal rhabdomyosarcoma (ERMS) and more effective chemotherapy options are needed for these patients. Vinorelbine is a semisynthetic vinca alkaloid that has clinical activity in relapsed rhabdomyosarcoma (RMS) when used alone or in combination with cyclophosphamide.

AIMS: The goal of our study was to evaluate whether RMS histology subtype influences response rate to vinorelbine alone or in combination.

MATERIALS & METHODS: Five Phase 2 trials that enrolled RMS patients were included in the meta-analysis. Two studies evaluated vinorelbine alone, two studies evaluated vinorelbine in combination with low dose …

Hslic Academic Health Department (Ahd) Grant Annual Report, Gale G. Hannigan

Administrative Materials

No abstract provided.

Blood Pressure Classification Status In Children With Ckd Following Adoption Of The 2017 American Academy Of Pediatrics Guideline, Derek K. Ng, Megan K. Carroll, Susan L. Furth, Bradley A. Warady, Joseph T. Flynn, Sahar Fathallah-Shaykh, Anjali Nayak, Martin Turman, Tom Blydt-Hansen, Cynthia Wong, Steve Alexander, Ora Yadin, Elizabeth Ingulli, Robert Mak, Cheryl Sanchez-Kazi, Asha Moudgil, Caroline Gluck, Carolyn Abitbol, Marissa Defrietas, Chryso Katsoufix, Wacharee Seeherunvong, Larry Greenbaum, Lyndsay Harshman, Craig Langman, H Ann & Robert, Sonia Krishnan, Amy Wilson, Stefan Kiessling, Margaret Murphy, Siddharth Shah, Janice Sullivan, Sushil Gupta, Samir El-Dahr, Nancy Rodig, Allison Dart, Meredith Atkinson, Arlene Gerson, Tej Matoo, Zubin Modi, Alejandro Quiroga, Bradley Warady, Rebecca Johnson, Vikas Dharnidharka, Stephen Hooper, Susan Massengill, Liliana Gomez-Mendez, Matthew Hand, Joann Carlson, Hanan Tawadrous, Craig Wong, Frederick Kaskel, Shlomo Shinnar, Jeffrey Saland, Marc Lande, George Schwartz, Anil Mongia, Donna Claes, Mark Mitsnefes, Katherine Dell, Hiren Patel, Pascale Lane, Rulan Parekh, Amira Al-Uzri, Kelsey Richardson, Larry Copelovitch, Elaine Ku, Joshua Samuels, Poyyapakkam Srivaths, Samhar Al-Akash, Patricia Seo-Mayer, Victoria Norwood, Cynthia Pan, Sharon Bartosh

Pediatrics Research and Scholarship

Accurate detection of hypertension is crucial for clinical management of pediatric chronic kidney disease (CKD). The 2017 American Academy of Pediatrics (AAP) clinical practice guideline for childhood hypertension included new normative blood pressure (BP) values and revised definitions of BP categories. In this study, we examined the effect of applying the AAP guideline’s normative data and definitions to the Chronic Kidney Disease in Children (CKiD) cohort compared with use of normative data and definitions from the 2004 Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents.

Examining The Relationship Between Anxiety And Depression Symptoms, Protective Behavioral Strategies And Opioid Use Outcomes, Melissa Rose Hatch

Psychology ETDs

Protective behavioral strategies (PBS), behaviors individuals use to reduce negative consequences of substance use, have been shown to mediate and moderate the relationship between mental health and substance use outcomes. The present study aimed to examine the relationships between anxiety and depression symptoms and opioid PBS on risky opioid use and opioid-related consequences. Participants in this secondary data analysis were non-treatment seeking individuals who reported past-month opioid use (n=257). Structural equation modeling was used to examine 1) PBS as a mediator of the relationship between anxiety/depression symptoms and opioid use outcomes, and 2) anxiety/depression symptoms as a moderator …

Neutrosophic Sets And Systems, Vol. 55, 2023, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

A Reconfigurable Architecture For Matrix Multiplication For Low Power Applications, Jeffrey Love

Electrical and Computer Engineering ETDs

This thesis presents a hardware architecture for performing matrix multiplication via a systolic array to reduce time complexity and power consumption. The proposed architecture, the Neural Network Accelerator (NNA), was designed in Verilog HDL to perform 8-bit multiplication to reduce the resources required to implement the NNA on low-power FPGAs. The NNA’s open architecture is designed to support radiation test for fault tolerant designs targeting space applications. Commercial hardware architecture information is not public knowledge, which led us to build our own matrix multiplication architecture so that we could later study its feasibility for space applications.

The NNA was compared …

The Quantum Computational Utility Of Symmetry-Protected Topological Order: From Near-Term Advantages To Universal Measurement-Based Quantum Computing, Austin Kevin Daniel

Physics & Astronomy ETDs

Quantum computers offer new avenues to approach difficult problems by taking advantage of the strange and often nonintuitive phenomena present in quantum physics. Though many quantum algorithms are believed or known to outperform the best known classical algorithms, the fundamental mechanism granting them their power remains elusive. In measurement-based quantum computation (MBQC), two key resources have been show to enable universal and provably nonclassical quantum computations, respectively. These are symmetry-protected topological order (SPTO), a notion describing a class of quantum magnets with hidden long-range correlations in their entanglement structure, and quantum contextuality, the fact that a quantum measurement outcome inherently …

Multi-Factor Disturbance Regimes Drive Soil Fungal Community Composition Across A Southwestern Us Riparian Cottonwood Landscape, Rich Wagner

Biology ETDs

In southwestern US riparian cottonwood forests, anthropogenic changes have replaced the structuring force of seasonal flooding with novel multi-factor disturbance regimes, driving these ecosystems to new states. While the impetus for restoration is high, little attention has been paid to understanding belowground feedbacks from these new drivers. Using high-throughput sequencing of environmental DNA, we compared the impacts of fires, exotic plants, restoration practices and lower levels of disturbance on soil fungal community composition and diversity across a riparian cottonwood landscape in New Mexico. We focused on mycorrhizal fungi for the benefits they may confer upon cottonwoods. We found that along …

Transcriptional Regulation Of Stem Cell Function In The Drosophila Central Nervous System, Amalia S. Parra

Biology ETDs

Development of multicellular organisms depends on coordination of various molecular mechanisms to ensure proper tissue size and structure. This is accomplished through intrinsic and extrinsic cues that regulate cell growth and proliferation both spatially and temporally. These well-coordinated signals are present from early developmental stages and remain active throughout development to ensure tissue structure is appropriate for function. This is particularly important in early cell types that form specialized lineages such as stem cells or those found throughout the body such as epithelia. While much progress has been made in understanding growth regulatory mechanisms, several fundamental aspects remain unknown. This …

Assessing Verbal Memory Task Performance And Intractable Epilepsy: The Associations Among Hippocampal Volume Ratio, Seizure Demographic Factors And Memory Indices, Alexis Gabrielle Burks

Psychology ETDs

Epilepsy affects 3.4 million people in the United States and may affect their memory performance. This study investigated the relationships between memory performance, hippocampal volume ratio, and demographic factors in adults with intractable epilepsy in standardized memory tasks and an experimental memory task designed to be repeated daily. Participants underwent electrode implantation surgery and completed comprehensive neuropsychological assessments prior to surgery including an experimental memory task during their stay in the hospital. Correlation, ANOVA, and regression analyses were completed. The standardized memory tasks and the experimental memory task were significantly correlated. Hippocampal volume ratio was not significantly correlated to memory …

Deformation At Uturuncu Volcano, Bolivia: Modeling The Effect Of Volatile Movement In The Hydrothermal System, Karissa Rosenberger

Earth and Planetary Sciences ETDs

Deformation at volcanos is often a precursor to an eruption, but sometimes volcanos experience uplift without actually erupting. Determining the mechanisms behind this deformation and whether it will lead to an eruption is an important part of understanding volcanic systems. Uturuncu volcano in Bolivia has been experiencing deformation for decades, but the last time it erupted was 250,000 years ago. The reason behind this deformation is unknown, but one possible cause is volatiles moving into the hydrothermal system and getting trapped, causing the volume to increase and the surface to uplift. To test this hypothesis, the current volume change of …

“With All Deliberate Speed”: The Ironic Demise Of (And Hope For) Affirmative Action, Vinay Harpalani

Faculty Scholarship

Is affirmative action in university admissions about to end? As the United States Supreme Court prepares to decide lawsuits against Harvard and the University of North Carolina Chapel Hill (UNC), the outlook for race-conscious admissions policies is not good. Even before its recent rightward shift, the Court had long been hostile to such policies, and many observers think it will now overturn Grutter v. Bollinger and end them altogether. Such a ruling would be a painful and paradoxical twist for civil rights advocates. In a classic turn of Orwellian irony, the plaintiffs challenging affirmative action now call themselves Students for …

Generalized Owa Operator Of Orthopair Neutrosophic Numbers And Their Application In Multiple Attribute Decision-Making Problems, Jiancheng Chen, Jun Ye, Angyan Tu

Neutrosophic Sets and Systems

No abstract provided.

Theory On Duplicity Of Finite Neutrosophic Rings, T. Chalapathi, K. Kumaraswamy Naidu, D. Harish Babu, F. Smarandache

Neutrosophic Sets and Systems

No abstract provided.

An Asymmetric Measure Of Comparison Of Neutrosophic Sets, Surender Singh, Sonam Sharma

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic N-Valued Refined Sets And Topologies, Murad Ara

Neutrosophic Sets and Systems

No abstract provided.

A Comparative Study Of Fuzzy Cognitive Maps And Neutrosophic Cognitive Maps On Covid Variants, Regan Murugesan, Yamini Parthiban, R. Narmada Devi, Kala Raja Mohan, Sathish Kumar Kumarave

Neutrosophic Sets and Systems

No abstract provided.

Hyperbolic Sine Similarity Measure Of Svnss For Open-Pit Mine Slope Stability Classification And Assessment, Yi Ding, Djun Ye

Neutrosophic Sets and Systems

No abstract provided.

20230501_Zines And Za, Kaylee Nauer

HSLIC Blog Post

No abstract provided.

Unm Hslic Organizational Chart 2023, Sally Bowler-Hill

HSLIC Organizational Charts

No abstract provided.

Collaborative Approaches To Improving Medical Subject Headings, Violet Fox, Kelleen Maluski

Posters and Presentations

No abstract provided.

Subjected: Investigating The Impact Of Mesh Terms On Underrepresented Groups, Lorin Jackson, Jamia Williams, Kelleen Maluski, Alexis Ellsworth-Kopkowski

Posters and Presentations

No abstract provided.

Evidence Against Routine Use Of Glucagon For Prostate Mri, Steven C. Eberhardt

Radiology Research and Scholarship

No abstract provided.

Closed Neutrosophic Dominating Set In Neutrosophic Graphs, Amir Majeed, Nabeel Arif

Neutrosophic Sets and Systems

No abstract provided.

A Neutrosophic Evaluation Method Of Engineering Certification Teaching Effect Based On Improved Entropy Optimization Model And Its Application In Student Clustering, Jingyuan Li, Fangwei Zhang, Y Jun, Yuanhong Liu, Jianbiao Hu

Neutrosophic Sets and Systems

No abstract provided.

Analysis Of Teaching-Learning Efficiency Using Attribute Based Double Bounded Rough Neutrosophic Set Driven Random Forests, B Praba, Balambal Suryanarayanan, D. Nagarajan, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Speech Recognition Algorithm For Speech Under Stress By Machine Learning, D. Nagarajan, S. Broumi, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.

Water Quality Evaluation Using Generalized Correlation Coefficient For M-Polar Neutrosophic Hypersoft Sets, Muhammad Saqlain, Muhammad Riaz, Natasha Kiran, Poom Kumam, Miin-Shen Yang

Neutrosophic Sets and Systems

No abstract provided.