Digital Commons Network^™

Dissecting The Functional Impairment Of Wild-Type P53 In Human Glioblastoma, Leopoldo A. García-Montaño, Yamhilette Licon Munoz, Frank Martinez, Kandee Gallegos, Huining Kang, Sara G.M Piccirillo

Brain & Behavioral Health Research Day

Glioblastoma is the most common malignant brain tumor in adults. In contrast to several cancers, where the tumor suppressor gene TP53 is altered, most glioblastoma patients retain a non-mutant TP53 gene. However, the survival of these patients is similar to that of mutant patients, suggesting that p53 is nonfunctional. To test this hypothesis, we analyzed data from The Cancer Genome Atlas, identified potential regulators of p53, and we will test their function in patient-derived cells.

Neuron Specific Gene Family Members Nsg1 & Nsg2 Differentially Affect Long-Term Potentiation, Learning And Memory, Antonio D. Serrano Rodriguez, Amber Zimmerman, Sandy Wilson, David Linsebardt, Jonathan Brigman, Jason Weick

Brain & Behavioral Health Research Day

Non-Expert Summary:

The neuron-specific gene family (NSG1-3) plays crucial roles in regulating the movement and processing of key proteins within neurons, particularly those involved in Alzheimer's disease and synaptic strength regulation. While NSG1 is known for its importance in proper synaptic function, NSG2's role is less understood. Surprisingly, deleting NSG2 selectively enhanced learning and memory, contrary to predictions. Electrophysiology experiments revealed NSG1 and NSG2 have opposite effects on synaptic plasticity, shedding light on their distinct molecular mechanisms.

Funding:

5R01NS116051-04

Eeg Acquisition Methods During The First Year Of Life: Unm Pilot Of Healthy Brain And Child Development Study (Hbcd), Alexandria Wiesel, Lidia Enriquez Marquez, Lawrence Leeman, Ludmila N. Bakhireva, James F. Cavanagh

Brain & Behavioral Health Research Day

Background:

The HEALthy Brain and Child Development (HBCD) is the largest multi-site longitudinal prospective study in the US. The national cohort is composed of local pregnant persons and children who continue with HBCD for 5+ years. HBCD seeks to examine brain and child development amongst substance and environmental exposures, social, cultural, and genetic influences.

Methods:

Repeated electroencephalography (EEG) assessments are performed throughout HBCD, starting at Visit 3 (3-9 months). EEG signals and corresponding stimuli are analyzed to measure event-related potentials (ERPs). EEG acquisition includes 4 age-adjusted tasks recorded via MagstimEGI 128 channel net, EKG lead, and Net Station Acquisition. Video …

The Location Of Spreading Depolarizations Influence Tissue Outcomes In A Transient Mcao Model Of Stroke, Michael C. Bennett, C William Shuttleworth

Brain & Behavioral Health Research Day

Spreading depolarizations (SDs) have been strongly linked to advancing secondary injury in ischemic stroke but may also provide beneficial effects to brain tissue that is not metabolically depleted. In the current study, we sought to identify whether SDs initiated remotely can alter secondary injury expansion. Infarct size was significantly reduced in mice with transient MCAo when SDs were induced in brain regions located outside of the vulnerable stroke penumbra suggesting a neuroprotective effect of SD.

Funding: NS129351, NS106901, GM109089

Building Community Through Learning Traditional Irish Music, Laura Olson

Music ETDs

This thesis foregrounds traditional Irish music and the role it plays in building community. I demonstrate how the genre is defined and transmitted plays an important role in how inclusive the genre can be and where changes need to be made to be more welcoming to new individuals. Playing or singing in musical groups has been shown to combat loneliness but there has been little focus on specific music genres, especially those that are instrumental in nature. This thesis shows that instrumental music can be another tool to combat loneliness and promote overall health and wellbeing using the vehicle of …

Entre La Realidad Y La Ficción: Una Charla Con Irene Vasco, Irene Vasco

LAII Events

Les invitamos a participar de un evento con Irene Vasco para que conozcan acerca de sus investigaciones para el libro, La joven maestra y la gran serpiente (uno de los mejores libros ilustrados para niños del New York Times en 2023).

Design And Analysis Of Free Piston Stirling Engines For Microreactor Applications, Phat D. Doan

Nuclear Engineering ETDs

Through the development of microreactors, a free piston Stirling engine (FPSE) is an excellent candidate to support the development of the microreactors applications. This study proposes a 20 kWe design of the FPSE for microreactor applications. The model has been developed and analyzed through a MATLAB code that was verified and benchmarked with both RE-1000 engine’s experiment data and Sage software. The MATLAB code has been developed from scratch using the first and second order approximation to simulate the engine’s steady state operation. There are three operating conditions that were applied to the code such as ideal isothermal, ideal adiabatic, …

Unm Hslic Organizational Chart 2024, Sally Bowler-Hill

HSLIC Organizational Charts

No abstract provided.

Hsc Connects Newsletter - March 14, 2024, Unm Hsc Communications

HSC Connects Newsletters

Weekly newsletter of the UNM Health Sciences Center.

Neuroplasticity In The Dentate Gyrus: A Multimethod Investigation On Hippocampal Ltp Following Prenatal Alcohol Exposure, Monica Goncalves-Garcia

Psychology ETDs

Studies have demonstrated alcohol-related deficits in LTP associated with histaminergic and glutamatergic impairments. The histaminergic H3R inverse agonist ABT-239 has shown promise in reversing these deficits. The present study focuses on another H3R inverse agonist, SAR-152594, and its impact on LTP deficits following moderate PAE. The findings reveal that systemic administration of 1 mg/kg of SAR-152594 reverses deficits in potentiation fEPSPs in adult male rats exposed to moderate PAE. Time-frequency analyses of evoked responses indicate PAE-related reductions in power during the fEPSP and increased power during later components of evoked responses, both reversed by SAR-152594. These results provide further evidence …

Investigating The Structural Ensemble And Dynamic Interactions Of Protein Interacting With C-Kinase 1 (Pick1) Using Computational Tools, Amy E. Stevens

Chemistry and Chemical Biology ETDs

Protein Interacting with C Kinase-1 (PICK1) is a scaffolding protein that offers a promising solution to support individuals suffering from substance use disorders. While many efforts have been put towards identifying small-molecule drugs with the potential to target PICK1 and ultimately support individuals suffering from the effects of substance use disorders, all efforts have so far fallen short. The purpose of this work is to use computational tools to assist the design of a small-molecule inhibitor of PICK1 while also advancing the knowledge of its biological functions. This work provides information that is currently missing the field by (1) revealing …

03/11/2024 Meeting, Varina A. Kosovich

Meeting Minutes

No abstract provided.

Hsc Connects Newsletter - March 8, 2024, Unm Hsc Communications

HSC Connects Newsletters

Weekly newsletter of the UNM Health Sciences Center.

Looking To The Mountain: Sacred Lands, Healing Cultures, Albuquerque Biopark Botanic Garden

LAII Events

The year 2024 marks the 100th Anniversary of the designation Gila Wilderness by Aldo Leopold, representing a landmark opportunity to re-affirm and re-imagine our relationships to New Mexico and these remarkable landscapes.

Looking to the Mountains: Sacred Lands, Healing Cultures provides an opportunity for all ages to celebrate the natural and cultural history of New Mexico through music, poetry, art, and educational activities sponsored by the University of New Mexico and hosted by the ABQ BioPark.

For further information about the Ancestral Gila Homeland Project and Events see: https://gilawildernesscentennial.wordpress.com

03-07-24 Hsc Committee Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

03.07.24 HSC Committee Agenda

03-07-2024 Hsc Committee Minutes, Helen Maestas

HSC Committee (A subcommittee of the UNM Board of Regents)

03-07-2024 HSC Committee Minutes

Theft, Consumption, And Gender In Domestic Service (Mar Del Plata, Argentina, 1950–1980), Inés Pérez

LAII Events

In her remote lecture for the Department of History’s celebration of Women’s History Month, Dr. Pérez will use court records on "servant theft" to examine popular notions of social equality and justice, as well as gender and consumption, in Peronist Argentina. Following the lecture, graduate students from History and Latin American Studies will offer comments for discussion with Dr. Pérez. Refreshments will be provided.

Capoeira And The Nordeste, Jessica Carey-Webb

LAII Events

Join us for a lightening talk by Dr. Jessica Carey-Webb, followed by a capoeira workshop! No Portuguese knowledge needed.

To Infinity & Beyond: From Citation Analysis To Understanding Open Access Publishing, Robyn Gleasner, Robinson Lewis Worley

Posters and Presentations

The University of New Mexico Health Sciences Library and Informatics Center conducted a citation analysis to determine where faculty are publishing and open access publishing trends. The actions based on the results of this analysis including gaps in the collection, acquisitions decisions, and emerging publishing trends will be shared.

Mbe Growth Of Sb Based Alloys Using Interfacial Misfit Arrays For Mwir Devices, Fatih Furkan Ince

Optical Science and Engineering ETDs

This thesis explores the monolithic integration of antimonide based narrow bandgap semiconductors on commercially available substrates for mid-wave infrared (MWIR) devices. The research focuses on the integration and growth of antimonide based alloys using the interfacial misfit dislocation (IMF) arrays to enhance the cost efficiency, manufacturability and performance. The study particularly investigates the relaxation mechanisms of antimonide alloys on InAs and InP substrates, assessing the impact of mismatch strain on the quality of epilayers. The IMF arrays are examined using high-resolution transmission electron microscopy (HR-TEM) and x-ray diffraction (XRD), revealing information about the effective strain relief mechanisms behind IMF arrays …

Measuring And Explaining The Differences In Corruption Between Europe And Latin America. Are We Getting Closer Or Further Apart?, Manuel Villoria Mendieta, Latin American And Iberian Institute

LAII Events

Dr. Villoria will discuss data on corruption in Europe and Latin America,using cultural, structural, and institutional lenses to explain differences in these regions. He will also discuss how populism and the radicalization corruption generates can seriously jeopardize the objective understanding of corruption and the possibilities of combating this problem.

Evaluation Of Sustainable Waste Valorization Using Treesoft Set With Neutrosophic Sets, Ali Alqazzaz, Karam M. Sallam

Neutrosophic Sets and Systems

This study proposed a neutrosophic set framework with TreeSoft Set for sustainable waste valorization selection. The neutrosophic set is used to overcome uncertainty and vague information in the evaluation process. The neutrosophic set has three membership degrees: truth, indeterminacy, and falsity. The multi criteria decision-making (MCDM) methodology deals with various criteria to evaluate waste valorization. The VIKOR method is an MCDM method used to rank the alternatives. The numerical example was created with 12 criteria and 10 alternatives. Three decision-makers and experts are invited to evaluate the requirements and options. We used the bipolar neutrosophic numbers to replace the opinions …

A Python Framework For Neutrosophic Sets And Mappings, Giorgio Nordo, Saeid Jafari, Arif Mehmood, Bhimraj Basumatary

Neutrosophic Sets and Systems

In this paper we present an open source framework developed in Python and consisting of three distinct classes designed to manipulate in a simple and intuitive way both symbolic representations of neu trosophic sets over universes of various types as well as mappings between them. The capabilities offered by this framework extend and generalize previous attempts to provide software solutions to the manipulation of neutrosophic sets such as those proposed by Salama et al. [21], Saranya et al. [23], El-Ghareeb [7], Topal et al. [29] and Sleem [26]. The code is described in detail and many examples and use cases …

Study Of The Relationship Among Economic Variables In Cattle Production In A Region Of Peru, Based On Plithogenic Statistics, Ketty Marilú Moscoso-Paucarchuco, Michael Raiser Vásquez-Ramírez, Humberto Rafael Yupanqui-Villanueva, Wilfredo Fernando Yupanqui-Villanueva, Omar Arturo Vivanco-Nuñez, Manuel Michael Beraún-Espíritu, Rafael Jesús Fernández-Jaime, Edgar Gutiérrez-Gómez

Neutrosophic Sets and Systems

This paper is an in-depth study that starts from a preliminary one, where we surveyed 141 ranchers from the town of Coto-Coto in Peru to obtain as much information as possible about the relationship between two economic variables, Activity Cost and Financial Management. Furthermore, we study the correlation of the first one of them with three other economic vari ables. To do this, we process the survey data using logical operators with the support of the plithogenic statistics theory. These results given in the form of plithogenic values are logically aggregated and were converted to crisp values and studied through …

Optimization Of Triangular Neutrosophic Based Economic Order Quantity Model Under Preservation Technology And Power Demand With Shortages, S. Loganayaki, N. Rajeswari, K. Kirupa, S. Broumi

Neutrosophic Sets and Systems

The primary objective of this article is to develop a mathematical model and determine the optimal policies of an inventory system involving power demand and controlled deterioration through preservation technology. This model comes in handy in a power demand-oriented inventory system with demand high at the end of the period. The model incorporates backlogged shortages and linear holding cost. The triangular neutrosophic numbers (TNN’s) are used for a nuanced representation of uncertain and imprecise inventory-related expenses. An efficient algorithm is constructed to minimize the total cost, and obtain optimal positive inventory time, optimum cycle time and minimum preservation technology investment. …

Enhancing Medical Image Quality Using Neutrosophic Fuzzy Domain And Multi-Level Enhancement Transforms: A Comparative Study For Leukemia Detection And Classification, A. A. Salama, Mahmoud Y. Shams, Huda E. Khalid, Doaa E. Mousa

Neutrosophic Sets and Systems

Medical image processing has become a critical research area due to the vast amounts of digital image data available. However, medical images often suffer from poor illumination and low visibility of significant structures, requiring image enhancement to improve image quality before processing. In this paper, we propose a technique for enhancing medical images by removing noise and improving contrast based on three different enhancing transforms. The proposed technique embeds the image into a neutrosophic fuzzy domain, where it is mapped into three different levels of trueness, falseness, and indeterminacy, and each level is processed individually using the enhancement transforms. We …

Neutrosophy Transcends Binary Oppositions In Mythology And Folklore, Florentin Smarandache

Neutrosophic Sets and Systems

This article is a brief foray into the intricate realm of mythological and folkloric composite entities. Our analysis posits that these hybrid and superhybrid creatures serve as compelling evidence that the human psyche consistently transcends binary oppositions as in neutrosophy. Across diverse cultures and epochs, the human mind exhibits a propensity for nuanced and neutrosophic vantage points, defying simplistic categorizations. Additionally, we make some remarks pertaining to the subject matter, and open up a few less conventional questions.

A Novel Method For Solving The Time-Dependent Shortest Path Problem Under Bipolar Neutrosophic Fuzzy Arc Values, Vidhya K, Saraswathi A, Broumi Said

Neutrosophic Sets and Systems

The Shortest path problem is highly relevant in our daily lives, addressing uncertainties like traffic conditions and weather variations. To handle such uncertainties, we utilize Fuzzy Numbers. This paper focuses on Bipolar Neutrosophic Fuzzy Numbers, which have dual positive and negative aspects. They provide a robust framework for representing arc (node/edge) weights, signifying uncertain travel times between nodes. Importantly, these weights can change over time in bipolar neutrosophic fuzzy graphs. Our study introduces an extended Bellman-Ford Algorithm for identifying optimal paths and minimum times with time-dependent Bipolar Neutrosophic Fuzzy arc weights. We demonstrate its effectiveness through a step-by-step numerical example …

Neutrosophic Doubt Fuzzy Bi-Ideal Of Bs-Algebras, P. Ayesha Parveen, M. Himaya Jaleela Begum

Neutrosophic Sets and Systems

In this research paper, our aim is to introduce the new concept of neutrosophic doubt fuzzy bi-ideal of BS algebras as an extension of doubt fuzzy bi-ideal of BS-algebras and investigated its algebraic nature. Neutrosophic doubt fuzzy bi-ideal of BS-algebras is also applied in Cartesian product. Finally, we also provide the homomorphic behaviour of Neutrosophic doubt fuzzy bi-ideal of BS-algebras.

Neutrosophic Vision Of The Expected Opportunity Loss Criterion (Neol) Decision Making Under Risk, Maissam Jdid, Florentin Smarandache

Neutrosophic Sets and Systems

One of the major challenges facing decision-makers at the present time is obtaining complete information about the issue under study, due to the unstable conditions of the work environment that are beyond the control of decision-makers, which requires them to reach an optimal decision in light of these circumstances and fluctuations and to benefit from the data that is collected. Collected by specialists to determine the appropriate probability distribution corresponding to random cases of nature, here we are faced with the issue of making a decision in the event of risk because the probability distribution is a distribution linked to …