Digital Commons Network^™

Computational Design Of Peptides And Proteins Through Machine Learning Approaches, Emily J. Hendrix

Chemistry and Chemical Biology ETDs

Advancements in machine learning have emerged as a pivotal tool in computational biochemistry, offering new advancements to address challenges in protein structure and function. However, current machine-learning approaches offer limited insight in understanding protein dynamics. The purpose of this work is to combine traditional physics-based computational tools, such as molecular dynamics and coarse-grained simulations, with recently developed AI-driven computational tools to bridge gaps and advance the understanding of proteins in both structural and dynamic aspects. I investigated several approaches such as (i) traditional physics-based methods to study protein conformation and ensembles; (ii) identifying a peptide inhibitor for the PICK1 PDZ …

Reassembling Riparian Ecosystems: Stream Restoration Effects On Vegetation, Arthropods, And Aquatic-Terrestrial Connectivity, Katelyn P. Driscoll

Biology ETDs

Riparian areas exist at the aquatic-terrestrial interface and provide disproportionate ecosystem services, yet multiple stressors have degraded these zones globally. Stream restoration seeks to reverse degradation, but rigorous evaluation of treatment effectiveness remains limited. I conducted a before-after-control-impact (BACI) study in the southern Rocky Mountains to evaluate two stream restoration treatments—beaver dam analogs (BDAs) and plug-and-ponds (P&Ps)—across three dimensions of riparian ecosystem response. Using Bayesian analysis, I quantified treatment effects on functional diversity and composition of riparian plant communities. Using generalized linear mixed models, I evaluated restoration effects on riparian arthropod abundance, richness and guild composition across lateral gradients and …

Assessing The Impact Of Multi-Physics Effects On Photovoltaic Module Degradation Using Computational Modeling, James Yuan Hartley

Mechanical Engineering ETDs

This dissertation describes research to develop and apply multi-physics simulation capabilities using finite element methods to analyze photovoltaic module damage mechanisms. Analyses of full-scale solar modules under mechanical load are presented, including experimental validation against measurements of external deflection and internal strain. Module damage by solar cell breakage and interconnection fatigue are discussed, and the applicability of simplifying analyses using mathematical plate theory is assessed. Detailed sub-module component models undergoing thermal-mechanical stressors are also presented, to identify the design features and materials most influential to stress generation and to assess the representativeness of using sub-module assemblies in accelerated testing. Finally, …

Al-Manfiyun Exiliados: Voices Of The Lebanese Diaspora In Mexican Literature, Mia Del Rosario

Spanish and Portuguese ETDs

This thesis explores two key works of Mexican literature published in the late 20^th century in terms of their cultural relevance in the Mexican literary sphere. The novels En el verano, la tierra by Carlos Martínez Assad and Las hojas muertas by Bárbara Jacobs center around the infrequently-explored identities of Lebanese immigrants to Mexico and their Mexican-born descendants through a sociocultural lens, discussing their identity negotiation in the context of 20^th-century Mexico, which was in the process of redefining its national identity after the Mexican Revolution. During this time, people of ethnicities that did not fall into …

A Constructional Approach To Multimodal Linguistic Analysis, Fredy A. Mendieta Rodriguez

Spanish and Portuguese ETDs

This dissertation investigates the systematic organization of co‑speech gestures in referential communication, using data from Spanish‑speaking monolinguals and Spanish–English bilinguals. While traditional gesture research treats pointing as a universal phenomenon, the current analyses show that gestural productions display internal phonological patterning and context‑conditioned variability that parallels spoken constructions. Quantitative results demonstrate how referential distance and communicative context (find‑it versus misunderstanding situations) shape the selection of embodied phonological features—handshape, orientation, movement, and beats—revealing consistent associations between form and interactional demands. Qualitative analyses trace how gestural realizations reduce across discourse as shared understanding emerges. A new complexity metric, based on token frequency …

Corazones Urbanos: Literary Cartographies And Southwest Cities In The Mexican American Spatial Imaginary, Jorge A. Hernández Jr.

Spanish and Portuguese ETDs

Corazones Urbanos: Literary Cartographies and Southwest Cities in the Mexican American Spatial Imaginary examines how Mexican American writers from Tucson, San Antonio, and Albuquerque narrate, critique, and reimagine urban space across the U.S. Southwest in the twentieth century. Integrating literary studies, cultural geography, urban history, and critical regionalism, the project analyzes responses to racialized development, urban renewal, and gentrification that have displaced Mexican American communities from historic downtowns. Moving beyond borderlands and transnational models, it advances a critically regional approach attentive to local histories, municipal policies, and community pressures shaping urban life. Through close readings of creative and nonfiction texts …

Design, Fabrication, And Characterization Of Silicon Nitride Microresonator Optical Frequency Combs, Lala Rukh

Optical Science and Engineering ETDs

Optical frequency combs consist of equidistant optical frequencies and have numerous applications ranging from optical metrology to medical diagnostics. Initially, frequency combs were based on bulky mode-locked lasers, but advancements in integrated photonics enabled the generation of frequency combs in chip-scale resonators (microcombs) using Kerr nonlinearity. These miniaturized systems present various challenges, including increased propagation losses, enhanced thermal effects, and the extension of microcombs to visible wavelengths. In this dissertation, I will focus on addressing these challenges in silicon nitride (SiN) resonators. First, this thesis focuses on the fabrication of high-Q SiN resonators and the impact of fabrication parameters on …

A Quantum Phase Space Description Of Local Noise In Atomic Ensembles, Andrew Kolmer Forbes

Physics & Astronomy ETDs

Nonclassicality in quantum sensors can improve sensitivity, but often increases susceptibility to noise. Thus, modeling physically relevant noise sources and analyzing their effect on quantum metrology are both of importance to the field of quantum sensing. In this dissertation, I demonstrate that local noise sources, which are present in almost all many-spin systems, can be tractably modeled when assuming permutation symmetry of the noise, and we show that many common local noise sources can be mapped to a Fokker-Planck equation on quantum phase space. We apply this description of noise to study quantum sensing using noisy probe states and establish …

Optical Nuclear Spin Detection In Diamond And Varifocal Metasurface Optics, Maxwell D. Aiello

Physics & Astronomy ETDs

This dissertation presents two experimental investigations at the intersection of quantum sensing and precision optical instrumentation. The primary project demonstrates optically detected nuclear magnetic resonance (NMR) of ¹³C nuclear spins in diamond, using state-selective Landau-Zener transitions under microwave frequency sweeping to bidirectionally transfer spin polarization between nitrogen-vacancy (NV) electron spins and remote ¹³C nuclear spins. This enables optical polarization and readout of large ensembles of polarized nuclear spins at low magnetic fields and room temperature, with spin dephasing times limited by longitudinal relaxation of nearby NV electron spins. The secondary project reports the design, fabrication, and characterization of …

Realizing The Long Wavelength Array Swarm, Craig Anthony Taylor

Physics & Astronomy ETDs

Sensitive modern radio interferometers are costly to build and operate at the university level. The `swarm telescope' concept addresses this challenge by enabling the collaborative use of individual telescope systems, overseen by separate institutions, that come together to form a more powerful and manageable facility. This dissertation focuses on demonstrating this concept using the Long Wavelength Array (LWA) by commissioning an aperture synthesis telescope consisting of interconnected LWA stations, called the LWA Swarm. The presented work details building a cost-efficient prototype LWA platform -- the LWA--North Arm station -- to enable synthesis imaging using the 3-element interferometer comprised of LWA1, …

A Multi-Frequency Investigation Of Compact Symmetric Objects, Evan E. Sheldahl

Physics & Astronomy ETDs

Some of the brightest objects in the radio sky are jetted active galactic nuclei (AGN), supermassive black holes in the centers of galaxies that accelerate relativistic electrons into twin radio jets. One of the biggest questions surrounding AGN is how they produce radio jets in the first place. We search for an answer to this question by exploring a class of AGN that have uniquely well-constrained physical properties and are thought to be in an early stage of AGN development: compact symmetric objects (CSOs). Throughout our journey with these remarkable sources, we quantify their efficacy as calibrator sources for radio …

Sexual Violence By Government Security Forces: Leaders, Institutions, And Culture, Margaret Avera

Political Science ETDs

I assess how the interaction between leader preferences, regime type, and agent personal motives impacts patterns of sexual violence. I ask, “Why do some government security forces perpetrate sexual violence while others do not?” and “How does the interaction between leader motives and institutions impact victimization patterns?” I found that police corruption was correlated with sexual violence by government security forces, but military corruption was not. My findings indicate the importance of moving beyond a conflict scope and distinguishing between different types of state security actors. In addition, I use natural language processing methods to collect disaggregated allegation data to …

Quantifying Co2 And Ch4 Fluxes In A Semi-Arid Floodplain: Assessing Spatial And Temporal Drivers, Miles E. Kelsey

Earth and Planetary Sciences ETDs

Rivers transport sediment and carbon across Earth’s surface, and their floodplains can store carbon over decades to millennia, making them important to terrestrial carbon management. While soil carbon can persist long term, it may be released as greenhouse gases through processes like methanogenesis and heterotrophic respiration. Environmental controls on these fluxes remain poorly constrained across floodplains in different climate and geomorphic setting, but especially in semi-arid systems where measurements are limited. To address this gap, we quantified CO₂ and CH₄ fluxes along the Middle Rio Grande (New Mexico, USA) using 227 chamber measurements collected May to November 2025 at three …

Heavy Metal And Metalloid Accumulation In The Gallinas River Following The Hermit's Peak / Calf Canyon Wildfire, Olivia A. Kelly

Geography ETDs

This study evaluates the persistence and bioavailability of heavy metals and metalloids in the Gallinas River three years after the Hermit’s Peak/Calf Canyon Wildfire of 2022 using a multicompartment sampling framework that includes water, sediment, and benthic macroinvertebrate tissue analysis via inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Results indicate that the Hermit’s Peak/Calf Canyon Fire continues to influence the hydrogeochemical condition of the Gallinas River. Sediments contain elevated concentrations of several metals and metalloids, and these same elements are detectable in macroinvertebrate tissues, linking sediment contamination to biological uptake. Zinc (Zn), silicon …

Nanoscale Structure And Spontaneous Self-Assembly Of Hydrothermal Organic Products, Glorianne P. Dorce

Chemistry and Chemical Biology ETDs

Carbon nanomaterials derived from citric acid and urea exhibit behaviors that challenge conventional structure–property models based on static bulk descriptions. This study examines how precursor pairing and reaction duration, post‑synthetic thermal history, and time‑dependent aging govern nanoscale organization and optical response. Through controlled synthesis and processing, distinct nanostructures with tunable structural and spectroscopic profiles are generated.

A multiscale framework integrating nano‑FTIR, atomic force microscopy, and thermal analysis reveals chemical heterogeneity and continuous structural reorganization across length scales. By correlating local chemical environments with optical behavior, we show that fluorescence efficiency and photostability depend on specific nanoscale architectures rather than average …

Technical Advancements In Single-Molecule Spectroscopy For High-Throughput Measurement Of Long-Time Dynamics, Quyen B. Le

Chemical and Biological Engineering ETDs

Single-molecule fluorescence spectroscopy is a powerful technique for resolving transient biomolecular dynamics and quantifying free energy landscapes, kinetics, and binding interactions. However, two fundamental limitations restrict its broader application: slow, labor-intensive data acquisition and the limited observation time imposed by fluorophore photobleaching. These limitations hinder its use in drug discovery and biomedical engineering applications that require both high-throughput and access to long-time dynamics. In this work, both challenges are addressed through technical advancements. First, a simple, generalizable approach is introduced to automate data acquisition, eliminating manual intervention during experiments. This increases the acquisition rate by more than an order of …

Shelter From The Storm: Public Library Value And Community Adaptive Capacities, Margo Gustina

Economics ETDs

This dissertation contributes to theoretical framing within the discipline of library science, while building out empirical methods for quantitatively valuing broadly loved public libraries. Chapter 1 lays the foundation for understanding how analysis public libraries must always be set within regional contexts. Chapter 2 demonstrates that positive voter valuation of public libraries is driven by proximity to a library building by using data from public funding referendum events. Chapter 3 estimates a reduction of 0.75 percentage point (p=0.002) in graduation rates where public libraries were closed (but school instruction was in-person) from COVID closures. Chapter 4 builds on the previous …

Unpacking The Roots Of School Vouchers: A Critical Discourse Analysis Of Its Origins And The Arizona Model, Swechha Singh

Language, Literacy, and Sociocultural Studies ETDs

Critical Race Theory (CRT) gained prominence in mainstream political discourse following President Trump issuance of Executive Order 13950, Combating Race and Sex Stereotyping, which intensified political debate surrounding CRT, diversity initiatives, and educational curricula. This study used Fairclough’s Critical Discourse Analysis to examine how ideological forces gave rise to the enactment of school vouchers. Using CRT as a theoretical lens, the study examined historical and contemporary data to explore how ideology functioned to advance an expansive education policy agenda, including Arizona’s Empowerment Scholarship Account program. This study offers evidence of the impact of the anti-CRT movement, as well as sustained …

Empowering Pedagogical Practice Through Autoethnography Within The Context Of Family Literacy Projects, Sarah M. Johnson

Language, Literacy, and Sociocultural Studies ETDs

Family Literacy Projects being used in the high school setting to promote cultural and linguistic identities. The Family Literacy Project is used to bridge the gap between student identities at school and the identities at home. The purpose of this study was for the teacher to reflect in an autoethnographic study of herself in relation to the context of community, pedagogy, and the perceived needs and changes of the project for both students and the school’s culture. Through the autoethnographic study, the focus of the Family Literacy Project is in its importance to the school, community, students, and teachers was …

La Raza In The U.S.-Mexico Borderlands: A Comparative Regional Study Of Mexican American Elite Identity-Making From Texan Independence To The Mexican Revolution, Davis Diego Massey

History ETDs

After the U.S. annexed much of Mexico following the Mexican-American War, Mexicans in  the incorporated regions began to think of themselves as a racial group within the U.S. rather  than a distinctive nationality. The 1848 Treaty of Guadalupe Hidalgo promised citizenship  rights to all Mexicans in the area. The Treaty promises rarely were put into practice, as they  were left up to the enforcement of territories and states. Even where enforced, the rights of  citizenship were restricted and defined on the basis of race. Local laws excluded  Afro-Mexicans and Mexican Natives from exercising the rights promised by the Treaty. This …

Helium Effects In High Entropy Alloys For Fusion Reactor Plasma Facing Components, Shane Evans

Nuclear Engineering ETDs

The plasma facing materials (PFMs) within fusion reactors, such as the divertor, must be able to withstand high temperature (>1000 K) for extended durations of time, in addition to extreme flux from neutrons, helium (He) ash, and neutral species such as deuterium and tritium. These materials must withstand these conditions while maintaining their selected mechanical properties, minimal sputter yield, and low fuel retention. In recent years refractory high entropy alloys (RHEAs) have been investigated due to their improved mechanical and irradiation-resistant properties when compared to pure W, the current material for PFMs. In this work RHEAs have undergone fusion …

Development Of A Lead-Lithium Eutectic Magnetohydrodynamic Loop For Corrosion Studies, Xavier S. Angus

Nuclear Engineering ETDs

Lead–lithium eutectic (LLE) is a leading candidate coolant and tritium breeder for fusion reactor blankets due to its favorable heat transfer properties and high tritium breeding ratio. However, LLE is highly corrosive and, in the strong magnetic fields present in fusion reactors, experiences magnetohydrodynamic (MHD) effects that can produce significant pressure drops and flow instabilities. Understanding corrosion behavior in these extreme environments is essential for assessing the viability of LLE blanket systems. This work presents the design and construction of a forced-convection LLE corrosion loop to study corrosion behavior at temperatures up to 425 °C and flow velocities up to …

Design And Analysis Of An Intermediate Heat Exchanger And Passive Decay Heat Removal System For A Generic Fluoride Salt-Cooled High-Temperature Reactor Application, Bao Hoang Nguyen

Nuclear Engineering ETDs

Generation IV reactors, such as the Fluoride salt-cooled High-temperature Reactor (FHR), feature efficient heat transfer and passive heat removal systems. However, accurately predicting thermal behavior under steady-state and transient conditions remains challenging. This work designs and evaluates a twisted tube heat exchanger (TTHX) serving as an intermediate heat exchanger (IHX) and a reactor cavity cooling system (RCCS) serving as a passive decay heat removal system for a generic FHR (gFHR), integrating both systems into a system-level MELCOR model. The TTHX was first designed and assessed using a MATLAB-based framework, followed by detailed MELCOR simulations. The results demonstrate effective heat transfer …

Sensitivity-Informed Resonance Parameter Cross Section Adjustments, Matthew Juan Lazaric

Nuclear Engineering ETDs

This work details the process of developing several new features into the MCNP6.3 Monte Carlo code for use in uncertainty quantification and reduction. These new capabilities, which include the CLUTCH method of calculating k-eigenvalue cross section sensitivities and the Windowed Multipole method of calculating cross sections, are implemented and verified against previous implementations and existing cross section data, respectively. These capabilities are then combined to produce sensitivities of k-eigenvalue to resonance parameters, which are verified against direct perturbation sensitivity estimates. The resonance parameters are calibrated using linear Bayesian methods and the accuracy of the resulting cross section is evaluated via …

Representativeness And Sensitivity Analysis Of Accident Tolerant Fuel Cladding Behavior In Reactivity-Initiated Accidents, Melissa Andrea Moreno

Nuclear Engineering ETDs

Accident Tolerant Fuels (ATFs) such as FeCrAl are being developed to enhance safety margins in light water reactors during transients like Reactivity Initiated Accidents (RIAs). This dissertation evaluates the accuracy and representativeness of TRACE thermal hydraulic models for predicting FeCrAl C36M cladding behavior under steady state and transient flow boiling conditions. Benchmarking against University of New Mexico separate effects experiments shows that TRACE reproduces key thermal trends but underpredicts cladding temperatures near CHF by approximately 25 to 30%. A calibrated uncertainty and global sensitivity analysis, using Sobol indices, demonstrates that CHF and cladding temperature variability are dominated by mass flux, …

In-Situ Measurement Of Dynamic Deuterium Retention In Tungsten-Based Alloys Under Plasma Exposure, Ethan Gabriel Rashap

Nuclear Engineering ETDs

Nuclear fusion is a promising pathway for sustainable energy production, but the performance of plasma-facing materials remains a key challenge for reactor operation. In particular, hydrogen isotope retention in tungsten—the leading candidate material for divertor components—affects tritium inventory, fuel recycling, and overall material lifetime. In this work, the temperature-dependent deuterium retention behavior of W–Ti and W–TiTa alloys was experimentally investigated under fusion-relevant ion irradiation conditions between 400 and 700 K. In-situ nuclear reaction analysis (NRA) was used to track retention during plasma exposure and subsequent cooldown, providing depth-resolved insight into deuterium accumulation and release. The results show that deuterium retention …

Continuous Polygenic Trait Evolution Under Brownian Motion With Gaussian Mixture Models, Mary S. Hopkins

Mathematics & Statistics ETDs

Gaussian mixed-models (GMMs) show promise as a tool for modeling polygenic trait evolution for multiple taxa with established phylogenetic comparative methods (PCMs). When phenotypic traits are influenced by more than one gene, neither a gene tree nor a species tree may be completely adequate to model specific cross-taxa dependencies. In such cases common solutions include using trees inferred from concatenated DNA sequences [35, 95] and consensus gene trees [35]. The GMM-based model, first proposed by Jiang in 2017 [55] allows traits to evolve on more than one tree with distinct topologies. This approach provides a framework for trait evolutionary modeling …

Bayesian Designs For Two-Arm Clinical Trials With Time-To-Event Endpoints: Incorporating Historical Data Through Power Priors, Sara Hajraf H. Almutiri

Mathematics & Statistics ETDs

Bayesian methods provide a flexible framework for time-to-event analysis by incorporating prior information. The power prior offers a systematic way to borrow information from historical data. This approach is especially valuable in clinical research, where historical data can enhance inference in early-phase trials with limited sample sizes. This dissertation develops Bayesian approaches for two-arm survival studies using both closed-form and simulation-based methods. The closed-form inference is derived under exponential and Weibull survival models. Under the proportional hazards framework, the posterior is derived through a normal approximation to the log hazard ratio, allowing inference on the treatment effect when the variance …

Automation, Migration, And Development: Geography Of Job Precarity In South Asia And North Africa, Keshav Bhattarai, Ambika P. Adhikari

Himalayan Research Papers Archive

This article examines how accelerating automation and the adoption of artificial intelligence (AI) in advanced economies reshape labor markets across the Global South through interconnected channels of production, migration, and remittances. Drawing on the theories and practices of economic geography, labor economics, and development studies, the analysis conceptualizes automation as a transnational shock that contracts demand for migrant labor while simultaneously amplifying employment precarity in labor-surplus economies. The article advances a geographically grounded framework linking technology adoption in core industries with labor displacement, youth unemployment, and urban labor saturation in South Asia and North Africa. It further highlights the macroeconomic …

Fault Location In Dc Microgrids Using Traveling Waves, Sajay Krishnan Paruthiyil

Electrical and Computer Engineering ETDs

In DC power systems, rapid fault location is crucial for maintaining reliable operation, particularly with the prevalence of DC-DC converters. This study investigates fault location techniques in DC systems utilizing Traveling Waves (TWs). Following data normalization, multi-resolution analysis employs discrete wavelet transform to capture high-frequency patterns of TW's wavelet coefficients. Parseval's theorem is utilized to quantify the energy of these coefficients. First, a curve-fitting technique is employed to estimate fault locations in DC microgrids. Then, two transfer learning approaches are proposed: first approach integrates Parseval energy curves into a Gaussian process estimator, while second employs feedforward neural network for fault …