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Mechanistic Study Of Dna Ligase Iv-Mediated Double-Strand Break Repair In Non-Homologous End Joining, Tasmin Naila, Alan E. Tomkinson

Biomedical Sciences ETDs

Non-homologous end joining (NHEJ) is a crucial double-strand break repair pathway in mammalian cells, resolving DNA damage from ionizing radiation and during V(D)J recombination. Although DNA Ligase IV is the only mammalian DNA ligase involved in NHEJ, it functions as a single-turnover enzyme in vitro. Recent cryo-electron microscopy (cryo-EM) studies revealed two LigIV molecules at the NHEJ synapse, supporting the hypothesis that two ligase molecules are needed for DSB repair by NHEJ. This study aims to validate this hypothesis by providing evidence for coordinated ligation at optimal distance and polarity preference for catalytic activity by LigIV. We determined that coordination …

The Principles Of (Partial Locality, Partial Indeterminacy, Partial Nonlocality) And (Multi Locality, Multi Indeterminacy, Multi Nonlocality), Florentin Smarandache

Neutrosophic Sets and Systems

This article introduces new neutrosophic principles aiming to extend and generalize the concepts of locality and nonlocality by addressing scenarios involving indeterminacy, together with partiality and multitude, in physics, mechanics, cosmology, biology, medicine, chemistry, economics, ecology, sociology. Locality refers to interactions or processes confined within a limited region of space or time. But there may be a Total (100%) Locality, or a Partial Locality (less than 100% and greater than 0%). The effects are constrained to the immediate environment. Contrariwise, NonLocality refers to interactions or connections between entities separated by space or time. The changes in one location have instantaneous …

Soft Sets Extensions: Innovating Healthcare Claims Analysis, Daniela Gifu, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In the dynamic arena of healthcare research, where the complexities of data often rival the intricacies of biological systems, the ability to model and analyze such multifaceted datasets is crucial. This comprehensive review delves into the evolution and application of Soft Sets and their extensions, including HyperSoft Sets, SuperHyperSoft Sets, IndetermSoft Sets, IndetermHyperSoft Sets, and TreeSoft Sets, in healthcare claims data analysis.

Summary Report Of Discussions At The Ana Forum 2024, Berkeley, Ca “How Can The North American Nepali Diaspora Contribute To Nepal’S Economic Development?”,, Ambika P. Adhikari

Himalayan Research Papers Archive

The ANA 2024 annual convention, organized on ANA’s 42nd founding anniversary, was held in the San Francisco Bay Area (Berkeley and Oakland) in California, where hundreds of ANA members and friends had gathered. The convention consisted of several forums, sessions, and cultural programs. As always, the convention included a Nepal-related forum “How Can the North American Nepali Diaspora Contribute to Nepal’s Economic Development?” The Forum took place from 1:30-2:30 pm on Saturday July 20, 2024. Four panelists, including the moderator, spoke at the forum. About 45-50 individuals attended the session. Guest panelist, Dr. Minendra Rijal sent a message as he …

The Role Of Elevation In The Migration, Physiology, And Genomic Diversification Of Birds, Jessie L. Williamson

Biology ETDs

Elevational gradients cause profound eco-climatic variation across short distances. Partial pressure of oxygen (PO₂) is a severe challenge that organisms face at high elevations; due partly to specialization on PO₂, most Neotropical bird species have narrow elevational ranges. However, a small fraction are elevational generalists that span sea level to high elevations, and a subset undertake extreme migratory journeys from low to high elevations biannually. My dissertation combines diverse approaches across levels of biological organization to understand how elevation impacts the ecology, evolution, physiology, and migration of montane birds. I examined ‘extreme’ elevational …

Engineered Nucleic-Acid Binding Intrinsically Disordered Proteins For Biomedical Applications, Telmo Diez Perez

Biomedical Engineering ETDs

This dissertation explores the use of intrinsically disorder proteins (IDPs) in biomedical applications related to the detection and biosensing of nucleic-acid species. We engineer several low critical solution temperature (LCST) nucleic-acid binding elastin-like polypeptides (ELPs) as model IDPs and study their potential in biomedical application via interactions with short single-stranded (ss) DNA, tRNA and viral RNAs. First, we engineer a simple polycationic ELP capable of recruiting DNA on demand in a DNA-protein-rich condensate via LLPS. Moreover, we develop a modified Flory-Huggins theory to quantify the partitioning of DNA and protein upon coacervate formation with and without salts. We then design …

Operators Based On Multiple Generalized Set-Valued Neutrosophic Quadruple Sets, Abdullah Kargın, Memet Şahin, Kübra Arıtı Şiğva

Neutrosophic Sets and Systems

In this study, as a generalized form of multiple valued neutrosophic numbers and neutrosophic quadruple numbers, multiple generalized set-valued neutrosophic quadruple numbers and sets are defined and their basic properties are given. Thus, a new structure is obtained in which multi-valued neutrosophic sets and neutrosophic quadruple sets are used together. Also, optimistic union, pessimistic union, average union, pessimistic intersection, optimistic intersection, average intersection operators are defined for multiple generalized set-valued neutrosophic quadruples. Thus, multiple generalized set-valued neutrosophic quadruple sets were made usable in decision-making applications. Researchers can obtain more objective results in decision making applications by using these operators.

Trf-Bwm-Neutrosophic-Topsis Strategy Under Svns Environment Approach And Its Application To Select The Most Effective Water Quality Parameter Of Aquaponic System, Pragnaleena Debroy, Priyanka Majumder, Surapati Pramanik, Lalu Seban

Neutrosophic Sets and Systems

The rapid emergence of aquaponics presents a promising solution for food production in arid regions, heavily reliant on maintaining optimal water quality parameters for overall success. However, monitoring and controlling these parameters can be complex and costly, involving numerous sensors and actuators. Focusing on the most significant parameter for fish growth could alleviate some of this complexity and promote sustainability by ensuring a balanced system. This study introduces a novel fuzzy-based Multiple Criteria Decision Making (MCDM) methodology, combining Trapezoidal Fuzzy with the Best Worst Method (BWM) and Neutrosophic-TOPSIS strategy, to identify the primary water quality parameters impacting fish growth. Through …

Total Domination In Uniform Single Valued Neutrosophic Graph, T. P. Sreelakshmi, K. Uma Samundesvari

Neutrosophic Sets and Systems

In graph theory, the neutrosophic graph is a new extension of the intuitionistic fuzzy graph and fuzzy graph. It offers greater accuracy and flexibility in scheduling and implementing numerous real-life issues. The introduction of neutrosophic graphs has opened up an excellent opportunity to portray real-world situations with incomplete and ambiguous information. These neutrosophic graph models are used in many industrial and scientific domains to simulate various problems. This article offers a new approach for calculating the total dominating set of a given single-valued neutrosophic graph using neutrosophic strong arcs. An example is illustrated for calculating the total dominating sets of …

Excited State Processes In Radical Elaborated Platinum Donor-Acceptor Complexes, Sangita Paudel

Chemistry and Chemical Biology ETDs

Organo-transition metal complexes are being widely studied to understand their photophysical properties for their wide range of applications as efficient emitters in organic light emitting diodes (OLEDs), light emitting electrochemical cells (LEECs), etc. Cyclometalated organo-transition metal complexes such as cyclometalated square planar platinum(II) complexes are becoming suitable candidates for such applications because of their highly efficient luminescence. Understanding the excited properties of such complexes is useful in designing highly efficient and color tunable phosphors with desired excited state lifetimes. We aim to explore the influence of radical substituents on electronic structure, luminescence quantum efficiencies, and excited state lifetimes by synthesizing …

Labor Market Penalties For Foreign Degrees Among College Educated Immigrants: Update Using 2018 Data, Eunice T. Ajibade

Economics ETDs

This paper revisits the questions posed by Arbeit and Warren in their 2013 study, "Labor market penalties for foreign degrees among college-educated immigrants," using updated data from the 2018 National Survey of College Graduates (NSCG). The original study, which analyzed data from 2003, focused on the economic and employment disadvantages faced by immigrants with degrees from foreign institutions in an increasingly globalized workforce. This updated analysis includes data on 21,071 college-educated immigrants to explore whether the geographic origin of an academic degree continues to influence access to high-quality employment opportunities and whether such impacts differ by gender. My findings reveal …

Visualization Of Species Tree Likelihood Under The Multispecies Coalescent Model, Jaimasan Sutton

Mathematics & Statistics ETDs

A commonly used tool for evolutionary biologists is a phylogenetic tree that represents the ancestry of a set of species and the evolution of traits. Statistical models can be used to predict the probabilities of gene trees which represent ancestral relationships of genes sampled from species. Because of this, we are able to represent the likelihood of a species tree, which represents the evolutionary history of a set of species, as a function of the counts of gene tree topologies, where each gene tree represents the ancestry of a specific genetic locus for multiple species. Because we can represent these …

Connecting Climate And Geography With Diversification And Conservation Of A Western North American Endemic Mammal, Sorex Monticola, Antonia Androski

Biology ETDs

Repeated glacial cycles of the Pleistocene initiated complex sequences of divergence and secondary contact with gene flow for many North American species. In my first chapter, I expand our understanding of the phylogeography of the montane shrew, Sorex monticola, with range-wide genetic sampling and geospatial analyses to reconstruct the history of clades within this species and test whether evolutionarily divergent clades occupy distinct abiotic niches. In my second chapter, I build upon these hypotheses, providing the first estimates of evolutionary relationships and timing of diversification based on genome-wide markers. In my third chapter, I use a systematic review of the …

The Feasibility Of An Acute Bout Of High Intensity Interval Vs Continuous Moderate-Intensity Exercise On Cognition In Chronic Stroke Patients, Anna M. Welch, Marissa Ramirez, Christine Mermier, Flavio De Castro Magalhaes, Jessia D. Richardson, Alyssa Bailly, Terence Moriarty

Health, Exercise, and Sports Sciences ETDs

Objective: The purpose of the present study was to assess the feasibility of chronic stroke patients safely completing an acute 30-minute session of high-intensity interval exercise (HIIE) compared to moderate-intensity aerobic exercise (MIE) on a treadmill, with a focus on cognitive outcomes. Design: This feasibility study utilized a randomized controlled crossover trial with two experimental sessions separated by at least 7 days to minimize practice effects on cognitive assessments. Subjects: Five chronic stroke survivors (m=4, f=1) participated in two randomly assigned experimental sessions (n=5, 60.4 ± 11.3 years, 39.8 ± 41.4% body fat, 32.7±6.3 body mass index [kg/m²])., either a …

Mixed Potential Sensor For Natural Gas Leak Detection Design, Manufacturing, And Simulation, Sleight Halley

Chemical and Biological Engineering ETDs

There is a need for a low-cost robust sensor accurately detecting leaks from oil and gas infrastructure. This work presents the development of an electrochemical sensor based on an yttria stabilized zirconia (YSZ) electrolyte with La_0.87Sr_0.13CrO₃, Indium Tin Oxide (In₂O₃ 90 wt%, SnO₂ 10 wt%), Au, Pt electrodes. Selectivity to target gasses of the three sensing electrodes in conjunction with machine learning allows for the accurate discrimination between possible methane sources as well as the quantification of methane concentration. Sensor sensitivity is improved through a low-ionic conductivity substrate of magnesia …

Grievability And The Contingency Of Life Value In Twenty-First-Century Science Fiction, Emily A. Reiff

English Language and Literature ETDs

Using Judith Butler’s framework of grievability, this dissertation explores twenty-first-century science fiction by British, Irish, and Caribbean authors whose novels grapple with legacies of colonialism and imperialism that relied on dehumanization and subjugation. Beginning with Sarah Maria Griffin’s Spare and Found Parts (2016), chapter one explores neocolonial rationales—purportedly based on health—which recreate colonial divisions of class and labor and enforce systems of diminishing grievability in a post-apocalyptic Irish context. Chapter two contends that Kazuo Ishiguro’s Klara and the Sun (2021) illustrates the danger inherent to value systems that center “normative” embodiment in worlds that reconfigure hypercapacitated human beings as the …

Host-Microbiome Interactions In The Teleost Brain, Amir Mani Varnoosfaderani

Biology ETDs

This dissertation investigates host-microbial interactions within the teleost brain, previously considered sterile. Reviewing current literature highlights significant gaps in understanding teleost brain immunity, despite prevalent neurotropic diseases. We mapped the immune profiles of rainbow trout brains and meninges, revealing the olfactory bulbs as the immune effector part of the brain and the optic tectum as a nod2 expression hub. High il6 and il10 levels were noted in the telencephalon. A persistent bacterial community within healthy salmonid brains shares diversity with gut and blood microbiota. Brain bacterial isolates exhibit genomic signatures for brain colonization and polyamine biosynthesis. The microbiota shifts across …

Dental Hygiene Program Admission Criteria Key Indicators To National Board Success, Kacy Goetz

Dental Hygiene ETDs

The study evaluates the admission criteria of entry-level dental hygiene programs in the United States and their relationship to National Dental Hygiene Board Examination (NDHBE) success rates. An online survey was distributed to 327 programs, gathering data on admission criteria and NDHBE outcomes through a 16-question Microsoft Forms survey. With a response rate of 16% (53 respondents), the survey found that GPA was the most common admission criterion used by 92% of programs. The results indicated a strong negative correlation between high school GPA and NDHBE success. The study also evaluated NDHBE pass rates with board review courses taken. The …

A Comparison Of Cognitive Impairment In Health Anxiety, Generalized Anxiety Disorder, And Posttraumatic Stress Disorder And The Moderating Role Of Social Connectedness, Kaitlyn B. Schodt

Psychology ETDs

Mood symptomatology often negatively impacts cognitive functioning; however, little is known about how some disorders, like health anxiety, might be unique contributing factors. Social connectedness has been found to protect against cognitive decline, and thus might mitigate some of the mental health-related negative effects on cognitive functioning. The current study aimed to: 1) examine the associations between PTSD, generalized anxiety disorder (GAD), and health anxiety symptomatology and cognitive functioning, and between 2) social connectedness and cognitive functioning, as well as the moderating roles of 3) social connectedness and 4) biological sex and race/ethnicity in the association between mental health symptomatology …

Theoretical And Spectroscopic Insights Into Molybdenum- And Tungsten-Sulfur Bonding, Jesse Lepluart

Chemistry and Chemical Biology ETDs

Molybdenum and tungsten chemistry in biology is dominated by bonding interactions with sulfur and the other chalcogens. The highly-conserved structures of these enzymes’ active sites suggest an early evolution in the history of life, with molybdenum and/or tungsten enzymes likely expressed by the last universal common ancestor. Despite their active site similarities, molybdenum and tungsten enzymes catalyze a diverse array of reactions via equally diverse mechanisms. A deep understanding of the electronic structures of these enzyme active sites and their catalytic intermediates is key to understanding this remarkable chemistry.

The work presented here aims to deepen the understanding of molybdenum …

Support For Climate Shaping The Mitochondrial Dna Contact Zone In The Audubon's Warbler, Kyana Nina Montoya

Biology ETDs

Mitochondrial introgression has potential consequences for physiology and adaptation, but its causes are poorly understood. The Audubon’s Warbler (AUWA; Setophaga coronata auduboni) provides a case study to examine those causes as mitochondrial introgression has swept through part of the range. The northern mitochondrial genome (mtDNA) introgressed from the Myrtle Warbler (MYWA; S. c. coronata) and is 4% divergent from the southern mtDNA. Incomplete introgression suggests discordant AUWAs conferred a selective advantage in the north; it was hypothesized that energetic demands associated with migration formed this advantage. We tested two hypotheses to explain partial introgression and the mtDNA distribution …

Patterns Of Stand Structure And Species Composition Through Time And Space In A Piñon- Juniper Woodland In The Southwestern Us, Kyle H. Gonterman

Biology ETDs

Piñon- juniper (PJ) woodlands in the Southwest United States are expected to see mortality and structural change in response to climate change. The extent to which this habitat structures itself as well as its response to these changes over time are not well known yet and have not been examined to this extent for the location of this study within the Sevilleta National Wildlife Refuge. Within a small range, we discovered these woodlands consist of persistent woodland, shrubby woodland, and juniper savanna in which structural, spatial, and regeneration patterns differ. In this study, we discovered the specific differences between these …

Ponderosa Pine Plant Community Response To High-Severity Wildfire In The Jemez Mountains, Samantha Brodley

Biology ETDs

Climate change related temperature increases, and precipitation shifts, along with an increase in fuel loads have rendered large areas of the Southwest more prone to high-severity fire for longer periods of time throughout each year. Fire adapted forests that experience high-severity, stand replacing fires are not consistently experiencing dominant tree species regeneration, and appear, in some cases, to be shifting into novel systems. We collected and analyzed up to 11 years of understory plant community data in ponderosa pine (Pinus ponderosa) forests in the Jemez Mountains, New Mexico, to address early forest regeneration after high and low severity …

Conservation Genomic Investigation Of A Threatened Trout Species Endemic To The Gila River, David Thomas Camak

Biology ETDs

Climate change is a looming threat to the persistence of species, especially aquatic, imperiled species. Species native to desert streams are at a particular disadvantage, as many species already face drought, floods, wildfires, and threats from nonnative species, all of which are thought to be exacerbated by climate change. Species such as the threatened Gila Trout (Oncorhynchus gilae) already have small ranges and persist in fragmented and isolated habitats that limits gene flow between populations. Therefore, it is important to understand the current genomic status of such populations to be able to predict the future effects of climate …

Effect Of Air Filtration On Water Quality During Atmospheric Water Harvest In The Southwest United States, A.J. Barney

Civil Engineering ETDs

Access to sustainable drinking water is a concern across the globe. Atmospheric water harvest (AWH) offers a potential supplemental drinking water source. However, the sources and processes affecting AWH water quality are not well understood and must be thoroughly studied to consistently utilize AWH for drinking water. The objective of this research is to assess how removing particulate matter (PM) 2.5 and PM10 in the air used to produce AWH with air-filters affects the water quality of AWH. AWH samples were collected simultaneously with three identical dehumidifiers, utilizing three different air-filter configurations (no-filter, MERV8, and MERV12) in Albuquerque, NM from …

A Cultural Responsiveness Model To Support Parent's Practices In Families With Autistic Children: A Culturally Relevant Self- Compassion Program For Nigerian Mothers, Ekene Anastesia Odumegwu

Individual, Family, and Community Education ETDs

The goal of this intervention of self-compassion, mindfulness, and self-kindness focuses on training Nigerian mothers raising autistic children to enhance their psychological well-being. The intervention will assist Nigeran mothers living in Nigeria with developing their self- compassion. Building resilience for Nigerian mothers' self-compassion will help them to improve their physical and psychological health by becoming more mindful of their own pains and suffering when raising their child with Autism. Also, the proposed intervention will help Nigerian mothers to focus their attention and energy on how ways that might reduce the trauma and challenges experienced in parenting children with autism.

This …

A Phenomenological Exploration Of Language Shift Of Ikalanga In Botswana: Implications For Language Revitalization, Annah Sephene Macha

Language, Literacy, and Sociocultural Studies ETDs

This study explores the phenomenon of language shift among the Bakalanga community in Botswana, focusing on the gradual displacement of the iKalanga language by dominant languages such as Setswana and English that hold official status for education and broader communication. iKalanga faces significant challenges, as minority languages face extinction globally, the Bakalanga’s experience reflects broader trends where dominant languages supplant indigenous ones in education and wider communication. This research employed a phenomenological approach to investigate how the Bakalanga transmit knowledge amidst this language shift. Data was collected through focus groups, life history narratives, documents, and individual interviews, and analyzed using …

Insight Into Complexity: Novel Information Theoretic Analysis Of Spatiotemporal Interactions, Humayra Tasnim

Computer Science ETDs

Complex systems are comprised of different components. Interactions and associations among these components define the functionality of the system. For example, T cells must directly interact with virally infected cells to kill them. This research characterizes the most relevant components of complex systems by analyzing interacting relationships using information theoretic measures. It emphasizes the importance of spatial and temporal dynamics, which occur when components share spatial proximities or temporal sequences. Novel information theoretic analyses are proposed for quantifying the degree of association among system components, which is key to defining the spatiotemporal dynamics. One focus of this work is the …

The Borders Of Embodiment: Transgression, Transformation, And Corporeality In Chicanx Speculative Fiction, Chrysta Carson Wilson

English Language and Literature ETDs

This dissertation develops a clearer vision of Chicanx Speculative Fiction (SF) as its own genre anchored to the experiences and histories of the Chicanx community, with a particular interest in the avenues through which race and gender shape the experience of embodiment. SF resists hegemonic narratives that justify racial hierarchies and reveals both the cultural and concrete pressures exerted on Chicanx bodies in the United States as a minoritized and often exploited community. Furthermore, my analysis illustrates that Chicanx writers utilize elements of SF to defamiliarize traditional notions of race, class, and nationality. Through the use of defamiliarization, Chicanx SF …

A Stable Isotope Study To Investigate Water Movement In The Los Lagos Region Of Southern Chile, Kritan Subedi

Civil Engineering ETDs

The Los Lagos region in southern Chile, located in northwest Patagonia, features rain-fed agricultural lands, glacial lakes, forests, farmlands, and volcanic soils. This study investigates water movement within a micro-basin using stable isotope analysis and hydrological modeling over eight weeks. It aims to develop a conceptual model of water movement by elucidating interactions between precipitation, soil water, and streamflow. Findings highlight the critical role of deeper soil layers in sustaining streamflow during dry spells and indicate that soil acts as a buffer, maintaining hydrological continuity despite variable precipitation. Improved understanding of these dynamics can inform watershed management and water resource …