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Spatial Stochastic Modeling Of The Erbb Receptor Family, Meghan Pryor Sep 2014

Spatial Stochastic Modeling Of The Erbb Receptor Family, Meghan Pryor

Chemical and Biological Engineering ETDs

ErbB transmembrane receptors are a family of 4 receptor tyrosine kinases that interact with one another through homo and heterodimer interactions. When these dimers form, the kinase domains on the receptor tails interact with one another, transphosphorylating one another, initiating a signal cascade. The signaling pathways these receptors participate in are responsible for many different cell functions including apoptosis, growth, and proliferation. The overexpression of these receptors has been linked to various forms of cancer, emphasizing the importance of understanding how these receptors interact with one another to trigger these cascades. Single Particle Tracking experiments have provided more precise and …

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September 9, 2014 Finance & Facilities (F&F) Committee Meeting, Evp For Administration Sep 2014

September 9, 2014 Finance & Facilities (F&F) Committee Meeting, Evp For Administration

Finance and Facilities Committee

Documents related to the September 9, 2014 Board of Regents' Finance and Facilities Committee Meeting. (Agenda, Minutes, eBook, Notice)

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Adobe Medicus 2014 5 September-October, Health Sciences Library And Informatics Center Sep 2014

Adobe Medicus 2014 5 September-October, Health Sciences Library And Informatics Center

adobe medicus

No abstract provided.

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Mph Principles Of Public Health: Fall 2014 Syllabus, Nina Wallerstein, Robert Rhyne, Jonathan Eldredge Aug 2014

Mph Principles Of Public Health: Fall 2014 Syllabus, Nina Wallerstein, Robert Rhyne, Jonathan Eldredge

Principles of Public Health 2010-2017

No abstract provided.

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Abq Free Press, August 13, 2014, Abq Free Press Aug 2014

Abq Free Press, August 13, 2014, Abq Free Press

ABQ Free Press

No abstract provided.

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August 5, 2014 Finance & Facilities (F&F) Committee Meeting, Evp For Administration Aug 2014

August 5, 2014 Finance & Facilities (F&F) Committee Meeting, Evp For Administration

Finance and Facilities Committee

Documents related to the August 5, 2014 Board of Regents' Finance and Facilities Committee Meeting. (Agenda, Minutes, eBook, Notice)

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08-01-2014 El Centro News, El Centro De La Raza Aug 2014

08-01-2014 El Centro News, El Centro De La Raza

Newsletters

No abstract provided.

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Environment Restoration Operations Consolidated Quarterly Report (January - March) - July 2014, Sandia National Laboratories/Nm Jul 2014

Environment Restoration Operations Consolidated Quarterly Report (January - March) - July 2014, Sandia National Laboratories/Nm

Environmental Restoration

Environmental Restoration Operations Consolidated Quarterly Report, July 2014 for the Department of Energy, National Nuclear Security Administration, Sandia Corporation that addresses all quarterly reporting (January through March 2014) required under the Hazardous and Solid Waste Amendments Module of the Resource Conservation and Recovery Act Permit, the Compliance Order on Consent and the Chemical Waste Landfill Closure Plan for Sandia National Laboratories/New Mexico, Environmental Protection Agency identification number NM5890110518.

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Choreographer As Coach: Facilitating Engagement During The Dance Making Process, Emily D. Bryan Jul 2014

Choreographer As Coach: Facilitating Engagement During The Dance Making Process, Emily D. Bryan

Theatre & Dance ETDs

Dance is formed from the interactions between the choreographer and the dancers that occur during the workshop and rehearsal phase of the dance making process. The choreographer's art is brought to life not solely through the creation of the choreography, but through the interpretation of the choreography in the bodies of the dancers. Thus, the time spent coaching dancers is an important piece of the choreographer's work. Artists have written about the value of dancers in their work, and educators provide theories about training dancers in the classroom, but little has been written about practical methods for the professional choreographer …

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Heidegger And The Ethics Of The Earth: Eco-Phenomenology In The Age Of Technology, Tara Kennedy Jul 2014

Heidegger And The Ethics Of The Earth: Eco-Phenomenology In The Age Of Technology, Tara Kennedy

Philosophy ETDs

Martin Heidegger came to see the history of Western metaphysics as a series of ontotheological epochs. These epochs, he argues, culminate in the age informed by the metaphysics of Friedrich Nietzsche. According to this ontotheological paradigm, entities are nothing more than meaningless resources to be optimized. This paper argues that this is the source of the environmental crises we face. In order to see our way through and beyond this nihilistic ontotheological age, we must recognize the ontological source of all existence, that which Heidegger called being as such. The philosophical tradition of phenomenology offers us an ideal method for …

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Changes In Student Proving Skills And Attitudes Following A Cooperative Learning Seminar, Martha Byrne Jul 2014

Changes In Student Proving Skills And Attitudes Following A Cooperative Learning Seminar, Martha Byrne

Mathematics & Statistics ETDs

This dissertation details research studies designed to explore undergraduate math students beliefs and attitudes about mathematical proof, ability to compose valid proofs, and ability to read and validate purported proofs written by other students. In two studies, a cohort of seminar participants were assessed twice on their attitudes and beliefs about mathematical proof, their ability to compose proofs, and their ability to validate arguments. Between assessments, these participants worked on carefully crafted problem sets in a Cooperative Learning environment. In each study, a cohort of comparison participants took both assessments but did not engage in structured, cooperative work in the …

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Sex Differences In The Relationship Between White Matter Connectivity And Creativity, Sephira Ryman Jul 2014

Sex Differences In The Relationship Between White Matter Connectivity And Creativity, Sephira Ryman

Psychology ETDs

Creative cognition emerges from a complex network of interacting brain regions. This study investigated the relationship between the structural organization of the human brain and aspects of creative cognition quantified by divergent thinking tasks. Diffusion weighted imaging (DWI) was used to obtain fiber tracts from 83 segmented cortical regions. This information was represented as a network and metrics of connectivity organization, including connectivity strength, clustering and efficiency were computed, and their relationship to personal levels of creativity was examined. Permutation testing identified significant sex differences in the relationship between global connectivity and creativity as measured by divergent thinking tests. Females …

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"I Don't Approve Of That Way Of Running A Family": Transient Children, Institutions, And Interventions In California Through The Great Depression And Dust Bowl, Jairo Marshall Jul 2014

"I Don't Approve Of That Way Of Running A Family": Transient Children, Institutions, And Interventions In California Through The Great Depression And Dust Bowl, Jairo Marshall

History ETDs

This thesis studies the state of California's responses to migratory families and children during the Depression and Dust Bowl. In particular, it emphasizes the growth of several state bureaucracies during this time, including the Department of Public Health, the Department of Education, and the Youth Authority. It also engages with local nonprofit relief agencies as well as county agencies, which functioned as direct aid providers to migrants. The efforts to provide relief to migrant families are explained, as are the surrounding rhetorical frameworks used to discuss the perceived negative attributes of migrant children. These discourses influenced administrators, California residents, and …

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Effects Of Dietary Stimulators Of Metabolism And Mitochondrial Biogenesis In Vitro And In Vivo: Implications For Metabolic Disease, Roger Vaughan Jul 2014

Effects Of Dietary Stimulators Of Metabolism And Mitochondrial Biogenesis In Vitro And In Vivo: Implications For Metabolic Disease, Roger Vaughan

Health, Exercise, and Sports Sciences ETDs

Background: Commercially available dietary products advertised to promote weight loss are an under researched but heavily purchased commodity in the United States. Despite only limited evidence, interest in dietary supplements continues to increase. Obesity is an increasingly prevalent and preventable morbidity with multiple behavioral, surgical and pharmacological interventions currently available. Commercially available dietary supplements are often advertised to stimulate metabolism and cause rapid weight and/or fat loss, although few well controlled studies have demonstrated such effects. This work uniquely summarizes the current evidence evaluating the efficacy of several over-the-counter thermogenic products for their effects on resting energy expenditure. Additionally, this …

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Impacts Of Diurnally Exposed Slime Layer Hydrogen Sulfide Concentrations In Sewer Atmosphere, Mark Holstad Jul 2014

Impacts Of Diurnally Exposed Slime Layer Hydrogen Sulfide Concentrations In Sewer Atmosphere, Mark Holstad

Civil Engineering ETDs

Hydrogen sulfide (H2S) is a major issue in wastewater collection systems. H2S can cause rapid damage to wastewater infrastructure, affects the publics quality of life through odor issues and is a safety concern for sewer workers. Relatively recent development and introduction of H2S data loggers has shown that H2S concentrations in the sewer headspace demonstrate a diurnal pattern that is not explained by current models. Odor complaints and toxicity are primarily a result of the peak concentration levels and may be more accurately predicted through a better understanding of the diurnal H2S concentration patterns. Biological slime layer grows in the …

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Biosensing Of Matrix Metalloproteinase Activity With Cd-Free Quantum Dots, John Plumley Jul 2014

Biosensing Of Matrix Metalloproteinase Activity With Cd-Free Quantum Dots, John Plumley

Nanoscience and Microsystems ETDs

Quantum dots (QDs) have become attractive in the biomedical field on account of their superior optical properties and stability, in comparison to traditional fluorophores. QDs also have properties which make them ideal for complex in vivo conditions. However, toxicity has been a chief concern in the eventual implementation of QDs for in vivo applications such as biosensing and tumor imaging. Commercially available QDs contain a notoriously noxious Cd component and therefore continuous research has gone into developing QDs without toxic heavy metals, generally Cd, that would still yield comparable performance in terms of their optical properties. Nonetheless, even in the …

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Development And Kinetic Modeling Of Multiplex Microsphere Assays For High-Throughput Discovery Of Protease Active Small Molecule Compounds, Jingsh Zhu Jul 2014

Development And Kinetic Modeling Of Multiplex Microsphere Assays For High-Throughput Discovery Of Protease Active Small Molecule Compounds, Jingsh Zhu

Nanoscience and Microsystems ETDs

In this dissertation, we have designed a series of recombinant fluorescent full-length protease substrates containing the cleavage sites separated by a biotinylation tag and a GFP domain, which can be associated with streptavidin-coated microspheres/nanospheres. We have developed microsphere-based platforms to detect the cleavage activities of several proteases simultaneously. In addition, we have performed high-throughput screening (HTS) to identify potential inhibitors for the Bacillus anthracis lethal factor protease (LF) and the Botulinum neurotoxin type A & F light chain proteases (BoNT/A & F LC). In order to select the efficient inhibitors, a chemical library of 350,000 compounds was screened with the …

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School-Age Children's Perception Of Stress In The Hospital: A Draw And Tell Story, Susan Wechter Jul 2014

School-Age Children's Perception Of Stress In The Hospital: A Draw And Tell Story, Susan Wechter

Nursing ETDs

The purpose of this study was to explore the perceptions of stress for hospitalized school-age child, seven to nine years of age, through a child-centered draw and tell technique. Over 3 million children are hospitalized every year (NACHRI, 2012). Hospitalization of children is reserved for increasingly complex care. Since the 1960s, it has been well known that hospitalization can be a traumatic experience for children (King & Ziegler, 1981; Thompson, 1986; Vernon, Foley, Simpowicz, & Schulman, 1965; Visintainer & Wolfer, 1975). This experience elicits feelings of fear, uncertainty, pain and discomfort that can affect a child's healing, behavior and health …

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The Role Of Disability In Buffy The Vampire Slayer, Amanda H. Heggen Jul 2014

The Role Of Disability In Buffy The Vampire Slayer, Amanda H. Heggen

Special Education ETDs

The social construction of disability posits that media play an important role in the construction of disability. Few studies have systematically examined the role of disability in film or television. Engaging in a multiple perspective analysis, this dissertation examined the role of disability in the television series Buffy the Vampire Slayer. Data were analyzed with a content analysis, a thematic analysis, and an ideological rhetorical criticism. Disability was found to be used as a tool of character, plot, and atmosphere development. The data also suggested that negative assumptions of disability, often reinforcing of stereotypes, were readily apparent in the series …

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Unm Shock Tube Modernization, Clinton Lee Corbin Jul 2014

Unm Shock Tube Modernization, Clinton Lee Corbin

Mechanical Engineering ETDs

The UNM shock tube in the Mechanical Engineering department has been in continuous operation since its creation in 2007. During this time, significant discoveries in the field of Richtmyer-Meshkov instabilities has been made with this shock tube. While conducting these experiments, limitations on the operational aspects and data quality aspects of this research tool have been found. To further advance the state of the art, it was necessary to address these limitations to allow the research to continue to push boundaries and discover new science.

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Pathologizing And Criminalizing Intoxication: Addiction, Psychoactive Drugs, And The Ideological Underpinnings Of The War On Drugs, David Korostyshevsky Jul 2014

Pathologizing And Criminalizing Intoxication: Addiction, Psychoactive Drugs, And The Ideological Underpinnings Of The War On Drugs, David Korostyshevsky

History ETDs

Since the Enlightenment, Anglo-American temperance thinkers—who were usually clergymen and physicians—have expressed broader concerns about intoxication and addiction with rhetoric that simultaneously pathologized and criminalized the unsanctioned use of psychoactive substances. During the first half of the eighteenth century, a period known as the Gin Craze, rising levels of urban drunkenness in England came under the sustained gaze of temperance-minded doctors and churchmen, who used a shared language of contagion, disease, and slavery to problematize intoxication simultaneously as a medical and criminal condition. Building on Enlightenment English temperance thought, which was transferred into the United States by physician Benjamin Rush, …

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Education Data: A Case Study Of Three Northern New Mexico School Districts In The Utilization Of The Standards Based Assessment Data, Jennifer Sallee Jul 2014

Education Data: A Case Study Of Three Northern New Mexico School Districts In The Utilization Of The Standards Based Assessment Data, Jennifer Sallee

Teacher Education, Educational Leadership & Policy ETDs

In the current era of standards-based reforms and a new accountability movement research has credited data driven decision making as key to successful schools. Teachers and principals' ability to use data can improve student achievement and move schools forward. This dissertation explores teacher's and principal's perceptions of the successful use of New Mexico Standards Based Assessment student achievement data as it relates to four themes: professional development, collaboration, school and district systems, and leadership. Elementary school teachers and principals were surveyed on what facilitated or posed potential barriers to effectively using the New Mexico Standards Based Assessment data. The survey …

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Comparison Of E. Coli And Y. Pestis Lps Tlr4 Time Course On P388d1 Macrophages Using Fluorescent Conjugated Antibodies, Julia Kleven Jul 2014

Comparison Of E. Coli And Y. Pestis Lps Tlr4 Time Course On P388d1 Macrophages Using Fluorescent Conjugated Antibodies, Julia Kleven

Electrical and Computer Engineering ETDs

The innate immune system enables cellular response to infectious agents, and protein interactions are essential for this response. However, the protein interactions involved in cellular response to pathogens are not completely understood. Clarifying the manner in which proteins bind and respond to infectious agents is necessary for development of potential therapeutics or preventative measures. Fluorescent probes and fluorescent microscopy are used to aid in the visualization of these components, but proteins associated with or spanning the cellular membrane are on the nanometer scale, smaller than some microscopes can image, which makes it difficult to accurately localize the proteins of interest. …

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Development Of Novel Synthetic Methods For Size-Tunable Synthesis Of Superparamagnetic Iron Oxide Nanoparticles, Erika Vreeland Jul 2014

Development Of Novel Synthetic Methods For Size-Tunable Synthesis Of Superparamagnetic Iron Oxide Nanoparticles, Erika Vreeland

Chemical and Biological Engineering ETDs

The properties of magnetic nanoparticles vary dramatically with size, so reproducibly controlling size is critical for practical applications. This is particularly true when moving into clinical settings, where regulatory approval requires demonstrated reproducibility in efficacy that can only be achieved with excellent size control. A number of methods for the synthesis of magnetic nanoparticles have been published, although the thermal decomposition of iron(III) precursors in organic solvents has been shown to yield high quality particles with low shape and size dispersity. Currents methods lack reproducibility resulting from non-stoichiometric starting materials, and reliance on reaction parameters, such as temperature ramp rate, …

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Nanoparticle Cerium Oxide And Mixed Cerium Oxides For Improved Fuel Cell Lifetime, Stephen Stewart Jul 2014

Nanoparticle Cerium Oxide And Mixed Cerium Oxides For Improved Fuel Cell Lifetime, Stephen Stewart

Chemical and Biological Engineering ETDs

While there is a rich body of literature concerning of properties of bulk cerium oxide and cerium cations in solution, the discussion has been inappropriately applied to nanoscale cerium oxide resulting in many unexpected or unexplained results. In particular, there is very limited understanding about the properties of cerium oxide and its potential use as a radical scavenger, and how the catalytic properties of cerium oxide change as the particle size approaches the nanoscale. For example, the involvement of Ce+4 and Ce+3 cations in reactions such as hydrogen peroxide decomposition have been investigated for both cerium cations and bulk cerium …

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Poly(N-Isopropyl Acrylamide)-Coated Surfaces: Investigation Of Cytotoxicity With Mammalian Cells And The Mechanism Of Cell Detachment, Marta Cooperstein Jul 2014

Poly(N-Isopropyl Acrylamide)-Coated Surfaces: Investigation Of Cytotoxicity With Mammalian Cells And The Mechanism Of Cell Detachment, Marta Cooperstein

Chemical and Biological Engineering ETDs

With the increase in life expectancy and with growing numbers of an aging population, there is a rising need worldwide for replacement tissues and organs. One way to address this growing need is through engineered tissues, such as those generated from stimulus-responsive polymers. Stimulus-responsive polymers undergo a physical or chemical change when a stimulus is applied. One such material is poly(N-isopropyl acrylamide), (pNIPAM), which undergoes a conformation change in a physiologically relevant temperature range to release intact mammalian cell monolayers capable of being used to engineer tissues. Two factors currently limit the use of cell sheets for this purpose: 1) …

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Modeling Of Kinetically Limited Growth Rate For Solution-Synthesized Germanium Nanocrystals, Nicholas Shoop Jul 2014

Modeling Of Kinetically Limited Growth Rate For Solution-Synthesized Germanium Nanocrystals, Nicholas Shoop

Chemical and Biological Engineering ETDs

Solution synthesis is a common method of generating semiconductor nanocrystals. For solution synthesis, many studies have assumed that the growth rate is diffusion-limited with an unphysically low diffusion constant. In this thesis, a model is developed that considers both diffusion and surface kinetics. The diffusion coefficient of Ge monomers through the solvent, octadecene, at elevated synthesis temperatures is estimated to be on the order of 10-5 to 10-4 cm2/sec, while the mass transfer boundary layer thickness is estimated to be on the order of a few nanometers, similar to the nanocrystal size. These two realistic conditions strongly suggest that the …

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Beyond The Paint And Ink: Asar Oaxaca Resistance And Getting Up Arte Pal Pueblo, Mike L. Graham De La Rosa Jul 2014

Beyond The Paint And Ink: Asar Oaxaca Resistance And Getting Up Arte Pal Pueblo, Mike L. Graham De La Rosa

Latin American Studies ETDs

This thesis aims to address the ways in Oaxacan street artists frame alternative realities within art and interviews about their art. Asamblea de Artistas Revolucionarios de Oaxaca or ASARO, is a revolutionary artist collective that currently works in Oaxaca Mexico. They place their art in publically accessible areas and comment on local, national and international social issues. Through ethnographic interviews and participant observation with members of ASARO along with critical discourse analysis of their images, I explore the ways getting up is accomplished. The combination of ethnographic field work paired with a critical approach deepens an understanding of what influences …

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Using Nd Isotopes To Understand Changes In Continental Weathering Flux In Mid-Pennsylvanian (Desmoinesian) Carbonate Cycles, Phil Ragonese Jul 2014

Using Nd Isotopes To Understand Changes In Continental Weathering Flux In Mid-Pennsylvanian (Desmoinesian) Carbonate Cycles, Phil Ragonese

Earth and Planetary Sciences ETDs

Decades of study on Phanerozoic sedimentary deposits indicates that changes in Earth's orbital parameters are one of the main drivers of climate change on the 104-105 yr time scales, however understanding the relationships between climate change on coeval marine and continental deposits is difficult due to post-depositional erosion and tectonic processes. Nd isotopes measured in marine carbonates are a proxy for regional-scale continental weathering flux (CWF) and can help resolve these difficulties because its short residence time (less than ocean mixing times). This study focuses on cyclic Middle Pennsylvanian (Desmoinesian) marine successions from the Pedregosa (Arizona) and Bird Spring (southern …

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Extrinsic Evidence, Parol Evidence, And The Parol Evidence Rule: A Call For Courts To Use The Reasoning Of The Restatements Rather Than The Rhetoric Of Common Law, David G. Epstein, Timothy Archer, Shalayne Davis Jul 2014

Extrinsic Evidence, Parol Evidence, And The Parol Evidence Rule: A Call For Courts To Use The Reasoning Of The Restatements Rather Than The Rhetoric Of Common Law, David G. Epstein, Timothy Archer, Shalayne Davis

New Mexico Law Review

No abstract provided.

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