Digital Commons Network^™

Studies On The Effect Of Glycolysis And Pi(3,5)P2 On V-Atpase Activity, Dennis Ralph Dominguez

Biomedical Sciences ETDs

We studied two signals that regulate the yeast vacuolar proton pump, V-ATPase, glucose and PI(3,5)P2.  V-ATPase regulation by glucose is linked to the glycolytic enzyme PFK-1. Chapter one investigates the relationship between V-ATPase and glycolysis in cells overexpressing the PFK-1 subunit Pfk2p.  We measured: (i) PFK-1 activity to determine the effect on PFK-1 function; and (ii) NADH autofluorescence to determine the effect on glycolysis. PFK2 overexpression decreased PFK-1 catalytic activity. However, the NADH synthesis rate increased by 1.4 – 2.6-fold, suggesting that excess Pfk2p enhanced the apparent glycolytic capacity of the cells. Vacuolar acidification was measured after the glucose concentration …

The Cost Of Direct And Indirect Potable Water Reuse In A Medium Sized Inland Community, Jason Glenn Herman

Architecture and Planning ETDs

In the face of increasing population, development pressures, and climate change, many regions around the world face freshwater shortages. Planned potable water reuse can improve sustainability and reliability of water supplies by providing drinking water from wastewater. Most potable reuse research has focused on large coastal communities with relatively high mean household incomes. However, the US Department of Interior predicts that “hot spots” of conflict over water in the arid West are “highly likely” in numerous small-to-medium-sized inland communities with low-to-moderate household income levels. Potable reuse options may be different for larger, wealthier coastal communities as compared to small-to-medium-sized inland …

Search In T Cell And Robot Swarms: Balancing Extent And Intensity, George M. Fricke

Computer Science ETDs

This work investigates effective search and resource collection algorithms for swarms. Deterministic spiral algorithms and L ́evy search processes have been shown to be optimal for single searchers. We extend these strategies to swarms of robots and populations of T cells and measure performance under a variety of conditions.

Search extent and intensity lie on a continuum: more intensive patterns search thoroughly in the local area, while extensive patterns cover more area but may miss targets nearby. We show that the most efficient trade-off between search intensity and extent for swarms depends strongly on the distribution of targets, swarm size …

Identification & Evaluation Of Dna Ligase Inhibitors: Predicting The Binding Of Small Molecules To The Dna Binding Domain By Molecular Modeling, Timothy Richard Lloyd Howes

Biomedical Sciences ETDs

The phosphodiester backbone of DNA is maintained by DNA ligases. In human cells, there are three genes that encode DNA ligase polypeptides with distinct but overlapping functions. A series of small molecule inhibitors of human DNA ligases were previously identified using a rational structure-based approach. Three of these inhibitors, L82, a DNA ligase I selective inhibitor, and L67, an inhibitor of DNA ligases I and III, and L189, an inhibitor of all three human DNA ligases, have related structures. Here I present and characterize L82-G17 a next-generation ligase I specific inhibitor. L82-G17 is a potent ligase I uncompetitive inhibitor that …

Using Statistical Techniques To Estimate Rooted Species Trees From Unrooted Gene Trees, Ayed Rheal Alanzi

Mathematics & Statistics ETDs

Methods for inferring species trees from gene trees motivated by incomplete lineage

sorting typically use either rooted gene trees to infer a rooted species tree, or use

unrooted gene trees to infer an unrooted species tree, which is then typically rooted

using one or more outgroups. Theoretically, however, it has been known since 2011

that it is possible to infer the root of the species tree directly from unrooted gene

trees without assuming an outgroup. The present work is the first that we know of

which attempts to infer the root of a species tree using unrooted gene trees as …

Alone In A Crowd: Perceived Social Relationships And Health Outcomes For Clergy, Christopher G. Ford

Psychology ETDs

The purpose of this study was to understand more about the relative contributions of different measures of social relationships to mental and physical health. This was done through secondary analysis of a clergy health intervention (n = 616), a population with unique professional and personal relationship characteristics. Hierarchal multiple regression was used in three steps to control for demographics, measures of perceived social relationships (e.g., social support, social engagement, social isolation, and relationship satisfaction), and whether or not clergy worked alone or with clergy colleagues. The results demonstrated that the relationship variables entered together, after controlling for demographics, were particularly …

The War Against Teachers: How The Discourse Of A Nation At Risk Set The Agenda For Contemporary New Mexico Education Policy, Christine P. Wernle

Language, Literacy, and Sociocultural Studies ETDs

A Nation at Risk (ANAR) represented a paradigm shift in national education policy and public education discourse. This Critical Discourse Analysis utilizing the theoretical framework of Fairclough and Wodak (1997) found five major recurring themes between ANAR, national and state discourse, and NMTEACH (as referenced in the Final Report and Recommendations of the New Mexico Effective Teaching Task Force, 2011): 1) The Establishment of Pedagogic Authority; 2) The Common-Senseness of Education; 3) Anti-Teacher Rhetoric and the Artificial Support of Teachers; 4) Deracialisation of Educational Policy and Color-Blind Ideology; and 5) The Movement from Symbolic to Physical Violence. This study has …

Cd82 Membrane Scaffolding Regulates Hematopoietic Cell Functions, Christina Marie Termini

Biomedical Sciences ETDs

Through their ability to self-renew and differentiate, hematopoietic stem/progenitor cells (HSPCs) maintain the adult blood and immune systems. The microenvironment, or niche, in which HSPCs reside, serves as a critical regulator of HSPC functions. As previous work has identified the tetraspanin CD82 as a mediator of HSPC-niche interactions, we aimed to determine the mechanism by which this occurs. Our data demonstrate that CD82 expression and scaffolding regulate HSPC interactions with niche components by organizing the α4 integrin subunit into tightly packed nanoclusters. The HSPC niche can also protect acute myeloid leukemia (AML) cells from therapeutics. Therefore, we next examined how …

Humanature Relations In Oman: Connections, Disconnections And Globalization, Maryam A. Alhinai

Communication ETDs

In this dissertation, I explore agricultural practices as a window into ecocultural communication. Using agricultural practices of villagers in Village G, Oman, as a case study, I explore the ways in which villagers and government officials conceptualize humanature relations and the forces that enhance and/or impede these relations. My specific goals for this study were: (1) to build an interpretive understanding of ecocultural orientations of villagers and officials in Oman and how they conceptualize their humanature relations; (2) to critically examine ideologies and uncover structural forces that enable/constrain humanature relations; and (3) to co-create community engagement work that honors the …

The Argentina Meat Deal, Lennart Bruce

New Mexico Quarterly

No abstract provided.

Reflections On The Alianza, Peter Nabokov

New Mexico Quarterly

No abstract provided.

Psychosocial Aspects Of Urban Violence, Judd Marmor

New Mexico Quarterly

No abstract provided.

Toward A Theory Of The Humanities, Frances M. Myers

New Mexico Quarterly

No abstract provided.

Full Issue, University Of New Mexico Press

New Mexico Quarterly

No abstract provided.

Minerva At The Peace Corps, Natalie Petesch

New Mexico Quarterly

No abstract provided.

Menchen And Individualism, Earl Black

New Mexico Quarterly

No abstract provided.

Full Issue, University Of New Mexico Press

New Mexico Quarterly

No abstract provided.

Reviews, University Of New Mexico Press

New Mexico Quarterly

No abstract provided.

Herr Bauer, John Skolle

New Mexico Quarterly

No abstract provided.

Notes In Transit, John Tatschl

New Mexico Quarterly

No abstract provided.

Full Issue, University Of New Mexico Press

New Mexico Quarterly

No abstract provided.

New Mexico's Fossil Record, Stuart A. Northrop

New Mexico Quarterly

No abstract provided.

Index, University Of New Mexico Press

New Mexico Quarterly

No abstract provided.

Dystopian Science Fiction: New Index To The Human Situation, Mark R. Hillegas

New Mexico Quarterly

No abstract provided.

Full Issue, University Of New Mexico Press

New Mexico Quarterly

No abstract provided.

Books, University Of New Mexico Press

New Mexico Quarterly

No abstract provided.

Books, University Of New Mexico Press

New Mexico Quarterly

No abstract provided.

The Seventh Annual Unm Research Lecture Science In Space, Victor H. Regener

New Mexico Quarterly

No abstract provided.

The Dancer And The Dance, Joel Nugent

New Mexico Quarterly

No abstract provided.

Death In Africa, Margot Astrov

New Mexico Quarterly

No abstract provided.