Digital Commons Network^™

Early Mississippian Ocean Anoxia Triggering Organic Carbon Burial And Enhancing Late Paleozoic Ice Age Onset: Evidence From Uranium Isotopes Of Marine Limestones, Keyi Cheng

Earth and Planetary Sciences ETDs

The Early Mississippian (Tournaisian) positive δ¹³C excursion (or TICE) is one of the largest recorded in the Phanerozoic and the organic carbon (OC) burial associated with its development is hypothesized to have driven global cooling and increased glaciation. We are testing the hypothesis that expanded ocean euxinia/anoxia drove widespread OC burial and the TICE and we are testing this hypothesis using uranium isotopes (δ²³⁸U) of Lower Mississippian marine limestones from southern Nevada as a global seawater redox proxy.

δ²³⁸U trends record a prominent mid-Tournaisian negative excursion (~0.30‰ magnitude) lasting ~1 My. The lack of …

Intratypic Genetic Variability Of Human Adenovirus Type 4: Implication For Viral Pathogenesis, Camden Roy Bair

Biomedical Sciences ETDs

Human adenovirus type 4 (HAdV-E4) is a causative agent of acute respiratory disease and conjunctivitis worldwide. Two major lineages of HAdV-E4 genomic variants have been identified by their distinct BamHI restriction profiles: prototype-like (p-like) strains and the a-like genomic variants. Recent molecular epidemiology studies have shown a predominance of a-like genomic variants detected in association with disease which suggests a-like strains have a fitness advantage or they may be more pathogenic. The impact of HAdV-E4 intratypic genetic variability on in vitro and in vivo phenotypes relevant to pathogenesis is a major gap in knowledge. I hypothesize that HAdV-E4 comprises two …

Improving Proton Pump Inhibitor Prescription Practices As A Means To Decreasing Nosocomial Infections, Jens Langsjoen

Biomedical Sciences ETDs

Proton pump inhibitors (PPIs) are commonly prescribed to treat stomach acid related illnesses, but increase the risk of hospital acquired infections. Measuring hospital PPI overuse trends and provider willingness to adopt PPI reduction interventions can inform the feasibility of reducing PPI overuse. We: (1) interviewed physicians, pharmacists and IT leaders to determine options for hospital PPI reduction, (2) analyzed electronic health record data to determine patterns of PPI overuse, and (3) surveyed providers regarding their willingness to adopt PPI reduction interventions. PPI use was inappropriate in 32% of inpatient encounters locally and 38% nationally. ICU exposure increased the odds of …

Low Loading Gold Vapor Deposited Electrode For High Sensitivity As (Iii) Detection, Tybur Casuse

Civil Engineering ETDs

The objective of this thesis is to develop a method for detection of arsenite, As (III), using a thin film of gold (Au) vapor deposited onto carbon paper as an electrode. Currently, availability of drinking water arsenic (As) concentration information for rural communities is diminished due to high cost per sample analysis and limited access to analytical laboratories which can accurately determine concentrations near the 10 maximum contaminant level (MCL) set by the World Health Organization (WHO) and the US Environmental Protection Agency (EPA). The use of a minimal amount of gold aids in decreasing the cost of an electrode. …

Tauopathies, Novel Optogenetic Tools, And The Future Of Artificial Intelligence In Medicine, Jessica Lee Binder

Biomedical Sciences ETDs

To this day, there is no cure for Alzheimer’s disease (AD) and related dementias (ADRD). With the daunting rise at an exponential rate of ADRD burden and related deaths, the necessity to find a new line of attack is vital. Pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Attempts have been made to promote clearance of pathological tau (p-Tau) from neurons via autophagy. Transcription factor EB (TFEB) has shown to clear p-Tau from neurons via autophagy. However, sustained TFEB activation and autophagy can create burden on cellular …

Characterization Of Single- And Multi-Phase Shock-Accelerated Flows, Patrick John Wayne

Mechanical Engineering ETDs

Experiments conducted in the Shock Tube Facility at the University of New Mexico are focused on characterization of shock-accelerated flows. Single-phase (gaseous) initial conditions consist of a heavy gas column of sulfur hexafluoride seeded with approximately 11% acetone gas by mass. Visualization of the image plane for gaseous initial conditions is accomplished via planar laser-induced fluorescence (PLIF) with a high-powered Nd:YAG ultraviolet laser and an Apogee Alta U-42 monochrome CCD camera, with a quantum efficiency > 90%. Multi-phase (gas-solid) initial conditions consist of glass micro-beads deposited on small 1-cm diameter discs of specific surface chemistry, mounted flush with the bottom wall …

A Dialectical Relational Analysis Of Tesol Quarterly 2006 Special Issue On Race: Discourse, Race, And White Supremacist Ideology, Ginger A. Looney

Language, Literacy, and Sociocultural Studies ETDs

Although the field of TESOL is not racially neutral this dialectical relational analysis examined (1) what discourses did the authors use to deploy race in the articles in the 2006 TESOL Quarterly Special Issue on Race (TQSIR)? and (2) how do these discourses work to either conform to, or resist white supremacist ideology? Analysis of the texts identified four key discourse: racialization, whiteness, emotional labor of racism, and sonic and optic negation of racism. These discourses were examined in the domains of scholarship, curriculum, teachers, and students. In 21 instances, these four discourses work to resist white supremacist ideology. …

Biology Student Perceptions Of Information Literacy Instruction In The Context Of An Essential Skills Workshop Series, Amy Jankowski, Yadéeh E. Sawyer

University Libraries & Learning Sciences Faculty and Staff Publications

The University Libraries at the University of New Mexico reconfigured their established library instruction program for biology as part of a broader grant-funded essential skills workshop series for STEM students. This initiative standardized supplementary instruction through seven in-person and online workshops delivered to students through the Biology Department’s four core undergraduate laboratory courses. Post-workshop feedback data were gathered from students throughout the two-year grant period. The present study analyzes this data set—including 3,797 completed student surveys from both library and non-library workshops over the course of four semesters—with the goal of understanding STEM student perceptions of the value of information …

Strategies To Combat Drug-Resistant Tuberculosis: Inhalable Microparticles Formulated With Anti-Tubercular Antibiotics And Efflux Pump Inhibitors, Elliott K. Miller

Pharmaceutical Sciences ETDs

Mycobacterium tuberculosis (Mtb) is an intracellular pathogen which can remain dormant within the human body for years (latent tuberculosis), and once active requires extensive multidrug therapies for treatment. Long-term antibiotic(s) exposure have led to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains which require novel treatment approaches to combat Mtb resistance. Mtb may also utilize efflux pumps to expel antibiotics and promote bacterial survival, potentially mediating drug tolerance, which has been hypothesized to contribute to antibiotic resistance. Efflux pump inhibitors (EPIs) such as verapamil (VER) may potentiate effects of first-line anti-tubercular drugs (ATDs) such as rifampicin …

The Patent Lawyer’S Guide To Fascism, Andrew C. Michaels

New Mexico Law Review

This essay presents an unusual and potentially valuable way of thinking about the patent system. It is worth considering the ways in which the structure of private law may affect our susceptibility to undesirable forms of societal organization. This essay considers how a well-structured patent system could potentially reduce our susceptibility to fascism by: (1) promoting an ethos of independent creative thought, and (2) facilitating market entry by startups, thereby reducing market concentration and possibly reducing authoritarian hierarchy. One legitimate utilitarian aim of the patent system might be to thus promote horizontal individualism, which could tend to work against fascism’s …

Ethnic Identity And Genetic Ancestry In New Mexicans Of Spanish-Speaking Descent, Meghan Elizabeth Healy

Anthropology ETDs

This dissertation focuses on a regional population, New Mexicans of Spanish-speaking descent (NMS), to explore the nature of identity-related substructure in admixed populations and its implications for research and policymaking. We looked at the relationship between ethnic/ethnoracial identity and genomic ancestry in NMS in two studies. In the first, we collected genomic ancestry data using 270 autosomal microsatellites in 98 New Mexicans who self-identified as Hispanic or Latino and provided more detailed information on their ethnoracial identities. We tested for genetic substructure in this sample along with 13 other admixed samples from the Americas. The New Mexican sample showed evidence …

Identification Of A Novel Class Of Er-Selective Ligands Lacking Cross-Reactivity To Gper, Richard Anthony Pepermans

Biomedical Sciences ETDs

Estrogen plays multiple roles in health and disease, exerting its effects through the classical estrogen receptors (ERα and ERβ) and the G protein‑coupled estrogen receptor (GPER). Current ER‑targeting ligands, including the therapeutic ERα antagonist tamoxifen, have been shown to cross‑activate GPER. This cross‑activation is hypothesized to contribute to clinically observed endocrine resistance in breast cancer, highlighting the potential benefit of truly ER‑selective antagonists. We report the identification of a novel class of ER‑selective ligands that lack cross‑reactivity towards GPER, identifying a truly ER‑selective agonist (AB‑1) and antagonist (AB‑82P). Importantly, AB‑82P degrades a clinically relevant ERα mutant and exhibits inhibitory effects …

A Microfluidics-Based Cross-Flow Filtration Platform For Rapid Processing Of Amphiphilic Biomarkers From Blood, Kiersten D. Lenz

Biomedical Engineering ETDs

Early and accurate detection of bacterial infections can help save lives, prevent the spread of disease, and decrease the overuse of antibiotics. Our team at the Los Alamos National Laboratory has developed novel assays to detect bacterial biomarkers from patient blood at the point-of-care in order to facilitate a universal diagnostic platform. However, these biomarkers are amphiphilic in nature, and this biochemical property causes them to be sequestered by high-density and low-density lipoproteins (HDL and LDL) in the host’s blood. Extraction of the bacterial biomarkers from the lipoprotein complexes is thereby required for the development and deployment of a diagnostic …

Unm Pathology Pathfinder Summer 2019, Unm Department Of Pathology

Newsletters

No abstract provided.

Multi-Sector General Permit Stormwater Pollution Prevention Plan 2019 Revision V. 11, National Technology & Engineering Solutions Of Sandia, Llc

2015 Multi-Sector General Permit

Stormwater discharges from industrial activities at Sandia National Laboratories/New Mexico (SNL/NM) are eligible for coverage under the National Pollutant Discharge Elimination System (NPDES) Multi-Sector General Permit (MSGP). This Stormwater Pollution Prevention Plan (SWPPP) was prepared by National Technology and Engineering Solutions of Sandia (NTESS) for the Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia Field Office (SFO), owner of SNL/NM, located in Albuquerque, NM. This SWPPP was prepared in compliance with the 2015 MSGP (effective June 4, 2015) and includes a description, potential pollutant sources, and control measures for each permitted site; and stormwater monitoring and compliance plans.

Water Security And Wildfire In Municipal Source Watersheds Of The Western United States, Matthew V. Segura

Water Resources Professional Project Reports

The goal of this study is to investigate water resource security for large metropolitan areas in the western United States and to identify cities that are at potential risk of water resource degradation due to wildfire. In this study, source watersheds for western cities are identified and ranked based on the potential resistance and resilience of their water supply to wildfire impacts. Next, the wildfire hazard potential of each of these catchments is determined and erosion potential estimates are used to infer how water quality will be impacted if the watersheds burn. The findings identify large populous cities that receive …

Inventory Of Restoration Needs Of National Forest Lands Of The Contiguous United States: An Assessment Using Watershed And Terrestrial Ecosystem Classification Tools, Kevin Carns

Water Resources Professional Project Reports

Ecological restoration assists the recovery of degraded ecosystems by returning their structure, processes, and functions to within their natural range of variation, improving long term sustainability and resilience. The United States Forest Service has sought to increase the pace and scale of restoration treatments on lands that it manages in order to continue to provide important ecosystem services including timber production, fish and wildlife habitat, grazing, watershed protection, and recreation. The Agency developed two classification systems to identify restoration need on Forest Service managed lands, the Watershed Condition Classification (WCC) and the Terrestrial Condition Assessment (TCA). These two classification systems …

Found In Space: A Cross-Linguistic Analysis Of Second Language Learners In English Map Task Performance, Susan K. Metheny

Language, Literacy, and Sociocultural Studies ETDs

Understanding the relationship between first and second language use in the area of spatial language has broader implications for our understanding of language learning and consequences for the construction of bilingual assessment instruments for second language learners. This study shows that observing and interpreting the task of map drawing and the related behavior of explaining maps can be a way to explore the linguistic emergence of the conceptualization of spatial language (at a moment of simultaneous and synchronized incarnation). Altogether, 50 dyads (pairs) participated in the New Mexico Map Task Project; the project included native speakers of English, Russian, Japanese, …

Submittal Of Mixed Waste Landfill Annual Long-Term Monitoring & Maintenance Report, April 2018-March 2019 For Sandia National Laboratories/New Mexico, Epa Id Number Nm5890110518, June 2019, Sandia National Laboratories/Nm Snl

Facilities-Units

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories /New Mexico (SNL/NM) personnel submitted the Mixed Waste Landfill (MWL) Annual Long-Term Monitoring and Maintenance Report for the April 2018 through March 2019 reporting period to the New Mexico Environment Department (NMED) in accordance with the requirements of Section 4.8.1 of the MWL Long-Term Monitoring and Maintenance Plan (LTMMP). The LTMMP became effective on January 8, 2014.

The MWL is a 2.6-acre Solid Waste Management Unit (SWMU 76) located in the north-central portion of SNL/NM Technical Area III that has undergone corrective action. As of March 13, 2016, …

Triplet Population Dynamics And Excited State Relaxation In Chalcogenophene Polymers, Benjamin D. Datko

Chemistry and Chemical Biology ETDs

The conventional understanding of intersystem crossing in multichromophoric conju- gated polymers is usually depicted via a pure electronic model, neglecting contributions of vibrations or conformational order. Obtaining accurate structure-function correlations on spin-conversion processes involving photogenerated singlet excitons to triplet excitons and the excited state dynamics requires sensitivity to the subtle conformational ordering within conjugated polymers. This dissertation seeks to understand the kinetics of multi-exciton singlet-triplet interactions and the excited state relaxation of chalcogen containing (S, Se) conjugated polymers. Utilizing single molecule modulation spectroscopy allows determi- nation of triplet formation of individual conjugated polymer chains and aggregates. This technique resolves triplet-induced …

Trends In Health, Stress, And Migration In The Pre-Contact Southwest United States, Alexis O'Donnell

Anthropology ETDs

The major goal of this dissertation was to examine migration and its impacts on health through use of dental morphological and paleopathological data. The case study is the Southwest United States between A.D. 1200-1400s. The second chapter, written with Corey Ragsdale, Biological Distance and the Fate of the Gallina in the American Southwest, examines where the Gallina people may have gone upon abandoning their homes in the late A.D. 1200s. We used dental data for 492 individuals and mean measure of divergence (biodistance) analysis to examine several hypotheses regarding where the Gallina went. We find that the Gallina may have …

“When You Don't Believe Something Is Real, You Can't Actually Advocate For Or Support It”: Trans* Inclusion In K-12 Schools, Susan W. Woolley

Intersections: Critical Issues in Education

Drawing on interviews, ethnographic observations, and survey data, the author examines the ways teachers, administrators, and policy makers conceptualize and influence school environments for students of all genders. This article engages queer studies in education and disability theory to analyze the inclusion of trans* students in schools. Looking at the implementation of the New York City Department of Education’s Transgender and Gender Nonconforming Student Guidelines in K-12 schools, the author questions how we can understand and address the gap between educational practice and policy to create schools that are inclusive of trans* students. How does the denial that transgender and …

Situating Giving Back For Native Americans Pursuing Careers In Stem: “You Don’T Just Take, You Give Something Back”, Janet Page-Reeves, Gabriel Leroy Cortez, Yoenesha Ortiz, Mark Moffett, Kathy Deerinwater, Douglas Medin

Intersections: Critical Issues in Education

This article explores how a desire to give back influences Native Americans pursuing education and careers in science, technology, engineering and mathematics (STEM). We present analysis of data from 51 interviews with Native students and STEM professionals. Despite the compelling evidence of the core significance of a community orientation among Native Americans, insufficient attention has been given to thinking about the unique challenges faced by STEM professionals in devising ways to give back and how this relates to the continuing problem of under-representation of Native Americans in STEM. Here we propose strategies for universities and industry to honor Native ways …

Full Issue (Spring 2019)

Intersections: Critical Issues in Education

No abstract provided.

The University Of New Mexico Orthopaedics Research Journal 2019, Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

Tumor Heterogeneity As A Predictor Of Response To Neoadjuvant Chemotherapy In Locally Advanced Rectal Cancer, Alissa Greenbaum, David R. Martin, Thèrése Bocklage, Ji-Hyun Lee, Scott A. Ness, Ashwani Rajput

Pathology Research and Scholarship

BACKGROUND: Neoadjuvant chemoradiotherapy (nCRT) is the standard of care for locally advanced adenocarcinoma of the rectum, but it is currently unknown which patients have disease that will respond. This study tested the correlation between response to nCRT and intratumoral heterogeneity using next-generation sequencing assays.

PATIENTS AND METHODS: DNA was extracted from formalin-fixed, paraffin-embedded biopsy samples from a cohort of patients with locally advanced rectal adenocarcinoma (T3/4 or N1/2 disease) who received nCRT. High read-depth sequencing of > 400 cancer-relevant genes was performed. Tumor mutations and variant allele frequencies were used to calculate mutant-allele tumor heterogeneity (MATH) scores as measures of intratumoral …

Clearing The Muddy Waters: Is Lack Of Motivational Interviewing Quality Accounting For Mixed Findings And Can Measuring Fidelity Help?, Lauren N. Rowell

Psychology ETDs

ABSTRACT

Objective: The SMART ED study was a randomized, controlled trial of 3 brief interventions in ER settings targeting high-risk substance use. Findings in the main study indicated that there was no difference in outcomes for groups receiving minimal, rather than more extensive, behavioral interventions. This secondary analysis investigated the quality of (MI) sessions in the SMART ED study to examine the hypothesis that better quality of MI would be associated with improved client outcomes.

Method: The Motivational Interviewing Treatment Integrity Code (MITI 3.0) was used to evaluate 388 sessions, yielding indicators of MI Quality including Overall Spirit (MI Spirit), …

Gold King Mine Spill: Environmental Law And Legal Protections For Environmental Responders, Clifford J. Villa

Faculty Scholarship

On August 5, 2015, EPA contractors working at the Gold King Mine in southwestern Colorado accidently released approximately three million gallons of contaminated mine water into the drainage of the Animas River. The water contained metals which created a bright orange plume that coursed down the Animas River and into the connecting San Juan River for many days, attracting nationwide attention and creating great concern for many local communities. The plume touched at least three states, three tribes, and numerous municipalities. The release fortunately did not prove an environmental catastrophe as many people feared at the time. However, it did …

Science For All: Exploring Science Communication For Public Engagement In Culturally Diverse Scenarios In The Americas, Denisse Helena Vasquez-Guevara

Latin American Studies ETDs

Universities in the United States and Ecuador must meet various policy guidelines concerning research and teaching that address the needs of their local communities. In Ecuador, the higher education law requires that universities undertake research and public outreach projects that respond to societal needs. In the United States, Carnegie Research Classifications motivate universities to serve their publics by carrying out community-engaged research. However, evaluations of public outreach projects and community-engaged research have consistently demonstrated that the segments of society that are ostensibly served by these initiatives are not meaningfully engaged in them; members of the public are treated as, and …

Teacher Perceptions Of Environmental Science In Rural Northwestern New Mexico Public Schools, Marie Quiahuitl Julienne

Organization, Information and Learning Sciences ETDs

In this study, I explored what teachers perceive as the factors that impact their teaching of environmental science in rural secondary level schools in northwestern New Mexico. I adapted Bronfenbrenner’s (1994) ecological systems model, based on four environmental subsystem levels (microsystem, mesosystem, exosystem, and macrosystem), as the conceptual framework to address the major research question of this study, and developed 18 interview questions to explore teachers’ perceptions of factors that influence their teaching of environmental science. I investigated the perspectives science teachers have about environmental science topics and the influences they perceive that affect how they teach environmental science, and …