Digital Commons Network^™

Drinking Water Governance For Whom? An Institutional Analysis Of Rural Drinking Water Systems In New Mexico, Tucker Colvin

Geography ETDs

Rural community drinking water systems in New Mexico are facing many challenges, including a lack of personnel, deteriorating infrastructure, lack of funds, overly burdensome and confusing regulation, environmental concerns, and concerns over water rights. Governing agencies are creating vulnerability by making managers prioritize some issues and neglect others. Water systems designated a Mutual Domestic Water Consumers Associations are especially problematic because they are small and managed by volunteers but have as much regulatory burden as larger municipalities. I use the theory of institutional work to explain how an institution that was originally designed to help low-income and rural communities is …

Cold-Inducible Rna Binding Protein (Cirp) Impedes Proliferation And Inflammation In The Pymt Mouse Model For Breast Cancer, Daniel Albino Lujan

Biomedical Sciences ETDs

RNA binding proteins (RBPs) regulate gene expression by controlling mRNA export, translation, and stability. When altered, some RBPs allow cancer cells to grow, survive, and metastasize. Cold-inducible RNA binding protein (CIRP) is overexpressed in a subset of breast cancers, induces proliferation in breast cancer cell lines, and inhibits apoptosis. We generated a transgenic mouse model overexpressing human CIRP in the mammary epithelium to ask if it plays a role in mammary gland development. We also assessed the effects of CIRP on breast tumorigenesis using breeding crosses with the PyMT mouse model for breast cancer. CIRP decreased proliferation at the lactational …

Dental Therapists Providing Access To Oral Health Care To Children In Florida, Shankisha D. Sizemore

Dental Hygiene ETDs

The state of Florida has proposed the establishment of the dental therapy mid-level provider to alleviate the lack of access to oral health care of the underserved population. Despite the success in other states opposition exists this workforce model. The purpose of this research is to evaluate the attitudes of Florida school-based nurses regarding the development of dental therapists to address the states oral health access issues. A survey queried a random sample of 300 Florida school-based nurses regarding dental therapy and access to oral health care issues among the school age children population. Twenty-three school-based nurses responded (7.8%). Results …

Evolutionary Ecology Of Host-Parasite Relationships: Role Of Host Ecology, Phylogeny, And Demographics In Shaping Parasite Evolution, Erika Taylor Gendron

Biology ETDs

Host-parasite systems exist across complex and ecologically heterogeneous landscapes, and may occur across taxonomically and ecologically disparate host species. Under these conditions, mechanisms underlying microevolutionary processes (i.e. gene flow, genetic drift) are not always clear, and may be mediated by numerous co-occurring factors specific to individual hosts. Host traits such as host immunology, demographics, phylogeny and ecology may act in concert to shape host-parasite relationships, and ultimately evolutionary processes. The research described herein used phylogeographic, phylogenomic, and population genetic methods to further understanding of how host traits impact the evolutionary ecology of trematode systems, using avian schistosomes (Digenea: Schistosomatidae) as …

2020-04-11/12 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Samuel Anyona, Evans Raballah, Perez Olewe, Hannah Groves, Danielle Rivera, Estefania Montanez, Rachel D. King, Cristian Bologa, Jeremy Yang, Tudor I. Oprea, Orrin Myers, Andrew S. Rowland, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

No NM church gatherings. NM a testing champ. Consolidation of elderly care. NM case update. 50-state disaster. Ventilator haggling. Economy reopening planning. PPE decontamination. Hospital ward contamination. Prolonged return to normal. FEMA projections. WHO tracking app. China SEIR model. Hubei epi. Mortality best measure. Covid-19 wave 2. Public should wear masks. Civil liberties. Safe grocery shopping. School closure impact. CDC caretaker guidelines. Psychiatric mobilization. Keep newborns with mom. C-section protocol. Italian obstetrics. Pediatric cardiac catherization. Chinese anesthesiology consensus. Cancer guidelines. Neuro-oncologic Tx. Radiology algorithm. Lung ultrasonography. ARF care. VTE common and predictable. Liver transplantation. Auto-immune treatments. Extracorporeal kidney …

Backyard Wildlife Refuges In Albuquerque, Nm: An Urban Land Ethic In Practice, Laurel E. Ladwig

Geography ETDs

In the urban setting, biodiversity conservation requires intentionally creating spaces humans and wildlife can share. An urban land ethic can guide this process. Developing and practicing this ethic requires asking questions that consider approaches from multiple disciplines and avoid anthropocentric framing. Both More-Than-Human and Critical Physical Geography bring multiple knowledges into conversation to make complex realities visible. This project explores these fields of scholarship as guides for reconciling the needs of the land community.

Sharing familiar spaces creates opportunities for developing ethical relationships between humans, non-humans, and natural systems. Wildlife gardening creates habitat in our residential and community areas, providing …

Reinventing Maternity In Chariton's Callirhoe, Christine Ellis

Foreign Languages & Literatures ETDs

This project analyzes Chariton’s construction of maternity in his Greek novel Callirhoe. I argue that Chariton heavily employs intertexts and allusions throughout his novel, especially with regard to his female protagonists. Through these allusions, Chariton is not only able to insert himself and his work within the literary canon, but he is also able to develop his genre by juxtaposing his heroine with those of the genres of tragedy and epic. Topics of analysis range from debates about killing one’s child to the importance of marital memory. By the end of his novel, Chariton is able both to establish …

Driver Of Avian Haemosporidian Diversity And Host Specificity In The Solomon Islands, Xena Marie Mapel

Biology ETDs

Avian haemosporidians are protist parasites that are distributed worldwide. We investigated these parasites in a tropical South Pacific archipelago to answer two questions: 1) Which community characteristics influence haemosporidian diversity; 2) Does host specificity vary across islands? To answer these questions we sequenced a mitochondrial gene and created linear models to establish relationships between select variables and diversity. In addition, we calculated host breadth of each lineage and constructed models to infer predictors of diversity. The percent of infected individuals on each island was correlated with island area. Haemosporidian phylogenetic diversity on a given island was associated with the proportion …

2020-04-09 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Samuel Anyona, Evans Raballah, Shawn Stoicu, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Hannah Groves, Danielle Rivera, Estefania Montanez, Rachel D. King, Andrew S. Rowland, Orrin Myers, Kristine Tollestrup, Tudor I. Oprea, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

Today we began curating the firehose of National Library of Medicine COVID-19 Literature released daily. NM Governor gave weekly update. School online instruction starts Monday. Tribal communities in crisis. COVID-19 scams. NY food banks overwhelmed. Public sentiment survey. Arizona tracing outbreak with genomics. Abortion controversy continues. WHO Solidarity-II antibody study. South Korea epidemiology released. Preventing second COVID-19 wave. Institutional case reporting required. Gynecological procedure safety. Rationing ethics and advanced directives. CDC advice on exposed critical workers. Triaging urological procedures. Pathology safety and remote work. Healthcare workforce expansion. Involve and educate medical students. CDC no longer recommends hydroxychloroquine (HCQ). …

2020-04-07 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Anastasiya Nestsiarovich, Praveen Kumar, Hannah Groves, Danielle Rivera, Estefania Montanez, Tudor I. Opera, Andrew S. Rowland, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

Today we celebrate World Health Day: JAMA suggests ways to support healthcare workers in the crisis. NM Emergency orders extended. Some NM prisoners freed. Pueblos threatened by outbreaks. CDC to provide $186M in state funding for surveillance programs. Colleges hit hard financially. Nine states refuse to issue stay-at-home order. Wuhan cautiously ends its 76-day lockdown. Lack of cough and fever for children creates special challenges. Fauci JAMA interview tomorrow. WHO guidelines and megatrial of 4 therapies. Numerous CDC guidelines. 23 clinical trials registered today. One negative result on hydroxychloroquine efficacy. In vitro screens suggest promising FDA drugs for …

Unm Staff Council: Diversity, Equity & Inclusion Committee Letter Condemning Racist Threats Against Faculty Member, Unm Staff Council

Black History at UNM

Open letter by UNM Staff Council Diversity, Equity & Inclusion Committee, condemning racist attacks on a UNM faculty member with 439 signatories.

An Introduction To The Collection [Get In Good Trouble: A Collection Of Essays By Millennial Law Scholars], Verónica C. Gonzales

Faculty Scholarship

Get in Good Trouble: A Collection of Essays by Millennial Law Scholars Introduction by Verónica C. Gonzales-Zamora with essays by Kinda Abdus-Saboor, Ernestine Chaco, Marcus Gadson, Verónica Gonzales-Zamora, Camilo Romero, Lysette Romero Córdova, Morenike Saula, Joseph Schremmer, and Hon. Roshanna Toya. Afterword by Marcus Gadson. In response to the global pandemic, legal education in the United States shifted almost immediately to new tools and methods of delivery. Unsure of the lasting impact of these shifts, law faculty and law students around the country remain in limbo preparing for different scenarios when instruction resumes. Millennial law professors and scholars, with decades …

Inlp Newsletter, April 2020, Indigenous Nations Library Program

Monthly Newsletters

No abstract provided.

Pkcδ Causes Sepsis-Induced Cardimyopathy By Inducing Mitochondrial Dysfunction, Leroy C. Joseph, Michael V. Reyes, Kundanika R. Lakkadi, Blake H. Gowen, Gyorgy Hasko, Konstantinos Drosatos, John P. Morrow

Pathology Research and Scholarship

Sepsis-induced cardiomyopathy (SIC) is associated with increased patient mortality. At present, there are no specific therapies for SIC. Previous studies have reported increased reactive oxygen species (ROS) and mitochondrial dysfunction during SIC. However, a unifying mechanism remains to be defined. We hypothesized that PKCδ is required for abnormal calcium handling and cardiac mitochondrial dysfunction during sepsis and that genetic deletion of PKCδ would be protective. Polymicrobial sepsis induced by cecal ligation and puncture (CLP) surgery decreased the ejection fraction of wild-type (WT) mice but not PKCδ knockout (KO) mice. Similarly, WT cardiomyocytes exposed to lipopolysaccharide (LPS) demonstrated decreases in contractility …

Association Of Immunophenotype With Expression Of Topoisomerase Ii Α And Β In Adult Acute Myeloid Leukemia, Andrew P. Michelson, Shannon Mcdonough, Cheryl L. Willman, Eric R. Koegle, John E. Godwin, Stephen H. Petersdorf, Alan F. List, Megan Othus, Frederick R. Appelbaum, Jerald P. Radich, Mahrukh K. Ganapathi, Anjali S. Advani, Ram N. Ganapathi

Pathology Research and Scholarship

Anthracyclines used in the treatment of acute myelogenous leukemia (AML) inhibit the activity of the mammalian topoisomerase II (topo II) isoforms, topo II α and topo IIβ. In 230 patients with non-M3 AML who received frontline ara-C/daunorubicin we determined expression of topo IIα and topo IIβ by RT-PCR and its relationship to immunophenotype (IP) and outcomes. Treatment outcomes were analyzed by logistic or Cox regression. In 211 patients, available for analysis, topo IIα expression was significantly lower than topo IIβ (P < 0.0001). In contrast to topo IIα, topo IIβ was significantly associated with blast percentage in marrow or blood (P = 0.0001), CD7 (P = 0.01), CD14 (P < 0.0001) and CD54 (P < 0.0001). Event free survival was worse for CD56-negative compared to CD56-high (HR = 1.9, 95% CI [1.0-3.5], p = 0.04), and overall survival was worse for CD-15 low as compared to CD15-high (HR = 2.2, 95% CI [1.1-4.2], p = 0.02). Ingenuity pathway analysis indicated topo IIβ and immunophenotype markers in a network associated with cell-to-cell signaling, hematological system development/function and inflammatory response. Topo IIβ expression reflects disease biology of highly proliferative disease and distinct IP but does not appear to be an independent variable influencing outcome in adult AML patients treated with anthracycline-based therapy.

The Mk2 Pathway Is Linked To G-Csf, Cytokine Production And Metastasis In Gastric Cancer: A Novel Intercorrelation Analysis Approach, Fares Qeadan, Pranshu Bansal, Joshua A. Hanson, Ellen J. Beswick

Pathology Research and Scholarship

BACKGROUND: Gastric cancer is associated with chronic inflammation, but there is still much to understand about the tumor microenvironment and the underlying tumor-promoting mechanisms. The Map kinase-activated protein kinase 2 (MK2) pathway is a regulator of inflammatory cytokine production that we have been studying in gastrointestinal cancers. Here, we set out to determine the significance of this gene in gastric cancer along with its downstream mediators and if there were differences in the primary tumors with and without metastasis.

METHODS: Human gastric cancer tissues with and without metastasis were examined for MK2 expression and cytokine profile in organ culture supernatants. …

Neutrosophic Geometric Programming (Ngp) With (Max-Product) Operator, An Innovative Model, Huda E. Khalid

Neutrosophic Sets and Systems

No abstract provided.

Multisite Egfr Phosphorylation Is Regulated By Adaptor Protein Abundances And Dimer Lifetimes, Emanuel Salazar-Cavazos, Carolina Franco Nitta, Eshan D. Mitra, Bridget S. Wilson, Keith A. Lidke, William S. Hlavacek, Diane S. Lidke

Pathology Research and Scholarship

Differential epidermal growth factor receptor (EGFR) phosphorylation is thought to couple receptor activation to distinct signaling pathways. However, the molecular mechanisms responsible for biased signaling are unresolved due to a lack of insight into the phosphorylation patterns of full-length EGFR. We extended a single-molecule pull-down technique previously used to study protein-protein interactions to allow for robust measurement of receptor phosphorylation. We found that EGFR is predominantly phosphorylated at multiple sites, yet phosphorylation at specific tyrosines is variable and only a subset of receptors share phosphorylation at the same site, even with saturating ligand concentrations. We found distinct populations of receptors …

2020-03-16 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Show Us The Money: How Patchwork State Freedom-Of-Information Laws Impede Accountability In High School Athletics, Frank D. Lomonte, Harrison O'Keeffe

New Mexico Law Review

High school sports have evolved into a large, complex business enterprise, complete with seven-figure broadcast contracts and $60 million stadiums rivaling collegiate facilities. Some 8 million Americans take part in school-sponsored competitive athletics each year, and their health and safety is of undeniable public concern. Because of their popularity and outsized cultural significance, interscholastic sporting events regularly become theaters of combat for the political and social issues of the day, from desegregation to women's equality to LGBT rights. Yet despite the intense public interest in interscholastic sports, the public's ability to stay informed about how sporting events are organized and …

Sclerosing Epithelioid Mesenchymal Neoplasm Of The Pancreas - A Proposed New Entity, Olca Basturk, Britta Weigelt, Volkan Adsay, Jamal K Benhamida, Gokce Askan, Lu Wang, Maria E. Arcila, Giuseppe Zamboni, Noriyoshi Fukushima, Rodrigo Gularte-Mérida, Arnaud Da Cruz Paula, Pier Selenica, Rahul Kumar, Fresia Pareja, Christopher A. Maher, John Scholes, Yoshinao Oda, Donatella Santini, Leona A. Doyle, Iver Petersen, Uta Flucke, Christian Koelsche, Samuel J. Reynolds, Aslihan Yavas, Andreas Von Deimling, Jorge S. Reis-Filho, David S. Klimstra

Pathology Research and Scholarship

We have encountered pancreatic tumors with unique histologic features, which do not conform to any of the known tumors of the pancreas or other anatomical sites. We aimed to define their clinicopathologic features and whether they are characterized by recurrent molecular signatures. Eight cases were identified; studied histologically and by immunohistochemistry. Selected cases were also subjected to whole-exome sequencing (WES; n = 4), RNA-sequencing (n = 6), Archer FusionPlex assay (n = 5), methylation profiling using the Illumina MethylationEPIC (850k) array platform (n = 6), and TERT promoter sequencing (n = 5). Six neoplasms occurred in females. The mean age …

Hobnail Cells In Encapsulated Papillary Thyroid Carcinoma: Report Of 2 Cases With Immunohistochemical And Molecular Findings And Literature Analysis, Shweta Agarwal, Qandeel Sadiq, Ibrahim Ortanca

Pathology Research and Scholarship

Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland with most tumors behaving in an indolent fashion. However, morphologic variants have been described, such as tall cell, diffuse sclerosing, columnar cell etc. which are biologically more aggressive. One of these variants includes the more recently described hobnail variant (HVPTC) which shows micropapillae and presence of large cells with apically placed hyperchromatic nuclei, reverse polarity, and eosinophilic cytoplasm, akin to hobnail cells. The presence of >30% hobnail cells in a PTC deserves categorization as a hobnail variant. This variant is usually associated with extra thyroidal extension, …

Drug Resistance Of Previously Treated Tuberculosis Patients With Diabetes Mellitus In Shandong, China, Wan-Mei Song, Yi-Fan Li, Jin-Yue Liu, Ning-Ning Tao, Yao Liu, Qian-Yun Zhang, Ting-Ting Xu, Shi-Jin Li, Qi-Qi An, Si-Qi Liu, Chun-Bao Yu, Lei Gao, Cui-Xiang Yu, Min Zhang, Huai-Chen Li

Pathology Research and Scholarship

BACKGROUND: Although the association between diabetes mellitus (DM) and tuberculosis (TB) has been well-documented for centuries, evidence of the link between diabetes and drug resistance among previously treated TB patients remains limited and inconsistent.

METHODS: An observational study was performed that involved 1791 retreated TB-no DM patients (refers to TB cases without diabetes) and 93 retreated TB-DM patients (refers to TB cases with diabetes) in Shandong, China from 2004 to 2017. Baseline data including demographic and clinical characteristics, drug susceptibility test (DST) results, and diabetes status were collected. Categorical baseline characteristics were compared by Fisher's exact or Pearson Chi-square test. …

A Deep Learning Convolutional Neural Network Can Recognize Common Patterns Of Injury In Gastric Pathology, David R. Martin, Joshua A. Hanson, Rama R. Gullapalli, Fred A. Schultz, Aisha Sethi, Douglas P. Clark

Pathology Research and Scholarship

CONTEXT.—: Most deep learning (DL) studies have focused on neoplastic pathology, with the realm of inflammatory pathology remaining largely untouched.

OBJECTIVE.—: To investigate the use of DL for nonneoplastic gastric biopsies.

DESIGN.—: Gold standard diagnoses were blindly established by 2 gastrointestinal pathologists. For phase 1, 300 classic cases (100 normal, 100

RESULTS.—: For Phase 1, receiver operating curves showed near perfect agreement with the gold standard diagnoses at an AD percentage cutoff of 50% for normal (area under the curve [AUC] = 99.7%) and

CONCLUSIONS.—: A convolutional neural network can serve as an effective screening tool/diagnostic aid for

Dynamic Imaging Of Ldh Inhibition In Tumors Reveals Rapid In Vivo Metabolic Rewiring And Vulnerability To Combination Therapy, Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P Norenberg, W Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers

Pathology Research and Scholarship

The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to determine whether LDH is a feasible drug target are lacking. We describe an LDHi with potent, on-target, in vivo activity. Using hyperpolarized magnetic resonance spectroscopic imaging (HP-MRSI), we demonstrate in vivo LDH inhibition in two glycolytic cancer models, MIA PaCa-2 and HT29, and we correlate depth and duration of LDH inhibition with direct anti-tumor activity. HP-MRSI also reveals a metabolic rewiring that occurs in vivo within 30 min …

The Impact Of An Undergraduate Biology Class On Donor Recruitment At A Hospital-Based Blood Donor Center, Alexis R. Peedin, Yara A. Park, Marshall A. Mazepa, Thomas Neish, Jay S. Raval, R Chad Siniard

Pathology Research and Scholarship

OBJECTIVES: A biology class, BIOL 294H, taught undergraduates about platelet donation while partnering with the University of North Carolina's (UNC's) hospital-based Blood Donation Center to recruit apheresis platelet donors. We identified our platelet donors' demographics and learned how BIOL 294H affected recruitment.

METHODS: Every platelet donor presenting to the UNC Blood Donation Center from February 7, 2017, to March 10, 2017, was asked to complete an electronic 10-question survey.

RESULTS: A total of 159 unique donors completed the survey; 64% were female and 75% were between ages 18 and 25 years. Overall, 70% were UNC undergraduate students. Over half (56%) …

Recommendations For Clinical Laboratory Testing For Protein C Deficiency, For The Subcommittee On Plasma Coagulation Inhibitors Of The Isth, Peter C. Cooper, Anna Pavlova, Gary W. Moore, Kieron P. Hickey, Richard A. Marlar

Pathology Research and Scholarship

Inherited protein C (PC) deficiency increases risk of venous thromboembolism (VTE) by 5 to 10-fold in thrombosis-prone families; however, heterozygous PC deficiency alone does not determine that a subject has thrombophilia. Protein C deficient subjects, who lack additional inherited risk factors such as factor V Leiden or have no major acquired risk factors, may not suffer from VTE. In addition, PC deficiency may be acquired, often due to vitamin K antagonist treatment or liver disease. In contrast, homozygous or compound heterozygous PC deficiencies are rare and serious disorders, and affected infants are often in families with no history of PC …

Evaluation Of Commercial Next-Generation Sequencing Bioinformatics Software Solutions, Rama R. Gullapalli

Pathology Research and Scholarship

Next-generation sequencing (NGS) diagnostics continue to expand rapidly in clinical medicine. An ever-expanding menu of molecular biomarkers is deemed important for diagnostic, prognostic, and therapeutic assessment in patients. The increasing role of NGS in the clinic is driven mainly by the falling costs of sequencing. However, the data-intensive nature of NGS makes bioinformatic analysis a major challenge to many clinical laboratories. Critically needed NGS bioinformatics personnel are hard to recruit and retain in small- to mid-size clinical laboratories. Also, NGS software often lacks the scalability necessary for expanded clinical laboratory testing volumes. Commercial software solutions aim to bridge the bioinformatics …

Echo Telementoring For Pain, Palliative Care, And Opioid Management: Progress, Challenges, And Future Goals, Joanna G. Katzman

Project ECHO Bibliography

The article in this issue of Pain Medicine by Flynn et al., “Pain Management Telementoring, Long-term Opioid Prescribing, and Patient-Reported Outcomes,” demonstrates patient-level reductions in opioid doses in patients whose clinicians actively participate in pain telementoring as compared with patients whose clinicians participate in pain telementoring at a low level. These outcome data reflect the growing body of evidence that telementoring may improve opioid prescribing and pain management practices.

Clinical Diagnostics And Treatment Strategies For Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia, Richard C. Harvey, Sarah K. Tasian

Pathology Research and Scholarship

Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like ALL) accounts for 15% to 30% of B-cell acute lymphoblastic leukemia in older children, adolescents, and adults and is associated with high rates of conventional treatment failure and relapse. Current clinical trials are assessing the efficacy of the addition of tyrosine kinase inhibitors (TKIs) to chemotherapy for children and adults with Ph-like ALL harboring ABL class translocations or CRLF2 rearrangements and other JAK pathway alterations. However, real-time diagnosis of patients can be quite challenging given the genetic heterogeneity of this disease and the often cytogenetically cryptic nature of Ph-like ALL-associated alterations. In this …