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Molecular Interplay Between Dormant Bone Marrow-Resident Cells (Bmrcs) And Ctcs In Breast Cancer., Debasish Boral, S Ray Kenney, Dario Marchetti, Haowen N. Liu Jun 2020

Molecular Interplay Between Dormant Bone Marrow-Resident Cells (Bmrcs) And Ctcs In Breast Cancer., Debasish Boral, S Ray Kenney, Dario Marchetti, Haowen N. Liu

Pathology Research and Scholarship

Despite widespread knowledge that bone marrow-resident breast cancer cells (BMRCs) affect tumor progression, signaling mechanisms of BMRCs implicated in maintaining long-term dormancy have not been characterized. To overcome these hurdles, we developed a new experimental model of clinical dormancy employing patient-isolated Circulating Tumor Cells (de novo CTCs) and their injection in xenografts with subsequent tumor monitoring and CTC characterization (ex vivo CTCs). We hypothesized that significant distinctions exist between signaling pathways of bone marrow-homing vs metastasis-competent CTCs upon transplantation in xenografts. Comparative transcriptomic analyses of ex vivo vs de novo CTCs identified increased mTOR signaling-a critical pathway frequently dysregulated in …


Less Is More: A Case Study Of Consolidating Two Database A–Z Lists For Better Staff And User Experiences, Todd Quinn Jun 2020

Less Is More: A Case Study Of Consolidating Two Database A–Z Lists For Better Staff And User Experiences, Todd Quinn

University Libraries & Learning Sciences Faculty and Staff Publications

This case study describes the consolidation and migration of the University of New Mexico’s University Libraries’ two database A–Z lists. A subject librarian led the nine-month project that included most subject librarians, the electronic resources team, the Director of Collections, and the Web & Discovery Librarian. The project also provided the University Libraries with the opportunity to review the resources on the lists, update descriptions, and create new workflows for adding and managing a single list.


2020-06-12/13/14 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Jenny Situ, Clinton Onyango, Perez Olewe, Cristian Bologa, Orrin Myers, Douglas J. Perkins Jun 2020

2020-06-12/13/14 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Jenny Situ, Clinton Onyango, Perez Olewe, Cristian Bologa, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: NM case count. Increased road travel. ABQ ART to resume. Film industry to reopen. US Highlights: Policy advocacy to end mass Incarceration. International Highlights: COVID-19 cases in Italy. Temperature checks at Canada airports. Economics, Workforce, Supply Chain, PPE: Epidemiology Highlights: Mask stability. Supply operations management. Masks going to transport companies. Digital tools for awareness. Customers like clean stores. Epidemiology: Michigan hospitalization risk factors. Ranking the risks of reopening. Pandemic growth rate scaling. Outbreak detection and contract tracing. Worldwide mortality report. Screening pregnant women. Social learning model for pandemics. Healthcare Policy Recommendations: Re-opening of sports centers. Minimize …


Association Between Self-Reported Dyspnea And Depressive Symptoms In New Mexico Uranium Workers, Shiva Sharma Jun 2020

Association Between Self-Reported Dyspnea And Depressive Symptoms In New Mexico Uranium Workers, Shiva Sharma

Biomedical Sciences ETDs

BACKGROUND: Uranium workers risk experiencing dyspnea, a lung disease symptom. Previous studies found associations between dyspnea and depressive symptoms in lung disease, but this requires further study in occupational cohorts.

METHODS: This study evaluated the association between dyspnea and depressive symptoms in former uranium workers screened by New Mexico Radiation Exposure Screening & Education Program. Dyspnea and depressive symptoms were evaluated through questionnaires, Modified Medical Research Council Dyspnea Scale and a modified Patient Health Questionnaire-2, respectively. Logistic regression models were applied to cross-sectional analyses. Generalized linear models were applied to longitudinal analyses.

RESULTS: Cross-sectional analyses demonstrated higher dyspnea scores were …


2020-06-03/04 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Jenny Situ, Ariel Hurwitz, Morgan Edwards-Fligner, Clinton Onyango, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins Jun 2020

2020-06-03/04 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Jenny Situ, Ariel Hurwitz, Morgan Edwards-Fligner, Clinton Onyango, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: Navajo Nation to end weekend curfew. NM case count. Navajo Nation case updates. Food distribution by PepsiCo. APS to get funding. US Highlights: 5 vaccine candidates. Arizona’s increased cases. Some states postpone primaries. Pork plant infections. Economics, Workforce, Supply Chain, PPE: Impact on global supply chains. Residency selection process disrupted. Facemask filtration efficiency. Resources for underserved countries. Epidemiology Highlights: Morbidity and mortality in Africa. Healthcare Policy Recommendations: Need for social distancing. Psychological support guide. Return to work guidelines. Practice Guidelines: Anesthesia recommendations for ECT. Extracorporeal membrane oxygenation outcomes. Testing: Roche Elecsys IL-6 test is authorized by …


Application Of Pender’S Health Promotion Model In Preventing Pediatric Unintentional Injury And Booster Seat Use, Kendall Travis Jun 2020

Application Of Pender’S Health Promotion Model In Preventing Pediatric Unintentional Injury And Booster Seat Use, Kendall Travis

Theoretical Foundation in Advanced Practice Nursing

No abstract provided.


2020-06-01/02 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Jenny Situ, Alexandra Yingling, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins Jun 2020

2020-06-01/02 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Jenny Situ, Alexandra Yingling, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: New public health order. First coronavirus death in state prison. NM case count. ABQ black lives matter protest. Santa Fe Fiesta canceled. U2 drummer donated to Navajo. US Highlights: Americans’ COVID-19 survey. Immunity for essential businesses in 4 states. International Highlights: Tiananmen Square closed to vigil. Shared approaches helpful for Africa. Economics, Workforce, Supply Chain, PPE: Face masks effective. Distance and Mask combined key to success. Economic effect on dental practice. Dow predicted to fall before new high. Epidemiology Highlights: Other causes of death increase. Virus not losing potency. Protests may spread virus. Wastewater surveillance. Healthcare …


Traumatic Injury Results In Prolonged Circulation Of Ultralarge Von Willebrand Factor And A Reduction In Adamts13 Activity, Mitchell R. Dyer, William E. Plautz, Margaret V. Ragni, Wyeth Alexander, Shannon Haldeman, Jason L. Sperry, Francis X. Guyette, Brian S. Zuckerbraun, Marian A. Rollins-Raval, Jay S. Raval, Matthew D. Neal Jun 2020

Traumatic Injury Results In Prolonged Circulation Of Ultralarge Von Willebrand Factor And A Reduction In Adamts13 Activity, Mitchell R. Dyer, William E. Plautz, Margaret V. Ragni, Wyeth Alexander, Shannon Haldeman, Jason L. Sperry, Francis X. Guyette, Brian S. Zuckerbraun, Marian A. Rollins-Raval, Jay S. Raval, Matthew D. Neal

Pathology Research and Scholarship

BACKGROUND: Increases in plasma von Willebrand Factor (VWF) levels, accompanied by decreases in the metalloprotease ADAMTS13, have been demonstrated soon after traumatic injury while downstream effects remain unclear.

STUDY DESIGN AND METHODS: A cohort of 37 injured trauma patients from a randomized control trial investigating the use of prehospital plasma transfusion were analyzed for activity and antigen levels of ADAMTS13 and VWF at 0 and 24 hours after admission. Relevant clinical data were abstracted from the medical records. Trauma patient plasma was analyzed via agarose gel electrophoresis to evaluate the effects of injury on VWF multimer composition compared to healthy …


Relationships Of P16 Immunohistochemistry And Other Biomarkers With Diagnoses Of Cervical Abnormalities: Implications For Last Terminology, Philip E. Castle, Rachael Adcock, Jack Cuzick, Nicolas Wentzensen, Norah E. Torrez-Martinez, Salina M. Torres, Mark H. Stoler, Brigitte M. Ronnett, Nancy E. Joste, Teresa M. Darragh, Patti E. Gravitt, Mark Schiffman, William C. Hunt, Walter K. Kinney, Cosette M. Wheeler Jun 2020

Relationships Of P16 Immunohistochemistry And Other Biomarkers With Diagnoses Of Cervical Abnormalities: Implications For Last Terminology, Philip E. Castle, Rachael Adcock, Jack Cuzick, Nicolas Wentzensen, Norah E. Torrez-Martinez, Salina M. Torres, Mark H. Stoler, Brigitte M. Ronnett, Nancy E. Joste, Teresa M. Darragh, Patti E. Gravitt, Mark Schiffman, William C. Hunt, Walter K. Kinney, Cosette M. Wheeler

Pathology Research and Scholarship

CONTEXT.—: Lower Anogenital Squamous Terminology (LAST) standardization recommended p16

OBJECTIVE.—: To describe the relationships of p16 IHC and other biomarkers associated with cervical cancer risk with biopsy diagnoses.

DESIGN.—: A statewide, stratified sample of cervical biopsies diagnosed by community pathologists (CPs), including 1512 CIN2, underwent a consensus, expert pathologist panel (EP) review (without p16 IHC results), p16 IHC interpretation by a third pathology group, and human papillomavirus (HPV) genotyping, results of which were grouped hierarchically according to cancer risk. Antecedent cytologic interpretations were also available.

RESULTS.—: Biopsies were more likely to test p16 IHC positive with increasing severity of CP …


Submittal Of Mixed Waste Landfill Annual Long-Term Monitoring & Maintenance Report, April 2019-March 2020 For Sandia National Laboratories/New Mexico, Epa Id Number Nm5890110518, June 2020, Sandia National Laboratories/Nm Jun 2020

Submittal Of Mixed Waste Landfill Annual Long-Term Monitoring & Maintenance Report, April 2019-March 2020 For Sandia National Laboratories/New Mexico, Epa Id Number Nm5890110518, June 2020, Sandia National Laboratories/Nm

Facilities-Units

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories /New Mexico (SNL/NM) personnel submitted the Mixed Waste Landfill (MWL) Annual Long-Term Monitoring and Maintenance Report for the April 2019 through March 2020 reporting period to the New Mexico Environment Department (NMED) in accordance with the requirements of Section 4.8.1 of the MWL Long-Term Monitoring and Maintenance Plan (LTMMP). The LTMMP became effective on January 8, 2014.

The MWL is a 2.6-acre Solid Waste Management Unit (SWMU 76) located in the north-central portion of SNL/NM Technical Area III that has undergone corrective action. As of March 13, 2016, …


Big Trouble In Little Texas The Chicano Movement In Southern New Mexico, 1968–1977, Jamie Bronstein Jun 2020

Big Trouble In Little Texas The Chicano Movement In Southern New Mexico, 1968–1977, Jamie Bronstein

New Mexico Historical Review

No abstract provided.


An Integrative Neutrosophic Model Focused On Personality (Inmfp) For The Adequate Management Of The Level Of Work Stress, Roberto Aguilar Berrezueta, Edwin Marcelo Sandoval, Bolívar Villalta Jadán, Diego Palma Rivera Jun 2020

An Integrative Neutrosophic Model Focused On Personality (Inmfp) For The Adequate Management Of The Level Of Work Stress, Roberto Aguilar Berrezueta, Edwin Marcelo Sandoval, Bolívar Villalta Jadán, Diego Palma Rivera

Neutrosophic Sets and Systems

Stress is an inevitable way of adapting each individual to the challenges of the surrounding environment. When the adaptation is done in a negative way and produces physiological or psychological imbalances in the person, then stress is called distress. However, stress is not always harmful to the person, there is stress in situations of joy or happiness, which is known by eustress. In the work environment, distress can cause physical and mental health problems for workers and therefore damage to the dynamics of the job. This paper aims to propose an index of occupational stress measurement based on the Integrative …


Multi-Sector General Permit Stormwater Pollution Prevention Plan 2020 Revision V. 12, National Technology & Engineering Solutions Of Sandia, Llc, Carolyn Daniel Jun 2020

Multi-Sector General Permit Stormwater Pollution Prevention Plan 2020 Revision V. 12, National Technology & Engineering Solutions Of Sandia, Llc, Carolyn Daniel

2015 Multi-Sector General Permit

Stormwater discharges from industrial activities at Sandia National Laboratories/New Mexico (SNL/NM) are eligible for coverage under the National Pollutant Discharge Elimination System (NPDES) Multi-Sector General Permit (MSGP). This Stormwater Pollution Prevention Plan (SWPPP) was prepared by National Technology and Engineering Solutions of Sandia (NTESS) for the Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia Field Office (SFO), owner of SNL/NM, located in Albuquerque, NM. This SWPPP was prepared in compliance with the 2015 MSGP (effective June 4, 2015) and includes a description, potential pollutant sources, and control measures for each permitted site; and stormwater monitoring and compliance plans.


Priorization Of Educational Strategies On Nutrition And Its Correlation In Anthropometry In Children From 2 To 5 Years With Neutrosophic Topsis, Clara Elisa Pozo-Hernández, Edid Tatiana Mejía-Álvarez, Manuel Jaramillo Burgos, Fanny Jara Vaca Jun 2020

Priorization Of Educational Strategies On Nutrition And Its Correlation In Anthropometry In Children From 2 To 5 Years With Neutrosophic Topsis, Clara Elisa Pozo-Hernández, Edid Tatiana Mejía-Álvarez, Manuel Jaramillo Burgos, Fanny Jara Vaca

Neutrosophic Sets and Systems

The study carried out at the Tajamar Health Center allows the evaluation of the educational strategies to be followed by the mothers of children aged from 2 to 5 years, leading to the definition of a correct nutrition pattern and its correlation with the value of anthropometry by applying the TOPSIS Neutrosophic method. A descriptive, qualitative, quantitative and field study was conducted. In order to determine the level of knowledge of the children's mothers, we used the survey as a technique; which allowed to identify the status of nutrition in which they are and whether the growth and development of …


Neutrosophic Decision Map For Critical Success Factors Prioritization In A Museum Of Religious Art, Ximena Cangas Oña, Manuel Jaramillo Burgos, Géssica Adriana Calderón Vallejo, Marcela Orellana Cepeda Jun 2020

Neutrosophic Decision Map For Critical Success Factors Prioritization In A Museum Of Religious Art, Ximena Cangas Oña, Manuel Jaramillo Burgos, Géssica Adriana Calderón Vallejo, Marcela Orellana Cepeda

Neutrosophic Sets and Systems

Visits to museums represent a way of keeping culture in memory of new generations. Getting to know the details that characterize each muse logical installation is a fundamental task for workers in the sector. That is why, depending on the knowledge that people have about the place, room recommendations are a problem of decision-making that are currently addressed. The present investigation proposes a method for the recommendation of museum rooms through the use of Neutrosophic Cognitive Map. A case study is applied where the proposal for the recommendation of rooms of the religious art museum of La Concepción in Riobamba …


Pestel Analysis Of Environment State Responsibility In Ecuador, Alba Rosa Pupo Kairuz, Dionisio Vitalio Ponce Ruiz, Gonzalo Favián Viteri Pita, Fernando Samuel Bustillo Mena Jun 2020

Pestel Analysis Of Environment State Responsibility In Ecuador, Alba Rosa Pupo Kairuz, Dionisio Vitalio Ponce Ruiz, Gonzalo Favián Viteri Pita, Fernando Samuel Bustillo Mena

Neutrosophic Sets and Systems

The care and conservation of the environment is currently a task to ensure human survival. Various are the negative environmental impacts to which the planet is subjected. Quantifying the adverse events that the planet faces constitutes an activity little addressed by science. The present investigation describes a solution to the problem posed from the development of a method for environmental evaluation. It uses a multicriteria approach and models its inference by means of Neutrosophics Cognitive Maps.


Von Willebrand Factor As A Thrombotic And Inflammatory Mediator In Critical Illness, William E. Plautz, Zachary A. Matthay, Marian A. Rollins-Raval, Jay S. Raval, Lucy Z. Kornblith, Matthew D. Neal Jun 2020

Von Willebrand Factor As A Thrombotic And Inflammatory Mediator In Critical Illness, William E. Plautz, Zachary A. Matthay, Marian A. Rollins-Raval, Jay S. Raval, Lucy Z. Kornblith, Matthew D. Neal

Pathology Research and Scholarship

The endothelial exocytosis of high-molecular-weight multimeric von Willebrand factor (vWF) may occur in critical illness states, including trauma and sepsis, leading to the sustained elevation and altered composition of plasma vWF. These critical illnesses involve the common process of sympathoadrenal activation and loss of the endothelial glycocalyx. As a prothrombotic and proinflammatory molecule that interacts with the endothelium, the alterations exhibited by vWF in critical illness have been implicated in the development and damaging effects of downstream pathologies, such as disseminated intravascular coagulation and systemic inflammatory response syndrome. Given the role of vWF in these pathologies, there has been a …


Extracting And Standardizing Medical Examiner Data To Improve Health, Shamsi Daneshvari Berry, Heather J H Edgar May 2020

Extracting And Standardizing Medical Examiner Data To Improve Health, Shamsi Daneshvari Berry, Heather J H Edgar

Pathology Research and Scholarship

Data from medical examiner offices are not commonly used in informatics but may contain information not in medical records. However, the vast majority of data is not standardized and is available only in large free text fields. We sought to extract information from the medical examiner database using Canary, a natural language processing tool. The text was then standardized to fit the selected normative answer list for each field. Multiple terminology and vocabulary standards from a variety of settings were utilized as data came from the medical examiner and interviews with next of kin. Thirty-seven percent of the metadata fields …


2020-05-23/24/25/26 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Janice Gonzales, Alex Castillo Smith, Timothy Campbell, Jenny Situ, Alexandra Yingling, Perez Olewe, Gregory Mertz, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins May 2020

2020-05-23/24/25/26 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Janice Gonzales, Alex Castillo Smith, Timothy Campbell, Jenny Situ, Alexandra Yingling, Perez Olewe, Gregory Mertz, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: NM hospitals meet benchmarks. NM case count. Reopening healthcare updated guidelines. Mescalero declares emergency. Stalled capital funds for budget. Emergency spending under scrutiny. BCBS special healthcare enrollment period. NM SC guidance for CYFD. Mass gatherings impossible very soon. NM mayors divided on Gov’s communication. No 4th July event in Roswell. Life span of COVID-19 on surfaces. US Highlights: US curbs travel from Brazil. International Highlights: Anti-science sentiment. Japan ends lockdown. Chilean healthcare limited. Economics, Workforce, Supply Chain, PPE Highlights: Negative effects of masks. False sense of security. Epidemiology Highlights: Uncontrolled COVID-19 spread. Dutch children play minor …


Ecuador’S New Water Legal Framework (Lorhuya, 2014): An Assessement Of The First Five Years Of Implementation Through The Lens Of Plurinationality And Campesino’S Buen Vivir, Martina Nebbiai May 2020

Ecuador’S New Water Legal Framework (Lorhuya, 2014): An Assessement Of The First Five Years Of Implementation Through The Lens Of Plurinationality And Campesino’S Buen Vivir, Martina Nebbiai

Latin American Studies ETDs

A preliminary assessment of the first five years of implementation of Ecuador’s new Ley Organica de Recursos Hidricos, Usos y Aprovechamiento de Agua (LORHUyA, 2014), exlploring its impact on small irrigators communities, through the lens of Buen Vivir. A communication-based action research and political ecology of water in Ecuadorian marginalized Campesino communities, elucidating the repercussions of state-centralized water policy on the customary water management systems, and the disconnect between policy as determined nationally vs implemented locally. This research investigates the gap between Ecuador’s plurinational recognition of cultural rights, epistemic diversity, citizens’ participation and community control outlined by Buen Vivir, …


2020-05-18 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Fiona Nguyen, Ryen Ormesher, Melissa Cossé, Susie Pham, Jenny Situ, Alexandra Yingling, Cristian Bologa, Kristine Tollestup, Orrin Myers, Douglas J. Perkins May 2020

2020-05-18 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Fiona Nguyen, Ryen Ormesher, Melissa Cossé, Susie Pham, Jenny Situ, Alexandra Yingling, Cristian Bologa, Kristine Tollestup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM Highlights: NM COVID safety guidelines. NM case count. Navajo Nation case count. Gadsden school district kitchens closures. ABQ non-COVID patient treatment delay. NM factory shutdowns. US Highlights: Moderna Inc. vaccine shows promise. US cases exceed 1.5 million. US states reopen. NY slowly reopening. Michigan vaccines decrease. CDC antibody study. International Highlights: WHO independent review. Economics, Workforce, Supply Chain, PPE Highlights: Maxillofacial surgeries down. PPE skin damage. Epidemiology Highlights: Infections may overwhelm ICE facilities. High estimated US infections. LA antibody testing results. Super-spreader in church. Hospital staff antibody response. No effect of climate. Healthcare Policy Recommendations: Pairing assistance …


Antagonizing Serotonin 2a (5-Ht2a) Receptors Attenuates Methamphetamine-Induced Reward And Blocks Methamphetamine-Induced Anxiety-Like Behaviors In Adult Male Rats, John T. Madden May 2020

Antagonizing Serotonin 2a (5-Ht2a) Receptors Attenuates Methamphetamine-Induced Reward And Blocks Methamphetamine-Induced Anxiety-Like Behaviors In Adult Male Rats, John T. Madden

Psychology ETDs

Methamphetamine (Meth) is a highly addictive and widely abused psychostimulant. Research indicates that the selective 5-HT2A receptor antagonist M100907 attenuates several psychostimulant-induced behaviors, including conditioned place preference (CPP). However, these findings have not yet been extended to Meth. The present study investigated the effects of M100907 on the acquisition of Meth-CPP and Meth-induced anxiety.

Adult male rats were tested using an unbiased two-chamber apparatus across eight consecutive days. Prior to Meth administration, rats were pretreated with M100907 and placed into their initially non-preferred chamber. After four Meth conditioning sessions, the effects of M100907 on Meth-induced changes in CPP were …


Assessing Drought Vegetation Dynamics At The Landscape Scale In Semiarid Grass- And Shrubland Using Mesma, Rowan Converse May 2020

Assessing Drought Vegetation Dynamics At The Landscape Scale In Semiarid Grass- And Shrubland Using Mesma, Rowan Converse

Geography ETDs

New Mexico experienced substantial impacts of regional-scale drought from 2011-2014. Global climate change may make such events a new normal for the southwest: drought events are expected to increase in both frequency and severity over the coming century. While semiarid grasslands recover quickly from short-term drought, the cumulative impacts of climate change may reduce the resiliency of these systems over time. Remote sensing methods can allow efficient and cost-effective comparison of ecosystem recovery from drought events over time using long-running imaging systems like Landsat. We investigate the efficacy of using multi-endmember spectral mixture analysis (MESMA) to quantify the impacts of …


"Fat Is A Queer Issue, Too": Complicating Queerness And Body Size In Women's Sexual Orientation And Identity, Hannah R. Long May 2020

"Fat Is A Queer Issue, Too": Complicating Queerness And Body Size In Women's Sexual Orientation And Identity, Hannah R. Long

Communication ETDs

This dissertation explores the experiences of self-identified Lesbian-Bisexual-Queer-Transgender (LBQT) women wearing U.S. clothing size 1x and up. Drawing on research within queer theory, fat studies, and Crip theory, the main goal of this study is to explore how these women engage in their embodied everyday performances of the body and identity, particularly through looking at relationship to body and self, intersectional complications, and navigation of physical and discursive space(s). Through analyzing their narratives collected in in-depth interviews, I find that fatness contributes to how people see desire for their selves and others, community, and space-taking. Additionally, within the narratives of …


Ecologically Driven Changes In Subsistence Strategies: An Examination Of Bone Cross-Sectional Geometrical Properties In Hunter-Gatherers From Australia And Early Agriculturists From Belize, Ethan C. Hill May 2020

Ecologically Driven Changes In Subsistence Strategies: An Examination Of Bone Cross-Sectional Geometrical Properties In Hunter-Gatherers From Australia And Early Agriculturists From Belize, Ethan C. Hill

Anthropology ETDs

The primary purpose of this dissertation was to examine how changes to ecological context can urge subsistence level populations to adopt new subsistence strategies. This was accomplished by using metrics of bone strength to infer temporal behavior change in Holocene (10,000 BP – present) skeletal samples from southern Australia and southern Belize. The first paper, An Examination of the Cross-sectional Geometrical Properties of the Long Bone Diaphyses of Holocene Foragers from Roonka, South Australia, was written in collaboration with Osbjorn Pearson, Arthur Durband, Keryn Walshe, Kristian Carlson, and Frederick Grine. We compared long bone data for 69 individuals at Roonka …


Exosomal Secretion Of A Psychosis-Altered Microrna Regulates Glutamate Receptor Expression; Effects Of Antipsychotics And Maternal Immune Activation, Stephen Kwaku Amoah May 2020

Exosomal Secretion Of A Psychosis-Altered Microrna Regulates Glutamate Receptor Expression; Effects Of Antipsychotics And Maternal Immune Activation, Stephen Kwaku Amoah

Biomedical Sciences ETDs

MicroRNAs are a subcategory of evolutionarily conserved small non-coding RNAs that are altered in psychiatric conditions. The ability of small secretory microvesicles known as exosomes to influence neuronal and glial function via their microRNA (miRNA) cargo has positioned them as a novel and effective method of cell-to-cell communication. Inflammation, which is evident in schizophrenia (SCZ) and bipolar disorder (BD), and antipsychotics usage may alter miRNA expression in the brain. However, little is known about the role of exosome-secreted miRNAs in the regulation of neuronal gene expression and their relevance for SCZ and BD. Here, we used miRNA profiling and qRT-PCR …


Investigating The Effects Of Accelerated Lithium Deposition On The Abuse Response Of Lithium-Ion Batteries, Eric J. Deichmann May 2020

Investigating The Effects Of Accelerated Lithium Deposition On The Abuse Response Of Lithium-Ion Batteries, Eric J. Deichmann

Chemical and Biological Engineering ETDs

Li deposition at the graphitic anode is widely reported in literature as one of the leading causes of capacity fade in lithium-ion batteries (LIBs). Previous literature has also linked Li deposition resulting from low-temperature and high-rate ageing to diminished safety characteristics, however no current research has probed the effects of Li deposition on the abuse response of well- characterized cells. Additionally, no previous studies have investigated the use of an accelerated Li deposition technique for probing the effects of Li deposition. Using overtemperature testing, a relationship between increased concentrations of Li deposition and exacerbated abuse response in 1Ah pouch cells …


Characterization Of And Cellular Mechanisms Underlying Spinal Non-Viral Interleukin-10 Gene Therapy Formulated With D-Mannose For Treatment Of Peripheral Neuropathic Pain, Arden Grace Vanderwall May 2020

Characterization Of And Cellular Mechanisms Underlying Spinal Non-Viral Interleukin-10 Gene Therapy Formulated With D-Mannose For Treatment Of Peripheral Neuropathic Pain, Arden Grace Vanderwall

Biomedical Sciences ETDs

Anti-inflammatory intrathecal non-viral interleukin-10 (IL-10) gene therapy provides enduring relief of chronic pain in numerous animal pain models. Co-administration of the mannose receptor (MR) ligand D-mannose (DM) improves non-viral IL-10 gene therapeutic efficacy, but questions remain regarding which pain-relevant tissues are critical for non-viral transgene expression resulting in long-lasting pain relief. Additionally, the role of endogenous IL-10 in non-viral IL-10 therapeutic effects is completely unknown.

Chapter I is an Introduction to the studies detailed in this dissertation, providing a historical perspective of the field of neuroinflammation and a framework upon which neuroimmune processes intersect with mechanisms underlying pathological pain. The …


Screening And Characterization Of A Pan-Gtpase Inhibitor, Leyla Akhadov May 2020

Screening And Characterization Of A Pan-Gtpase Inhibitor, Leyla Akhadov

Biomedical Engineering ETDs

Abnormal functioning of small GTPases is implicated in a variety of diseases, ranging from neurological and developmental diseases to cancer. In fact, mutant GTPases are found in up to 30% of cancers. Thus, small GTPases are a highly relevant target in drug discovery and development. High-throughput targeted screening of small molecules is the most productive method of discovering compounds that can give insights into drug development. This thesis describes improvements made to a high-throughput GTPase-targeted screening method to minimize confounding systematic error. It also describes the follow-up characterization of a compound that was identified in a high-throughput screen. The compound …


2020-05-12 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Ryen Ormesher, Samantha Paltrow-Krulwich, Allison Price, Timothy Campbell, Aly Raboff, Ariel Hurwitz, Avanika Mahajan, Alexandra Yinglng, Perez Olewe, Cristian Bologa, Tudor I. Oprea, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins May 2020

2020-05-12 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Ryen Ormesher, Samantha Paltrow-Krulwich, Allison Price, Timothy Campbell, Aly Raboff, Ariel Hurwitz, Avanika Mahajan, Alexandra Yinglng, Perez Olewe, Cristian Bologa, Tudor I. Oprea, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

MAT modeling update. Sandia Labs tribes fundraising. NM worker testing. NM case count. Gallup cases rise. Project ECHO COVID-19 guidance. Santa Fe Opera cancels. Fauci stresses federal guidelines. Twitter labels COVID-19 misinformation. NCAA financial woes. Treatment searches over animals. France surpasses Spain deaths. Wuhan to test all. 113-year old survivor. Isolation chamber. Pharmacy social distancing. WA Choir superspreader event. Infected pregnancy outcomes good. Immunity licenses ethical. Family bereavement services. Pharmacists maintain medication supplies. Psychological crisis intervention students. Guidelines are provided on managing OCD and COVID-19-related myocarditis. Call for helmet continuous positive airway pressure and prone positioning. Computational prediction …