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Articles 2851 - 2880 of 85765
Full-Text Articles in Entire DC Network
A Phenomenological Study Of The Lived Experiences Of New Mexico Charter Leaders Through The Covid-19 Pandemic, Nadine T. Torres
A Phenomenological Study Of The Lived Experiences Of New Mexico Charter Leaders Through The Covid-19 Pandemic, Nadine T. Torres
Teacher Education, Educational Leadership & Policy ETDs
The pandemic caused by the COVID-19 virus has impacted the educational landscape in unbelievable ways. The changes to the learning environment in schools required leaders to obtain and exercise different competencies. New Mexico charter leaders are leading in the new normal of public education. With the additional roles, requirements, and expectations brought on by the pandemic, leaders cannot return to their prior leadership practices. The purpose of this qualitative hermeneutic phenomenological study was to understand and give voice to the lived experiences of NM charter leaders working through the COVID-19 pandemic. The narrative of the participants highlighted four major themes: …
Long-Term Human Participation Detection Using A Dynamic Scene Analysis Model, Wenjing Shi
Long-Term Human Participation Detection Using A Dynamic Scene Analysis Model, Wenjing Shi
Electrical and Computer Engineering ETDs
The dissertation develops new methods for assessing student participation in long (>1 hour) classroom videos. First, the dissertation introduces the use of multiple image representations based on raw RGB images and AM-FM components to detect specific student groups. Second, a dynamic scene analysis model is developed for tracking under occlusion and variable camera angles. Third, a motion vector projection system identifies instances of students talking.
The proposed methods are validated using digital videos from the Advancing Out-of-school Learning in Mathematics and Engineering (AOLME) project. The proposed methods are shown to provide better group detection, and better talking detection at …
Data-Driven Stochastic Optimal Control Using Hilbert Space Embeddings Of Distributions, Adam J. Thorpe
Data-Driven Stochastic Optimal Control Using Hilbert Space Embeddings Of Distributions, Adam J. Thorpe
Electrical and Computer Engineering ETDs
Autonomous systems are increasingly being deployed in complex environments subject to real-world uncertainty. For such systems, it may be exceptionally difficult or even impossible to compute a simple mathematical model of the system--for instance due to the presence of human elements, complex mechanics or system dynamics, or learning-enabled components. Data-driven control has recently gained significant attention in this area, where observations taken from the system evolution are used to compute an implicit representation of the system that is amenable to analysis and control. However, data-driven algorithms for control present new challenges, and require new insights to enable their use. The …
B-Cell Monoclonal Antibodies For Management Of Relapse Remitting Multiple Sclerosis: A Cost Effectiveness Analysis, Sarah Glover
B-Cell Monoclonal Antibodies For Management Of Relapse Remitting Multiple Sclerosis: A Cost Effectiveness Analysis, Sarah Glover
Pharmaceutical Sciences ETDs
Multiple sclerosis (MS) is a neurodegenerative disease in which the central nervous system’s myelin sheath is degraded by auto-immune cells. Relapse remitting multiple sclerosis (RRMS) is the most common MS phenotype, accounting for ~85% of new diagnoses. Disease modifying therapies (DMTs) are used in RRMS to reduce the frequency of relapses and prevent disability progression. The present study performed a cost effectiveness analysis of three B-cell depleting monoclonal antibody DMTs: ocrelizumab, ofatumumab and rituximab, in comparison to commonly utilized interferon beta-1a (IFN-B1a). A Markov model was created to determine the impact of selected DMTs on the number of …
Creando La Confianza: Narratives On Mentorship Of Latina Professors At The University Of New Mexico, Maria G. Vielma
Creando La Confianza: Narratives On Mentorship Of Latina Professors At The University Of New Mexico, Maria G. Vielma
Spanish and Portuguese ETDs
Numerous scholars have investigated the significant role that representation and mentorship play in the success of Latinas and other women of color during their journey through higher education, from degree completion to faculty hiring and advancement (Vasquez 1982, Zambrana et. al. 1997, Valdez 2001, Cavazos & Cavazos 2010, Shayne 2020, Contreras et. al. 2022). However, little research exists surrounding the lived experiences that have shaped mentorship carried out by university faculty, specifically, mentorship carried out by bilingual Latina faculty in higher education. Through a Latina Feminist Epistemology implementing Oral History Methodologies, this thesis aims to understand the cycle of mentorship …
Botanical Empires: The Politics Of Plants In Theocritus' Idylls, Christian Rhoads
Botanical Empires: The Politics Of Plants In Theocritus' Idylls, Christian Rhoads
Foreign Languages & Literatures ETDs
This project identifies a system of plant-based identity politics in Theocritus’ Idylls. In Chapter One, I trace a paradigm of unequal reciprocal interactions, “plant-hubris,” throughout the erotic relationships of the Idylls as one partner acts violently against another who “overwaters” them with affection. I argue that characters in the Idylls use plants to explain their own relationship dynamics. In the second chapter I examine Idyll 1 and identify social commentary on culturally specific poetic competition that relies on vegetal imagery. The competition between the goatherd and Thyrsis in Idyll 1 is informed by both the immediate vegetal …
Application Of An Empirical Density Law Via Python For Aqueous Plutonium Nitrate Systems, Tara L. Robertson
Application Of An Empirical Density Law Via Python For Aqueous Plutonium Nitrate Systems, Tara L. Robertson
Nuclear Engineering ETDs
A predictive density tool has been developed to reduce bias and uncertainty in nuclear criticality safety calculations for aqueous plutonium nitrate systems. Multiple methods to calculate the density were reviewed and an empirical method was selected for use. The selected method was then implemented into a Python tool to calculate the solution density and the atom densities for an MCNP6.2 input file.
The Python tool has been validated and verified against the International Handbook of Evaluated Criticality Safety Benchmark Experiments to predict densities within ± 2.6%. The capability to calculate and utilize densities from this tool is a large improvement …
On The 3-Refined Neutrosophic Analytical Structures And Number Theoretical Concepts, Hamiyet Merkepci, Katy D. Ahmad
On The 3-Refined Neutrosophic Analytical Structures And Number Theoretical Concepts, Hamiyet Merkepci, Katy D. Ahmad
Neutrosophic Sets and Systems
No abstract provided.
On A Novel Security Scheme For The Encryption And Decryption Of 2×2 Fuzzy Matrices With Rational Entries Based On The Algebra Of Neutrosophic Integers And El-Gamal Crypto-System, Mohammad Abobala, Ali Allouf
On A Novel Security Scheme For The Encryption And Decryption Of 2×2 Fuzzy Matrices With Rational Entries Based On The Algebra Of Neutrosophic Integers And El-Gamal Crypto-System, Mohammad Abobala, Ali Allouf
Neutrosophic Sets and Systems
No abstract provided.
On The Symbolic 2-Plithogenic Number Theory And Integers, Hamiyet Merkepci, Ammar Rawashdeh
On The Symbolic 2-Plithogenic Number Theory And Integers, Hamiyet Merkepci, Ammar Rawashdeh
Neutrosophic Sets and Systems
No abstract provided.
A Review Study On Some Properties Of The Structure Of Neutrosophic Ring, Adel Al-Odhari
A Review Study On Some Properties Of The Structure Of Neutrosophic Ring, Adel Al-Odhari
Neutrosophic Sets and Systems
No abstract provided.
Neutrosophic Sets And Systems, Vol. 54, 2023, Special Issue On Neutrosophic Algebraic Structures, Neutroalgebra & Antialgebra And Superhyperalgebra & Neutrosophic Superhyperalgebra Contributions Of Researchers From The Arab World, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi, Mohammad Abobala
Neutrosophic Sets And Systems, Vol. 54, 2023, Special Issue On Neutrosophic Algebraic Structures, Neutroalgebra & Antialgebra And Superhyperalgebra & Neutrosophic Superhyperalgebra Contributions Of Researchers From The Arab World, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi, Mohammad Abobala
Neutrosophic Sets and Systems
No abstract provided.
Network Economics-Based Crowdsourcing In Online Social Networks, Natasha S. Kubiak
Network Economics-Based Crowdsourcing In Online Social Networks, Natasha S. Kubiak
Electrical and Computer Engineering ETDs
This thesis addresses the challenge of user recruitment by various competing marketing agencies (MAs) in Online Social Networks. A labor economics approach, following the principles of contract theory, is devised to enable MAs to reveal the potential of each participating user to contribute a personalized level of quality and quantity of information to the crowdsourcing process. The MAs objective is to maximize their personal benefit, i.e., total utility obtained, given its budget. The latter optimization problem is formulated as a Generalized Colonel Blotto (GCB) game among the MAs, where each MA aims at incentivizing each user to report its information. …
Improved Experimental Validation Of An Electromagnetic Subcell Model For Narrow Slots With Depth, Michael Anthony Illescas
Improved Experimental Validation Of An Electromagnetic Subcell Model For Narrow Slots With Depth, Michael Anthony Illescas
Electrical and Computer Engineering ETDs
The coupling of electromagnetic (EM) energy into a system can disrupt operation of essential electronics present within it. Metal enclosures are used to shield these systems from potentially harmful electromagnetic interference (EMI). Seams and gaps in such metal enclosures are minimized but unavoidable for reasons such as maintenance and repair. These seams and gaps create an entry point for EM energy to couple into the system. Entry points are often modeled by EM analysts as narrow slots defined by their length, width, and depth. The depth of these slots can become significant compared to the wavelength, introducing resonances associated with …
Self-Efficacy Influences Of Pre-Service Physical Education (Pe) Teachers Who Instruct Students With Disabilites (Swds), Emily Mason, Karen Gaudreault, Glenn Hushman, Victoria Shiver, Amanda Young
Self-Efficacy Influences Of Pre-Service Physical Education (Pe) Teachers Who Instruct Students With Disabilites (Swds), Emily Mason, Karen Gaudreault, Glenn Hushman, Victoria Shiver, Amanda Young
Health, Exercise, and Sports Sciences ETDs
The purpose of this study was to analyze what factors contribute to the self-efficacy/teacher efficacy (TE) of pre-service teachers (PSTs) as they instruct physical education (PE) to students with disabilities (SWDs). Self-efficacy theory, SET, (Bandura, 1977; Maddux, 2013) was used to make meaning of what SET tenets the PSTs found valuable as it pertained to boosting their teacher efficacy as they taught physical education to SWDs. Data collection involved three semi-structured interviews, three reflections, one critical incident account (Flanagan, 1954), ten to twelve non-participatory observations of the PSTs teaching PE in an elementary school with SWDs, informal conversations, email communication, …
Folsom Activity, Mobility, And Flaked Stone Technological Organization At The Rio Rancho Folsom Site, New Mexico Locus 4147 And As-2, William A. Skidmore-Farren
Folsom Activity, Mobility, And Flaked Stone Technological Organization At The Rio Rancho Folsom Site, New Mexico Locus 4147 And As-2, William A. Skidmore-Farren
Anthropology Graduate Student Publications
What are the similarities and differences within locus 4147/AS-2 technological organization? Determining the function of the site may reveal new adaptive strategies used by Paleoindian groups and perhaps tell us more about their social and technological organization. By measuring, identifying, analyzing, and comparing the lithic components of the locus 4147/AS-2, I hope to further our understanding of the Rio Rancho site’s function and technological organization. A study of the spatial distribution of various artifact types within the locus will also help determine the function. Chemical (XRF) and physical analysis of the variety of lithic materials from the sites will also …
The Effects Of Unsupervised Bodyweight Interval Training In Adults With Obesity, Gabriella Bellissimo, Fabiano Amorim, Christine Mermier, Ann Gibson, Len Kravitz, Jonathan Little, Flávio De Castro Magalhães, Zachary A. Mang, Quint Berkemeier, Alyssa Bailly, Jonathan Specht, Jessica Smith, Matthew J. Stork, Shandy Simpson, Natalie Robson, Jeremy Ducharme, Kelsey C. Bourbeau, Yu Yu Hsiao
The Effects Of Unsupervised Bodyweight Interval Training In Adults With Obesity, Gabriella Bellissimo, Fabiano Amorim, Christine Mermier, Ann Gibson, Len Kravitz, Jonathan Little, Flávio De Castro Magalhães, Zachary A. Mang, Quint Berkemeier, Alyssa Bailly, Jonathan Specht, Jessica Smith, Matthew J. Stork, Shandy Simpson, Natalie Robson, Jeremy Ducharme, Kelsey C. Bourbeau, Yu Yu Hsiao
Health, Exercise, and Sports Sciences ETDs
Objective: Bodyweight interval training (BW-IT) using a social media platform may appeal to those who do not wish to exercise in public or do not have access to specialized exercise equipment. We investigated the ability of a 6-week BW-IT program to improve cardiovascular and metabolic markers. Methods: Fourteen adults (30.7 ± 10.3 yrs.) with obesity (body mass index 35.5 ± 5.4 kg/m2) participated. Bi-weekly program progression was applied by increasing the duration of the work intervals to 60s with 60s active recovery. Peak oxygen consumption (V̇O2peak), isometric muscular strength, body composition, blood pressure (BP), and metabolic …
Hsc Citation Analysis, Robyn Gleasner, Lewis Worley
Hsc Citation Analysis, Robyn Gleasner, Lewis Worley
Posters and Presentations
No abstract provided.
Musical Pastiche, Nostalgia, And The Shaping Of Latinx Identity In Popular Streaming Media, Latin American And Iberian Institute, Jacqueline Avila
Musical Pastiche, Nostalgia, And The Shaping Of Latinx Identity In Popular Streaming Media, Latin American And Iberian Institute, Jacqueline Avila
LAII Events
This presentation examines the soundscapes and compositional techniques utilized by the EDM group the Mexican Institute of Sound (MIS) and its founder Camilo Lara in the 2021 album DF and in Netflix’s Latinx-focused dramady Gentefied (2020-21). The music created for both the album and the series feature musics of the past either sampled or referenced into a modern musical pastiche that evokes various forms of nostalgia.
Jacqueline Avila is an Associate Professor of Musicology at the University of Texas, Austin. Her research examines film music and the intersections of identity, tradition, and modernity in the Hollywood and Mexican film industries. …
The Rise Of Agenda Diversity In America: Its Cause And Consequences, John K. Wagner
The Rise Of Agenda Diversity In America: Its Cause And Consequences, John K. Wagner
Political Science ETDs
More than ever, Americans disagree on what issues are important. This diversity in the public agenda has received scant attention in recent years. Consequently, our understanding of why agenda diversity developed relies on a single analysis method, and we know next to nothing about the consequences for the American polity. Using a novel approach to measuring agenda diversity and an advanced experimental design, this dissertation demonstrates the causal connection between issue-based selective exposure to news and higher agenda diversity. Concerning its consequences, this work investigates congressional responsiveness. Results from a complex analysis of constituency public opinion, Congress bill sponsorship, and …
Reliability And Validity Of Single Axial Slice Vs. Multiple Slice Quantitative Measurement Of The Volume Of Effusion-Synovitis On 3t Knee Mri In Knees With Osteoarthritis, Greg Gilles, Arjun Vohra, Dagoberto Robles, Mihra S. Taljanovic, Erin L. Ashbeck, Chelsea Caruso, Jeffrey Duryea, Edward J. Bedrick, Ali Guermazi, C Kent Kwoh
Reliability And Validity Of Single Axial Slice Vs. Multiple Slice Quantitative Measurement Of The Volume Of Effusion-Synovitis On 3t Knee Mri In Knees With Osteoarthritis, Greg Gilles, Arjun Vohra, Dagoberto Robles, Mihra S. Taljanovic, Erin L. Ashbeck, Chelsea Caruso, Jeffrey Duryea, Edward J. Bedrick, Ali Guermazi, C Kent Kwoh
Radiology Research and Scholarship
Effusion-synovitis (ES) is recognized as a component of osteoarthritis, creating a need for rapid methods to assess ES on MRI. We describe the development and reliability of an efficient single-slice semi-automated quantitative approach to measure ES. We used two samples from the Osteoarthritis Initiative (OAI): 50 randomly selected OAI participants with radiographic osteoarthritis (i.e., Kellgren-Lawrence (KL) grade 2 or 3) and a subset from the Foundation for the National Institutes of Health Osteoarthritis Biomarker study. An experienced musculoskeletal radiologist trained four non-expert readers to use custom semi-automated software to measure ES on a single axial slice and then read scans …
Multilevel Optimization With Dropout For Neural Networks, Gary Joseph Saavedra
Multilevel Optimization With Dropout For Neural Networks, Gary Joseph Saavedra
Mathematics & Statistics ETDs
Large neural networks have become ubiquitous in machine learning. Despite their widespread use, the optimization process for training a neural network remains com-putationally expensive and does not necessarily create networks that generalize well to unseen data. In addition, the difficulty of training increases as the size of the neural network grows. In this thesis, we introduce the novel MGDrop and SMGDrop algorithms which use a multigrid optimization scheme with a dropout coarsening operator to train neural networks. In contrast to other standard neural network training schemes, MGDrop explicitly utilizes information from smaller sub-networks which act as approximations of the full …
Humor Styles, Psychological Well-Being, And Distress: Examining The Importance Of Resilience And Hope, Naila V. Decruz-Dixon
Humor Styles, Psychological Well-Being, And Distress: Examining The Importance Of Resilience And Hope, Naila V. Decruz-Dixon
Psychology ETDs
The current research study investigated the relationship between different adaptive and maladaptive styles of humor, psychological well-being, and distress measures. The sample for this cross-sectional analysis included 237 undergraduate students at the University of New Mexico. Zero-order correlation analyses of all the study variables revealed that adaptive humor styles were associated with greater psychological well-being and lower psychological distress symptoms while maladaptive humor styles were generally related to lower well-being and greater distress symptoms. All four humor styles were significantly associated with hope, while only affiliative and self-defeating humor were associated with resilience. Mediation analyses revealed that resilience was a …
04-07-23 Hsc Committee Agenda, Hsc Committee
04-07-23 Hsc Committee Agenda, Hsc Committee
HSC Committee (A subcommittee of the UNM Board of Regents)
No abstract provided.
Unm Hslic Organizational Chart 2023, Sally Bowler-Hill
Unm Hslic Organizational Chart 2023, Sally Bowler-Hill
HSLIC Organizational Charts
No abstract provided.
Priorities To Promote Participant Engagement In The Participant Engagement And Cancer Genome Sequencing (Pe-Cgs) Network, Anne Lr Schuster, Norah L. Crossnohere, Melinda Bachini, Cindy K. Blair, John D. Carpten, Elizabeth B. Claus, Graham A. Colditz, Li Ding, Bettina F. Drake, Ryan C. Fields, Katherine A. Janeway, Bethany M. Kwan, Heinz-Josef Lenz, Qin Ma, Shirz I. Mishra, Electra D. Paskett, Timothy R. Rebbeck, Charité Ricker, Mariana C. Stern, Andrew L. Sussman, Jessica C. Tiner, Jeffrey M. Trent, Joel Gw Verhaak, Nikhil Wagle, Cheryl Willman, John Fp Bridges, Participant Engagement And Cancer Genome Sequencing (Pe-Cgs) Network
Priorities To Promote Participant Engagement In The Participant Engagement And Cancer Genome Sequencing (Pe-Cgs) Network, Anne Lr Schuster, Norah L. Crossnohere, Melinda Bachini, Cindy K. Blair, John D. Carpten, Elizabeth B. Claus, Graham A. Colditz, Li Ding, Bettina F. Drake, Ryan C. Fields, Katherine A. Janeway, Bethany M. Kwan, Heinz-Josef Lenz, Qin Ma, Shirz I. Mishra, Electra D. Paskett, Timothy R. Rebbeck, Charité Ricker, Mariana C. Stern, Andrew L. Sussman, Jessica C. Tiner, Jeffrey M. Trent, Joel Gw Verhaak, Nikhil Wagle, Cheryl Willman, John Fp Bridges, Participant Engagement And Cancer Genome Sequencing (Pe-Cgs) Network
Pediatrics Research and Scholarship
Background:
Engaging diverse populations in cancer genomics research is of critical importance and is a fundamental goal of the NCI Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network. Established as part of the Cancer Moonshot, PE-CGS is a consortium of stakeholders including clinicians, scientists, genetic counselors, and representatives of potential study participants and their communities. Participant engagement is an ongoing, bidirectional, and mutually beneficial interaction between study participants and researchers. PE-CGS sought to set priorities in participant engagement for conducting the network's research.
Methods:
PE-CGS deliberatively engaged its stakeholders in the following four-phase process to set the network's research priorities …
Assessment Of Psychosocial And Neonatal Risk Factors For Trajectories Of Behavioral Dysregulation Among Young Children From 18 To 72 Months Of Age, Julie A. Hofheimer, Monica Mcgrath, Rashelle Musci, Guojing Wu, Sarah Polk, Courtney K. Blackwell, Annemarie Stroustrup, Robert D. Annett, Judy Aschner, Brian S. Carter, Jennifer Check, Elisabeth Conradt, Lisa A. Croen, Anne L. Dunlop, Amy J Elliott, Andrew Law, Leslie D. Leve, Jenae M. Neiderhiser, T Michael O'Shea, Amy L. Salisbury, Sheela Sathyanarayana, Rachana Singh, Lynne M. Smith, Andréa Aguiar, Jyoti Angal, Hannah Carliner, Cindy Mcevoy, Steven J. Ondersma, Barry Lester, Program Collaborators For Environmental Influences On Child Health Outcomes
Assessment Of Psychosocial And Neonatal Risk Factors For Trajectories Of Behavioral Dysregulation Among Young Children From 18 To 72 Months Of Age, Julie A. Hofheimer, Monica Mcgrath, Rashelle Musci, Guojing Wu, Sarah Polk, Courtney K. Blackwell, Annemarie Stroustrup, Robert D. Annett, Judy Aschner, Brian S. Carter, Jennifer Check, Elisabeth Conradt, Lisa A. Croen, Anne L. Dunlop, Amy J Elliott, Andrew Law, Leslie D. Leve, Jenae M. Neiderhiser, T Michael O'Shea, Amy L. Salisbury, Sheela Sathyanarayana, Rachana Singh, Lynne M. Smith, Andréa Aguiar, Jyoti Angal, Hannah Carliner, Cindy Mcevoy, Steven J. Ondersma, Barry Lester, Program Collaborators For Environmental Influences On Child Health Outcomes
Pediatrics Research and Scholarship
IMPORTANCE: Emotional and behavioral dysregulation during early childhood are associated with severe psychiatric, behavioral, and cognitive disorders through adulthood. Identifying the earliest antecedents of persisting emotional and behavioral dysregulation can inform risk detection practices and targeted interventions to promote adaptive developmental trajectories among at-risk children.
OBJECTIVE: To characterize children's emotional and behavioral regulation trajectories and examine risk factors associated with persisting dysregulation across early childhood.
DESIGN, SETTING, AND PARTICIPANTS: This cohort study examined data from 20 United States cohorts participating in Environmental influences on Child Health Outcomes, which included 3934 mother-child pairs (singleton births) from 1990 to 2019. Statistical analysis …
20230403_Join Us In Celebrating National Public Health Week, Gale G. Hannigan Phd
20230403_Join Us In Celebrating National Public Health Week, Gale G. Hannigan Phd
HSLIC Blog Post
No abstract provided.
Effective Utilization Of Battery-Supercapacitor Hybrid Energy Storage Systems In Dc Nano-Grids, Seyyed Ali Ghorashi Khalil Abadi
Effective Utilization Of Battery-Supercapacitor Hybrid Energy Storage Systems In Dc Nano-Grids, Seyyed Ali Ghorashi Khalil Abadi
Electrical and Computer Engineering ETDs
This PhD dissertation proposes novel control strategies to improve the flexibility and reliability of DC nanogrids by utilizing battery-supercapacitor hybrid energy storage systems (HESSs). The dissertation is divided into five sections, each addressing a specific challenge in DC nanogrids and proposing unique control strategies to overcome them. The proposed strategies include an adaptive control system for multiple nanogrids, a distributed power management strategy for a grid-connected DC nano-grid, a model predictive control strategy to improve voltage quality and stability in islanded DC nanogrids, a cloud HESS technology to improve voltage stability in clustered DC nanogrids, and a method of electric …
Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis, Hyeoncheol Kim, Luke B. Villareal, Zhaoli Liu, Mohammad Haneef, Daniel M. Falcon, David R. Martin, Ho-Joon Lee, Michael K. Dame, Durga Attili, Ying Chen, James Varani, Jason R. Spence, Olga Kovbasnjuk, Justin A. Colacino, Costas A. Lyssiotis, Henry C. Lin, Yatrik M. Shah, Xiang Xue
Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis, Hyeoncheol Kim, Luke B. Villareal, Zhaoli Liu, Mohammad Haneef, Daniel M. Falcon, David R. Martin, Ho-Joon Lee, Michael K. Dame, Durga Attili, Ying Chen, James Varani, Jason R. Spence, Olga Kovbasnjuk, Justin A. Colacino, Costas A. Lyssiotis, Henry C. Lin, Yatrik M. Shah, Xiang Xue
Pathology Research and Scholarship
Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive iron conditions, TFRC is expected to be reduced to lower iron uptake and toxicity. However, the mechanism whereby TFRC expression is maintained at high levels in iron-enriched cancer cells and the contribution of TFRC to cancer development are enigmatic. Here the work shows TFRC is induced by adenomatous polyposis coli (APC) gene loss-driven β-catenin activation in colorectal cancer, whereas TFRC-mediated intratumoral iron accumulation potentiates β-catenin signaling by directly enhancing the activity of tankyrase. Disruption of TFRC leads to a reduction of colonic iron levels and …