Digital Commons Network^™

Toward The Yeast Surface Display Of Microviridin B, Jillian Leigh Stafford

Chemistry and Chemical Biology ETDs

Humans have turned to natural products for medicinal therapeutics for millennia. In recent years, the ribosomally synthesized and post-translationally modified peptide (RiPP) class of natural products have garnered a lot of attention due to their ability for heterologous expression, relative ease of mutation, and vast biological activates. Microviridins are a family of RiPPs that contain a tricyclic cage-like structure through the formation of two lactone rings and one lactam ring catalyzed by two ATP-grasp ligase family enzymes. Microviridins are potent inhibitors of serine proteases and mutational studies of a small number of residues indicates the potential of peptide engineering protease …

The Value Of Belonging: A Comparison Of Professional Organizations' Membership Benefits, Laura Soito, Amy Jankowski

University Libraries & Learning Sciences Faculty and Staff Publications

The abundance of library associations provides many choices to academic librarians about where and how to belong. This exploratory article identifies and compares benefits of library professional organizations through content analysis of the groups' websites. Examination of the benefits described on the websites of 76 organizations indicates that they have a high degree of overlap. Many benefits are also achievable by participating in other external professional activities. While data were collected just prior to the start of the COVID-19 pandemic, thematic analysis of these benefits provides a framework for comparing the value of participation in formal and informal professional communities.

Using The 55-Word Story Method Of Reflection And Writing About Not Losing Hope In Humanity, Pearl Huynh, Ricardo Falcon, Tim Peterson, Codruta Soneru

Brain & Behavioral Health Research Day

Creative writing with 55-word stories can encapsulate key experiences. It stimulates reflection and professional growth. Their brevity adds insight and impact.

Draft 1:

I have so many mixed feelings about everything going on in the world right now. There is so much disagreement on everything and to me it feels like we can never get everyone on the same page. Whether it be political things, health care, Roe v. Wade, world hunger, vaccines, violence, etc.. Being a first-year medical student, it can be easy to forget about everything going on in the world as you are so busy trying to …

Ksrp Reduces The Migration And Invasion Of Glioblastoma Cells And Restricts Angiogenesis Of Human Brain Microvascular Endothelial Cells, Pearl Huynh, Robert Oliver, Gabriela Perales, Amy S. Gardiner

Brain & Behavioral Health Research Day

Glioblastoma multiforme (GBM) is a highly aggressive and invasive brain tumor that has been continuously challenging to treat. Combined treatment strategies, including surgical resection, radiotherapy, and chemotherapy, have improved patient outcomes, however, median survival time is less than 15 months. Thus, there is a critical need for new therapeutic targets and approaches. KSRP is a multi-functional RNA-binding protein that acts post-transcriptionally to regulate mRNA stability, splicing, and transport, as well as the biogenesis and function of microRNAs and other non-coding RNAs. Several studies have shown that KSRP expression is significantly associated with prolonged survival of glioblastoma patients. We recently identified …

Wagon Tracks Volume 37, Issue 2 (February 2023)

Wagon Tracks

Contents

2 On the Cover: Flint Hills Fire by Jim Richardson

4 Insights from your President

5 Joanne’s Jottings

6 2023 Symposium

7, 15, 21, 28 Trail News

8-10 Copies Found of Kanza Treaties: October 28, 1815, and August 16, 1825 by L. Stephen Schmidt

10 In Memoriam: Morris Alexander, John Conoboy

11 Roots Run Deep: Nicholas Gentry and George Franklin 1

12-15 Santa Fe Trail Documented in Marion County, Kansas by L. Stephen Schmidt

16-21 Rebecca Mayer's 1852 Honeymoon with 50 Men and 500 Mules by Joy Poole

22-27 Hell on Wheels: Las Animas and La Junta by Dr. …

Request For Modification No. 23-024 To Resource Conservation And Recovery Act (Rcra) Facility Operating Permit, Sandia National Laboratories, New Mexico, Environmental Protection Agency Identification Number Nm5890110518, March 2023, Sandia National Laboratories/Nm

Facility RCRA Permit

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and National Technology & Engineering Solutions of Sandia (NTESS) have requested modifications to the Resource Conservation and Recovery Act Facility Operating Permit (Permit) for Sandia National Laboratories/New Mexico. The requested modifications consist of revisions to the Mixed Waste Landfill (MWL) Long-Term Monitoring and Maintenance Plan (LTMMP), which is incorporated by reference into Permit Attachment M, "Long-Term Monitoring and Maintenance Plan for Solid Waste Management Units and Areas of Concern Granted Corrective Action Complete with Controls." The MWL is also known as Solid Waste Management Unit (SWMU) 76.

Groundwater monitoring at SWMU 76 …

Request For Modification No. 23-024 To Resource Conservation And Recovery Act (Rcra) Facility Operating Permit, Sandia National Laboratories, New Mexico, Environmental Protection Agency Identification Number Nm5890110518, March 2023, Sandia National Laboratories/Nm

Facilities-Units

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and National Technology & Engineering Solutions of Sandia (NTESS) have requested modifications to the Resource Conservation and Recovery Act Facility Operating Permit (Permit) for Sandia National Laboratories/New Mexico. The requested modifications consist of revisions to the Mixed Waste Landfill (MWL) Long-Term Monitoring and Maintenance Plan (LTMMP), which is incorporated by reference into Permit Attachment M, "Long-Term Monitoring and Maintenance Plan for Solid Waste Management Units and Areas of Concern Granted Corrective Action Complete with Controls." The MWL is also known as Solid Waste Management Unit (SWMU) 76.

Groundwater monitoring at SWMU 76 …

Characteristics Of Patient Navigation Programs In The Cancer Moonshot Accsis Colorectal Cancer Screening Initiative, Gloria D. Coronado, Renée M. Ferrari, Autumn Barnes, Sheila F. Castañeda, Mark Cromo, Melinda M. Davis, Mark Doescher, Kevin English, Jenna Hatcher, Karen E. Kim, Sarah Kobrin, David Liebovitz, Shiraz I. Mishra, Jesse N. Nodora, Wynne E. Norton, Jill M. Oliveri, Daniel S. Reuland, Sujha Subramanian, Jamie H. Thompson, Electra D. Paskett

Pediatrics Research and Scholarship

BACKGROUND: Although patient navigation has shown promise for increasing participation in colorectal cancer (CRC) screening and follow-up, little evidence is available to guide implementation of patient navigation in clinical practice. We characterize eight patient navigation programs being implemented as part of multi-component interventions of the National Cancer Institute's Cancer MoonshotSM Accelerating Colorectal Cancer Screening and Follow-Up Through Implementation Science (ACCSIS) initiative.

METHODS: We developed a data collection template organized by ACCSIS framework domains. The template was populated by a representative from each of the eight ACCSIS research projects. We report standardized descriptions of 1) the socio-ecological context in which the …

Saved Babies, Dead Doctors: Settler Colonial Anxiety And Strategic Rhetorics Of/In The Anti-Abortion Cultural Narrative, Cassidy Ellis

Communication ETDs

In this dissertation I identify and analyze the rhetoric that creates the anti-abortion cultural narrative and locate its toxic secrets by exposing the logics and ideologies the secrets obscure and sustain, and finally, ascertaining the strategic rhetorics that enable the narrative’s power and centrality. There are two primary arguments proposed in this dissertation. First, I argue that settler colonialism is the primary toxic secret nestled just beneath the surface of the anti-abortion cultural narrative. It is the secret that animates and sustains the narrative in service of maintaining settler colonial social order via control and maintenance of the population. Second, …

Concepts In Climate Change & Public Health Preparedness Ipep 305/Ipep 505, Heidi H. Rogers, Alexis Ellsworth-Kopkowski, Mary Pat Couig, Megan Tucker

InterProfessional Education Faculty Resources

No abstract provided.

Chamisa Volume 2 Full Pdf

Chamisa: A Journal of Literary, Performance, and Visual Arts of New Mexico and the Greater Southwest

No abstract provided.

The Onset Of Rare Earth Metallosis Begins With Renal Gadolinium-Rich Nanoparticles From Magnetic Resonance Imaging Contrast Agent Exposure, Joshua Deaguero, Tamara Howard, Donna Kusewitt, Adrian Brearley, Abdul-Mehdi Ali, James H. Degnan, Stephen Jett, John Watt, G Patricia Escobar, Karol Dokladny, Brent Wagner

Pathology Research and Scholarship

The leitmotifs of magnetic resonance imaging (MRI) contrast agent-induced complications range from acute kidney injury, symptoms associated with gadolinium exposure (SAGE)/gadolinium deposition disease, potentially fatal gadolinium encephalopathy, and irreversible systemic fibrosis. Gadolinium is the active ingredient of these contrast agents, a non-physiologic lanthanide metal. The mechanisms of MRI contrast agent-induced diseases are unknown. Mice were treated with a MRI contrast agent. Human kidney tissues from contrast-naïve and MRI contrast agent-treated patients were obtained and analyzed. Kidneys (human and mouse) were assessed with transmission electron microscopy and scanning transmission electron microscopy with X-ray energy-dispersive spectroscopy. MRI contrast agent treatment resulted in …

5 Simple Ways To Get A Wellness Committee Started, Kari J. Rezac

HSC Education Days

Much has been written about the increase in burnout, increase in rates of depression, and overall decrease in wellness for residents during COVID. Plenty of articles address different factors that could help to achieve wellness for residents including the popular Stanford model, which details the importance of personal resilience, workplace culture, professional fulfillment, and practice efficiency. However, little has been published about the wellness programs and committees that have been carried out during or post-COVID. What has been effective? What starts a wellness culture? Using UNM’s physical medicine and rehabilitation residency’s journey to wellness as a guide, this presentation will …

The Serial Effect, Kat Albrecht, Kaitlyn Filip

New Mexico Law Review

The “CSI Effect” theorizes that criminal juries can be unduly influenced by fictional crime dramas such that they demand a higher standard of forensic evidence than is available, or even possible to provide, in most criminal cases. The CSI Effect has a strong presence in the courtroom despite its narrow focus on forensic evidence and basis in fiction. This article explores a new media-induced effect that may prove to affect American juries even more insidiously: The Serial Effect. This article explores the rise of true crime podcasts and the legal cases featured within them through focus on Syed v. Maryland …

Independent Analysis And Interpretation Of The New Mexico Constitution: If Not Now, When?, The Honorable Linda M. Vanzi, Mark T. Baker

New Mexico Law Review

This article posits that the mode of analysis of state constitutional issues adopted by the New Mexico Supreme Court in State v. Gomez, as it has been applied in the civil context, has neither “promote[d] the development of a sound body of state constitutional jurisprudence” nor led to “consistent, predictable, and reasonable state court decision-making,” as some envisioned in 1998. Instead, it has often led to essentially automatic deference to federal precedent interpreting comparable provisions of the Federal Constitution and very limited, if any, consideration of protections afforded under our state constitution. In addition, the inconsistent application of the Gomez …

Humanized Patient-Derived Xenograft Models Of Disseminated Ovarian Cancer Recapitulate Key Aspects Of The Tumor Immune Environment Within The Peritoneal Cavity, Mara P. Steinkamp, Irina Lagutina, Kathryn J. Brayer, Fred Schultz, Danielle Burke, Vernon S. Pankratz, Sarah F. Adams, Laurie G. Hudson, Scott A. Ness, Angela Wandinger-Ness

Pathology Research and Scholarship

UNLABELLED: The importance of the immune microenvironment in ovarian cancer progression, metastasis, and response to therapies has become increasingly clear, especially with the new emphasis on immunotherapies. To leverage the power of patient-derived xenograft (PDX) models within a humanized immune microenvironment, three ovarian cancer PDXs were grown in humanized NBSGW (huNBSGW) mice engrafted with human CD34

SIGNIFICANCE: huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the tumor microenvironment.

Humanized Patient-Derived Xenograft Models Of Disseminated Ovarian Cancer Recapitulate Key Aspects Of The Tumor Immune Environment Within The Peritoneal Cavity, Mara P. Steinkamp, Irina Lagutina, Kathryn J. Brayer, Fred Schultz, Danielle Burke, Vernon S. Pankratz, Sarah F. Adams, Laurie G. Hudson, Scott A. Ness, Angela Wandinger-Ness

Pathology Research and Scholarship

UNLABELLED: The importance of the immune microenvironment in ovarian cancer progression, metastasis, and response to therapies has become increasingly clear, especially with the new emphasis on immunotherapies. To leverage the power of patient-derived xenograft (PDX) models within a humanized immune microenvironment, three ovarian cancer PDXs were grown in humanized NBSGW (huNBSGW) mice engrafted with human CD34

SIGNIFICANCE: huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the tumor microenvironment.

Gaps In The Screening Process For Women Diagnosed With Cervical Cancer In Four Diverse Us Health Care Settings, Chun R. Chao, Jessica Chubak, Elisabeth F. Beaber, Aruna Kamineni, Connie Mao, Michael J. Silverberg, Jasmin A. Tiro, Celette Skinner, Michael Garcia, Douglas A. Corley, Rachel L. Winer, Tina Raine-Bennett, Sarah Feldman, Cosette M. Wheeler

Pathology Research and Scholarship

BACKGROUND: Potential care gaps in the cervical cancer screening process among women diagnosed with cervical cancer in an era with increased human papillomavirus (HPV) testing have not been extensively evaluated.

METHODS: Women diagnosed with cervical cancer between ages 21 and 65 at four study sites between 2010 and 2014 were included. Screening histories were ascertained from 0.5 to 4 years prior to cervical cancer diagnosis. We identified potential care gaps in the screening history for each woman and classified them into one of three mutually exclusive types: lack of a screening test, screening test failure, and diagnostic/treatment care gap. Distributions …

Homeschool Educators’ Perspectives About Student Needs Within Occupational Therapy Scope Of Practice: A Pilot Study, Susan L. Iliff, Mary T. Hill, Rose White, Aubrey Alexander

Pediatrics Research and Scholarship

Homeschool educators (n = 31) were recruited to complete an electronic survey describing their perspectives. Findings indicated that many students had medical/academic needs, and accessed additional services such as occupational therapy (OT). Data analysis of open-ended questions revealed common categories: (a) curricula met or did not meet student needs (b) participants had experience-based, general or no knowledge of OT and (c) most felt homeschooling was a positive experience and expressed that limited resources were available. Further research is warranted to investigate available resources, specific needs, and how to best support students who homeschool.

Defining Variability In Evaluation And Management Of Children With Chronic Osteomyelitis, Ganga S. Moorthy, Angelique E. Boutzoukas, Daniel K. Benjamin, Philip M. Polgreen, Susan E. Beekmann, John S. Bradley, Walter Dehority

Pediatrics Research and Scholarship

Pediatric chronic osteomyelitis is a rare, debilitating condition lacking management guidelines. In a national survey of 162 pediatric infectious disease physicians through the Emerging Infections Network, tremendous variability in diagnostic approaches and management were noted, highlighting a need for prospective study to better define the spectrum of pathogens and disease.

20230118_Improvements For You By You, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

Effects Of Covid-19 Financial And Social Hardships On Infants' And Toddlers' Development In The Echo Program, Sara S. Nozadi, Ximin Li, Xiangrong Kong, Brandon Rennie, Deborah Kanda, Debra Mackenzie, Li Luo, Jonathan Posner, Courtney K. Blackwell, Lisa A. Croen, Assiamira Ferrara, Thomas G. O'Connor, Emily Zimmerman, Akhgar Ghassabian, Leslie D. Leve, Amy J. Elliott, Rebecca J. Schmidt, Jenna Ln Sprowles, Johnnye L. Lewis

Pediatrics Research and Scholarship

BACKGROUND: The financial hardships and social isolation experienced during the COVID-19 pandemic have been found to adversely affect children's developmental outcomes. While many studies thus far have focused on school-aged children and the pandemic-related impacts on their academic skills and behavior problems, relatively less is known about pandemic hardships and associations with children's development during their early years. Using a racially and economically diverse sample, we examined whether hardships experienced during the pandemic were associated with children's development with a particular focus on communication and socioemotional development.

METHODS: Participants from eight cohorts of the Environmental influences on Child Health Outcomes …

Book Review: Our Common Ground: A History Of America's Public Lands, Sandra B. Zellmer

Natural Resources Journal

No abstract provided.

In The Dark: The Scapegoating Of Renewables After Grid Failures, Teddy Gonzalez, Jillian Knox

Natural Resources Journal

Renewable energy is increasingly scapegoated as the primary cause of weather-related power outages and other grid failures, despite substantial evidence to the contrary. Disinformation campaigns framing renewables as unreliable are driven by two factors: the increasing frequency of power outages and the growing pressures facing fossil fuel energy stakeholders. Over the past decade, power outages in the United States have doubled, primarily due to increased extreme weather, aging energy infrastructure, and a rapidly changing resource mix. At the same time, the energy transition is placing unprecedented competitive pressure on the coal and gas industry and on the nation’s utilities. These …

Planned Adaptation And Implementation Of The Community Guide Recommendations For Increasing Physical Activity In Rural Community Settings: A Qualitative Study, Julia Meredith Hess, Sally M. Davis

Pediatrics Research and Scholarship

BACKGROUND: The purpose of this paper is to report on the implementation of an evidence-based model, VIVA, which was developed to translate physical activity (PA) recommendations to rural environments and was scaled-up to 12 rural communities across New Mexico. Our longitudinal qualitative research describes processes of planned adaptation in the rural context with an exploration of inner and outer context adaptations that consider important implementation constructs including leadership, partnership and collaboration.

MATERIALS & METHODS: An enhanced version of the RE-AIM framework was used to formulate community-level engagement and process questions essential to implementation science. Qualitative methods, using a thematic approach …

Stonehenge: Not So Blank Slates, Piper M. Lincoln

2024 Award Winners

No abstract provided.

Arresting Assembly: An Argument Against Expanding Criminally Punishable Protest, Allison Freedman

Faculty Scholarship

ARRESTING ASSEMBLY: AN ARGUMENT AGAINST EXPANDING
CRIMINALLY PUNISHABLE PROTEST
ALLISON M. FREEDMAN

ABSTRACT

In recent years, public protests have shed light on societal inequities that had previously gone unheard. Yet instead of responding to protesters’ concerns, many state legislators are attempting to silence disenfranchised groups by introducing hundreds of “anti-protest” bills. This is a recent phenomenon and one that is accelerating—the largest wave of “anti-protest” bills was introduced on the heels of the most robust protest movement in recent history, Black Lives Matter during the summer of 2020.

Although it is clear that legislators are attempting to tamp down public …

Research Task 03 Matched Guise, Pdf File

El Español de Nuevo México y Colorado Contemporáneos

No abstract provided.

Investigating The Potential Effect Of Pollinators On The Alpine Plant Diversity Of The Southern Rocky Mountains: A Community Phylogenetic Approach, Jeremiah Westerman

2024 Award Winners

No abstract provided.

Optimal Agricultural Land Use: An Efficient Neutrosophic Linear Programming Method, Maisam Jdid, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

The increase in the size of the problems facing humans, their overlap, the division of labor, the multiplicity of departments, as well as the diversity of products and commodities, led to the complexity of business and the emergence of many administrative and production problems. It was necessary to search for appropriate methods to confront these problems. The science of operations research, with its diverse methods, provided the optimal solutions. It addresses many problems and helps in making scientific and thoughtful decisions to carry out the work in the best way within the available capabilities. Operations research is one of the …