Digital Commons Network^™

Screening And Characterization Of A Pan-Gtpase Inhibitor, Leyla Akhadov

Biomedical Engineering ETDs

Abnormal functioning of small GTPases is implicated in a variety of diseases, ranging from neurological and developmental diseases to cancer. In fact, mutant GTPases are found in up to 30% of cancers. Thus, small GTPases are a highly relevant target in drug discovery and development. High-throughput targeted screening of small molecules is the most productive method of discovering compounds that can give insights into drug development. This thesis describes improvements made to a high-throughput GTPase-targeted screening method to minimize confounding systematic error. It also describes the follow-up characterization of a compound that was identified in a high-throughput screen. The compound …

20200515_A Big Thank You This National Hospital Week, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

2020-05-15 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Ryen Ormesher, Melissa Cossé, Timothy Campbell, Jenny Situ, Randy Ko, Ariel Hurwitz, Alexandra Yingling, Perez Olewe, Tudor I. Oprea, Cristian Bologa, Gregory Mertz, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

Governor clarifies health orders. NM childhood deaths high. NM workplace investigations. NM case count. Navajo emergency orders. $77M NM testing/tracing. NM convalescent plasma. NM unemployment claims slow. NM food bank challenges. Farmington Mall protest. $3T bill opposition. Lancet FDA revival call. UK Roche antibody testing. Swedish excess mortality. End of Slovenia pandemic. US invest in COVID-19 vaccine. Safe decontamination N95 respirators. Business occupancy load. 10 years of life lost burden. Forecasting models predict deaths. Infection fatality rate 8%. Resilient medical education. Restrictions: human rights law. Guidelines for nursing homes. Managing hematology and oncology patients. Abbott test accuracy. Lab …

2020-05-14 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Lynnmarie Jarratt, Fiona Nguyen, Lauren Tagliaferro Epler, Susie Pham, Timothy Campbell, Jenny Situ, Randy Ko, Aly Raboff, Jennifer Thompson, Hannah Dowdy-Sue, Alexandra Yingling, Eric Kruger, Cristian Bologa, Tudor I. Oprea, Jens Langsjoen, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM restrictions loosen. NM case count. Navajo Nation case count. 9 state parks open. Sunport revenue loss. Trump projects vaccine delivery. Wisconsin court case. Smokers quit. Ireland reopening. Danish schools open. Philippine typhoon evacuation. PPE-induced pressure injuries and facial dermatoses. U.S. mask stockpile. PPE for surgeons. Intubation time with aerosol box. Consumer spending with social restrictions. Suicide increase expected. Undetected virus homeless. Chinese infection control. 5% Spain infected. Sanitizing booth. Healthcare worker infection routes. Kawasaki disease France. CDC Kawaski guidance. Italian deaths characterized. CDC reopening school guidance. COVID-19 and epistemology. Monitoring misleading claims. UN mental health policy brief. …

2020-05-14 A Message From Chancellor Roth, Paul B. Roth

HSC Chancellor Messages During COVID-19

No abstract provided.

2020-05-14 A Message From The Executive Vice Chancellor, Richard Larson

HSC Chancellor Messages During COVID-19

No abstract provided.

Diffuse Flux And Carbon Isotope Composition Of Carbon Dioxide Emitted From Valles Caldera, Yellowstone Caldera, And Southwestern Utah Geothermal Sites, Kristen Rahilly

Earth and Planetary Sciences ETDs

Carbon dioxide (CO₂) has the lowest solubility in silicate melt and is one of the most abundant and earliest degassed species present in volcanic and geothermal systems. A significant quantity of CO₂ is passively degassed through soils in volcanic and geothermal systems, called diffuse degassing. In Chapter 1, I measure the diffuse CO₂ flux over the site of a prospective enhanced geothermal system in southwestern Utah. I conclude that the CO₂ emitted from soils in the enhanced geothermal site is biogenically-sourced. In Chapter 3, I examine the diffuse CO₂ flux from Roosevelt Hot Springs …

2020-05-13 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Emma Wolinsky, Fiona Nguyen, Ryen Ormesher, Melisa Cossé, Allison Price, Timothy Campbell, Avanika Mahajan, Alexandra Yingling, Perez Olewe, Cristian Bologa, Tudor I. Oprea, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

APS virtual graduation. NM Governor update. Free testing for all. NM 2020 census challenges. BCBS $1M COVID-19 donation. NM case count. Most tribes infected. Increased NM Medicaid enrollment. UNM revenue losses. UNM limited operations continue. No dine-in eating yet. Clothing store reopening measures. Aid package. Consumer prices tumble. Public guidance adherence survey. Healthcare resource prediction. Food insecurity. Supply system comparison. Pentagon PPE award. Ensemble mortality model. 4.4% French infections. Asymptomatic spread. Traffic infection correlation. Comorbid COPD/smoking mortality. Airplane transmission contained. CDC COVID-19 statistics. WHO: endemic virus risk. Iceland tracking app impact. WHO: prison management. Quality of life. Containment …

2020-05-13 A Message From Chancellor Roth, Paul B. Roth

HSC Chancellor Messages During COVID-19

No abstract provided.

20200513_Pubmed Interface Changes - There's A Workshop For That, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

2020-05-12 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-05-12 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Ryen Ormesher, Samantha Paltrow-Krulwich, Allison Price, Timothy Campbell, Aly Raboff, Ariel Hurwitz, Avanika Mahajan, Alexandra Yinglng, Perez Olewe, Cristian Bologa, Tudor I. Oprea, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

MAT modeling update. Sandia Labs tribes fundraising. NM worker testing. NM case count. Gallup cases rise. Project ECHO COVID-19 guidance. Santa Fe Opera cancels. Fauci stresses federal guidelines. Twitter labels COVID-19 misinformation. NCAA financial woes. Treatment searches over animals. France surpasses Spain deaths. Wuhan to test all. 113-year old survivor. Isolation chamber. Pharmacy social distancing. WA Choir superspreader event. Infected pregnancy outcomes good. Immunity licenses ethical. Family bereavement services. Pharmacists maintain medication supplies. Psychological crisis intervention students. Guidelines are provided on managing OCD and COVID-19-related myocarditis. Call for helmet continuous positive airway pressure and prone positioning. Computational prediction …

20200511_Hslic Is Documenting Covid-19 And Needs Your Help, Jonathan M. Pringle

HSLIC Blog Post

No abstract provided.

2020-05-11 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-05-11 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Lynnmarie Jarratt, Fiona Nguyen, Ryen Ormesher, Melisa Cossé, Susie Pham, Timothy Campbell, Jenny Situ, Randy Ko, Alexandra Yinglng, Elly Munde, Cristian Bologa, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM case counts. Navajo Nation documentary. Medicaid reimbursement increase. Excess NYC mortality. German R0>1. Chile COVID-19 certificates. High female incidence in Quebec. Swab 3D printing. Evidence lacking school reopening. Cloth mask review. WHO 2nd wave warning. Higher mortality in minorities. Environmental transmission controls. Behavior change. Correctional environment guidelines. Wuhan hospital transformation. Maximizing GI training. Threat and conformity. Recommendations on managing COVID-19 (first Italian SARS patients), and obesity and metabolic syndrome. Guidelines for neurologists. Ethics of off-label drugs use. Abbott antibody test approval. CRISPR test FDA approval. Viral sample inactivation. HCQ+azithromycin no benefit. Public-Private partnership for clinical trials. …

2020-05-09/10 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Melissa Cossé, Lauren Tagliaferro Epler, Timothy Campbell, Jenny Situ, Aly Raboff, Alexandra Yingling, Perez Olewe, Cristian Bologa, Tudor I. Oprea, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM gets remdesivir. NM case update. Dental services resume. NM prison testing. Educator age risk. Stuart Kauffman dashboard. Long-term care fatalities. Fauci in quarantine. US farmer support. US vaccinations down. South Korea bar shutdown. German rebound lockdown easing. Managing glove skin reactions. Neurosurgery down 70%. Impact airline travel ban. CDC meat packing report. UK distancing impact. 9-day incubation. Low fatality rate estimates. Improving social connection. Social distancing and mask use effective. Parents under stress. Nurse psychological stress. Israel Internal Medicine Tx strategies. Education management. Recommendations are given on endoscopy procedures, management of adrenal insufficiency and of IBD, on …

2020-05-08 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Ryen Ormesher, Lauren Tagliaferro Epler, Jenny Situ, Aly Raboff, John Powell, Alexandra Yingling, Cristian Bologa, Tudor I. Oprea, Gregory Mertz, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

UNM drug repurposing. NM cases. Doctors Without Borders. SNAP benefits online. NM 7th highest unemployment. Virtual LemonAid tonight. New N98 masks. Healthcare supply chain challenge. EMS lack resources. Infection risk in healthcare workers. COVID-19 on medical education. Human disinfectant chambers. Evidence of seroconversion. Dangers of considering herd immunity. Wastewater-based surveillance. More youths infected. Reconstructing ship spread. Pharmacoepidemiologic analysis. Clinicopathologic characteristics. Cancer treatment impact. Reduced voluntary psychiatric admission in Italy. Operating room management. Humidifiers reduce transmission. Phone contact tracing ethics. Call for patient database. Immunity certification program. Guidelines on tracheostomy, IBD, nose bleeding, pituitary tumors, and hematopoietic stem cells …

Factors Which Influence The Education Of Local Anesthesia In Dental Hygiene, Angela D. Cook, Angela D. Cook

Dental Hygiene ETDs

ABSTRACT Dental hygienists, like most students, learn according to formal curriculum that is defined by goals, competencies, and required subject matter for examinations.¹ They also learn through an intense socialization process known as “the hidden curriculum”. The “hidden curriculum” is not defined in student textbooks nor classroom lectures, but is demonstrated through case studies, research, and an experience shared between colleagues.¹ The purpose of this study was to assess the determining factors that influence what dental hygiene instructors are teaching hygiene students on the use of articaine when administering dental blocks, and to assess if the “hidden curriculum” …

2020-05-08 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Dna Methylation Signature For Ezh2 Functionally Classifies Sequence Variants In Three Prc2 Complex Genes, Sanaa Choufani, William T. Gibson, Andrei L. Turinsky, Brian H Y Chung, Tianren Wang, Kopal Garg, Alessandro Vitriolo, Ana S A Cohen, Sharri Cyrus, Sarah Goodman, Eric Chater-Diehl, Jack Brzezinski, Michael Brudno, Luk Ho Ming, Susan M. White, Sally Ann Lynch, Carol Clericuzio, I Karen Temple, Frances Flinter, Vivienne Mcconnell, Tom Cushing, Lynne M. Bird, Miranda Splitt, Bronwyn Kerr, Stephen W. Scherer, Jerry Machado, Eri Imagawa, Nobuhiko Okamoto, Naomichi Matsumoto, Guiseppe Testa, Maria Iascone, Romano Tenconi, Oana Caluseriu, Roberto Mendoza-Londono, David Chitayat, Cheryl Cytrynbaum, Katrina Tatton-Brown, Rosanna Weksberg

Pediatrics Research and Scholarship

Weaver syndrome (WS), an overgrowth/intellectual disability syndrome (OGID), is caused by pathogenic variants in the histone methyltransferase EZH2, which encodes a core component of the Polycomb repressive complex-2 (PRC2). Using genome-wide DNA methylation (DNAm) data for 187 individuals with OGID and 969 control subjects, we show that pathogenic variants in EZH2 generate a highly specific and sensitive DNAm signature reflecting the phenotype of WS. This signature can be used to distinguish loss-of-function from gain-of-function missense variants and to detect somatic mosaicism. We also show that the signature can accurately classify sequence variants in EED and SUZ12, which encode two other …

2020-05-07 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Emma Wolinsky, Ryen Ormesher, Lauren Tagliaferro Epler, Timothy Campbell, Jenny Situ, Jennifer Thompson, Ryota Shimada, Ariel Hurwitz, Avanika Mahajan, Sandra Boettcher, Alexandra Yingling, Perez Olewe, Cristian Bologa, Gregory Mertz, Krisitne Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM cases. Gallup shutdown extended. Gallup hospital crisis. NM assisted living testing. University student financial relief. FDA fraudulent products. Trump/Pence test negative. India displaced repatriated. Use facemasks. Facemasks cause skin damage. PPE protocol. Michigan reopens. Illegal drug prices up. Failing masks from China. Distribution of remdesivir. CDC PPE video. Low German R0. Stay-at-home lowers Rt. Detention facility epidemiology. Saliva transmission. Healthcare informatics shortcomings. Resource allocation ethics. Uninsured drug discounts. Safer food delivery. Bat coronavirus grant axed. Dispelling common misinformation. Recommendations on managing cardiac arrest, cardiac electrotherapy and electrophysiology, hematologic malignancy, ophthalmologic screening and procedures, the use of ACEIs …

Improving End-Of-Life Care On Navajo Through Education, Johanna G. Bahe

Doctor of Nursing Practice Scholarly Projects

End-of-life care (EOLC) is an essential component of comprehensive healthcare and has been shown to improve the quality of life of patients and their families by preventing and relieving pain caused by physical, psychosocial, and spiritual complications. Many rural communities lack access to EOLC, specifically certified palliative and hospice services. The lack of this specialty in rural areas directly affects the experience of healthcare staff. The absence of education for rural healthcare staff and the importance of culturally sensitive care among indigenous people are key concepts in this study.

The purpose of this study was to measure the knowledge, confidence, …

2020-05-07 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

I Am An Island Of Positives Amidst Such Great Loss, Mary Lemon

New Mexicans Reflect on Health and Wellness During COVID-19

Happy to notice I now love my job because of the pandemic

20200507_Song Advisory- Hslic Library Likes Playlist Part 2, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

2020-05-06 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-05-06 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Fiona Nguyen, Melissa Cossé, Lauren Tagliaferro Epler, Stephen Esguerra, Allison Price, Timothy Campbell, Hannah Dowdy-Sue, Ariel Hurwitz, Avanika Mahajan, Alexandra Yingling, Clinton Onyango, Cristian Bologa, Tudor I. Oprea, Gregory Mertz, Kristine Tollestrup, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM COVID case update. Temporary hospitals for non-COVID patients. Mandatory face coverings for businesses. NM income shortfall. Potential $2 billion NM budget deficit. Relief fund for rural health care providers. Meals for children, seniors, and tribal members. National parks phased reopening. Rural hunger program. Bangladesh to make remdesivir. Healthcare worker infections. Indian police force infections. Shanghai Disneyland reopens. Mask diaper linings. Mask/respirator review. Hospitals need bailouts. Provider financial resources. African lockdown hunger. Virus jumped late 2019. Mortality rates decrease. Early case in France. International reopening recommendations. WHO: don’t rush reopening. CDC: prison management. Timing important. Dedicated COVID-19 facility. …

A Review Of Major Role Of Vitamin D3 In Human Immune System And Its Possible Use For Novel Corona Virus Treatment, Florentin Smarandache, Victor Christianto

Branch Mathematics and Statistics Faculty and Staff Publications

the evidences showing major role of Vitamin D3 in human immune system and its potential use for novel corona virus treatment. Our argument is based on research finding that corona virus has viral envelope glycoproteins. In this regard, Vitamin D3 proves to offer various beneficial effects, including immunomodulatory effect, in order to break the glycoproteins envelope of the virus. One of the greatest benefit of vitamin D3 is the fact that it is easy to get 10,000 - 20,000 IU of daily intake requirement, by sunbathing for more or less twenty minutes. Such a method is likely applicable in many …

2020-05-05 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-05-05 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Alex Castillo Smith, Anistasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Lynnmarie Jarratt, Fiona Nguyen, Ryen Ormesher, Samantha Paltrow-Krulwich, Stephen Esquerra, Allison Price, Jenny Situ, Aly Raboff, Ryota Shimada, Ariel Hurwitz, Alexandra Yingling, Cristian Bologa, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM cases. Navajo cases. NM remdesivir inaccessible. Infected prison staff. No early prison releases. Unemployment beats working. NM $97M food benefits. UNM $50M revenue loss. Meat packer testing. Fall school reopening planning. Gym/salon reopening plans. 91k absentee ballots. Santa Fe closes polling stations. NM oil/gas pollution oversight. Prisons vulnerable. WH rejects FEMA report. Schools plan reopening. Italian mafia concerns. UK overtakes Italy. Symptom tracker early warning. Ethanol for FFP2 masks. Counterfeit masks. Mask skin damage. Mutant coronavirus more contagious. Hospital contamination zones. Disease prevalence estimation. Successful control measures. Average contagious period. Genetic epidemiology. Managing healthcare resources. Exercise and …