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Survival Percentage And Outgrowth Collection Kit (Spock) Development And Usage To Analyze Targets Of The Transcription Factor Gcn4 For Their Impact On Chronological Lifespan In The Model Organism S. Cerevisiae, Daniel Paul Felker

Biomedical Sciences ETDs

Plate reader-based methods for high-throughput measurement of growth rate, cellular survival, and chronological lifespan are a compelling addition to the already powerful toolbox of budding yeast Saccharomyces cerevisiae genetics. These methods have overcome many of the limits of traditional yeast biology techniques, but also present a new bottleneck at the point of data-analysis. Herein, we describe SPOCK (Survival Percentage and Outgrowth Collection Kit), an R-based package for the analysis of data created by high-throughput plate reader based methods. This package allows for the determination of chronological lifespan, cellular growth rate, and survival in an efficient, robust, and reproducible fashion. To …

Application Of Bismuth Oxychloride As A Colorimetric Uv Sensor Material, Kyle James Troche

Nanoscience and Microsystems ETDs

Sunlight contains about 9% UV radiation with roughly one-third of it penetrating the atmosphere and reaching the Earth’s surface. UV radiation from the sun is classified into three different types: UVA (315- 499 nm), UVB (280- 314nm), and UVC (100- 279 nm). Prolonged exposure to artificial UV radiation or direct sunlight can still induce many adverse effects such as sunburn, weakening of the immune system, and skin cancer. A wide variety of photoresistor, photodiode and colorimetric UV sensors are currently being researched to help monitor UV radiation. Our research is focused on developing a colorimetric UV sensor that is inherently …

Controlling The Emission Of Volatile Platinum Oxides To The Vapor Phase In Diesel Oxidation Catalysts, Arnab Ghosh

Nanoscience and Microsystems ETDs

Pt-based catalysts are used for the treatment of emissions from vehicles, particularly in Diesel oxidation catalysts (DOCs). Three-way catalysts are treated at temperatures ranging from 950℃-1050℃ while DOCs are aged at 800℃ for 50 hrs. At 800°C, Pt reacts with O₂ to form PtO₂ which has a high vapor pressure and can be transported through the vapor phase. These accelerated aging conditions lead to the formation of large Pt particles causing a loss of catalytic activity. In this thesis, we used model thin-film catalysts that made it possible to quantify the emission of Pt to the vapor phase …

Fine-Mapping Of Human Antibody Specificity In Response To Natural Chlamydia Trachomatis Infection Utilized To Inform Vaccines Against Adhesion Factors, Amanda L. Collar

Biomedical Sciences ETDs

Chlamydia trachomatis (Ct) is the causative pathogen for the most common bacterial sexually transmitted infection worldwide and can cause serious medical consequences in women, including pelvic inflammatory disease, ectopic pregnancy, and infertility. For these reasons, a Ct vaccine is urgently needed, yet, its development remains a significant challenge. One barrier to producing a Ct vaccine is the gap in knowledge of protective immune responses for Ct infection, including the role that antibodies may play. Therefore, I aimed to characterize the human antibody response to natural urogenital Ct infection in women using Deep Sequence-Coupled Biopanning. Further, I leveraged these findings to …

Three Essays In Risky Health Behavior And Racial Discrimination, Aakrit Joshi

Economics ETDs

This dissertation consists of three applied essays that empirically explore questions related to understanding the implication of public policy, practices, and interventions for vulnerable populations. The first chapter outlines the scope of the dissertation.

The second chapter examines the contemporary effects of historical redlining, practices that restricted access to mortgage financing for racial minorities, on residential property values. Using “redlining” geographical boundaries created in 1930s for Seattle, WA and Richmond, VA, and detailed housing data, econometric analysis finds that properties just inside a redlined boundary continue to sell at significantly discounted price compared to similar houses in non-redlined areas. These …

Surface Acoustic Wave Characterization And Interdigitated Transducer Optimization For Studying Stress-Enhanced Phenomena, Brian D. Rummel

Nanoscience and Microsystems ETDs

Surface acoustic wave devices have not yet achieved their full potential as the effects of standing acoustic fields on stress-sensitive phenomena in semiconductor systems have been largely unexplored. From this perspective, it is necessary to develop novel methods to characterize surface acoustic wave devices quantitatively and prepare an experimental platform to probe stress-enhanced processes. In this dissertation, interdigitated transducer devices are fabricated on gallium arsenide to evaluate their potential impact on strain-enhanced phenomena. A novel Raman characterization technique characterizes the surface stress induced by a standing acoustic field, revealing stress values on the order of 10⁸ Pa. FEM software …

Examination Of Ionization In Cesium Diode Pumped Alkali Lasers With An Ion Chamber Diagnostic, Benjamin Oliker

Optical Science and Engineering ETDs

Diode pumped alkali lasers (DPALs) are leading candidates for future high power applications, with many potential utilities for the military, aerospace, communications, and scientific diagnostics. A critical step in their development is measurement and understanding of unwanted ionization processes that occur inside the laser, which decrease efficiency, reduce the usable alkali population, and increase heat load. In this dissertation, direct measurement of the ionization rate of a cesium DPAL gain medium are made for the first time, via application of an ion chamber diagnostic. Results will demonstrate that the rate of ionization is slow compared to pump absorption, with a …

Examining Parental Perceptions And Experiences Regarding Social Skills Interventions For Children With Autism Spectrum Disorder, Mary Jimerson

Special Education ETDs

ABSTRACT

Individuals with autism spectrum disorder (ASD) and their families often engage in various interventions to address social skills as this is a core area of development and often described as a challenge for individuals with ASD. Although interventions may vary in service delivery and the interventionists’ training and background, all encompass social skills interventions. The purpose of this study was to conduct a qualitative investigation to explore the experiences and perceptions family members had while their child participated in social skills interventions. Five family members participated in this study which included a questionnaire and an individual interview. Qualitative analyses …

The Value Of An Education - An Exploratory Study Of The Relationship Between Cultural And Institutional Values And First-Generation Native American Student Success, Michelle L. Lee

Teacher Education, Educational Leadership & Policy ETDs

The purpose of this study was to explore the value and meaning that first-generation American Indian students place on higher education. Are these values different from those of the institution and how does that impact their educational journey? Finding purpose and meaning in your education encourages continued commitment to your educational goals. I conducted a single-site qualitative study at a Southwestern Non-Tribal Community University (SWNTCU), collecting data through an arts-based inquiry methodology employing photovoice narrative as a tool. To situate these narratives, I utilized an Indigenous paradigm interweaving Tribal Critical Race Theory, Relationality, and an Indigenous Wellness Model (Brayboy, 2006; …

Does Nurses Confidence Improve After Attending A Training For Teaching Home Infusion Patients?, Carol Menorah Young Dnp

Doctor of Nursing Practice Scholarly Projects

Discharge can be a difficult step for patients and their families and a challenging task for nurses. Poor instructions have a negative impact on the patient population. In addition, improper and incomplete discharge information negatively affects the posthospital recovery period and may cause the patient to return to the hospital for the same episode of care. Returning to the hospital emergency room or readmission for the same episode of care will increase the dangers to the patient’s health and recovery plan and increase the cost of individual healthcare. The patient population ranks the quality of discharge information via their responses …

Decentralized Intelligent Decision Making In Cyber Physical Social Systems, Nathan Patrizi

Electrical and Computer Engineering ETDs

The accelerated evolution towards jointly considering the physical, cyber, and social space is expected to dramatically increase the interest of the research and industrial community to build efficient, resilient, and secure Cyber Physical Social Systems. In this dissertation, we focus our research activities on devising decentralized intelligent decision making models, frameworks, and algorithms to support the smooth operation of Cyber Physical Social Systems. The proposed decentralized intelligent decision making models are jointly exploiting theories from the field of Economics, such as Game Theory and Contract Theory, and from the field of Computer Science, such as Reinforcement Learning concepts. Reinforcement learning …

A Mixed Methods Study Of Preferred Learning Environments For Ethical Development Of Graduate Students In Research Ethics Education, Sue Wilder

Organization, Information and Learning Sciences ETDs

The purpose of this mixed methods study was to examine graduate student preferences for the types of learning environments that support ethical development in research ethics education. The initial quantitative phase of this study used the Learning Environment Preferences (LEP) survey to provide a baseline measure of intellectual development up to position 5 of the Perry scheme (Moore, 2000; Perry, 1970). Quantitative results highlighted preferences for the role of student/peers and classroom atmosphere, and significant findings were found relative to international students, older students, and women in terms of their preferences for learning environments that support higher level, relativistic thinking. …

Climate Change And Community Health: Heat Waves, Yhari Martinez

Climate Change and Public Health Preparedness

No abstract provided.

Adults Perspectives Of Friendships And Social Interaction Between Students With And Without Complex Support Needs During A Pandemic, Jorden Morales

Special Education ETDs

Social interactions and friendships are important for all individuals including those with complex support needs (CSN). The voices of adults including parents/guardians, primary caregivers, teachers, and related service providers who responded to a survey provided insight into supporting social interactions and friendships for children with CSN during the Covid-19 pandemic This mixed methods study used thematic analysis to explore participants’ responses to open-ended questions while multiple choice questions were analyzed through descriptive statistics. Additionally, this study included a research narrative to speak to the various roles I hold related to this study (i.e., parent, educator, researcher). Three themes emerged from …

Nurse Driven Antibiotic Stewardship, Dr. Judy Liesveld R. White

Doctor of Nursing Practice Scholarly Projects

Abstract

Antibiotic use has increased tremendously and has led to antimicrobial resistance. Because it is a growing problem across healthcare systems around the world, healthcare systems and organizations must combat the detrimental effects of inappropriate use of antibiotics. The development of antibiotic stewardship programs is crucial to providing high quality, safe patient care. The work ofthis project intends to form a basic understanding ofa nurses' role as a member of the antibiotic team. Most healthcare systems have operated by a pharmacy driven antibiotic team concept and have just recently included nurses as a missing component to a full functioning team. …

The Use Of Appreciative Inquiry In Identifying Pueblo Core Values, Kristyn N. Yepa

Doctor of Nursing Practice Scholarly Projects

This study used appreciative inquiry to identify core values or concepts essential to the Jemez Pueblo community to inform an evaluation framework used by community strength-based programs in Jemez Pueblo. Key informant interviews and a focus group were conducted in Jemez Pueblo with key program staff and tribal leaders. The audio recordings were transcribed and analyzed using inductive reasoning to identify core values. In addition, grounded theory was used to develop a conceptual model from the themes generated from the analysis. The PICOT question was, "Can the Appreciative Inquiry method help uncover core values of a Pueblo community?"

20220512_Jon Eldredge Named Nlm Fellow, Sally Bowler-Hill

HSLIC Blog Post

No abstract provided.

'Ahora Estamos Más Unidos': Claiming Resilience In The Musical And Visual Aftermath Of The El Paso Mass Shooting, Eduardo Garcia

Music ETDs

The El Paso Wal-Mart Mass Shooting on August 3, 2019, prompted swift response from the local community to create artistic spaces of remembrance. This study examines the musical (mariachi and corrido) and visual (altares, murals, and memorials) manifestations present at makeshift and formal memorials for the victims. I analyze how members of the El Paso-Ciudad Juárez borderland situated their artistic work in the aftermath of the shooting. I argue that these artists responded to the attack with symbolic acts of resilience rooted in cultural and collective memory, embodiment of trauma, and the lived experience of corporeal …

Nurses In New Mexico: Their Awareness Of Safe Harbor As Reflected In A Survey During A Time Of Covid-19, Ashley R. Gonzales

Doctor of Nursing Practice Scholarly Projects

The healthcare industry is highly regulated to ensure patients receive safe, high-quality, patient-centered care. Even with these regulations, patient outcomes remain poor, given the high expenditure and percentage of the gross domestic product that healthcare comprises in the United States. Nurses make up the largest proportion of the healthcare field and are often overlooked when it comes to policies to ensure their practice remains safe and licenses protected. Nurses are the eyes and ears of their board-certified providers and detect subtle changes in a patient’s condition. However, such attention to detail can be executed only when the nurses can care …

Individuals With Metabolic Syndrome Show Altered Fecal Lipidomic Profiles With No Signs Of Intestinal Inflammation Or Increased Intestinal Permeability, Mia J. Coleman, Luis M. Espino, Hernan Lebensohn, Marija V. Zimkute, Negar Yaghooti, Christina L. Ling, Jessica M. Gross, Natalia Listwan, Sandra Cano, Vanessa Garcia, Debbie M. Lovato, Susan L. Tigert, Drew R. Jones, Rama R. Gullapalli, Neal E. Rakov, Euriko G. Torrazza Perez, Eliseo F Castillo

Pathology Research and Scholarship

BACKGROUND: Metabolic Syndrome (MetS) is a clinical diagnosis where patients exhibit three out of the five risk factors: hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, hyperglycemia, elevated blood pressure, or increased abdominal obesity. MetS arises due to dysregulated metabolic pathways that culminate with insulin resistance and put individuals at risk to develop various comorbidities with far-reaching medical consequences such as non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. As it stands, the exact pathogenesis of MetS as well as the involvement of the gastrointestinal tract in MetS is not fully understood. Our study aimed to evaluate intestinal health in human subjects …

Swog 1318: A Phase Ii Trial Of Blinatumomab Followed By Pomp Maintenance In Older Patients With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia, Anjali S. Advani, Anna Moseley, Kristen M. O'Dwyer, Brent L. Wood, Min Fang, Matthew J. Wieduwilt, Ibrahim Aldoss, Jae H. Park, Rebecca B. Klisovic, Maria R. Baer, Wendy Stock, Rupali R. Bhave, Megan Othus, Richard C. Harvey, Cheryl L. Willman, Mark R. Litzow, Richard M. Stone, Elad Sharon, Harry P. Erba

Pathology Research and Scholarship

PURPOSE: Chemotherapy outcomes in older patients with Philadelphia (Ph) chromosome-negative B-acute lymphoblastic leukemia (ALL) are very poor. Here, we evaluated blinatumomab as induction and consolidation therapy followed by prednisone, vincristine, 6-mercaptopurine, and methotrexate (POMP) maintenance chemotherapy in this patient population.

PATIENTS AND METHODS: Patients were treated at National Clinical Trial Network sites. Eligibility criteria included age ≥ 65 years and newly diagnosed Ph chromosome-negative B-ALL. Patients received blinatumomab as induction for one-two cycles until attainment of response (complete remission (CR) and CR with incomplete count recovery). Patients then received three cycles of consolidation with blinatumomab followed by 18 months of …

Tungsten-Enhanced Breast Cancer Metastasis To The Bone Is Associated With Alterations In The Bone Niche., Cameron J. Chock, Alicia Bolt

Pharmaceutical Sciences ETDs

The objective of this thesis project was to investigate the effects of tungsten on breast cancer metastasis to the bone niche, using the 4T1 orthotopic breast cancer model. Oral tungsten (15 ppm) exposure did not affect primary tumor growth. However, following tungsten exposure there were marked changes in the bone niche, including increased metastasis of 4T1 tumor cells and increased osteolysis. Further analysis of the bone niche indicates that enhanced metastasis is associated with a pro-tumorigenic immune suppressive environment, including increased number of granulocytic myeloid derived suppressor cells and increased gene expression of the pro-inflammatory cytokine IL-1β and the activated …

20220510_Hslic's Biomedical Informatics Seminar Series Presents- Chris Shaffer, Ms, Ahip, David Lucero

HSLIC Blog Post

No abstract provided.

Nurse Job Satisfaction In The Midst Of A Pandemic, Reynaldo Gonzales

Doctor of Nursing Practice Scholarly Projects

Strategies and intervention for nursing recruitment and retention are critical needs at the hospital unit management level especially during this time of coronavirus disease of 2019 (COVID-19) pandemic.

Research Question: What are the unit-levels of nurse job satisfaction among eight satisfaction dimensions (i.e., satisfaction with extrinsic rewards, scheduling, family/work balance, co-workers, interaction, professional opportunities, praise/recognition, and control/responsibility) in an acute medical-surgical unit?

Objectives The objective of this project is to systematically obtain unit-level input to explore nurses’ views and experiences as it relates to job satisfaction.

Methodology: This is a descriptive cross-sectional convenience study measuring job satisfaction among Registered Nurses …

20220506_Mental Health Awareness Month, Brandon Carroll, David Lucero

HSLIC Blog Post

No abstract provided.

Stroke Recovery During The Covid-19 Pandemic: A Position Paper On Recommendations For Rehabilitation, Suzanne Perea Burns, Talya K. Fleming, Sam S. Webb, Alice Sau Han Kam, Jaimee D P Fielder, Grace J. Kim, Xiaolei Hu, Mary Thelander Hill, Emily A. Kringle

Pediatrics Research and Scholarship

Health care delivery shifted and adapted with the COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus 2. Stroke care was negatively affected across the care continuum and may lead to poor community living outcomes in those who survived a stroke during the ongoing pandemic. For instance, delays in seeking care, changes in length of stays, and shifts in discharge patterns were observed during the pandemic. Those seeking care were younger and had more severe neurologic effects from stroke. Increased strain was placed on caregivers and public health efforts, and community-wide lockdowns, albeit necessary to reduce the spread …

Building Question Formulation Skills Among Dental Hygiene Students, Jonathan Eldredge, Christine N. Nathe

Posters and Presentations

No abstract provided.

Early Outpatient Treatment For Covid-19 With Convalescent Plasma., David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Evan M. Bloch, Bryan Lau, Aarthi G. Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie-Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C. Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley

Pathology Research and Scholarship

BACKGROUND: Polyclonal convalescent plasma may be obtained from donors who have recovered from coronavirus disease 2019 (Covid-19). The efficacy of this plasma in preventing serious complications in outpatients with recent-onset Covid-19 is uncertain.

METHODS: In this multicenter, double-blind, randomized, controlled trial, we evaluated the efficacy and safety of Covid-19 convalescent plasma, as compared with control plasma, in symptomatic adults (≥18 years of age) who had tested positive for severe acute respiratory syndrome coronavirus 2, regardless of their risk factors for disease progression or vaccination status. Participants were enrolled within 8 days after symptom onset and received a transfusion within 1 …

20220505_Aapi Resource Center Opening, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

Developing A Faculty Roles Crosswalk For Health Sciences Librarians, Laura J. Hall, Jonathan Eldredge

Posters and Presentations

No abstract provided.