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Hsc Connects Newsletter - December 15, 2023, Unm Hsc Communications

HSC Connects Newsletters

Weekly newsletter of the UNM Health Sciences Center.

Aleukemic Chronic Myeloid Leukemia Without Neutrophilia And Thrombocytosis: A Report From The Bcr::Abl1 Pathology Group, Daniel Rivera, Wei Cui, Juehua Gao, Deniz Peker, Qian-Yun Zhang, Rajan Dewar, Lianqun Qiu, Sergej Konoplev, Zhihong Hu, Koji Sasaki, Aileen Y. Hu, Shuyu E, Meng Liu, Hong Fang, Wei Wang, Guilin Tang, Jane F Apperley, Andreas Hochhaus, Jorge E. Cortes, Joseph D. Khoury, L Jeffrey Medeiros, Elias Jabbour, Shimin Hu

Pathology Research and Scholarship

Chronic myeloid leukemia (CML) is characterized by leukocytosis with left-shifted neutrophilia, basophilia, eosinophilia, and variable thrombocytosis. However, extremely rare cases of patients with CML without significant leukocytosis and thrombocytosis (aleukemic phase [ALP] CML, or CML-ALP) have been reported. Due to its rarity and limited awareness, there remains a significant knowledge gap concerning the pathologic diagnosis, disease progression, and optimal patient management and outcomes. In this multi-institutional study, we investigated 31 patients with CML-ALP. Over half (54.8%) of patients had a history of or concurrent hematopoietic or nonhematopoietic malignancies. At time of diagnosis of CML-ALP, approximately 26.7% of patients exhibited neutrophilia, …

Environmental Ozone Exposure, Gestational Health, And The Lung-Placental Axis, Russell Hunter

Biomedical Sciences ETDs

Adverse gestational outcomes of pregnancy are a globally occurring threat to fetomaternal health, with limited clinical prognostic and intervention strategies aside from premature labor induction. Epidemiological data shows strong correlations between gestational exposure to air pollution and the incidence of adverse gestational outcomes. The research presented here was designed to evaluate potential murine models of gestational exposure, as well as quantify maternal cardiovascular damage therein. These studies employ radiotelemetry, echocardiography, single cell RNA-sequencing, and untargeted lipidomic analyses in efforts to study these effects. Results implicate cardiovascular responses to mid-gestational ozone exposure as evidenced by decreased maternal cardiac output and increased …

Interrogation Of The Molecular Mechanisms That Finetune Fcεri Signaling And Mast Cell Outcomes, Derek A. Rinaldi

Biomedical Sciences ETDs

FcεRI is the ITAM receptor primarily responsible for the allergic response and immune hypersensitivity diseases such as asthma. Regulation of the strength of both FcεRI signaling, and the resulting outcomes, is accomplished via a complex array of molecular mechanisms whose interactions remain unclear. Here, I explored how the biophysical properties of antigens, crosstalk between FcεRI and integrin signaling and Arf6-mediated control of trafficking and exocytosis tune mast cell outcomes. I first found significant differences in FcεRI aggregation, phosphorylation and granule secretion after crosslinking with the multivalent antigen DNP-BSA or the small, trivalent antigen DF3. I also revealed a bi-directional, Syk-mediated …

A Descriptive Analysis Of Fatal Outcomes In Immune Thrombotic Thrombocytopenic Purpura In The Ustma Ttp Registry, Mouhamed Yazan Abou-Ismail, Chong Zhang, Angela Presson, Shruti Chaturvedi, Ana G. Antun, Andrew Farland, Ryan Woods, Ara Metjian, Yara Park, Gustaaf De Ridder, Briana Gibson, Raj S. Kasthuri, Darla K. Liles, Frank Akwaa, Todd Clover, Lisa Baumann Kreuziger, Meera Sridharan, Ronald S. Go, Keith R. Mccrae, Harsh Vardhan Upreti, Radhika Gangaraju, Nicole Katlyn Kocher, X Long Zheng, Jay S. Raval, Camila Masias, Spero R. Cataland, Andrew David Johnson, Elizabeth Davis, Michael D. Evans, Marshall Mazepa, Ming Y. Lim

Pathology Research and Scholarship

No abstract provided.

12/11/2024 Meeting, Varina A. Kosovich

Meeting Minutes

No abstract provided.

Amicus Curiae Brief Of The Navajo Nation, Paul Spruhan

Faculty Scholarship

The Navajo Nation Labor Commission ("NNLC" or "Commission") invited the Navajo Nation Department of Justice ("DOJ") to file an amicus brief in this matter. As discussed more fully below, the DOJ recommends that the NNLC hold an evidentiary hearing to gather facts necessary to conduct a full jurisdictional analysis under Montana and determine whether the Northern Apache County Special Healthcare District ("NACSHCD") has sovereign immunity. The fact gathering process is necessary given the fact-intensive analysis under both Montana and Arizona's sovereign immunity laws. As the Navajo Supreme Court has instructed, the proper threshold inquiry is whether jurisdiction exists over the …

12-07-2023 Hsc Committee Minutes, Helen Maestas

HSC Committee (A subcommittee of the UNM Board of Regents)

12-07-2023 HSC Committee Meeting Minutes

Liquid Biopsy: From Concept To Clinical Application, Catherine Alix-Panabières, Dario Marchetti, Julie E. Lang

Pathology Research and Scholarship

The diagnosis and treatment of cancer presents a physical and mental burden to the patient, often involving diagnostic biopsies and surgeries or chemotherapeutic approaches with severe side-effects. Advances which enable early detection of cancer and close monitoring of the disease course without invasive procedures, and which can underpin a tailored approach to treatment, can therefore make a big difference to the quality of life of patients. Liquid biopsies can be used to access tumor cells and tumor DNA circulating in the blood. Monitoring these species can provide a minimally invasive and repeatable means to detect cancer, or gain information about …

Ai In Higher Education And Research, Leo Lo, Laura J. Hall

Biomedical Informatics Seminar Series (BioMISS)

Description:

Artificial Intelligence holds great promise for higher education from helping students learn more efficiently to entering the job market better prepared for the future. It’s also transforming the way in which faculty conduct research. This session of the BioMISS seminar series will focus on AI trends and explore application in research.

Learning Objectives

1. Learn about how generative AI is being integrated into higher education, with some specific examples from initiatives at the University of New Mexico (UNM).
2. Gain a greater understanding of generative AI capabilities and limitations.
3. Insight into the importance of critically assessing information produced by AI …

20231206_New Materials At Hslic, Moses L. Moya

HSLIC Blog Post

No abstract provided.

20231206_Joseph V. Scaletti Papers Processed, Abbie Weiser

HSLIC Blog Post

No abstract provided.

20231205_Library’S Entry-Level Floor Is Getting A Refresh!, Sally Bowler-Hill

HSLIC Blog Post

No abstract provided.

20231204_Fuel For Finals December 4th-8th, Varina Kosovich

HSLIC Blog Post

No abstract provided.

Preferences For Cpstf-Recommended Intervention Approaches For Increasing Cancer Screening Among Screen-Eligible Adults In Zuni Pueblo, Usa., Nicholas Edwardson, Mikaela Kosich, V Shane Pankratz, Judith Sheche, Kate Cartwright, Deborah Kanda, Samantha Leekity, Shiraz I. Mishra

Pediatrics Research and Scholarship

We identified preferences toward Community Preventive Services Task Force (CPSTF)-recommended intervention approaches among screen-eligible Zuni Pueblo members in New Mexico, USA and assessed if there were significant differences in those preferences, with the goal of informing the selection of intervention approaches for use in the Zuni Pueblo. We utilize data from a population-based survey (n = 280) focused on 15 CPSTF-recommended intervention approaches designed to improve screening for cervical, breast, and/or colorectal cancer screening. Model-adjusted results suggest some intervention approaches garnered significantly higher support than others. We offer six, data-driven recommendations for consideration by public health practitioners as they endeavor …

Preferences For Cpstf-Recommended Intervention Approaches For Increasing Cancer Screening Among Screen-Eligible Adults In Zuni Pueblo, Usa, Nicholas Edwardson, Mikaela Kosich, V Shane Pankratz, Judith Sheche, Kate Cartwright, Deborah Kanda, Samantha Leekity, Shiraz I Mishra

Pediatrics Research and Scholarship

We identified preferences toward Community Preventive Services Task Force (CPSTF)-recommended intervention approaches among screen-eligible Zuni Pueblo members in New Mexico, USA and assessed if there were significant differences in those preferences, with the goal of informing the selection of intervention approaches for use in the Zuni Pueblo. We utilize data from a population-based survey (n = 280) focused on 15 CPSTF-recommended intervention approaches designed to improve screening for cervical, breast, and/or colorectal cancer screening. Model-adjusted results suggest some intervention approaches garnered significantly higher support than others. We offer six, data-driven recommendations for consideration by public health practitioners as they endeavor …

Iron Promotes Glycolysis To Drive Colon Tumorigenesis., Zhaoli Liu, Luke Villareal, Lavanya Goodla, Hyeoncheol Kim, Daniel M. Falcon, Mohammad Haneef, David R. Martin, Li Zhang, Ho-Joon Lee, Daniel Kremer, Costas A. Lyssiotis, Yatrik M. Shah, Henry C. Lin, Hui-Kuan Lin, Xiang Xue

Pathology Research and Scholarship

Colorectal cancer (CRC) is the third most common cancer and is also the third leading cause of cancer-related death in the USA. Understanding the mechanisms of growth and progression of CRC is essential to improve treatment. Macronutrients such as glucose are energy source for a cell. Many tumor cells exhibit increased aerobic glycolysis. Increased tissue micronutrient iron levels in both mice and humans are also associated with increased colon tumorigenesis. However, if iron drives colon carcinogenesis via affecting glucose metabolism is still not clear. Here we found the intracellular glucose levels in tumor colonoids were significantly increased after iron treatment.

20231201_On The Road With Hslic Outreach, Deirdre Caparoso

HSLIC Blog Post

No abstract provided.

Post-Wildfire Export Regimes Of Solutes Along The Gallinas-Pecos River-Santa Rosa Fluvial Network, Asmita Kaphle

Civil Engineering ETDs

Wildfires significantly contribute to water pollution when ash and sediments, including nutrients and metals, are released into fluvial systems, impacting aquatic ecosystems and surrounding communities. This study focuses on the impacts of the Hermits Peak-Calf Canyon Fire on the Gallinas and Pecos watersheds. It employs five monitoring stations along a 190km fluvial network to assess solute export regimes post-fire, where grab samples were collected for nutrient and metal analyses for a period of more than a year. The metrics used for characterizing mobilization, chemostatic, or dilution patterns indicated mobilization for most solutes at all sites upstream of Santa Rosa Lake. …

Chair Care: Where Beauty Meets Health - A Feasibility Project, Anna Rutins, Camille Velarde, Brian Serna

Posters and Presentations

No abstract provided.

20231130_Hslic's Biomedical Informatics Seminar Series Presents- Leo S. Lo, Edd, Mlis, Mfa, And Laura Hall, Mfa, Mba, Brandon Carroll

HSLIC Blog Post

No abstract provided.

20231128_Introducing Unm’S Jove Subscription, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

20231127_Hslic 2023-2024 Seed Funding Grant Recipients Expand Access And Conduct Research, Sally Bowler-Hill

HSLIC Blog Post

No abstract provided.

20231127_Course Reserves Have Moved, Kaylee Nauer

HSLIC Blog Post

No abstract provided.

20231121_Hslic's Student Computing Updated With Statistical Software, Tim Mey

HSLIC Blog Post

No abstract provided.

Study Of The Pampay Mass (Burial Of Offering) At The Summit Of The Andean Snow-Capped Mountain As An Example Of (T,I,F)-Neutrosophic Social Structure, Edgar Gutiérrez-Gómez, Ketty Marilú Moscoso-Paucarchuco, Manuel Michael Beraún-Espíritu, Fabricio Miguel Moreno-Menéndez, Rafael Jesús Fernández-Jaime, Wilfredo Fredy Paco-Huamani, Michael Raiser Vásquez-Ramírez, Jesús César Sandoval-Trigos

Neutrosophic Sets and Systems

No abstract provided.

Using Neutrosophic Trait Measures To Analyze Impostor Syndrome In College Students After Covid-19 Pandemic With Machine Learning, Riya Eliza Shaju, Meghana Dirisala, Muhammad Ali Najjar, Ilanthenral Kandasamy, Vasantha Kandasamy, F. Smarandache

Neutrosophic Sets and Systems

No abstract provided.

Heptagonal Neutrosophic Topology, Kungumaraj E, Durgadevi S, Tharani N. P

Neutrosophic Sets and Systems

No abstract provided.

20231117_Hslic Scholarship Day, Amy Weig-Pickering

HSLIC Blog Post

No abstract provided.

A Moving Target Architecture As A Side-Channel Countermeasure, Rachel M. Cazzola

Electrical and Computer Engineering ETDs

We investigate a novel side-channel attack countermeasure called Side-channel Power analysis Resistance for Encryption Algorithms using Dynamic partial reconfiguration (SPREAD). The countermeasure leverages a strategy that is best characterized as a moving target architecture. Modern field-programmable gate array (FPGA) architectures provide support for dynamic partial reconfiguration (DPR), a feature that allows real-time reconfiguration of portions of the programmable logic (PL) while the FPGA continues to carry out computing tasks. Using the Advanced Encryption Standard (AES), the proposed moving target architecture leverages DPR to change the implementation characteristics of the substitution boxes (SBOX) in real time. We present experimental hardware results …