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Molecular Characterization Of A Unique Population Of Human Cortical Interneurons; Implications For Primate-Specific Development, Crina Peterson

Biomedical Sciences ETDs

The human brain consists of 86 billion neurons compared to rodent brain, which consists of 75 million neurons, and the underlying mechanisms for the increased complexity of the primate cortex are not fully elucidated. However, an increase in specific cell populations, including calretinin-expressing (CALB2/CR) interneurons (INs), has been identified. In my thesis work, I demonstrate that human pluripotent stem cells (hPSCs) differentiated to neurons by default patterning give rise to this CR population in vitro, providing a method to study their development.

Chapter I reviews cortical development and hPSCs as an appropriate proxy for studying human cortical development. Chapter …

“Don’T Make Fun Of The Residents!” Revisiting The Sunbelt’S Vanishing Communities: Mobility And Suburban Development, 1900-1990, Jerry D. Wallace

History ETDs

“Don’t Make Fun of the Residents” examines home ownership and suburban development over the last one hundred years in the borderlands, American West, and Sunbelt regions. In this dissertation I argue that mobility shaped urban planning, neighborhood design, and architectural identity in the Sunbelt over the course of the twentieth century. “Don’t Make Fun of the Residents” places architectural identity at the center of this dissertation discussion to understand the origins of the Sunbelt as a geographic and intellectual space. I focus in particular on smaller cities in the intermountain West---New Mexico, Texas, Colorado, Arizona, and California---an area that has …

Anomaly Detection In Smart Grids Using Multi-Task Gaussian Processes, Aman Karra

Electrical and Computer Engineering ETDs

The availability of data and computing infrastructure in smart grids creates new challenges that invite solutions based on algorithmic techniques. A particular problem of interest in these systems is fault detection. It is difficult to characterize faults because of the number of different ways in which these faults can occur. Moreover, simulating a faulty mode of the system can be expensive. This work addresses fault detection by framing it as the task of detecting anomalies in the sensor data of smart grids. The assumption made is that faults are events of low probability. But no reliance is made on any …

Investigations Of Geochemical Variations With Depth At The First 15 Drill Sites On Mars Analyzed By The Chemcam Instrument Onboard The Curiosity Rover And Supported By Laboratory Studies And Analog Research At The Valle Grande Paleolake, Valles Caldera, New Mexico, Usa, Ryan S. Jackson

Earth and Planetary Sciences ETDs

The ChemCam instrument collected a wealth of data during the first 15 drill campaigns and on the distribution of trace elements at Yellowknife Bay, Mars. The drill sites investigation showed that most sites were geochemically homogenous down the depth of the drill hole. Two sites in the Stimson formation contained a vertical gradient of decreasing silica down > 3 cm. This gradient may be the result of groundwater flow and is likely recent, within 2.3 Ma. The trace element research was grounded with an analog study at the Valle Grande paleolake in New Mexico. We observed progressive alteration in the minerology …

How Bojack Horseman Got Too Real: Audience Engagement And A Critique Of Capitalism, Camille Le Pioufle

Foreign Languages & Literatures ETDs

What can a cartoon tell us about the state of capitalist societies? This study examines the case of Netflix adult animated TV show BoJack Horseman (2014-2020) with the aim of understanding the mechanisms at play in the formation of the critique of capitalism. It investigates the narrative and cinematographic devices employed by the show to construct a realistic portrayal of American capitalist system and its harmful consequences on individuals and society in general.

Through the analysis of realism, self-referentiality and intertextuality, the star system, and processes of subsumption and commodification, this work comes to the conclusion that BoJack Horseman ‘got …

A Practical Methodology To Detect, Quantify And Characterize Experimental Uncertainties In The Dynamic Testing Of Structures, James L. Woodall

Civil Engineering ETDs

This thesis investigates the uncertainty in the experimental context of structural dynamics. This thesis proposes a method to estimate both the effect of boundary conditions, as well as two different methods to detect the location of sensors on a specimen. Firstly, this thesis proposes a technique to predict the dynamic behavior of any point along a cantilever beam with an uncertain transverse elastic restraint. Secondly, this thesis investigates the estimation of the location of a sensor given the output data of a physical experiment with two different methods. Small errors in the sensor location may go unnoticed in the frequency …

Effects Of Environmental Change On Ancestral Pueblo Fishing In The Middle Rio Grande, Jonathan William Dombrosky

Anthropology ETDs

It has long been assumed that fishes were unimportant in the diet of past Pueblo people in the U.S. Southwest. Yet, small numbers of fish remains are consistently recovered from Late pre-Hispanic/Early Historic archaeological sites in the Middle Rio Grande of New Mexico. The end of drought conditions may have impacted food choice and fishing decisions during this time. I use behavioral ecology to understand how fishing could have been an optimal food-getting strategy for Ancestral Pueblo farmers. Stable isotope analysis offers a way to account for environmental change. I provide a refined ¹³C Suess correction model to support …

Self-Breakdown Study Of Spherical Electrodes In Air Spanning Pressures From Atmosphere To 2000 Psia, And Stress Times From Seconds To Nanoseconds, Joseph G. Felix

Electrical and Computer Engineering ETDs

In this research, a self-breakdown switch with 12.7 mm diameter spherical electrodes and a 380-micron gap was assembled and the effect of pressure and stress time on breakdown voltage and closure time were measured. Specifically, the pressure was varied from atmosphere to 2000 psia and the stress time was varied from seconds to nanoseconds. Few studies have investigated equivalent ranges of pressure and charge times on sub millimeter gap switches with electric field intensities reaching 2 MV/cm. The correlation of the parameters and switch behavior are explored in this study. In addition, the effects of humidity and electrode surface deformities …

Effects Of Message Frame And Cultural Orientations On Covid-19 Prevention Behaviors, Mika Hashimoto

Communication ETDs

This study aimed to explore effective message strategies to promote COVID-19 prevention behaviors among college students. Due to the fewer symptoms and lessened impact of COVID-19 in this population, young adults tend to have low perceived risk that results in low engagement in preventive behaviors. Also, some people may hold beliefs or values that are contrary to preventive behaviors. Thus, applying message framing theory, this study tested the effects of perceived risk and cultural orientation on adherence to prevention behaviors. The results showed that perceived risk and cultural orientation were associated with intention to maintain physical distance and wearing a …

Expectancy-Value Theory: Why Do We Choose The Path We Do In Doctoral Nursing Education?, Tammy Ladue

Theoretical Foundation in Advanced Practice Nursing

No abstract provided.

Hbme1 And Ck19 Expression In Non-Invasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (Niftp) Vs Other Follicular Patterned Thyroid Lesions, Qandeel Sadiq, Radhika Sekhri, Daniel T Dibaba, Qi Zhao, Shweta Agarwal

Pathology Research and Scholarship

BACKGROUND: Thyroid neoplasms with follicular architecture can have overlapping morphologic features and pose diagnostic confusion among pathologists. Various immunohistochemical stains have been investigated as potential diagnostic markers for PTC, among which HBME1 and CK19 have gained popularity. Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) poses similar diagnostic challenges with interobserver variability and is often misdiagnosed as adenomatoid nodule or follicular adenoma. This study aims to evaluate expression of HBME1 and CK19 in NIFTPs in comparison to other well-differentiated thyroid neoplasms and benign mimickers.

METHOD: Seventy-three thyroid cases diagnosed over a period of 3 years at Methodist University Hospital, …

Learning Intermediate Representations For Question Answering Systems, Zakery T. Clarke

Computer Science ETDs

Question answering systems are models that can perform natural language processing (NLP) on a question, retrieve an answer from a datasource, and communicate it to a user. In question answering systems, it is important for the system to learn an underlying representation for a piece of text. There are many systems that have achieved incredible accuracy on question answering datasets such as the Stanford Question and Answer Dataset (SQuAD), but these systems often encode their knowledge in a manner that is impossible to verify. Many current models would benefit more from verifiability, than marginal accuracy improvements.

We propose a method …

Attitudes Towards Treating Injured Patients In Urgent Care, Erin Beverly

Doctor of Nursing Practice Scholarly Projects

There has been published literature on the topic of clinician bias and the effects of bias on patient care, however, a review of the literature did not yield any research on the topic of clinician bias towards treating patients injured in motor vehicle accidents (MVA’s). There has been concern about clinicians not preferring to see patients injured in MVA’s however this is only anecdotal. If this topic is to be addressed through quality improvement efforts, there should first be scholarly evidence to support these efforts. This study employed a prospective survey of a convenience sample of clinicians who practice in …

Justice, Health & Disability: Applying Justice And Humanbecoming Paradigms To The Experiences Of Individuals Living With Spinal Cord Injury, Brian Grover

Theoretical Foundation in Advanced Practice Nursing

No abstract provided.

Steve's Oral History, Julian T. Gunther

Oral Histories HIST300, Spring 2021

This is an oral history I conducted with my father, about growing up in the 50's and 60's with his grandfather being in a high up position in the mafia, and how it affected him, and his family.

Regional Domesticities: Recalling, Rewriting, And Redefining Gender And Domesticity In The Greater Southwest, A. Laurie Lowrance

English Language and Literature ETDs

This dissertation examines how Native American and Mexican American women in the greater Southwest negotiated domestic expectations within their own cultures while navigating the demands of encroaching Anglo culture to produce something new: hybrid domesticities rooted in the region, which I call regional domesticities. Chapter 1 focuses on María Amparo Ruiz de Burton and connects her novels Who Would Have Thought It? and The Squatter and the Don to the rhetoric of the Overland Monthly. Chapter 2 explores bicultural collaborations between Native American and Anglo women and focuses on Sarah Winnemucca’s Life Among the Piutes and Helen Sekaqueptewa’s Me …

Stripped And Exploited Blackness: Black Nude Men In The Art Of F. Holland Day And John Singer Sargent, David P. Saiz

Art & Art History ETDs

Black representation in late-nineteenth to early-twentieth-century U.S. art and visual culture is primarily dominated by racist depictions produced by white elite (usually male) artists. Exploiting Black male nude subjects in their art production, F. Holland Day and John Singer Sargent are inextricably tied to this complicated legacy. For Day, his African series featuring U.S.-born model, J.R. Carter, extracts the subject from his time and place to present him as an exotic African subject/object. On the other hand, Sargent encounters Black Bahamian laborers at Miami’s Villa Vizcaya where he then documents his subjects in watercolor as bathers in the surrounding subtropical …

Mckenna Johnston Oral History Interview 4/18/2021, Mckenna M. Johnston, Tony Atkinson, Cheri Atkinson

Oral Histories HIST300, Spring 2021

No abstract provided.

Developing The Minimum Dataset For The New Mexico Decedent Image Database, Shamsi Daneshvari Berry, Philip J. Kroth, Heather J H Edgar, Teddy D. Warner

Pathology Research and Scholarship

BACKGROUND: A minimum dataset (MDS) can be determined ad hoc by an investigator or small team; by a metadata expert; or by using a consensus method to take advantage of the global knowledge and expertise of a large group of experts. The first method is the most commonly applied.

OBJECTIVE: Here, we describe a use of the third approach using a modified Delphi method to determine the optimal MDS for a dataset of full body computed tomography scans. The scans are of decedents whose deaths were investigated at the New Mexico Office of the Medical Investigator and constitute the New …

Climatic Controls Of Plant Productivity, Phenology, And Physiology In Drylands, Alesia Jane Hallmark, Scott L. Collins, Marcy E. Litvak, Christopher D. Lippitt, Andrew D. Richardson

Biology ETDs

Drylands play a critical role in global carbon dynamics. Anthropogenic climate change is causing these hot and dry regions to become increasingly hotter, drier, and more variable. This is especially concerning as drylands are some of the most sensitive regions to changes in aridity. It is critical to understand how dryland plant species might react to a changing climate. In this dissertation, I explored the relative effects of plant community composition and dominant species abundance on determining ecosystem-wide carbon dynamics. I compared the population stability of 98 dryland plant species and related stability to phenological traits. Lastly, I related branch …

A Triple Oxygen Isotope Analysis Of Altered Oceanic Crust And Its Buffering Effect On The Steady State Oxygen Isotope Composition Of Seawater, Jesse P. Mcgunnigle

Earth and Planetary Sciences ETDs

The secular chemical marine sediment trend showing an increase in δ¹⁸O over geologic time has traditionally been investigated using δ¹⁸O modelling of ancient ocean compositions, ocean surface temperatures, and sample diagenetic alteration. This study presents a triple oxygen isotope mass balance for the oceans using high precision δ¹⁸O and Δ'¹⁷O measurements of altered oceanic crust. The mass balance model predicts an ice-free seawater with δ¹⁸O = -0.29‰ and Δ’¹⁷O = -0.002‰ with steady state reached at approximately (0.5 to 1)×10⁹ years. Modifications to the hydrothermal alteration and …

Implementation Of Uniform Interpolationalgorithms, Jose A. Castellanos Joo

Computer Science ETDs

This thesis discusses algorithms for the uniform interpolation problem and presents their implementation for the following theories: (quantifier-free) equality with uninterpreted functions (EUF), unit two-variable per inequality (UTVPI), and theoretic aspects for the combination of the two previous theories. The uniform interpolation algorithms implemented in this thesis were originally proposed in \cite{KAPUR2017}. Refutational proof-based solutions are the usual approach of many interpolation algorithms \cite{10.1007/978-3-642-00768-2_34, mcmillan2011interpolants, 10.1007/978-3-540-24730-2_2}. The approach taken in \cite{KAPUR2017} relies on quantifier-elimination heuristics to construct a uniform interpolant using one of the two formulas involved in the interpolation problem. The latter makes it possible to study the complexity …

Umbilical Cord Milking Vs Delayed Cord Clamping And Associations With In-Hospital Outcomes Among Extremely Premature Infants, Neha Kumbhat, Barry Eggleston, Alexis S. Davis, Sara B. Demauro, Krisa P. Van Meurs, Elizabeth E. Foglia, Satyan Lakshminrusimha, Michele C. Walsh, Kristi L. Watterberg, Myra H. Wyckoff, Abhik Das, Sara C. Handley, Generic Database Subcommittee Of The Nichd Neonatal Research Network

Pediatrics Research and Scholarship

OBJECTIVE: To compare in-hospital outcomes after umbilical cord milking vs delayed cord clamping among infantsgestation.

STUDY DESIGN: Multicenter retrospective study of infants born(grade III or IV) intraventricular hemorrhage (IVH) by 36 weeks of postmenstrual age (PMA). Secondary outcomes assessed at 36 weeks of PMA were mortality, severe IVH, any IVH or mortality, and a composite of mortality or major morbidity. Outcomes were assessed using multivariable regression, incorporating mortality risk factors identified a priori, confounders, and center. A prespecified, exploratory analysis evaluated severe IVH in 2 gestational age strata, 22-24

RESULTS: Among 1834 infants, 23.6% were exposed to umbilical cord milking …

Hepatitis C Elimination Among People Incarcerated In Prisons: Challenges And Recommendations For Action Within A Health Systems Framework, Matthew J. Akiyama, Nadine Kronfli, Joaquin Cabezas, Yumi Sheehan, Prem H. Thurairajah, Richard Lines, Andrew R. Lloyd, International Network On Health And Hepatitis In Substance Users–Prisons Network

Project ECHO Bibliography

Hepatitis C virus (HCV) is a global public health problem in correctional settings. The International Network on Health and Hepatitis in Substance Users–Prisons Network is a special interest group committed to advancing scientific knowledge exchange and advocacy for HCV prevention and care in correctional settings. In this Review, we highlight seven priority areas and best practices for improving HCV care in correctional settings: changing political will, ensuring access to HCV diagnosis and testing, promoting optimal models of HCV care and treatment, improving surveillance and monitoring of the HCV care cascade, reducing stigma and tackling the social determinants of health inequalities, …

Non-Gaussian Measurements Of Coherent States Of Light For Metrology And Communication, Matthew Dimario

Physics & Astronomy ETDs

Conventional measurement technology is unable to extract the most amount of information possible from coherent states of light. Non-Gaussian measurements which can count individual photons can surpass the sensitivity limits of ideal conventional strategies, and approach the ultimate limits achievable given by quantum mechanics. This thesis presents investigations and demonstrations of these unconventional measurements, which utilize coherent operations and single photon counting. This thesis shows that non-Gaussian measurements can outperform conventional strategies in estimation tasks as well as a variety of communication problems. This thesis also investigates novel approaches and algorithms for building robustness to static and dynamic noise which …

The Impact Of Erythropoietin On Short- And Long-Term Kidney-Related Outcomes In Neonates Of Extremely Low Gestational Age. Results Of A Multicenter, Double-Blind, Placebo-Controlled Randomized Clinical Trial, David J. Askenazi, Patrick J. Heagerty, Robert H. Schmicker, Patrick Brophy, Sandra E. Juul, Stuart L. Goldstein, Sangeeta Hingorani, Jean Lowe, Penut Trial Consortium

Pediatrics Research and Scholarship

OBJECTIVE: To evaluate whether extremely low gestational age neonates (ELGANs) randomized to erythropoietin have better or worse kidney-related outcomes during hospitalization and at 22-26 months of corrected gestational age (cGA) compared with those randomized to placebo.

STUDY DESIGN: We performed an ancillary study to a multicenter double-blind, placebo-controlled randomized clinical trial of erythropoietin in ELGANs.

RESULTS: The prevalence of severe (stage 2 or 3) acute kidney injury (AKI) was 18.2%. We did not find a statistically significant difference between those randomized to erythropoietin vs placebo for in-hospital primary (severe AKI) or secondary outcomes (any AKI and serum creatinine/cystatin C values …

Coalition For Prisoners' Rights Newsletter, Vol. 46-C, No. 5, Coalition For Prisoners' Rights

Coalition for Prisoners' Rights Newsletters

No abstract provided.

Highly Accurate Chip-Based Resequencing Of Sars-Cov-2 Clinical Samples, Kendall Hoff, Xun Ding, Lucas Carter, John Duque, Ju-Yu Lin, Samantha Dung, Priyanka Singh, Jiayi Sun, Filip Crnogorac, Radha Swaminathan, Emily N. Alden, Xuechen Zhu, Ryota Shimada, Marijan Posavi, Noah Hull, Darrell L. Dinwiddie, Adam M. Halasz, Glenn Mcgall, Wei Zhou, Jeremy S. Edwards

Pediatrics Research and Scholarship

SARS-CoV-2 has infected over 128 million people worldwide, and until a vaccine is developed and widely disseminated, vigilant testing and contact tracing are the most effective ways to slow the spread of COVID-19. Typical clinical testing only confirms the presence or absence of the virus, but rather, a simple and rapid testing procedure that sequences the entire genome would be impactful and allow for tracing the spread of the virus and variants, as well as the appearance of new variants. However, traditional short read sequencing methods are time consuming and expensive. Herein, we describe a tiled genome array that we …

Diversity – Independent Factors Predict Elevated Extinction Rates, Dustin Perriguey, Corinne Myers, Jason Moore, Louis Scuderi

Earth and Planetary Sciences ETDs

Multiple linear regression was used to determine the relationships between diversity-independent factors (i.e., abiotic, climatic) 2, 5, and 10 Myrs-prior to the most elevated Phanerozoic extinctions. We constructed five abiotic variables from Phanerozoic proxy records1–5 to compare to extinction rates: mean temperature, temperature instability, carbon cycle instability, continental weathering rates, and habitat instability. All three models were statistically significant (P < 0.05) and explained > 70% of the variation in Alroy’s6 three-timer generic extinction rates. However, the 2 Myr-prior model explained the most variance in extinction rates and had the most predictive power, based on adjusted and predictive R2 (~ 72% and 41%, respectively). Carbon …

Diversity – Independent Factors Predict Elevated Extinction Rates, Dustin Perriguey

Earth and Planetary Sciences Faculty and Staff Publications

Multiple linear regression was used to determine the relationships between diversity-independent factors (i.e., abiotic, climatic) 2, 5, and 10 Myrs-prior to the most elevated Phanerozoic extinctions. We constructed five abiotic variables from Phanerozoic proxy records1–5 to compare to extinction rates: mean temperature, temperature instability, carbon cycle instability, continental weathering rates, and habitat instability. All three models were statistically significant (P < 0.05) and explained > 70% of the variation in Alroy’s6 three-timer generic extinction rates. However, the 2 Myr-prior model explained the most variance in extinction rates and had the most predictive power, based on adjusted and predictive R2 (~ 72% and 41%, respectively). Carbon …