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Family Roots And Research Journal Unm Emeritus Professor José A. Rivera, José A. Rivera Ph.D

Faculty Publications

This article is an abbreviated life narrative of UNM Emeritus Professor of Community and Regional Planning, José A. Rivera. It begins with highlights of his family ancestry and continues with an account of his educational experiences K-12 and into a decade of university life as a student while earning a bachelor’s, two master’s and a doctorate. He taught at UNM for 35 years while also conducting research in his areas of interest, mostly in community irrigation studies, mutual aid societies, and rural development. The main body in the article focuses on positions he held at UNM and on publications that …

Tnf Prevents Establishment Of Anti-Tumor Immunity And Elucidates Toxicities Following Myxoma Virus Based Oncolytic Virotherapy, Miriam Beatriz Valenzuela Cardenas

Biomedical Sciences ETDs

Tumor Necrosis Factor Alpha (TNF) can lead to tumor regression through its direct cytolytic activity, yet it has also been implicated to facilitate tumor progression. This scenario complicates the efficacy and applicability of TNF based therapeutics as treatment for malignancies. In the context of oncolytic virotherapy (OV) which uses replicating viruses to treat tumors and acts by triggering production of pro-inflammatory cytokines, exploring such mechanisms is vital. Here we show that a Myxoma based oncolytic virus (vPD1/IL12) can induce large amounts TNF. The presence of TNF in the context of vPD1/IL12 plays a detrimental role both for tumor regression by …

Targeting Myeloid Cell Iron Metabolism In Salmonella-Induced Colitis, Mariella Arcos Padilla

Biomedical Engineering ETDs

Salmonellosis is a severe infection caused by Salmonella enterica serovar Typhimurium, leading to significant global morbidity and mortality.

Previous studies have shown that mice lacking the iron storage protein ferritin heavy chain (FTH1) in myeloid cells exhibit worsened Salmonella infection. Nuclear receptor co-activator 4 (NCOA4) directs FTH1 autophagic degradation to release iron from storage during conditions of low iron. However, the role of myeloid NCOA4 in regulating bacterial infections remains unclear.

Here, we found that myeloid NCOA4 deficiency augments spleen iron levels and increases cellular iron accumulation, oxidative stress, and ferroptosis in bone marrow-derived macrophages (BMDM) cells. This deficiency also …

The Social Matter Of Opioids: Glitches In Immunity Beyond The Human, Nathan A. Leach

American Studies ETDs

The Social Matter of Opioids: Glitches in Immunity Beyond the Human examines the contemporary opioid crisis and its relationship to capitalism, imperialism, and biomedicine. This dissertation also considers how the twin processes of crisis and racialization relate to how human-opioid entanglements perform and transgress normative anthropological assumptions of difference. Through theories of biopolitics, Black feminism, queer of color critique, and psychoanalytic insight, I argue for a more critical account of the entanglement of humans with opioids where processes of capitalist and imperial crisis produce novel forms of social ontology. I substantiate this by examining speculative tissue economies, interspecies relationality, draconian …

Rational Design Of Nanoparticles For Overcoming Barriers Of Nucleic Acid Delivery: Applications In Cancer Therapeutics, Angelea M. Maestas-Olguin

Chemical and Biological Engineering ETDs

The use of exogenous nucleic acid technologies to modulate aberrant protein expression resulting from genetic mutations is a promising therapeutic approach for the treatment of diseases such as cancer. The promise of nucleic-based therapeutics is dependent on the development of platforms that effectively protect nucleic acids from nuclease degradation and deliver the nucleic acids to specific intracellular locations (nucleus or cytosol) of target cells. The application of nanotechnology for development of nucleic acid-based nanomedicines is poised to revolutionize the clinical landscape of cancer. In this dissertation, I demonstrated the rational design, synthesis and evaluation of a lipid coated mesoporous silica …

2024 Indigenous Child Language Research Center Handbook, Tamera C. Yazzie, Bethany G. Lycan, Ryan D. Smith, Cormac League, Melvatha R. Chee

Indigenous Child Language Research Center

This handbook is continuously being developed by the Indigenous Child Language Research Center at UNM to provide Indigenous communities with a description of our organization and our research methodologies to aid in their own child language research endeavors.

Identification Of Lncrnas Involved In The Host Response To Venezuelan Equine Encephalitis Virus Infection, Mahgol Behnia

Biomedical Sciences ETDs

Venezuelan equine encephalitis virus (VEEV) is an enveloped positive-sense RNA virus in the alphavirus genus of the Togaviridea family, that causes encephalitis in humans and equids. Currently no FDA-approved vaccine or treatment is available for human use, emphasizing the importance of studying host-VEEV interaction. lncRNAs are regulatory RNAs involved in modulation of antiviral pathways during viral infections. Here we report differential lncRNAs expression in primary mouse astrocytes and neurons during non-pathogenic (TC-83) but not pathogenic (TrD) VEEV infection. We further demonstrated that suppression of four lncRNAs increased TC-83 replication, with lncRNA small nucleolar RNA host gene 15 (Snhg15) increasing TC-83 …

Pink1-Deficiency Facilitates Mitochondrial Iron Accumulation And Colon Tumorigenesis, Mariella Arcos, Lavanya Goodla, Hyeoncheol Kim, Sharina P. Desai, Rui Liu, Kunlun Yin, Zhaoli Liu, David R. Martin, Xiang Xue

Pathology Research and Scholarship

Mitophagy, the process by which cells eliminate damaged mitochondria, is mediated by PINK1 (PTEN induced kinase 1). Our recent research indicates that PINK1 functions as a tumor suppressor in colorectal cancer by regulating cellular metabolism. Interestingly, PINK1 ablation activated the NLRP3 (NLR family pyrin domain containing 3) inflammasome, releasing IL1B (interleukin 1 beta). However, inhibiting the NLRP3-IL1B signaling pathway with an IL1R (interleukin 1 receptor) antagonist or NLRP3 inhibitor did not hinder colon tumor growth after PINK1 loss. To identify druggable targets in PINK1-deficient tumors, ribonucleic acid sequencing analysis was performed on colon tumors from pink1 knockout and wild-type mice. …

Resting-State Functional Connectivity Of Motivational Circuity After Tbi: A Comparison Between Medical Cannabis Users And Non-Users, Cidney Rae Robertson-Benta

Psychology ETDs

For many, symptom resolution occurs relatively quickly after traumatic brain injury (TBI), however some people experience symptoms that can last for months and even years. Apathy is a symptom that can cause disruption after TBI. While cannabis has been suggested to treat several symptoms and conditions related to TBI, given the historical association with apathy, investigation of the relationship is imperative. There is little research in the medical population, with even less in specific clinical samples - this study aims to bridge this gap. 52 participants with symptoms lasting at least 6 months were compared based on the use of …

Human Impacts On Mammal Diversity From The Pleistocene To The Present, Carson P. Hedberg

Biology ETDs

Humans have fundamentally altered the planet’s biodiversity. It is critical to characterize these changes, but also to understand how they impact the structure and function of modern ecosystems. This dissertation investigates how anthropogenically mediated species losses and/or introductions influence ecological function and community structure in mammals across multiple temporal and spatial scales. We found that selective loss of large-bodied mammals over the Late Quaternary has led to severe losses in functional diversity in modern ecosystems, suggesting megafaunal mammals contribute distinct ecological functions. These changes to mammal diversity and distribution over millennia have altered both global patterns in functional diversity and …

Antimicrobial Activity And Photostability Of Cationic Conjugated Polyelectrolytes, Mohammed Ismael Khalil

Chemical and Biological Engineering ETDs

Antimicrobial resistance is a growing global health concern, driving the need for novel

therapeutic strategies. This study explores the antimicrobial efficacy of conjugated

polyelectrolytes (CPEs) and oligo-phenylene ethynylenes (OPEs) in bacterial and viral

inactivation. Quantitative analysis revealed that light-activated CPEs and OPEs

effectively reduced bacterial viability within minutes, with significant log reductions

observed under both light and dark conditions. Additionally, the antiviral potential of a

cationic conjugated oligomer was investigated, demonstrating rapid and near-complete

inactivation of SARS-CoV-2 under visible light, both in solution and on filter materials.

Further analysis of their photophysical properties revealed that, even after

photobleaching, the compounds …

Things Fall(Ing) Apart: Deconstructing Humanism For History Teaching In A Posthumanist Society, Lou Ellis Brassington

Language, Literacy, and Sociocultural Studies ETDs

Abstract

This study is a reflective analysis of the discursive construction of the social studies and the teaching of history from medieval scholasticism, through Enlightenment humanism, and into our posthumanist landscape. As an exploration of the foundations of Western thought, with an emphasis on humanism as it has historically affected construction of the social studies, this investigation focuses on theorists, praxis, curriculum development, and teacher identity. My research examined the pedagogical and curriculum choices for the teaching of history along with the intersection of the humanities and humanism from the Enlightenment through the criticalities of the 20th century, and into …

Americans Face Migration: A Comparative Study Of State Immigration Policy By Region, 1865-1925, Brett S. Janos

History ETDs

This dissertation challenges the prevailing narrative of U.S. immigration policy by examining the pivotal role of state governments in shaping immigration patterns and regulations during the late 19th and early 20th centuries. Through a comprehensive regional analysis, this study highlights the diverse approaches taken by different states in attracting and managing immigrant populations. The research demonstrates the complex interplay between local, state, and federal authorities by comparing state-level policies.

This multi-layered approach reveals the ingenuity of state immigration boards and commissions and the complex interplay between state desires, regional characteristics, and the evolving federal response. Moreover, a vital contribution of …

Impact Of Irrigation Water Technification On Seven Directories Of The San Juan-Patoa River Using Plithogenic N-Superhypergraphs Based On Environmental Indicators In The Canton Of Pujilí, 2021, Yenson Vinicio Mogro Cepeda, Marco Antonio Riofrío Guevara, Emerson Javier Jácome Mogro, Rachele Piovanelli Tizano

Neutrosophic Sets and Systems

The study analyzed interactions among economic, environmental, and sociocultural factors in agricul-tural irrigation systems to evaluate and promote integral sustainability, using the application of plitho-genic n-SuperHyperGraphs. Significant interactions between vertex attributes were identified during the study's development. Results highlighted that optimizing economic profitability, implementing ecologi-cal pest management, and fostering social cohesion are essential for improving system sustainability. It is concluded that an interdisciplinary approach is critical for achieving comprehensive agricultural sus-tainability, proposing an evaluative model adaptable to local settings to strengthen sector resilience. Ad-ditionally, the application of plithogenic n-SuperHyperGraphs provides a useful tool across various study areas for management and …

Tree Tobacco Extract (Nicotiana Glauca) As A Plithogenic Bioinsecticide Alternative For Controlling Fruit Fly (Drosophila Immigrans) Using N-Superhypergraphs, Emerson Jácome Mogro, Jaime Rojas Molina, Gustavo José Sandoval Cañas, Pablo Herrera Soria

Neutrosophic Sets and Systems

Concern regarding the negative effects of synthetic pesticides has driven the development of bioinsecti-cides as sustainable alternatives. Consequently, Nicotiana glauca has gained prominence for its insecti-cidal properties due to phytochemical compounds effective against pests such as Drosophila immigrans. This study, therefore, evaluated the efficacy of Nicotiana glauca extract as a bioinsecticide by optimizing extraction parameters and analyzing its insecticidal action under laboratory conditions across eight combined treatments. For this purpose, multiple experimental combinations were analyzed through Plithogenic n-SuperHyperGraphs, allowing a multidimensional evaluation of the attributes and proper-ties of each treatment. Results indicated that treatment with 96% ethanol, 48 hours of …

Mixed Graph In Fuzzy, Neutrosophic, And Plithogenic Graphs, Takaaki Fujita, Florentin Smarandache

Neutrosophic Sets and Systems

Graph theory examines networks consisting of nodes (vertices) and the connections (edges) between them. Mixed graphs, which combine both undirected and directed edges, provide a versatile framework for representing relationships with symmetric and asymmetric connections across various systems. In this work, we introduce and analyze the concept of mixed graphs within the contexts of Fuzzy Graphs, Neutrosophic Graphs, and Turiyam Neutrosophic Graphs. By exploring their properties, interrelations, and potential applications, we aim to advance theunderstanding of uncertain graphs.

New Materialism And Public Lands: Opportunities For Human And Nonhuman Interactions At Petroglyph National Monument, Madilynn M. Nolen

Geography ETDs

Petroglyph National Monument (PETR) resides at the intersection of geology, urban development, and environmental preservation. As the site of convergence for these complex systems, this National Park site is an example of what kinds of interactions occur between humans and nonhumans and how these interactions mediate our broader understanding of material world. This project utilizes literature from more-than-human geographies and new materialism to examine how these interactions inform the management strategies of PETR. Through the interviews of 15 Volunteers-in-Parks and a focus group of five PETR employees, this project investigates what nonhuman entities are present on and around the monument, …

Poshuouinge — City At The Center, All Roads Lead To Poshu, Alice Ruth Gomez

Architecture and Planning ETDs

Poshuouinge was situated in the center of not only the space of the Lower Río Chama Valley, but in the center of the time the Valley was inhabited by Tewa ancestors between the 12th and 16th centuries. Its architecture ends the Coalition Period (AD 1200-1325) and begins the the Classic (AD 1325-1600), a time of population growth and prosperity, trade expansion and diversity, all due to major agricultural innovations unique to the Valley. The new style architecture lent itself to fewer restrictions for neighbors and visitors, and was replicated in some fashion in the Valley’s other nine largest communities. Poshuouinge’s …

Will Holmes Oral History Interview Oct 2024, Angelita Ybarra

Oral Histories HIST 300, Fall 2024

Oral History interview with Will Holmes discussing, family, football, footloose, and more.

Study Of Vegetated Islands Along The Middle Rio Grande Using Openet Satellite Toolbox, Athena Victoria Sophia Shapiro Esq.

Water Resources Professional Project Reports

Sustainable water management is a challenging issue facing most of the western United States. This study analyzed evapotranspiration predictions at 14 sites along the Middle Rio Grande, changes have occurred over time as these vegetated sand bar islands have developed. Additionally, this study examines the methods of predictions and analysis of evapotranspiration or ET rates along the river using OpenET. An added area of research is the understanding of the presence of vegetation on the sandbar islands. This was analyzed using satellite imaging data from OpenET, which was used to see how changes in vegetation density change ET values seen …

Drinking Water And Wastewater In Socioeconomically Disadvantaged Communities In New Mexico: The Utilization Of Geographic Information Systems To Identify Communities Most In Need Of Technical Assistance, Alejandra Gaytan Tellez

Water Resources Professional Project Reports

The goal of this study is to identify the most burdened New Mexico community water systems (CWSs) and publicly owned treatment works (POTWs) with National Pollutant Discharge Elimination System (NPDES) permits to be able to provide them with technical assistance to address their issues, such as health-based and monitoring and reporting violations. Additionally, technical assistance can help them access federal or state funding to improve the infrastructure within their systems. The study evaluated multiple factors to determine the systems with the highest level of burden and reported the results as value numbers. The CWSs were evaluated on 10 factors that …

El Único Pecado De Chepita Rodriguez, Maria G. Vielma

Regeneración: A Xicanacimiento Studies Journal

Cuento.

Myth And Monument In Old Town Albuquerque: Southwest Pietà And The War Of Presiding Histories, Eric Castillo

Regeneración: A Xicanacimiento Studies Journal

Luis Jiménez’s Southwest Pietà (1984) intended to combat cultural amnesia that obscured Native Americans’ and Mexicans’ contributions to the state. Jiménez’s Pietà sought to counter the iconography that shaped New Mexico’s colonialist heritage. But Old Town Albuquerque shrouds Native American and Mexican contributions to the region. Albuquerque’s public art has often been deployed as a wedge to write and rewrite narratives about land inhabitants, but the city’s public art tells a powerful story about race and place in New Mexico. This essay explores the socio-historical battle of land memorialization in Old Town Albuquerque and provides a geo-racial perspective about the …

The Queer Body And The Obstructed Gaze: Chicanx Performance Artists And The Power Of Self-Objectification, Tracie N. Amend

Regeneración: A Xicanacimiento Studies Journal

The Queer Body and the Obstructed Gaze: Chicanx Performance Artists and the Power of Self-Objectification

This article examines the ways in which four queer Chicanx performance artists have manipulated and obstructed the spectator’s gaze as a method for activating their abjection, performing self-objectification or fetishization, or asserting agency. As seminal Chicanx and queer performance artists, Luis Alfaro and Nao Bustamante set the stage for identity exploration through the corporeal and figurative display of excess: they invite in the spectator’s gaze to look at the queer brown body and challenge them to resist a reductive framing of their othered voluptuousness. In …

Teaching Manita/O New Mexico To Knowledge And Power Curators: Epistemologies Of The Manita Nuevo Mexicans/O, Keith E. Sanchez

Regeneración: A Xicanacimiento Studies Journal

This essay examines the cultural ecologies of Manita/o New Mexico and the educational model of La Academia de La Nueva Raza developed therein. The conclusion section offers a brief synthesis of applied pedagogical models of CCM and a sampling of culturally relevant experiential curricula concepts authored by me. The academic aim is to inform power and knowledge curators working within the Manita/o expression of the Chicana/o diaspora. The objective of this text is to create an infrastructural guide for further study and curricula development. The curriculum directed to teach and inspire professors, teachers, and public-policy makers are intended to …

Study Of The Immunoserological Patterns Of Respiratory Infections In Children Under 15 Years Of Age In The Riobamba Region Based On Refined Neutrosophic Statistics, Lizbeth Geovanna Silva Guayasamín, Christian Andrés Silva Sarabia, Lisbeth Josefina Reales Chacón, Isaac Germán Pérez Vargas, Natalia Eliana Cáceres Cadena, Cesar Lenin Pilamunga Lema, Carlos Antonio Escobar Suárez, María José Terán Bejarano

Neutrosophic Sets and Systems

Acute respiratory infection (ARI) is an important cause of consultation in the emergency room and depending on the general condition of the person; it can become complicated and lifethreatening. The general objective of this study is to identify the immunoserology of acute respiratory infections in children under 15 years of age in the city of Riobamba, Ecuador in 2023; it consists of a statistical study in 85 children and adolescents. This research made it possible to identify the presence or absence of acute respiratory infections. The infections found are provoked by viruses, atypical bacteria, or a combination of both pathogens. …

Mechanistic Study Of Dna Ligase Iv-Mediated Double-Strand Break Repair In Non-Homologous End Joining, Tasmin Naila, Alan E. Tomkinson

Biomedical Sciences ETDs

Non-homologous end joining (NHEJ) is a crucial double-strand break repair pathway in mammalian cells, resolving DNA damage from ionizing radiation and during V(D)J recombination. Although DNA Ligase IV is the only mammalian DNA ligase involved in NHEJ, it functions as a single-turnover enzyme in vitro. Recent cryo-electron microscopy (cryo-EM) studies revealed two LigIV molecules at the NHEJ synapse, supporting the hypothesis that two ligase molecules are needed for DSB repair by NHEJ. This study aims to validate this hypothesis by providing evidence for coordinated ligation at optimal distance and polarity preference for catalytic activity by LigIV. We determined that coordination …

Ms4 Swmpp 2024, National Technology & Engineering Solutions Of Sandia, Llc (Ntess) And Department Of Energy (Doe)

Municipal Separate Storm Sewer System (MS4) Permit

Stormwater discharges from Sandia National Laboratories/New Mexico (SNL/NM) are eligible for coverage under the National Pollutant Discharge Elimination System (NPDES) Municipal Separate Storm Sewer System (MS4) Permit. This Stormwater Management Plan (SWMP) was prepared by National Technology and Engineering Solutions of Sandia (NTESS) for the Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia Field Office (SFO), owner of SNL/NM, located in Albuquerque, NM.

The Principles Of (Partial Locality, Partial Indeterminacy, Partial Nonlocality) And (Multi Locality, Multi Indeterminacy, Multi Nonlocality), Florentin Smarandache

Neutrosophic Sets and Systems

This article introduces new neutrosophic principles aiming to extend and generalize the concepts of locality and nonlocality by addressing scenarios involving indeterminacy, together with partiality and multitude, in physics, mechanics, cosmology, biology, medicine, chemistry, economics, ecology, sociology. Locality refers to interactions or processes confined within a limited region of space or time. But there may be a Total (100%) Locality, or a Partial Locality (less than 100% and greater than 0%). The effects are constrained to the immediate environment. Contrariwise, NonLocality refers to interactions or connections between entities separated by space or time. The changes in one location have instantaneous …

Bizindan Miinawa (Listen Again), Matthew L.M. Fletcher

Tribal Law Journal

Johnson v. McIntosh was as fake as John Wayne’s teeth. That one was a property dispute, remember? Two wealthy, privileged, and powerful white people squared off over thousands of acres of land acquired from Indigenous nations who called the vast valley of Eagle River home. On one side, you had a former United States Supreme Court Justice; on the other, you had a wealthy political benefactor/beneficiary. No tribal nations or Indigenous peoples to be seen or heard from. And of course, the competing property claims at issue barely overlapped, if at all, thanks to stipulations of the parties at the …