Digital Commons Network^™

2020-04-06 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Anastasiya Nestsiarovich, Praveen Kumar, Hannah Groves, Rachel D. King, Estefania Montanez, Andrew S. Rowland, Orrin Myers, Kristine Tollestrup, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM case updates. Several NM policy and legislative actions. Federal vs. state conflict over medical supply lines. Healthcare workers sleep in cars to prevent family exposure. Same-day in-house testing at Cedars-Sinai. Debate over hydroxychloroquine Tx. Death rate differences: Germany and Italy. African innovations. Testing recommended with mild symptoms. CDC guidelines for law enforcement PPE. New WHO first responder training and CDC sign language resources. COVID-19 droplets can travel up to 27 feet. Transmission from the asymptomatic. Humidifiers help. Drug and vaccine progress.

2020-04-05 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Hannah Groves, Rachel D. King, Estefania Montanez, Andrew S. Rowland, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

Cumulatively: 624 coronavirus cases and 12 deaths in New Mexico. State to receive $1B in federal relief. Animals can be infected with coronavirus – individuals with COVID-19 should minimize contact with pets. CDC recommends everyone wear cloth face coverings in public, releases guidelines for pharmacies, and updates guidance on N95 respirator conservation. Repeat COVID-19 testing may be required for accurate incidence estimates. FDA-approved antiparasitic drug, Ivermectin, may kill the virus within 48 hours. Hydroxychloroquine evidence remains inconclusive. New drug targets identified for SARS-CoV-2.

An Introduction To The Collection [Get In Good Trouble: A Collection Of Essays By Millennial Law Scholars], Verónica C. Gonzales

Faculty Scholarship

Get in Good Trouble: A Collection of Essays by Millennial Law Scholars Introduction by Verónica C. Gonzales-Zamora with essays by Kinda Abdus-Saboor, Ernestine Chaco, Marcus Gadson, Verónica Gonzales-Zamora, Camilo Romero, Lysette Romero Córdova, Morenike Saula, Joseph Schremmer, and Hon. Roshanna Toya. Afterword by Marcus Gadson. In response to the global pandemic, legal education in the United States shifted almost immediately to new tools and methods of delivery. Unsure of the lasting impact of these shifts, law faculty and law students around the country remain in limbo preparing for different scenarios when instruction resumes. Millennial law professors and scholars, with decades …

Inlp Newsletter, April 2020, Indigenous Nations Library Program

Monthly Newsletters

No abstract provided.

"Plainly Read Like A Book": The Place Of The Hendricks-Hodge Expedition In Archaeological History, Klinton Burgio-Ericson

New Mexico Historical Review

No abstract provided.

Pkcδ Causes Sepsis-Induced Cardimyopathy By Inducing Mitochondrial Dysfunction, Leroy C. Joseph, Michael V. Reyes, Kundanika R. Lakkadi, Blake H. Gowen, Gyorgy Hasko, Konstantinos Drosatos, John P. Morrow

Pathology Research and Scholarship

Sepsis-induced cardiomyopathy (SIC) is associated with increased patient mortality. At present, there are no specific therapies for SIC. Previous studies have reported increased reactive oxygen species (ROS) and mitochondrial dysfunction during SIC. However, a unifying mechanism remains to be defined. We hypothesized that PKCδ is required for abnormal calcium handling and cardiac mitochondrial dysfunction during sepsis and that genetic deletion of PKCδ would be protective. Polymicrobial sepsis induced by cecal ligation and puncture (CLP) surgery decreased the ejection fraction of wild-type (WT) mice but not PKCδ knockout (KO) mice. Similarly, WT cardiomyocytes exposed to lipopolysaccharide (LPS) demonstrated decreases in contractility …

Book Reviews Spring 2020

New Mexico Historical Review

No abstract provided.

Who Decides: Is Water Life Or Capital? Contesting Visions Of Western Water Management In The 21st Century, Ceorl

Water Resources Professional Project Reports

There is an ideological divide between the goal of universal access to clean water and the outcomes of how water regulations are implemented. John Fleck, author of Water is for Fighting Over: and Other Myths about Water in the West and Sivas, et al. in California Water Governance in the 21st Century present contesting prescriptions for Western water management. The ideologies advocated by Fleck and Sivas, et al. differ as to who enacts and profits from each and exemplify the divide between the goals of water regulations and how they are implemented. Fleck regards water as property and an economic …

Give Me Liberty, Or Give Me Breath: A Call For Economic Justice, Verónica C. Gonzales

Faculty Scholarship

In Part I of this essay I interpret this unique moment in history through a retelling of the folk story La Llorona in order to identify the monsters and ghosts of the past and the present. Domino Renee Perez describes her own critical reflection of La Llorona as reinforcing 'a valuable lesson about power and authority' because her family’s 'storytelling circle was more than simply an arbitrary setting; it was a safe place for them to create, however problematically, a world of words, where they faced the dangers and challenges of life, embodied by a woman, and survived.' The lore …

Multisite Egfr Phosphorylation Is Regulated By Adaptor Protein Abundances And Dimer Lifetimes, Emanuel Salazar-Cavazos, Carolina Franco Nitta, Eshan D. Mitra, Bridget S. Wilson, Keith A. Lidke, William S. Hlavacek, Diane S. Lidke

Pathology Research and Scholarship

Differential epidermal growth factor receptor (EGFR) phosphorylation is thought to couple receptor activation to distinct signaling pathways. However, the molecular mechanisms responsible for biased signaling are unresolved due to a lack of insight into the phosphorylation patterns of full-length EGFR. We extended a single-molecule pull-down technique previously used to study protein-protein interactions to allow for robust measurement of receptor phosphorylation. We found that EGFR is predominantly phosphorylated at multiple sites, yet phosphorylation at specific tyrosines is variable and only a subset of receptors share phosphorylation at the same site, even with saturating ligand concentrations. We found distinct populations of receptors …

Wagon Tracks Volume 34, Issue 2 (February 2020), Santa Fe Trail Association

Wagon Tracks

2 On the Cover: -30 Degrees in the Sunshine

4 Insights from your President

5 Joanne's Jottings

7 Trail News

8 "A Taste of History": Films on the Santa Fe Trail

13 Newspapers Spread the News from Santa Fe and the Santa Fe Trail

23 Domestic Manufacturers and the Santa Fe Trade, 1831-1846

28 Chapter Reports

29 Membership Form

32 Calendar of Events

Outcomes Of Inflammatory Bowel Disease In Patients With Eosinophil-Predominant Colonic Inflammation, Tarik Alhmoud, Anas Gremida, Diego Colom Steele, Imaneh Fallahi, Wael Tuqan, Nina Nandy, Mahmoud Ismail, Barakat Aburajab Altamimi, Meng-Jun Xiong, Audra Kerwin, David Martin

Pathology Research and Scholarship

BACKGROUND: Inflammatory bowel disease (IBD) is characterised by acute intestinal mucosal inflammation with chronic inflammatory features. Various degrees of mucosal eosinophilia are present along with the typical acute (neutrophil-predominant) inflammation. The effect of intestinal eosinophils on IBD outcomes remains unclear.

METHODS: This is a retrospective study. Archived intestinal mucosal biopsy specimens of treatment-naïve IBD patients were examined by two pathologists. The number of eosinophils per high-power field was counted, and the mucosal inflammation was classified according to the eosinophilic inflammatory patterns. Clinical outcomes during the follow-up period were recorded.

RESULTS: 142 treatment-naïve IBD patients were included. Mean age was 39 …

Dynamic Imaging Of Ldh Inhibition In Tumors Reveals Rapid In Vivo Metabolic Rewiring And Vulnerability To Combination Therapy, Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P Norenberg, W Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers

Pathology Research and Scholarship

The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to determine whether LDH is a feasible drug target are lacking. We describe an LDHi with potent, on-target, in vivo activity. Using hyperpolarized magnetic resonance spectroscopic imaging (HP-MRSI), we demonstrate in vivo LDH inhibition in two glycolytic cancer models, MIA PaCa-2 and HT29, and we correlate depth and duration of LDH inhibition with direct anti-tumor activity. HP-MRSI also reveals a metabolic rewiring that occurs in vivo within 30 min …

Rtk Signaling Requires C3ar1/C5ar1 And Il-6r Joint Signaling To Repress Dominant Pten, Socs1/3 And Phlpp Restraint, Michael G. Strainic, Elliot Pohlmann, Christopher C. Valley, Ajay Sammeta, Wasim Hussain, Diane S. Lidke, M Edward Medof

Pathology Research and Scholarship

How receptor tyrosine kinase (RTK) growth signaling is controlled physiologically is incompletely understood. We have previously provided evidence that the survival and mitotic activities of vascular endothelial cell growth factor receptor-2 (VEGFR2) signaling are dependent on C3a/C5a receptor (C3ar1/C5ar1) and IL-6 receptor (IL-6R)-gp130 joint signaling in a physically interactive platform. Herein, we document that the platelet derived and epidermal growth factor receptors (PDGFR and EGFR) are regulated by the same interconnection and clarify the mechanism underlying the dependence. We show that the joint signaling is required to overcome dominant restraint on RTK function by the combined repression of tonically activated …

A Randomized Trial Of Erythropoietin For Neuroprotection In Preterm Infants, Sandra E Juul, Bryan A Comstock, Rajan Wadhawan, Dennis E Mayock, Sherry E Courtney, Tonya Robinson, Kaashif A Ahmad, Ellen Bendel-Stenzel, Mariana Baserga, Edmund F Lagamma, L Corbin Downey, Raghavendra Rao, Nancy Fahim, Andrea Lampland, Ivan D Frantz Iii, Janine Y Khan, Michael Weiss, Maureen M Gilmore, Robin K Ohls, Nishant Srinivasan, Jorge E Perez, Victor Mckay, Phuong T Vu, Jean Lowe, Karl Kuban, T Michael O'Shea, Adam L Hartman, Patrick J Heagerty, Penut Trial Consortium

Pediatrics Research and Scholarship

BACKGROUND: High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical models of neonatal brain injury, and phase 2 trials have suggested possible efficacy; however, the benefits and safety of this therapy in extremely preterm infants have not been established.

METHODS: In this multicenter, randomized, double-blind trial of high-dose erythropoietin, we assigned 941 infants who were born at 24 weeks 0 days to 27 weeks 6 days of gestation to receive erythropoietin or placebo within 24 hours after birth. Erythropoietin was administered intravenously at a dose of 1000 U per kilogram of body weight every 48 hours for …

Approaches To Urban Land Use Governance: Conservation Or Housing Development?, Zlata Nourie

Public Administration ETDs

Around the globe cities are growing and expanding in size. The increase in urban areas changes the face of our planet. Since every city, county, and state have a set amount of land that they can conserve or develop, this thesis investigates factors that impact land conservation or land development for housing. It also establishes the relations between land use, economic, social, and environmental processes in the selected area. From the very beginning, this paper researches different approaches to land use that help municipalities maintain and use their land resources.

The focus of this research is an area of land …

Issue No. 112: Spring 2020

La Crónica de Nuevo México

ii President’s Message

1 A Captive of the Apaches by Mark Santiago

7 Meet the Officers and Board of the Historical Society of New Mexico—Nancy Owen Lewis, HSNM Vice President

9 Historical Society of New Mexico News

11 New Books for Your New Mexico Bookshelf compiled by Richard Melzer

13 Book Review

14 Chronicling America—Historic American Newspapers

Effect Of Vancomycin Loading Doses On The Attainment Of Target Trough Concentrations In Hospitalized Children, Ella Dolan, Robert Hellinga, Matthew London, Keenan Ryan, Walter N. Dehority

Pediatrics Research and Scholarship

OBJECTIVE: Subtherapeutic vancomycin trough concentrations are common in children and may be associated with suboptimal therapeutic response. Our objective was to determine if vancomycin loading doses safely increase the frequency of target trough attainment in hospitalized children.

METHODS: Patients (≥6 months and15 mg/dL for invasive infections and >10 mg/dL for non-invasive infections.

RESULTS: A total of 151 patients were enrolled, with 77 in the control arm and 74 in the loading dose arm. There was no significant difference in the frequency of comorbidities or need for intensive care unit admission between the two arms. Those receiving a vancomycin loading dose …

Neonatal Hypoxic-Ischemic Encephalopathy Yields Permanent Deficits In Learning Acquisition: A Preclinical Touchscreen Assessment, Jessie R Maxwell, Amber J Zimmerman, Nathaniel Pavlik, Jessie C Newville, Katherine Carlin, Shenandoah Robinson, Jonathan L Brigman, Frances J Northington, Lauren L Jantzie

Pediatrics Research and Scholarship

Neonatal hypoxic-ischemic encephalopathy (HIE) remains a common problem world-wide for infants born at term. The impact of HIE on long-term outcomes, especially into adulthood, is not well-described. To facilitate identification of biobehavioral biomarkers utilizing a translational platform, we sought to investigate the impact of HIE on executive function and cognitive outcomes into adulthood utilizing a murine model of HIE. HIE mice (unilateral common carotid artery occlusion to induce ischemia, followed by hypoxia with a FiO

Perinatal Opioid Exposure Primes The Peripheral Immune System Toward Hyperreactivity, Jessie Newville, Jessie R Maxwell, Yuma Kitase, Shenandoah Robinson, Lauren L Jantzie

Pediatrics Research and Scholarship

The increased incidence of opioid use during pregnancy warrants investigation to reveal the impact of opioid exposure on the developing fetus. Exposure during critical periods of development could have enduring consequences for affected individuals. Particularly, evidence is mounting that developmental injury can result in immune priming, whereby subsequent immune activation elicits an exaggerated immune response. This maladaptive hypersensitivity to immune challenge perpetuates dysregulated inflammatory signaling and poor health outcomes. Utilizing an established preclinical rat model of perinatal methadone exposure, we sought to investigate the consequences of developmental opioid exposure on

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2020, Michael Haederle, Jana Fothergill, Rebecca Roybal Jones, Yamhilette Licon Muñoz, Robert Oliver, Rebecca Sena, Michele Sequeira, Leasure Shanley, Seth Fuller

Research Annual Reports

No abstract provided.

Editorial: Structure, Isotypes, Targets, And Post-Translational Modifications Of Immunoglobulins And Their Role In Infection, Inflammation And Autoimmunity, Jean Harb, Bridget S. Wilson, Sylvie Hermouet

Pathology Research and Scholarship

EDITORIAL published: 07 August 2020 doi: 10.3389/fimmu.2020.01761 Frontiers in Immunology | www.frontiersin.org 1 August 2020 | Volume 11 | Article 1761 Edited by: Deborah K. Dunn-Walters, University of Surrey, United Kingdom Reviewed by: Roberta Pelanda, University of Colorado School of Medicine, United States *Correspondence: Sylvie Hermouet [email protected] Specialty section: This article was submitted to B Cell Biology, a section of the journal Frontiers in Immunology Received: 29 May 2020 Accepted: 30 June 2020 Published: 07 August 2020 Citation: Harb J, Wilson BS and Hermouet S (2020) Editorial: Structure, Isotypes, Targets, and Post-translational Modifications of Immunoglobulins and Their Role in Infection, …

Tetraspanin Scaffold Proteins Function As Key Regulators Of Hematopoietic Stem Cells, Victoria D. Balise, Chelsea A. Saito-Reis, Jennifer M. Gillette

Pathology Research and Scholarship

Hematopoietic stem and progenitor cells (HSPCs) are responsible for the development, maintenance, and regeneration of all the blood forming cells in the body, and as such, are critical for a number of patient therapies. For successful HSPC transplantation, stem cells must traffic through the blood and home to the bone marrow (BM) microenvironment or "niche," which is composed of soluble factors, matrix proteins, and supportive cells. HSPC adhesion to, and signaling with, cellular and extracellular components of the niche provide instructional cues to balance stem cell self-renewal and differentiation. In this review, we will explore the regulation of these stem …

Instructional And Institutional Planning Guide For Online And Blended Instruction, Stephanie L. Moore Phd

University Libraries & Learning Sciences Faculty and Staff Publications

This job aid is designed to support programs, universities, and schools in developing quality online learning and engage in online or blended program and institutional planning. Part 1 is a Planning Guide for Institution / District level planning. Part 2 is a worksheet for online and blended instructional design and planning. It includes sections on teamwork and collaboration online, interaction and engagement, materials, technology selection, assessment, and development and implementation checklists to facilitate the design and development process. Part 3 is a coordination guide to help align instructional and institutional planning. This is a companion to workshops where material is …

Transboundary Hydrocarbon Resources: The Puerto Vallarta Draft Treaty, Alberto Szekely, Albert Utton, Carmen Pedrazzini, Ross Shipman

Natural Resources Journal

No abstract provided.

Water Resources Planning And Management In The United States Federal System: Long Term Assessment And Intergovernmental Issues, Leonard B. Dworsky, David J. Allee, Ronald M. North

Natural Resources Journal

No abstract provided.

Spring 2020_95.2_Full Issue

New Mexico Historical Review

No abstract provided.

Francisco Ramírez De Salazar And The Sobaipuris, John P. Wilson, Rick Hendricks

New Mexico Historical Review

No abstract provided.

Can Adaptive Management Help Alaska’S Natural Resource Managers Respond To Climate Change?, E. Barrett Ristroph

Natural Resources Journal

Many legal scholars have called attention to the inability of stationary natural resource management laws to respond to a changing climate. There are various proposals for remedying these laws, including the use of adaptive management, through which resource managers can monitor changes and adjust policies accordingly. Yet there are practical and political challenges to implementing adaptive management. This article considers the extent to which adaptive management has been or could be implemented in response to Alaska’s rapid climate change. Alaska is an important case study as it is warming far more quickly than many other parts of the globe, paving …

The Long View Of The Water/Energy Nexus: Hydropower’S First Century In The U.S.A., Carl J. Bauer

Natural Resources Journal

This paper offers a historical overview of the first century of hydropower in the US from today’s perspective of the water/energy nexus. Hydropower emerged as a technology in the 1880s and its development expanded until large dam building ended in the US in the 1970s-1980s. I summarize the century from the two different angles of the water sector and the electric power sector, as the roles and strategic importance of hydropower changed dramatically in the two sectors, in the parallel histories of water development and electric power development. The paper emphasizes the electricity side of the hydropower story because the …