Digital Commons Network^™

Comparing The Differences Of Hsp90Α And Hsp90Β In Native Protein Complex Incorporation, Daryna Serediuk

Honors Theses and Capstones

Epichaperomes are long-lasting, stable assemblies of chaperones, co-chaperones, and associated factors that facilitate cell survival in maladaptive cellular states. Their inhibition has emerged as an attractive therapeutic strategy for the treatment of cancer and neurodegenerative diseases (Rodina et al., 2016). Epichaperomes are hallmarks of robust proliferation in cancer cell populations across many cancer types and are abundantly present in several stem cell varieties, including induced pluripotent stem cells, human embryonic kidney cells, and cancer stem cells (Kishinevsky et al., 2018).

The core protein of the eukaryotic heat shock protein machinery, Heat Shock Protein 90 (Hsp90), is a central chaperone that …

2025 Town Of Walpole, New Hampshire Annual Report Of The Town Officials, Departments, Committees, And Walpole Fire District, Walpole Town Representatives

Walpole, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Town Of Merrimack, Nh Annual Report 2025, Merrimack Town Representatives

Merrimack, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Improving Operating Room First-Case On-Time Starts And Reducing Turnover Times: A Quality Improvement Project, Ashley Cote

Master's Theses and Capstones

Abstract

Background: Delays in first case on-time starts (FCOTS) contribute to decreased operating room (OR) efficiency, increased healthcare costs, workflow disruptions, and reduced staff and patient satisfaction. Evidence suggests that standardized workflows, improved communication, and Lean Six Sigma methodologies can improve perioperative efficiency and reduce delays.

Local Problem: Baseline data from a local OR microsystem demonstrated an FCOTS rate of 77%, below the organizational benchmark of 80%. Root cause analysis identified inconsistent preoperative workflows, communication gaps, and variable staff adherence to standardized processes as primary contributors to delayed first-case starts.

Methods: A quality improvement project utilizing the Define, Measure, Analyze, …

Ai-Enabled Urban Decision-Making: From Infrastructure To Policy Implementation, Amir Hosein Taherkhani

Doctoral Dissertations

Urban infrastructure systems face unprecedented compound threats from aging physical stock, climate-driven hazard escalation, and large-scale systemic shocks, yet the analytical tools available to decision-makers remain inadequate in both empirical scope and equity orientation. This dissertation advances urban resilience science along two complementary empirical frontiers.The first investigation develops a deep reinforcement learning framework for socially equitable, flood-aware bridge portfolio maintenance optimization. Using Proximal Policy Optimization, a portfolio of 19 flood-vulnerable bridges in Suffolk County, Massachusetts is optimized over a multi-year planning horizon integrating HAZUS-based flood hazard simulation across four return-period scenarios (10, 50, 100, and 500 years), HEC-18 hydraulic scour …

The Long And Short Of It: Exploring The Essential Dynamics Of Select Geophysical Flows, Adhithiya Sivakumar

Doctoral Dissertations

Geophysical flows are central to important climatological processes, yet their strong turbulence and additional complexities -- density stratification, wave-current interaction, and phase change -- make analytical prediction and direct numerical simulation infeasible in many regimes. This dissertation adopts a reductionist approach in which simplified representations -- often inspired by observed scale disparities -- are utilized to isolate and investigate the organizing mechanisms of these complex flows. Within this framework, three distinct but thematically connected problems are studied.

We first study Langmuir turbulence in the open ocean, in which surface gravity waves interact with wind-driven currents to organize the mixed layer …

Detection And Management Of Attacks On Synchronized Networks, Michael T. Spearman

Honors Theses and Capstones

The Precision Time Protocol (IEEE 1588) provides sub-microsecond clock synchronization across packet-switched networks and has become foundational infrastructure in 5G fronthaul, industrial control systems, and financial exchanges. Despite its criticality, most deployed PTP networks operate without active security monitoring, and no standardized detection mechanism exists for the class of attacks that deliberately stay below conventional jitter thresholds. This thesis investigates whether hardware-level ptp4l offset logs alone are sufficient to reliably detect two such attacks, slowly wandering packet delay injection and rogue master spoofing, and whether detection can occur before severe synchronization failure.

A hardware-in-the-loop testbed was constructed using two hosts …

The Garden Of The Machine: Simulated Wildness And Digital Domestication In American Literature 1970-2020, Cameron Netland

Doctoral Dissertations

Studying American literature produced during the Information Age, from 1970 to 2020, reveals an evolution of wild human resistance to the increasing powers of digital technology. These increasing powers include capturing attention, fostering dependence, and training behavior through a process I call digital domestication. Digital domestication distances people from wildness, and as William Cronon writes in “The Trouble with Wilderness”, “Learning to honor the wild—learning to remember and acknowledge the autonomy of the other—means striving for critical self-consciousness in all of our actions.” (20). Through this framework of wildness, one reads characters in fictional narratives resisting non-coercive new technologies as …

Ne 4-H Horse Forms And Scoresheets 2026, Hannah Majewski, 4-H

UNH Cooperative Extension

No abstract provided.

Nh 4-H Horse Quiz Bowl Packet, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Participation, Danielle M. Pillet-Shore

Faculty Publications

What does it take to participate in direct, naturally occurring social interaction? Conversation analytic (CA) studies reveal that “participation”—who participates, when, and how—is dynamic and locally, multimodally achieved by the people involved. Particularly in social situations when people are concurrently accessible to one another’s naked senses (Goffman, 1964), co-participation is enabled and performed through embodied and vocal resources including talk, gaze, facial displays, body orientation/posture, proximity, and gestures (e.g., M. H. Goodwin, 1999; C. Goodwin & M. H. Goodwin, 2005; Pillet-Shore, 2010; Sidnell, 2009). Using a multimodal CA lens, this chapter illuminates how “participation” is achieved in real-time, naturally occurring …

Your Wellness Wheel [Activity], Alyssa Lemmermann, Kendra Lewis

UNH Cooperative Extension

No abstract provided.

Simple Guide To Research Integrity For Undergraduate Researchers, Julie Simpson

Integrity in Research and Scholarship

Involving undergraduates in research is valuable for their education and important for their career development, vital for science, and rewarding for supervisors. Instilling the importance of research integrity as fundamental to the advancement of knowledge may be challenging, particularly for first time trainees, as they learn the research process and their attendant responsibilities. This simple guide was developed to assist researchers who oversee the work of undergraduate trainees address basic concepts and topics. After the core values which establish the basis for the integrity of research and scholarship broadly, the ordering of concepts/topics does not represent a hierarchy; the sequence …

A Simple Guide To Responsible Authorship And Publication, Julie Simpson, Patricia B. Condon, Bonnie Brown, William C. Clyde, James J. Connell, Ramonda Kindle, Nathan A. Schwadron, John E. Sparrow, Xueting Sun, Engin Taze, May-Win Thein, Anita R. Tucker, Karen T. Van Gundy, James Wible

Integrity in Research and Scholarship

This guide examines the following aspects of responsible authorship and publication practices:

1. The significance and goals of publication
2. Publication mechanisms and responsible practices
3. The importance and guiding principles of authorship
4. The definition and responsibilities of an author
5. Responsible writing practices

Please note that throughout this document there are links to examples of concepts/issues within certain disciplines for illustrative purposes. The examples may not be relevant to all disciplines so check guidance specific to the applicable discipline before proceeding. This guide was adapted from an online training module that was part of the University of New …

An Algorithm For Extracting Bathymetry From Icesat-2 Data That Employs Structure And Density Using Concentric Ellipses, Yuri Rzhanov, Kim Lowell

Faculty Publications

The ICESat-2 satellite collects LiDAR data along linear orbital tracks using a photon-counting green wavelength (532.27 nm) instrument. The utility of combining ICESat-2 data with satellite imagery for training and subsequently applying satellite-derived bathymetry models to provide estimates of shallow water depth is well-established. However, automating and improving the accuracy of the identification of ICESat-2 photon events (PEs) representing bathymetry remains a challenge. This article presents an algorithm for automated extraction of PEs reflected from the ocean floor (rather than the ocean surface or noise in the water column). The algorithm is unique in examining both the density of PEs …

Unh Faculty Senate Motion # Xxx-M5 Motion To Amend The Constitution For The Formation Of A Faculty Resources And Development Committee, Faculty Senate

Faculty Senate Motions

No abstract provided.

Faculty Senate Xxx 2025-2026 - December 8, 2025 Agenda, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

University Of New Hampshire 2025-2026 Faculty Senate Xxx - December 8, 2025 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Faculty Senate Xxx 2025-2026 - December 1, 2025 Agenda, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Fall 2025 Faculty Senate Newsletter, Faculty Senate

Faculty Senate Newsletter

No abstract provided.

Mechanistic Modeling Of Deformation Micromechanics In Commercially Pure Titanium Under Cyclic Bending To Post-Necking Regimes, Talukder Musfika Tasnim Oishi

Master's Theses and Capstones

This thesis investigates the deformation behavior of commercially pure titanium (CP–Ti) undercyclic bending under tension (CBT) through integrated experiments and multiscale modeling. Cyclic bending produces alternating tension and compression through the sheet thickness, delaying localization and enhancing ductility. Digital image correlation (DIC) measurements were used to quantify strain-path evolution and elongation-to-fracture (ETF). Finite-element simulations employing a continuum J2 plasticity model captured the macroscopic load–displacement response and width-dependent transition from uniaxial to plane-strain deformation. To incorporate micromechanical mechanisms, a dislocation-density-based crystal plasticity finite-element (CPFE) model with kinematic backstress was developed and calibrated using experimental data, accurately reproducing cyclic hardening and slip-system …

University Of New Hampshire 2025-2026 Faculty Senate Xxx - December 1, 2025 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Evolution Of Regulatory Pathways In Vibrio Fischeri Strains Impacts Biofilm Phenotypes And Symbiotic Capacity And Curriculum Interventions Differ In Their Impact On Microbiology Utility Value In Nursing Students, Jennifer Calawa

Doctoral Dissertations

Vibrio fischeri strains vary in their capacity to form mutualisms with animal hosts such as the Hawaiian bobtail squid Euprymna scolopes, yet these differences are often not explained by phylogeny. Successful colonization requires biofilm production, which is tightly controlled by a complex network of two-component system regulators including hybrid histidine kinases BinK and RemK, as characterized in the model symbiont strain ES114. Divergence in biofilm network architecture or regulatory logic may lead to strain-specific differences in biofilm formation, limiting symbiotic potential. Part I of this work investigates genetic divergence underlying reduced colonization capacity in strain H905, a planktonic isolate and …

Modular And Combined Particle Swarm Optimization Algorithms For Extraterrestrial Resource Prospecting, Gregory Hatfield

Master's Theses and Capstones

The success of future crewed and autonomous space missions hinges on effectively utilizing in-situ resources available in the extraterrestrial environment to sustain missions and habitation. Prior to extraction of resources, such missions will require robust and efficient methods for extraterrestrial resource prospecting. However, traditional global optimization techniques struggle with the complex and non-convex search spaces inherent to mapping and identifying resource deposits on extraterrestrial surfaces.

This research addresses the resource prospecting problem by developing and evaluating novel variants of the Particle Swarm Optimization (PSO). Here, four novel algorithms, their variants, and four combined algorithms are rigorously tested and confirmed. The …

Punitive Damages In Products Liability Revisited (1991-2024), Michael L. Rustad

The University of New Hampshire Law Review

No abstract provided.

The Skepticism Of Critical Legal Studies And The Function Of Moral Discourse, Paul J. Gudel

The University of New Hampshire Law Review

No abstract provided.

Floodings, Emilio R. Longoria

The University of New Hampshire Law Review

No abstract provided.

Faculty Senate Xxx 2025-2026 - November 10, 2025 Agenda, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

University Of New Hampshire 2025-2026 Faculty Senate Xxx - November 10, 2025 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

College For All And The Postsecondary Experiences Of Rural First-Generation College Students: Patterns Of Alignment With A Predominant Master Narrative, Andrew D. Coppens, Sarah Jusseaume, Jayson O. Seaman, Cindy L. Hartman, Erin H. Sharp

Faculty Publications

The aim of this study was to understand the experiences of rural, first-generation college (RFGC) students in relation to dominant culturally normative expectations about postsecondary educational and workforce trajectories. The study adopted patterns of engagement with a master narrative as both a conceptual framework and unit of analysis, examining both biography and cultural ecologies as well as highlighting agency in the lives and choices of study participants. Evidence is drawn from 4 in-depth narrative interviews with each of 14 RFGC students, conducted both at school and students’ homes, from rural and small-town communities. Results show that a master narrative of …