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Dust-Gas Dynamics Driven By The Streaming Instability With Various Pressure Gradients, Stanley Antedio Baronett May 2022

Dust-Gas Dynamics Driven By The Streaming Instability With Various Pressure Gradients, Stanley Antedio Baronett

UNLV Theses, Dissertations, Professional Papers, and Capstones

The radial pressure gradient (RPG), along the midplane of gaseous protoplanetary disks (PPD) – planetary nurseries – poses a severe obstacle to planet formation. Micron-sized dust grains, embedded in the disc, must quickly grow to kilometer-sized planetesimals – the building blocks of planets – before fatally drifting inwards, by RPG-induced gas drag, into a central host star. However, the RPG simultaneously powers one of the most robust processes to overcome this radial-drift barrier: the streaming instability (SI). Spontaneously triggered, the SI aerodynamically concentrates drifting dust via drag-induced, coupled interactions and feedback with the surrounding gas. In particular, the non-linear phase …

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Measuring Social Studies Teacher Self-Efficacy: Development Of A Valid, Reliable, And Fair Social Studies Self-Efficacy Scale, Leona Calkins May 2022

Measuring Social Studies Teacher Self-Efficacy: Development Of A Valid, Reliable, And Fair Social Studies Self-Efficacy Scale, Leona Calkins

UNLV Theses, Dissertations, Professional Papers, and Capstones

Social studies education provides unique opportunities for students to learn about the democratic process and, more importantly, how to engage in civic life to become active citizens. It is through meaningful social studies education that students are deliberately helped to understand the world, and are provided space to discuss, deliberate, and inquire about problems in the world, both past and present, and then learn how they can work to solve these problems (NCSS, 2013a; Parker, 2008). Considering the role of social studies education in helping develop active citizens, there has been a call for social studies teachers to provide instruction …

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Exploring Teachers’ Beliefs And Practices On Mathematical Discourse For Diverse Students In Inclusive Classrooms, Gloria A. Carcoba Falomir May 2022

Exploring Teachers’ Beliefs And Practices On Mathematical Discourse For Diverse Students In Inclusive Classrooms, Gloria A. Carcoba Falomir

UNLV Theses, Dissertations, Professional Papers, and Capstones

The recent implementation of rigorous standards in mathematics education has required shifts in classroom practices. Standards-based instruction places large emphasis on students’ conceptual understanding, requiring them to demonstrate high cognitive levels of mastery of the content through communication of their mathematical reasoning. Teachers and students’ mathematical discursive practices in the classroom can lead to meaningful discussions that integrate students’ explanation, justification, and arguments of ideas or claims and understanding of the content. Research on teachers’ discursive practices has shown that (a) teacher talk tends to dominate classroom instruction and (b) classroom discourse lacks frequent opportunities for teacher-student and peer interactions. …

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Towards Highly Sensitive Capacitance Measurements Of A Quantum Anomalous Hall Phase In Van Der Waal Heterostructures, Kayla Cerminara May 2022

Towards Highly Sensitive Capacitance Measurements Of A Quantum Anomalous Hall Phase In Van Der Waal Heterostructures, Kayla Cerminara

UNLV Theses, Dissertations, Professional Papers, and Capstones

One of the pioneering achievements in condensed matter physics of the 20th century is the observation of the quantum Hall e↵ect (QHE) in which the Hall resistance in a two-dimensional (2D) sample takes on quantized values in the presence of a strong perpendicular magnetic field. The precise quantization of the hall resistance to one part in a billion has provided a practical, worldwide resistance standard. A long-standing goal has been to realize a similar state of matter but without the need of a strong quantizing magnetic field. The quantum anomalous Hall e↵ect (QAHE) is such a state that is predicted …

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Examining The Attitudes Of Preservice Teachers Toward English Learners, Annie Chou May 2022

Examining The Attitudes Of Preservice Teachers Toward English Learners, Annie Chou

UNLV Theses, Dissertations, Professional Papers, and Capstones

The rapid growth of the K-12 English Learner (EL) student population in the United States raises concerns related to their learning and growth in schools. Teachers are central figures in their students’ achievement. The influence of teachers’ attitudes on student learning and development validates the need to examine these in research studies. What influences teachers’ attitudes is an important part of understanding teachers’ attitudes towards their EL students. Certain individual characteristics including teachers’ training, may be associated with their positive attitudes. Studies have shown that effective teacher preparation programs can change preservice teacher attitudes in general and specifically towards their …

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Built Environment, Land Use, And Crime: A Las Vegas Study, Stacey Lynn Clouse May 2022

Built Environment, Land Use, And Crime: A Las Vegas Study, Stacey Lynn Clouse

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study examined land use and crime against persons and crime against property in Las Vegas, Nevada at varying spatial levels of analysis. Using crime data provided by the Las Vegas Metropolitan Police Department and the Clark County Assessor’s office, results at the macro-level of analysis reveal that property crime rates concentrated on commercial, transportation, communication and utilities, and industrial land use, whereas violent crime concentrated at commercial, multi-residential, and civic, institutional, and recreational land use. Upon examining the subtypes of land use that generate or radiate more crime, property crime concentrated on transportation land use, class 1 resorts, and …

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Teaching Beliefs And Teaching Practices: A Sequential Mixed Methods Study Of Post-Secondary Mathematics Faculty, Katlyn K. Cox May 2022

Teaching Beliefs And Teaching Practices: A Sequential Mixed Methods Study Of Post-Secondary Mathematics Faculty, Katlyn K. Cox

UNLV Theses, Dissertations, Professional Papers, and Capstones

This mixed methods study explored the relationship between collegiate math instructors’ reported teaching practices, teaching beliefs, and actual teaching practices. Instructors reported their own teaching practices by survey. Qualitative participants were purposively sampled from the quantitative survey results. These qualitative participants presented their teaching beliefs through an initial interview. Afterward, actual teaching practices were confirmed through classroom observations. Lastly, instructors completed reflective interviews to address findings in the previously collected data.Through the survey instrument, this study established common teaching practices of collegiate math instructors. The study identified that on average the post-secondary math instructors in this sample employed between 26 …

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The Effects Of Winds On Accretion Disks And Spectra Of X-Ray Binaries And Active Galactic Nuclei, Shalini Ganguly May 2022

The Effects Of Winds On Accretion Disks And Spectra Of X-Ray Binaries And Active Galactic Nuclei, Shalini Ganguly

UNLV Theses, Dissertations, Professional Papers, and Capstones

Active galactic nuclei (AGNs) and X-ray binaries (XRBs) contain at their cores supermassive black holes (SMBH), and stellar mass black holes or neutron stars, respectively. These objects bind matter gravitationally, leading to the formation of accretion disks. The accretion of matter leads to efficient conversion of gravitational potential energy into radiation. When the force and/or energy imparted by this radiation on matter exceeds the attractive force due to the local gravitational field, it leads to the launching of matter in the form of outflows or winds. These outflows produce blueshifted (and occasionally redshifted) emission or absorption components in the spectra …

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The Effects Of Executive Function Between Anxiety And Math Achievement In Adolescents, Mckenzie Hall May 2022

The Effects Of Executive Function Between Anxiety And Math Achievement In Adolescents, Mckenzie Hall

UNLV Theses, Dissertations, Professional Papers, and Capstones

Anxiety in Children can develop into pervasive disorders in adulthood if not treated. Research shows dysfunctional Executive Function (EF) and anxiety are both shown to have a negative impact on math achievement in children and adolescents (Trezise & Reeve, 2018; Kalaycioglu, 2015; Owens, Stevenson, Hadwin & Norgate, 2012). Chung, Weyandt, and Swentosky (2014) found biological and neuropsychological support for EF as a unitary and multifaceted processor for regulating our emotional states as well as our daily procedures. Anderson’s (2002) model of Executive Control System (ECS) allows the factors of EF to be examined using a developmental approach towards EF processes. …

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The Dissolution And Recovery Of Critical Materials (Li2co3 And Uf6) From Ionic Liquid, Cassara Higgins May 2022

The Dissolution And Recovery Of Critical Materials (Li2co3 And Uf6) From Ionic Liquid, Cassara Higgins

UNLV Theses, Dissertations, Professional Papers, and Capstones

Lithium and uranium are critical materials in both the energy industry and for national security. Lithium is necessary for the next generation of batteries and 6Li is valuable for the production of tritium necessary for both fusion energy and to maintain our nuclear stockpiles. Uranium is a fuel source or precursor fuel source for commercially operating nuclear fission power. The monitoring of uranium hexafluoride (UF6) enrichment at foreign facilities is important for the monitoring of nuclear safeguards and enforcement of non-proliferation treaties. Recovery methods for lithium at the end of life of batteries are necessary to ensure abundance of the …

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A Survey Of The Br´Ezis-Nirenberg Problem And Related Theorems, Edward Huynh May 2022

A Survey Of The Br´Ezis-Nirenberg Problem And Related Theorems, Edward Huynh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Nonlinear elliptic partial differential equations on bounded domains arise in several different areas of mathematics that include geometry, mathematical physics, and the calculus of variations. The Br ́ezis-Nirenberg problem is concerned with a boundary-value problem that is intimately connected to the existence of positive solutions of the Yamabe problem, of non-minimal solutions to Yang-Mills functionals, and of extremal functions to several important inequalities. Results on existence and uniqueness have been obtained in cases when the exponent is sub-critical, but such results have not been obtained when the exponent is critical due to a lack of compactness. The earliest results obtained …

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Miocene Ichnofaunas And Mammalian Communities In The Great Basin Region, Nevada And California, Annmarie R. Jones May 2022

Miocene Ichnofaunas And Mammalian Communities In The Great Basin Region, Nevada And California, Annmarie R. Jones

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this dissertation is to document and interpret three new ichnofaunas and two fossil assemblages from the Neogene of Nevada and California. Ichnofossils are important for understanding behavior and geographical range of animals in the distant past and are key to locating and preserving sensitive material for future studies. I examined ichnofauna at three localities: two within the Mio-Pliocene Muddy Creek Formation of Nevada, and one within the Miocene China Ranch Beds of California. My research focuses primarily on (1) camelid and ursid ichnotaxa and how these new localities help in understanding the evolutionary history of these taxa …

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Modeling And Analysis Of Subcellular Protein Localization In Hyper-Dimensional Fluorescent Microscopy Images Using Deep Learning Methods, Yang Jiao May 2022

Modeling And Analysis Of Subcellular Protein Localization In Hyper-Dimensional Fluorescent Microscopy Images Using Deep Learning Methods, Yang Jiao

UNLV Theses, Dissertations, Professional Papers, and Capstones

Hyper-dimensional images are informative and become increasingly common in biomedical research. However, the machine learning methods of studying and processing the hyper-dimensional images are underdeveloped. Most of the methods only model the mapping functions between input and output by focusing on the spatial relationship, whereas neglect the temporal and causal relationships. In many cases, the spatial, temporal, and causal relationships are correlated and become a relationship complex. Therefore, only modeling the spatial relationship may result in inaccurate mapping function modeling and lead to undesired output. Despite the importance, there are multiple challenges on modeling the relationship complex, including the model …

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A Multiple Case Study: Exploration Of The Writing Instruction Practices Of Veteran High School English Teachers, Victoria Lindemann May 2022

A Multiple Case Study: Exploration Of The Writing Instruction Practices Of Veteran High School English Teachers, Victoria Lindemann

UNLV Theses, Dissertations, Professional Papers, and Capstones

The gift of literacy can be the greatest equalizer in a society or used as a weapon to marginalize. As writing instructors, it should be our job to help our students find their voice – to give voice to the voiceless (Friere, 1970). More research must uncover the influences beyond the classroom and how those influences inform veteran teachers’ decisions about their writing practices and instructional designs, specifically on how teachers engage students in writing. It is the writing of our thoughts and ideas that shares a piece of ourselves with the world around us.This study explored how experienced English …

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Effects Of Distributed Energy Resources On The Bulk Electric System, Stryder Loveday May 2022

Effects Of Distributed Energy Resources On The Bulk Electric System, Stryder Loveday

UNLV Theses, Dissertations, Professional Papers, and Capstones

The traditional power grid was designed with a centralized resource distribution in mind, with a relatively small number of large power generation facilities supplying the vast majority of load. With recent efforts to further diversify the power grid as well as an increased interest in renewable energy sources, there has been an unprecedented amount of new DistributedEnergy Resources (DERs) added to the grid within the last decade. This often heavily influences the local demand where these resources are installed, often causing power to flow in ways not anticipated by the original design of the grid. This thesis reviews the potential …

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Revisiting The Chemistry Of Uranium And Rhenium Fluorides: Implication To Fuel Cycle And Nuclear Forensics Science, James Amos-Aimé Louis-Jean May 2022

Revisiting The Chemistry Of Uranium And Rhenium Fluorides: Implication To Fuel Cycle And Nuclear Forensics Science, James Amos-Aimé Louis-Jean

UNLV Theses, Dissertations, Professional Papers, and Capstones

Fluorine plays a major role in the nuclear industry where F2(g) and HF(g) are critical to the preparation of UF6 and UF4. These materials are prepared for uranium enrichment to increase the isotopic concentration of 235U. During separation efforts, the isotope 99Tc (a high yield fission product, 6.1% from 235U) is extracted along with uranium and can be converted to binary technetium fluorides (i.e., TcF4, TcF6) during re-enrichment of used uranium material. This provides a route for 99Tc to reenter the reactor environment and affect the nuclear properties of fuel pellets made with reprocessed uranium. The objective of this work …

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Is Dietary Teaching Via Telehealth Effective In Lowering Hgba1c In Adult Patients With Prediabetes Or Type 2 Diabetes?, Mia Mccallum-Crawford May 2022

Is Dietary Teaching Via Telehealth Effective In Lowering Hgba1c In Adult Patients With Prediabetes Or Type 2 Diabetes?, Mia Mccallum-Crawford

UNLV Theses, Dissertations, Professional Papers, and Capstones

Prediabetes and Type 2 diabetes mellitus (T2DM) are two common conditions diagnosed in the primary care setting. Both conditions benefit from a healthy lifestyle, managing blood sugar levels, and getting diabetes self-management education and support (DSMES). Within the past two decades, the healthcare community in the US has witnessed a substantial rise in diabetes among adults. Overall, the self-management of diabetes continues to worsen nationally. The purpose of this project is to improve patients’ self-management of both Prediabetes and T2DM through nutrition and show how nutritional counseling via telehealth provided by a nurse practitioner can improve HgbA1C values over 3 …

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Viability Of Energy And Fuel Sources For Interstellar Travel; Design And Feasibility Of The Construction Of Manned Interstellar Space Shuttles, Lukas Mittelman May 2022

Viability Of Energy And Fuel Sources For Interstellar Travel; Design And Feasibility Of The Construction Of Manned Interstellar Space Shuttles, Lukas Mittelman

UNLV Theses, Dissertations, Professional Papers, and Capstones

The importance of proving the viability of interstellar transport and addressing its potential hazards and pitfalls is immense. If we do not look toward the future and examine what could be waiting for us, we are doing our children, our children’s children, and so on, a disservice. Here we must attempt to lay the groundwork for our future scientists, engineers, and adventurers. Asking and answering questions like, which propulsion and energy systems must we incorporate to send us through the cosmos? Will we utilize technologies known today, such as fossil fuel rockets, fission or fusion rockets, and antimatter drives (pion …

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Student-Athletes’ Career Adaptability, Academic Motivation And Athletic Motivation, Alexandria N. Petrolia May 2022

Student-Athletes’ Career Adaptability, Academic Motivation And Athletic Motivation, Alexandria N. Petrolia

UNLV Theses, Dissertations, Professional Papers, and Capstones

Many Division I student-athletes find the transition of graduating college, leaving the athletic arena, and entering the workforce to be extremely challenging to navigate. Due to the high demands of being an elite athlete and the prospect of continuing to compete professionally after graduation, an overwhelming majority of student-athletes expend little to no effort in exploring potential careers and are unlikely to take advantage of the opportunities available to them prior to graduation. This study aimed to examine the relationship between athletic career motivation, athletic motivation, and academic motivation to the skills necessary to navigate work responsibilities in career adaptability. …

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Characterization Of Physical And Dosimetric Aspects Of Srs Hyperarc Treatment Technique, Emma S. Rickels May 2022

Characterization Of Physical And Dosimetric Aspects Of Srs Hyperarc Treatment Technique, Emma S. Rickels

UNLV Theses, Dissertations, Professional Papers, and Capstones

HyperArc is a radiation therapy planning technique using stereotactic radiosurgical doses delivered via single isocenter volumetric modulated arcs (VMAT) for multi-lesion brain cancer. Due to the nature of these types of treatments it is imperative that the proper quality assurance is completed to ensure the safety of the patient. Geometric limits were assessed using a dose volume histogram (DVH) and known rotational errors of theoretical lesions of different dimensions and lengths from the isocenter. Dosimetric comparisons were evaluated using an ion chamber and Gafchromic EBT-XD film and portal dosimetry. The conclusions from these investigations were that patient rotation will result …

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New Mathematical Models For Acoustic Insertion Loss Of Fiberglass Lining In Hvac Duct, Michael Anthony Schwob May 2022

New Mathematical Models For Acoustic Insertion Loss Of Fiberglass Lining In Hvac Duct, Michael Anthony Schwob

UNLV Theses, Dissertations, Professional Papers, and Capstones

The design objectives for HVAC air distribution systems are thermal comfort, good indoor air quality, energy efficiency, low construction cost, and appropriate indoor noise levels. The last objective requires that the designer can predict the attenuation of sound transmitted through an air duct. One form of attenuation commonly introduced to an air distribution system to achieve interior noise criteria is fiberglass liner. Past research has been conducted to obtain reliable and accurate insertion loss (IL) data for duct with fiberglass liner. Empirical efforts have relied on limited data sets. Computational efforts have produced numerical models that are not practical for …

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Math Identity Experience Of College Students In Developmental Courses: The Effects Of Chronological Multicultural Mathematics, Jonah Shulman May 2022

Math Identity Experience Of College Students In Developmental Courses: The Effects Of Chronological Multicultural Mathematics, Jonah Shulman

UNLV Theses, Dissertations, Professional Papers, and Capstones

The present grant funded study by the Office of Research and Sponsored Projects investigated the effects of a chronological multicultural mathematics (CMM) framework on math identity and math achievement of student participants enrolled in two virtual post-secondary developmental math courses (N=9). The students were selected due to an inability to pass previous developmental courses or the placement exam to earn entrance into credit bearing math courses. An exploratory mixed methods case study utilized interviews, reflections, surveys, classwork, and grades to arrive at conclusions. Student participants were exposed to supplemental additions to the curriculum that provided elements of past (founders and …

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An Empirical Investigation Into The Impact Of Automated Grading, Alex James St. Aubin May 2022

An Empirical Investigation Into The Impact Of Automated Grading, Alex James St. Aubin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Context: Computer Science enrollment has seen increases in recent years. At the University of Nevada, Las Vegas we have seen an average year to year growth rate of 17.33% in the spring and 13.71% in the fall over the past 10 years in our entry level programming course. These enrollment increases have led to considerable additional costs for grading course material.Objective: The goal of this study is to determine the impact of automatic grading systems on students. If automatic grading is at least as effective as manual grading in practice, it may reduce cost under the context of at least …

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Tracing The Shadows Of Gothic Bach: An Overview Of J.S. Bach’S Keyboard Music In American Horror Films, Siyu Yang May 2022

Tracing The Shadows Of Gothic Bach: An Overview Of J.S. Bach’S Keyboard Music In American Horror Films, Siyu Yang

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Toccata and Fugue in D Minor, BWV 565, and the Goldberg Variations, BWV 988, have been by far the most prominent of J.S. Bach’s works to evoke evil and horror on screen. This “Horror Bach” association remains exclusively a subculture phenomenon in pop culture (almost universally outside of the classical music world). A historical overview of this cultural phenomenon suggests three factors that made these pieces become horror film music: 1) the popularity of the pieces, 2) the choice of instrumentation, and 3) popular cultural factors. This doctoral document also introduces this pop culture phenomenon of Bach to classical …

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A Development Of A Game-Theoretic Artificially Intelligent Neural Network Revenue Management Forecasting Model, Fatemeh Binesh May 2022

A Development Of A Game-Theoretic Artificially Intelligent Neural Network Revenue Management Forecasting Model, Fatemeh Binesh

UNLV Theses, Dissertations, Professional Papers, and Capstones

The aim of this dissertation is to create and test a risk induced game-theoretic price forecasting model. The models were tested with datasets from 3 Upper Midscale hotels in 3 locations (urban, interstate and suburb), one hotel from each location. The data was obtained from STR, a leading hospitality marketing company which consolidates all of the daily hotel data from hotels in the United States. Multiple error measures were used to compare the accuracy of models. Three LSTM models were proposed and tested; LSTM model 1 that relied on ADR to forecast ADR, LSTM model 2 that used ADR, supply, …

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Terrestrial Planet Formation In M-Dwarf And Binary Star Systems, Anna C. Childs May 2022

Terrestrial Planet Formation In M-Dwarf And Binary Star Systems, Anna C. Childs

UNLV Theses, Dissertations, Professional Papers, and Capstones

I examine circumbinary terrestrial planet formation in a gas free environment around various binary systems and terrestrial planet formation in a gaseous environment around M-dwarfs. While terrestrial cirumbinary planets have yet to be observed, this is likely due to observational bias. Motivated by recent observations of highly misaligned circumbinary gas disks, I perform a suite of n-body studies to understand the properties of terrestrial planets around various binary systems. In a polar alignment, a circumbinary disk is inclined by 90 degrees relative to the binary orbital plane. I find that terrestrial planet formation in a polar configuration may be as …

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Positive Solutions To Semilinear Elliptic Equations With Logistic-Type Nonlinearities And Harvesting In Exterior Domains, Eric Jameson May 2022

Positive Solutions To Semilinear Elliptic Equations With Logistic-Type Nonlinearities And Harvesting In Exterior Domains, Eric Jameson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Existing results provide the existence of positive solutions to a class of semilinear elliptic PDEs with logistic-type nonlinearities and harvesting terms both in RN and in bounded domains U ⊂ RN with N ≥ 3, when the carrying capacity of the environment is not constant. We consider these same equations in the exterior domain Ω, defined as the complement of the closed unit ball in RN , N ≥ 3, now with a Dirichlet boundary condition. We first show that the existing techniques forsolving these equations in the whole space RN can be applied to the exterior domain with some …

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Quality Assurance Procedures Implementation For Varian Truebeam, Yongquan Jiang May 2022

Quality Assurance Procedures Implementation For Varian Truebeam, Yongquan Jiang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Department of radiation oncology of Oncology Nevada updated its linear accelerator (LINAC) from Varian Clinac iX to a newer model known as Varian TrueBeam. The Varian TrueBeam LINAC includes 6x, 6xFFF (i.e., 6x without flattening filter known as flattening filter free), 10x, 10xFFF, 15x photon beams and 6e, 9e, 12e MeV electron beams. This system is also equipped with a 6 degree of freedom (DOF) couch, RapidArc, kV on board imager, MV portal imager and Cone Beam CT (CBCT) imaging. This system allows the clinical delivery of modern image guided radiation therapy (IGRT) modalities such as IMRT/VMAT, and SRS/SRT/SBRT. The …

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A Wearable Electronic Monitoring Device For Low Pressure Garment Applications And Temperature Analysis For Prevention Of Ulceration And Infection, Francisco Mata Carlos May 2022

A Wearable Electronic Monitoring Device For Low Pressure Garment Applications And Temperature Analysis For Prevention Of Ulceration And Infection, Francisco Mata Carlos

UNLV Theses, Dissertations, Professional Papers, and Capstones

The healing process of several medical conditions related to venous insufficiency and burn scar management can be improved by the proper application of pressure. Current practices for applying pressure to an extremity do not guarantee the consensus ideal interface pressures for such medical conditions. Applying a low pressure range (within 15 – 40 mm Hg) is challenging due to many factors, but especially because the actual pressure applied by a compression garment used on a patient is unknown. The proposed device, used to sense and display low pressure values, is described in detail throughout the chapters of this thesis.An electronic …

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An Educational Intervention In The Emergency Department For Adults Experiencing Vaso-Occlusive Crisis, Chericka S. Reese-Martin May 2022

An Educational Intervention In The Emergency Department For Adults Experiencing Vaso-Occlusive Crisis, Chericka S. Reese-Martin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Sickle cell anemia, often referred to as sickle cell disease (SCD), is an inherited blood disorder that affects millions of people globally and affects more than 100,000 Americans, mostly of African or Hispanic descent. The SCD arises from a genetic defect that alters the structure of hemoglobin. The modified hemoglobin causes red blood cells (RBCs) to become stiff, sticky, and sickle shaped. These deformed RBCs block blood flow, cause severe pain, organ and joint damage and strokes. The sickled cells do not deliver oxygen to organs and tissues as healthy cells do, causing slow, inevitable damage over decades and …

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