Digital Commons Network^™

Homeobox Transcription Factor Hbxa Influences Expression Of Over One Thousand Genes In The Model Fungus Aspergillus Nidulans, Sandesh S. Pandit, Jinfang Zheng, Yanbin Yan, Sophie Lorber, Olivier Puel, Sourabh Dhingra, Eduardo A. Espeso, Ana M. Calvo

Food for Health: Publications

In fungi, conserved homeobox-domain proteins are transcriptional regulators governing development. In Aspergillus species, several homeobox-domain transcription factor genes have been identified, among them, hbxA/hbx1. For instance, in the opportunistic human pathogen Aspergillus fumigatus, hbxA is involved in conidial production and germination, as well as virulence and secondary metabolism, including production of fumigaclavines, fumiquinazolines, and chaetominine. In the agriculturally important fungus Aspergillus flavus, disruption of hbx1 results in fluffy aconidial colonies unable to produce sclerotia. hbx1 also regulates production of aflatoxins, cyclopiazonic acid and aflatrem. Furthermore, transcriptome studies revealed that hbx1 has a broad effect on …

Preclinical Characterization Of The Efficacy And Safety Of Biologic N‑001 As A Novel Pain Analgesic For Post‑Operative Acute Pain Treatment, Derek Allen, Samerender Nagam Hanumantharao, Rylie Mcdonell, Karen‑Amanda Irvine, Peyman Sahbaie, David Clark, Paul H. Blum

School of Biological Sciences: Faculty Publications

Inhibition of actin remodeling in nerves modulates action potential propagation and therefore could be used to treat acute pain. N-001 is a novel protein analgesic engineered from several C. Botulinum toxins. N-001 targets sensory neurons through ganglioside GT1b binding and ADP-ribosylates G-actin reducing actin remodeling. The activity and efficacy of N-001 was evaluated previously in vitro and in a mouse inflammatory pain model. To assess the relevance of N-001 for treatment of acute post-surgical pain, the current study evaluated the efficacy of N-001 in a mouse hind-paw incision model by periincisional and popliteal nerve block administration combined with mechanical …

Homeobox Transcription Factor Hbxa Influences Expression Of Over One Thousand Genes In The Model Fungus Aspergillus Nidulans, Sandesh S. Pandit, Jinfang Zheng, Yanbin Yin, Sophie Lorber, Olivier Puel, Sourabh Dhingra, Eduardo A. Espeso, Ana M. Calvo

Department of Nutrition and Health Sciences: Faculty Publications

In fungi, conserved homeobox-domain proteins are transcriptional regulators governing development. In Aspergillus species, several homeobox-domain transcription factor genes have been identified, among them, hbxA/hbx1. For instance, in the opportunistic human pathogen Aspergillus fumigatus, hbxA is involved in conidial production and germination, as well as virulence and secondary metabolism, including production of fumigaclavines, fumiquinazolines, and chaetominine. In the agriculturally important fungus Aspergillus flavus, disruption of hbx1 results in fluffy aconidial colonies unable to produce sclerotia. hbx1 also regulates production of aflatoxins, cyclopiazonic acid and aflatrem. Furthermore, transcriptome studies revealed that hbx1 has a broad effect on the A. flavus …

Editorial: Rising Stars In Microbial Physiology And Metabolism: 2022, Nicole R. Buan, Ulrike Kappler

Department of Biochemistry: Faculty Publications

This Research Topic was initiated to highlight work by young authors, the rising stars in the field of microbial physiology and metabolism. Microbial physiology and metabolism is an interdisciplinary field of research that seeks to uncover how the metabolic pathways of a cell work together to determine cell fate and function, whether that be growth, replication, pathogenicity, predation, respiration and fermentation, homeostasis or death. Ultimately, researchers like the ones featured here seek to integrate biological information and physicochemical parameters to try to find the underlying rules governing microbial function so that we can understand, predict and design microbes and microbial …

Role Of Biotechnology In Creating Sustainable Agriculture, Saurav Das, Manjit Kumar Ray, Dinesh Panday, Piyush Kumar Mishra

Department of Agronomy and Horticulture: Faculty Publications

This narrative review paper discusses the role of biotechnology in the development of sustainable agriculture. The paper begins by defning sustanability and highlights the importance of biotechnology in establishing sustainable agriculture. Sustainable agriculture is an approach that prioritizes meeting current food and fiber production needs while conserving and enhancing natural resources for future generations. To achieve agricultural sustainability, it is necessary to strike a balance between economic viability, environmental stewardship, and social responsibility. This can be difficult, especially in the face of biotic and abiotic stresses such as pests, diseases, climate change, soil degradation, and water depletion. The prevalence of …

Negative Impact Of Chronic Pandemic-Specific Financial Stress On Food Security Among College Students, Julia N. Soulakova,, Lisa J. Crockett, Mary Schmidt-Owens, Eric W. Schrimshaw

Department of Psychology: Faculty Publications

Since the pandemic started, food insecurity has become a more serious issue for U.S. college students. The study goals were to evaluate whether pandemic-specific stress contributes to current food insecurity (as of February–March of 2022) and to determine which student characteristics are associated with food insecurity. We used the 2022 Spring American College Health Association— National College Health Assessment data (n = 620) collected at a public university. We estimated two multiple logistic regression models. The odds of having very low food security (OR = 8.65, 95% CI = 4.84:15.43) and low food security (OR = 2.87, 95% CI …

Sesame Eliciting And Safe Doses In A Large Sesame Allergic Population, Liat Nachshon, Joost Westerhout, W. Marty Blom, Benjamin Remington, Michael B. Levy, Michael R. Goldberg, Naama Epstein-Rigbi, Yitzhak Katz, Arnon Elizur

Department of Nutrition and Health Sciences: Faculty Publications

Background: Sesame is a significant food allergen causing severe and even fatal reactions. Given its increasing prevalence in western diet, sesame is listed as an allergenic food requiring labeling in the United States and EU. However, data on the population reaction doses to sesame are limited.

Methods: All sesame oral food challenges (OFCs), performed either for diagnosis or for threshold identification before the beginning of sesame oral immunotherapy (OIT) between November 2011 and July 2021 in Shamir medical center were analyzed for reaction threshold distribution. Safe-dose challenges with 90–120 min intervals were also analyzed.

Results: Two hundred …

Effects Of Feeding A Vitamin And Mineral Supplement To Cow-Calf Pairs Grazing Native Range, Jennifer L. Hurlbert, Friederike Baumgaertner, Kacie L. Mccathy, Timothy Long, Cody Wieland, Kevin K. Sedivec, Carl R. Dahlen

Department of Animal Science: Faculty Publications

Our objectives were to evaluate the impacts of providing vitamin and mineral (VTM) supplements to cow-calf pairs during the summer grazing period on cow and calf performance and liver concentrations of minerals. During a two-year period, 727 crossbred cows and their calves (initial cow BW = 601.7 ± 48.1 kg; calf BW = 87.8 ± 5.0 kg; n = 381 in year 1, n = 346 in year 2) from the Central Grasslands Research Extension Center (Streeter, N.D.) were blocked by parity (young [parity 1 to 3], and old [parity 4+]) and randomly assigned to pastures at the beginning …

Genotype By Environment Interaction And Heteroscedasticity Influence The Expression Of Parasite Resistance In Katahdin Sheep, Brian C. Arisman, Joan M. Burke, James L. M. Morgan, Ronald M. Lewis

Department of Animal Science: Faculty Publications

Increasingly, sheep producers are choosing breeds that express resistance to gastrointestinal parasites due to reduced efficacy of anthelminthic drugs. One such breed is Katahdin. Katahdins are raised in various climates and management systems in the United States, which can be combined into eco-management clusters to describe production environments more holistically. The objectives of this study were to determine if genotype by environment interaction (G × E) and heteroscedasticity existed across these eco-management clusters for traits indicative of parasite resistance. Body weights (BW), FAMACHA scores (FAM), and fecal egg counts (FEC) were collected at around 90 d in 3,527 Katahdin lambs …

Assessment Of The Immune Response In Patients With Insulin Resistance, Obesity, And Diabetes To Covid-19 Vaccination, Jędrzej Warpechowski, Paula Leszczyńska, Dominika Juchnicka, Adam Olichwier, Łukasz Szczerbiński, Adam Jacek Krętowski

Department of Nutrition and Health Sciences: Faculty Publications

The SARS-CoV-19 pandemic overwhelmed multiple healthcare systems across the world. Patients with underlying medical conditions such as obesity or diabetes were particularly vulnerable, had more severe symptoms, and were more frequently hospitalized. To date, there have been many studies on the severity of SARS-CoV-2 in patients with metabolic disorders, but data on the efficiency of vaccines against COVID-19 are still limited. This paper aims to provide a comprehensive overview of the effectiveness of COVID-19 vaccines in individuals with diabetes, insulin resistance, and obesity. A comparison is made between the immune response after vaccination in patients with and without metabolic comorbidities. …

Estimating Body Weight And Body Condition Score Of Mature Beef Cows Using Depth Images, Yijie Xiong, Isabella C.F.S. Condotta, J. A. Musgrave, Tami M. Brown-Bandl, J. Travis Mulliniks

Department of Animal Science: Faculty Publications

Obtaining accurate body weight (BW) is crucial for management decisions yet can be a challenge for cow–calf producers. Fast-evolving technologies such as depth sensing have been identified as low-cost sensors for agricultural applications but have not been widely validated for U.S. beef cattle. This study aimed to (1) estimate the body volume of mature beef cows from depth images, (2) quantify BW and metabolic weight (MBW) from image-projected body volume, and (3) classify body condition scores (BCS) from image-obtained measurements using a machine-learning-based approach. Fifty-eight crossbred cows with a mean BW of 410.0 ± 60.3 kg and were between 4 …

Studies Of The Role Of Mtorc1 In Modulating Intestinal Epithelial Barrier Function, Isaac Adediji

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Mechanistic target of rapamycin complex 1 (mTORC1) signaling impacts intestinal inflammation by modulating the production of cytokines in both intestinal epithelial cells and macrophages. Recent evidence revealed that THP-1-derived macrophages with elevated mTORC1 activity (THP-1shTSC2 macrophages), exhibited increased proinflammatory cytokine production when stimulated with lipopolysaccharide (LPS) compared to counterpart macrophages with repressed or baseline mTORC1 activity. Furthermore, it has been shown that mTORC1 governs intestinal barrier function as evidenced by elevated transepithelial electrical resistance (TEER) and para/transcellular permeability in Raptor-depleted Caco-2 cells (cells with repressed mTORC1 activity) compared to Caco-2 cells with elevated or baseline mTORC1 activity. The present study …

The Effect Of Genetic Taste Status On Swallowing: A Literature Review, Theresa S. Lee, Angela M. Dietsch, Rana H. Damra, Rachel W. Mulheren

Department of Special Education and Communication Disorders: Faculty Publications

Purpose

Swallowing and taste share innervation pathways and are crucial to nutritive intake. Individuals vary in their perception of taste due to factors such as genetics; however, it is unclear to what extent genetic taste status influences swallowing physiology and function. The purpose of this review article is to provide background on genetic taste status, review the evidence on the association between genetic taste status and swallowing, and discuss research and clinical implications.

Method

A comprehensive literature review was conducted using search terms related to swallowing and genetic taste status. Studies were included if they investigated the main effect of …

Effect Of Supplementation Prior To Artificial Insemination And During Gestation In Beef Females, Landon Folsom Tadich

Department of Animal Science: Dissertations, Theses, and Student Research

Objectives of Experiment 1 was to evaluate the impact of increased energy prior to AI on BW, ADG, and reproductive efficiency in heifers developed on range or in a dry lot. During the winter development period (131 ± 3.5 d/yr) heifers (n = 100/yr) were assigned to either upland range (RANGE) or fed a dry lot diet in two pens that either remained constant (DLLO) or increased in energy prior to AI (DLHI). Heifers developed on RANGE grazed upland winter range until 38 d prior to AI where they then received the DLLO diet. Pre-breeding BW was greater ( …

Mid-Gestation Maternofetal Inflammation Impacts Growth, Skeletal Muscle Glucose Metabolism, And Inflammatory Tone In The Ovine Fetus During Late Gestation, Zena Mariah Hicks

Department of Animal Science: Dissertations, Theses, and Student Research

Our 1^st and 2^nd studies assessed the impact of mid-gestation maternofetal inflammation on growth, skeletal muscle glucose metabolism, and inflammatory tone in the late gestation ovine fetus. The objective was to determine if inducing maternofetal inflammation during peak placental growth would lead to more profound IUGR characteristics in the fetus. MI-IUGR fetuses exhibited reduced body and skeletal muscle weights and hallmark asymmetric growth at late gestations. Fetuses had higher baseline glucose:insulin ratios and reduced glucose-stimulated insulin secretion. Moreover, hindlimb glucose oxidation was impaired independent of glucose uptake. Skeletal muscle specific glucose uptake and oxidation was reduced in MI-IUGR …

Contextualizing The Neural Vulnerabilities Model Of Obesity, Timothy D. Nelson, Eric Stice

Department of Psychology: Faculty Publications

In recent years, investigators have focused on neural vulnerability factors that increase the risk of unhealthy weight gain, which has provided a useful organizing structure for obesity neuroscience research. However, this framework, and much of the research it has informed, has given limited attention to contextual factors that may interact with key vulnerabilities to impact eating behaviors and weight gain. To fill this gap, we propose a Contextualized Neural Vulnerabilities Model of Obesity, extending the existing theory to more intentionally incorporate contextual factors that are hypothesized to interact with neural vulnerabilities in shaping eating behaviors and weight trajectories. We …

Tillage, Green Manuring And Crop Residue Management Impacts On Crop Productivity, Potassium Use Efficiency And Potassium Fractions Under Rice-Wheat System, Sandeep Sharma, Pritpal Singh, Hayssam M. Ali, Manzer Hussain Siddiqui, Javed Iqbal

Department of Agronomy and Horticulture: Faculty Publications

The conventional crop production practices including intensive tillage and open field crop residue burning in world’ largest rice-wheat system (RWS) are adversely affecting crop productivity besides deteriorating natural resources and ecosystems’ sustainability. In order to improve system productivity, potassium (K) use efficiency and apparent K balance, adoption of conservation tillage in a RWS with residue management is considered highly effective. We therefore, studied the effect of wheat straw retention and green manure (GM) in rice (main plot treatment), and tillage and rice residue management in subsequent wheat (sub-plot treatments) on crop productivity, K use efficiency and its transformation amongst different …

Equine Nutrition: Pasture Planning In Nebraska, Emma Vazquez

Honors Program: Senior Projects (Public)

This paper describes the rationale behind four infographics on equine nutrition and pasture planning. These infographics are intended to provide Nebraskan horse owners with general advice on setting up and maintaining their pastures. The first three infographics cover pasture basics when building, pasture care, and ideal grass types. These grass types are further broken down between Western and Eastern Nebraska. Additionally, the fourth infographic gives some insight into why forage is a staple in the equine diet based on the digestive system.

All four infographics have been posted to the University of Nebraska-Lincoln’s Horse Program social media pages in an …

Convergence And Transdisciplinary Teaching In Quantitative Biology, Robert Mayes, Joseph Dauer, David Owens

School of Natural Resources: Faculty Publications

The United States National Science and Technology Council has made a call for improving STEM (Science, Technology, Engineering, and Mathematics) education at the convergence of science, technology, engineering, and mathematics. The National Science Foundation (NSF) views convergence as the merging of ideas, approaches, and technologies from widely diverse fields of knowledge to stimulate innovation and discovery. Teaching convergency requires moving to the transdisciplinary level of integration where there is deep integration of skills, disciplines, and knowledge to solve a challenging real-world problem. Here we present a summary on convergence and transdisciplinary teaching. We then provide examples of convergence and transdisciplinary …

Arthropod Diversity In Phytotelmata Of Calathea Capitata (Zingiberales; Marantaceae) Host Plants From Peru, Divya Dendi, Timo Förster, Caroline S. Chaboo

Department of Entomology: Faculty Publications

Cryptic habitats are often overlooked in biodiversity surveys. Phytotelmata, or plant pools, are one type of cryptic habitat that supports diverse fauna in a miniature ecosystem. This study surveys the arthropod community of two types of phytotelmata, bracts and leaf rolls, on a single species, Calathea capitata (Ruiz and Pav.) Lindl. (Zingiberales: Marantaceae), from one Amazon site in Peru. Specimens were collected from eight bracts and eight leaf rolls. A total of 55 arthropods (36 adults, 19 juveniles) were found in both phytotelmata types. In the bract samples were found: spiders (Araneae: Corinnidae), beetles (Coleoptera: Carabidae, Erotylidae, Staphylindae), flies (Diptera: …

First Things First: Widespread Nutrient Deficiencies Limit Yields In Smallholder Oil Palm Fields, Hendra Sugianto, Juan Pablo Monzon, Iput Pradiko, Fatima A. Tenorio, Ya Li Lim, Christopher R. Donough, Sunawan, Suroso Rahutomo, Fahmuddin Agus, James Cock, Joni Amsar, Rana Farrasati, Ridho Iskandar, Juan I. Rattalino Edreira, Shofia Saleh, Heri Santoso, Antonius P. Tito, Nadib Ulfaria, Maja A. Slingerland, Patricio Grassini

Department of Agronomy and Horticulture: Faculty Publications

CONTEXT: Indonesia is the most important oil palm producing country. Nearly 40% of planted area is managed by smallholders, with yields well below the potential. Efforts to increase productivity have focused on the source of planting material, with little attention paid to plant nutrition.

OBJECTIVE: To assess the degree to which current productivity in smallholder oil palm fields is limited by nutrients in scenarios with distinct sources of planting material.

METHODS: We collected detailed data on leaf nutrient concentration from 30 fields to derive minimum sampling size needed to diagnose nutrient status. Subsequently, we collected data on …

Wildlife Ecological Risk Assessment In The 21st Century: Promising Technologies To Assess Toxicological Effects, Barnett A. Rattner, Thomas G. Bean, Val R. Beasley, Philippe Berny, Karen M. Eisenreich, John E. Elliott, Margaret L. Eng, Phyllis C. Fuchsman, Mason D. King, Rafael Mateo, Carolyn B. Meyer, Jason M. O'Brien, Christopher J. Salice

United States Geological Survey: Staff Publications

Despite advances in toxicity testing and the development of new approach methodologies (NAMs) for hazard assessment, the ecological risk assessment (ERA) framework for terrestrial wildlife (i.e., air‐breathing amphibians, reptiles, birds, and mammals) has remained unchanged for decades. While survival, growth, and reproductive endpoints derived from whole-animal toxicity tests are central to hazard assessment, nonstandard measures of biological effects at multiple levels of biological organization (e.g., molecular, cellular, tissue, organ, organism, population, community, ecosystem) have the potential to enhance the relevance of prospective and retrospective wildlife ERAs. Other factors (e.g., indirect effects of contaminants on food supplies and infectious disease processes) …

Biological Case Against Downlisting The Whooping Crane And For Improving Implementation Under The Endangered Species Act, Andrew J. Caven, Hillary L. Thompson, David M. Baasch, Barry K. Hartup, Amanda M. Hegg, Stephanie M. Schmidt, Irvin Louque, Craig R. Allen, Carter G. Crouch, Craig A. Davis, Joel G. Jorgensen, Jane E. Austin, Bethany L. Ostrom, Richard D. Beilfuss, George W. Archibald, Anne E. Lacy

School of Natural Resources: Faculty Publications

The Whooping Crane (Grus americana; WHCR) is a large, long-lived bird endemic to North America. The remnant population migrates between Aransas National Wildlife Refuge, USA, and Wood Buffalo National Park, Canada (AWBP), and has recovered from a nadir of 15-16 birds in 1941 to ~540 birds in 2022. Two ongoing reintroduction efforts in Louisiana and the Eastern Flyway together total ~150 birds. Evidence indicates the U.S. Fish and Wildlife Service (USFWS) is strongly considering downlisting the species from an endangered to a threatened status under the Endangered Species Act (ESA). We examined the current status of the WHCR through the …

Students’ Knowledge Of And Attitudes Toward Dairy Production: A Survey Methodology Report, Heather Akin, Babatope Akinyemi, Julia Mcquillan, Tami Brown-Brandl

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

This report presents findings from a pilot survey conducted among undergraduate and graduate students (N = 410) at the University of Nebraska-Lincoln about students’ perspectives on technology usage, consumption, and sustainability in dairy production systems. An interdisciplinary research team developed the survey instrument and report. The main purpose of this pilot study was to create and administer survey items to support further research on experiential education and outreach opportunities related to robotics in small-scale dairy production and rural economic development. Descriptive findings indicated that most students had some familiarity with dairy production and the nutritional aspects of dairy products …

Potassium Ion Channels As A Molecular Target To Reduce Virus Infection And Mortality Of Honey Bee Colonies, Christopher J. Fellows, Michael Simone‑Finstrom, Troy D. Anderson, Daniel R. Swale

Department of Entomology: Faculty Publications

Declines in managed honey bee populations are multifactorial but closely associated with reduced virus immunocompetence and thus, mechanisms to enhance immune function are likely to reduce viral infection rates and increase colony viability. However, gaps in knowledge regarding physiological mechanisms or ‘druggable’ target sites to enhance bee immunocompetence has prevented therapeutics development to reduce virus infection. Our data bridge this knowledge gap by identifying ATP-sensitive inward rectifier potassium ( K_ATP) channels as a pharmacologically tractable target for reducing virus-mediated mortality and viral replication in bees, as well as increasing an aspect of colony-level immunity. Bees infected with Israeli …

Oral Microbial Communities In Children, Caregivers, And Associations With Salivary Biomeasures And Environmental Tobacco Smoke Exposure, Jason A. Rothman, Jenna L. Riis, Katrina R. Hamilton, Clancy Blair, Douglas A. Granger, Katrine Katrine Whiteson

Department of Psychology: Faculty Publications

Human oral microbial communities are diverse, with implications for oral and systemic health. Oral microbial communities change over time; thus, it is important to understand how healthy versus dysbiotic oral microbiomes differ, especially within and between families. There is also a need to understand how the oral microbiome composition is changed within an individual including by factors such as environmental tobacco smoke (ETS) exposure, metabolic regulation, inflammation, and antioxidant potential. Using archived saliva samples collected from caregivers and children during a 90-month follow-up assessment in a longitudinal study of child development in the context of rural poverty, we used 16S …

Distinct Gene Expression Profiles Between Human Preterm-Derived And Adult-Derived Intestinal Organoids Exposed To Enterococcus Faecalis: A Pilot Study, Andrea C. Masi, Tatiana Y. Fofanova, Christopher A. Lamb, Jennifer Auchtung, Robert A. Britton, Mary K. Estes, Sasirekha Ramani, Simon J. Cockell, Jonathan Coxhead, Nicholas D. Embleton, Janet E. Berrington, Joseph F. Petrosino, Christopher J. Stewart

Food for Health: Publications

We read with interest the study by Kayisoglu et al¹ comparing the gene expression between embryo-derived and adult-derived intestinal organoids. Some innate immune system genes were differentially expressed between the two organoid types, suggesting a potential role of exposure to the environment, including gut microbiota, in shaping the intestinal gene expression. In extremely preterm infants (<32 weeks gestation), microbial–host interaction at the epithelial surface has been associated with various morbidities including late onset sepsis and necrotising enterocolitis.² Thus, preterm intestinal organoids may provide a specific and robust model for this population.

Mineral Composition Of Serially Slaughtered Holstein Steers Supplemented With Zilpaterol Hydrochloride, Andrea K. Watson, Trent J. Mcevers, Lee-Anne J. Walter, Nathan D. May, Jacob A. Reed, J. C. Macdonald, Galen E. Erickson, N. Andy Cole, Johnjohn P. Hutcheson, Ty E. Lawrence

Department of Animal Science: Faculty Publications

Calf-fed Holstein steers (n = 115; 449 ± 20 kg) were utilized in a serial harvest experiment. A baseline group of five steers was harvested after 226 d on feed (DOF), which was designated day 0. The remaining cattle were assigned randomly to 11 harvest groups, with slaughter every 28 d. Cattle were either not (CON) or were fed zilpaterol hydrochloride for 20 d followed by a 3 d withdrawal (ZH). There were five steers per treatment in each slaughter group ranging from days 28 to 308. Whole carcasses were divided into lean, …

Literature Review—Transthoracic Echocardiography, Computed Tomography Angiography, And Their Value In Clinical Decision Making And Outcome Predictions In Patients With Covid-19 Associated Cardiovascular Complications, Jędrzej Warpechowski, Adam Olichwier, Aleksandra Golonko, Marcin Warpechowski, Robert Milewski

Department of Nutrition and Health Sciences: Faculty Publications

The sudden outbreak of the COVID-19 pandemic posed a great threat to the world’s healthcare systems. It resulted in the development of new methods and algorithms for the diagnosis and treatment of both COVID-19 and its complications. Diagnostic imaging played a crucial role in both cases. Among the most widely used examinations are transthoracic echocardiography (TTE) and computed tomography angiography (CTA). Cardiovascular complications in COVID-19 are frequently associated with a severe inflammatory response, which results in acute respiratory failure, further leading to severe complications of the cardiovascular system. Our review aims to discuss the value of TTE and CTA in …

Diet-Microbiome-Immune Interplay In Multiple Sclerosis: Understanding The Impact Of Phytoestrogen Metabolizing Gut Bacteria, Peter C. Lehman, Sudeep Ghimire, Jeffrey D. Price, Amanda E. Ramer-Tait, Ashutosh K. Mangalam

Department of Nutrition and Health Sciences: Faculty Publications

Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic and environmental factors contributing to the pathobiology of the disease. Although HLA genes have emerged as the strongest genetic factor linked to MS, consensus on the environmental risk factors is lacking. Recently, the gut microbiota has garnered increasing attention as a potential environmental factor in MS, as mounting evidence suggests that individuals with MS exhibit microbial dysbiosis (changes in the gut microbiome). Thus, there has been a strong emphasis on understanding the role of the gut microbiome in the pathobiology of …