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Articles 2581 - 2610 of 32993
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Polycentric Governance In Nebraska, U.S., For Ground And Surface Water, Theresa Jedd, Anthony B. Schutz, Mark Burbach
Polycentric Governance In Nebraska, U.S., For Ground And Surface Water, Theresa Jedd, Anthony B. Schutz, Mark Burbach
School of Natural Resources: Faculty Publications
This chapter describes the locally driven, but centrally coordinated, water governance model in Nebraska, U.S. It offers a snapshot of water resources and the importance of agriculture, then moves to the relevant political institutions in the state, and federal controls related to water quantity. The focus of the chapter is on the Nebraska Department of Natural Resources’ (NeDNR) and Natural Resources Districts’ (NRDs) management of surface and groundwater, which has some distinct and some overlapping authority. The main area of overlap is in addressing the connection between ground and surface water, particularly in situations when either or both are over …
A Greenhouse Gas Emissions Inventory For Nebraska: Livestock And Coal Loom Large, Eric R. Holley, Adam Liska
A Greenhouse Gas Emissions Inventory For Nebraska: Livestock And Coal Loom Large, Eric R. Holley, Adam Liska
Adam Liska Papers
Mitigation of climate change requires the systematic identification and cataloging of emissions sources at city, state, and national levels. In this study, an inventory of annual greenhouse gas emissions from the state of Nebraska was created based on industry data, and emissions inventories were completed each year from 1990 to 2016. Nebraska’s net emissions were found to increase from 56.2 million metric tons of carbon dioxide equivalents (MMtCO2e) in 1990 to 87.4 MMtCO2e in 2016. Agriculture was found to be the sector with the most emissions (36 MMtCO2e) followed by electricity generation (21 MMtCO …
International Research Experience For Native American Students In Iot-Enabled Environmental Monitoring Technologies, J. Wang, J.M.D. Motschenbacher, A. Finley
International Research Experience For Native American Students In Iot-Enabled Environmental Monitoring Technologies, J. Wang, J.M.D. Motschenbacher, A. Finley
School of Natural Resources: Faculty Publications
No abstract provided.
A Search For Analogs Of Kic 8462852 (Boyajian’S Star): A Second List Of Candidates, Edward G. Schmidt
A Search For Analogs Of Kic 8462852 (Boyajian’S Star): A Second List Of Candidates, Edward G. Schmidt
Edward Schmidt Publications
In data from the Kepler mission, the normal F3V star KIC 8462852 (Boyajian’s star) was observed to exhibit infrequent dips in brightness that have not been satisfactorily explained. A previous paper reported the first results of a search for other similar stars in a limited region of the sky around the Kepler field. This paper expands on that search to cover the entire sky between declinations of +22°and +68°. Fifteen new candidates with low rates of dipping, referred to as “slow dippers” in Paper I, have been identified. The dippers occupy a limited region of the HR diagram and an …
Research And Creative Activity, July 01, 2021-June 30, 2022: Major Sponsored Programs And Faculty Accomplishments In Research And Creative Activity, University Of Nebraska-Lincoln, Office Of Research And Economic Development, University Of Nebraska-Lincoln
Research And Creative Activity, July 01, 2021-June 30, 2022: Major Sponsored Programs And Faculty Accomplishments In Research And Creative Activity, University Of Nebraska-Lincoln, Office Of Research And Economic Development, University Of Nebraska-Lincoln
Office of Research and Economic Development: Publications
Foreword by Bob Wilhelm, Vice Chancellor for Research and Economic Development:
This booklet highlights successes in research, scholarship and creative activity by University of Nebraska–Lincoln faculty during the fiscal year running July 1, 2021, to June 30, 2022.
It lists investigators, project titles and funding sources on major grants and sponsored awards that were active during the year; fellowships and other recognitions and honors bestowed on our faculty; books, chapters and creative literature published by faculty; performances, exhibitions and other examples of creative activity; patents and licensing agreements; and conference presentations. In recognition of the important role faculty play in …
‘Read For Nutrition’ Programme Improves Preschool Children’S Liking And Consumption Of Target Vegetable, Maha Elrakaiby, Saima Hasnin, Virginia C. Stage, Dipti Dev
‘Read For Nutrition’ Programme Improves Preschool Children’S Liking And Consumption Of Target Vegetable, Maha Elrakaiby, Saima Hasnin, Virginia C. Stage, Dipti Dev
Department of Child, Youth, and Family Studies: Faculty Publications
Objective: To determine whether the ‘Read for Nutrition’ programme would increase liking and consumption of broccoli (a target vegetable) in preschool children and test acceptability and practicality of the programme.
Design: Pilot pre-post intervention study, where childcare teachers received training and coaching followed by reading the book ‘Monsters Don’t Eat Broccoli’ multiple times with the children during a three-week intervention.
Setting: Five classrooms of Educare, Lincoln, Nebraska in 2018.
Participants: Sixty-nine (11 to 16 children per classroom) preschool-aged children and sixteen teachers (minimum, three per classroom).
Results: Average total consumption of broccoli increased 35 % (0·14 ounces or 0·05th cup) …
Towards Water Literacy: An Interdisciplinary Analysis Of Standards For Teaching And Learning About Humans And Water, Silvia‑Jessica Mostacedo‑Marasovic, Brooke Colleen Mott, Holly White, Cory T. Forbes
Towards Water Literacy: An Interdisciplinary Analysis Of Standards For Teaching And Learning About Humans And Water, Silvia‑Jessica Mostacedo‑Marasovic, Brooke Colleen Mott, Holly White, Cory T. Forbes
School of Natural Resources: Faculty Publications
Water is critical to sustain human existence. Water literacy involves understanding the interactions within and between natural and human dimensions of water systems to support informed decision-making, an important outcome for learners of all ages. It is therefore critical to foster water literacy in today’s global citizens, particularly through formal education. The purpose of this study, in tandem with a parallel study focusing on natural dimensions of water systems (Mostacedo-Marasovic et al., in press), is to examine water-related K-12 standards for teaching and learning about human dimensions of water systems to develop a comprehensive and transdisciplinary perspective on water education. …
A Survey On The Use Of Plastic Versus Biodegradable Bottles For Drinking Water Packaging In The United Arab Emirates, Himadri Rajput, Munjed A. Maraqa, Fatima Zraydi, Lina A. Al Khatib, Noor Ameen, Rime Ben Elkaid, Safia S. Al Jaberi, Noura A. Alharbi, Reka Howard, Ashraf Aly Hassan
A Survey On The Use Of Plastic Versus Biodegradable Bottles For Drinking Water Packaging In The United Arab Emirates, Himadri Rajput, Munjed A. Maraqa, Fatima Zraydi, Lina A. Al Khatib, Noor Ameen, Rime Ben Elkaid, Safia S. Al Jaberi, Noura A. Alharbi, Reka Howard, Ashraf Aly Hassan
Department of Statistics: Faculty Publications
Due to intensive utilization and extensive production, plastic waste is becoming a serious threat to the environment and human health. The situation is even worse in countries such as the United Arab Emirates (UAE), where single-use plastic water bottles add to the load of plastic pollution. The main objective of this survey was to assess the extent of bottled water utilization by the UAE residents and their awareness of the environmental concerns arising from single-use plastic bottles. The aim was also to evaluate their willingness to shift towards using biodegradable plastic bottles. This study involved the feedback of 2589 respondents …
Seasonal Variation In Terrestrial Invertebrate Subsidies To Tropical Streams And Implications For The Feeding Ecology Of Hart’S Rivulus (Anablepsoides Hartii), David C. Owens, Thomas N. Heatherly, Kent M. Eskridge, Colden V. Baxter, Steven A. Thomas
Seasonal Variation In Terrestrial Invertebrate Subsidies To Tropical Streams And Implications For The Feeding Ecology Of Hart’S Rivulus (Anablepsoides Hartii), David C. Owens, Thomas N. Heatherly, Kent M. Eskridge, Colden V. Baxter, Steven A. Thomas
Department of Statistics: Faculty Publications
Terrestrial invertebrates are important subsidies to fish diets, though their seasonal dynamics and importance to tropical stream consumers are particularly understudied. In this year-round study of terrestrial invertebrate input to two Trinidadian headwater streams with different forest canopy densities, we sought to (a) measure the mass and composition of terrestrial inputs with fall-in traps to evaluate the influences of seasonality, canopy cover, and rainfall intensity, and; (b) compare terrestrial and benthic prey importance to Anablepsoides hartii(Hart’s Rivulus), the dominant invertivorous fish in these streams, by concurrently measuring benthic and drifting invertebrate standing stocks and the volume and composition of …
Cranberry Polyphenols In Esophageal Cancer Inhibition: New Insights, Katherine M. Weh, Yun Zhang, Connor L. Howard, Amy B. Howell, Jennifer L. Clarke, Laura A. Kresty
Cranberry Polyphenols In Esophageal Cancer Inhibition: New Insights, Katherine M. Weh, Yun Zhang, Connor L. Howard, Amy B. Howell, Jennifer L. Clarke, Laura A. Kresty
Department of Statistics: Faculty Publications
Esophageal adenocarcinoma (EAC) is a cancer characterized by rapidly rising incidence and poor survival, resulting in the need for new prevention and treatment options. We utilized two cranberry polyphenol extracts, one proanthocyanidin enriched (C-PAC) and a combination of anthocyanins, flavonoids, and glycosides (AFG) to assess inhibitory mechanisms utilizing premalignant Barrett’s esophagus (BE) and EAC derived cell lines. We employed reverse phase protein arrays (RPPA) and Western blots to examine cancer-associated pathways and specific signaling cascades modulated by C-PAC or AFG. Viability results show that C-PAC is more potent than AFG at inducing cell death in BE and EAC cell lines. …
Genome-Wide Association Study Of Disease Resilience Traits From A Natural Polymicrobial Disease Challenge Model In Pigs Identifies The Importance Of The Major Histocompatibility Complex Region, Jian Cheng, Rohan Fernando, Hao Cheng, Stephen D. Kachman, Kyusang Lim, John C.S. Harding, Michael K. Dyck, Frederic Fortin, Graham S. Plastow, Piggen Canada Research Consortium, Jack C.M. Dekkers
Genome-Wide Association Study Of Disease Resilience Traits From A Natural Polymicrobial Disease Challenge Model In Pigs Identifies The Importance Of The Major Histocompatibility Complex Region, Jian Cheng, Rohan Fernando, Hao Cheng, Stephen D. Kachman, Kyusang Lim, John C.S. Harding, Michael K. Dyck, Frederic Fortin, Graham S. Plastow, Piggen Canada Research Consortium, Jack C.M. Dekkers
Department of Statistics: Faculty Publications
Infectious diseases cause tremendous financial losses in the pork industry, emphasizing the importance of disease resilience, which is the ability of an animal to maintain performance under disease. Previously, a natural polymicrobial disease challenge model was established, in which pigs were challenged in the late nursery phase by multiple pathogens to maximize expression of genetic differences in disease resilience. Genetic analysis found that performance traits in this model, including growth rate, feed and water intake, and carcass traits, as well as clinical disease phenotypes, were heritable and could be selected for to increase disease resilience of pigs. The objectives of …
Kryging: Geostatistical Analysis Of Large-Scale Datasets Using Krylov Subspace Methods, Suman Majumder, Yawen Guan, Brian J. Reich, Arvind K. Saibaba
Kryging: Geostatistical Analysis Of Large-Scale Datasets Using Krylov Subspace Methods, Suman Majumder, Yawen Guan, Brian J. Reich, Arvind K. Saibaba
Department of Statistics: Faculty Publications
Analyzing massive spatial datasets using a Gaussian process model poses computational challenges. This is a problem prevailing heavily in applications such as environmental modeling, ecology, forestry and environmental health. We present a novel approximate inference methodology that uses profile likelihood and Krylov subspace methods to estimate the spatial covariance parameters and makes spatial predictions with uncertainty quantification for point-referenced spatial data. The proposed method, Kryging, applies for both observations on regular grid and irregularly-spaced observations, and for any Gaussian process with a stationary isotropic (and certain geometrically anisotropic) covariance function, including the popular Matérn covariance family. We make use of …
Network Science: Fish Supply, Worlds Of Connections Sepa
Network Science: Fish Supply, Worlds Of Connections Sepa
Worlds of Connections Resources
Objective The student will understand how being a part of a network (e.g. different roles) influences an individual’s decision-making in addition to understanding positions of power within a fish supply network. The student will be able to identify fish transfer (and money) in a fish supply chain network while seeing how each participant’s goals compete with one another and are balanced by the network. The student will engage with NGSS Crosscutting Concept 4. Systems/System Models.
The Fishing Industry has been around for a very long time. Many jobs are tied to the industry, including people who actually catch the fish, …
Network Science: Ecology, Worlds Of Connections Sepa
Network Science: Ecology, Worlds Of Connections Sepa
Worlds of Connections Resources
Building a network using wooden blocks demonstrates that some pieces in a network are more important than others. Removing pieces of a network will change the structure, but removing the pieces that are most connected or more foundational to the network will have more significant impacts on the network. In an ecosystem network, the more connected the network, the more robust it is. Think about ecosystems and food webs as networks with varying degrees of robustness depending upon how many connections and kinds of connections they contain (e.g. if there are “hubs” or “key links” in the chain). In an …
Network Science: Play Dough Liaisons, Worlds Of Connections Sepa
Network Science: Play Dough Liaisons, Worlds Of Connections Sepa
Worlds of Connections Resources
Brokers play an important role in the access of information and transactions. What makes a person a broker is the fact that the parties the broker is connected to have no way of communicating with each other without the broker. This gives a broker power in what they choose to do with the information they have received. For more information, see the brokerage role sheet (Handout 2). According to the brokerage role sheet, there are five different types of brokers. The brokerage roles can all be depicted as having directed or undirected lines, except for the gatekeeper and the representative. …
Hands-On With Ne Stem 4u: For Budding Stemers In Grades 4-8, Ne Stem 4u Program
Hands-On With Ne Stem 4u: For Budding Stemers In Grades 4-8, Ne Stem 4u Program
Worlds of Connections Resources
Character Biographies 5
Chemistry: The Crystal Tree 10
Biology: Fruitful DNA 15 • Honey Purity Test 22 • Human DNA Extraction 26 • Model Cell 32 • Stethoscopes and Heart Rate 36
Engineering: Build a Catapult 41 • Building Bridges 47
Physics: Battling Balloons 51 • Balloon Popping 57 • Divin' Challenge 60 • Life Jackets and Buoyancy 65 • Simple Circuits 69 • Newton's Tower 75
Geology: Aquifers and Artesian Wells 80 • The Center of the Earth 84 • Mapping and Location Intelligence 88 • Seismology and Earthquakes 92 • Volcanoes 98
Mathematics: Hexaflexagons 102 • Stick Puzzle …
Measuring The Social And Ecological Performance Of Agricultural Innovations On Rangelands: Progress And Plans For An Indicator Framework In The Ltar Network, S. Spiegal, N. P. Webb, E. H. Boughton, R. K. Boughton, A. Bentley Brymer, P. E. Clark, C. D. Holifield Collins, D. L. Hoover Et. Al
Measuring The Social And Ecological Performance Of Agricultural Innovations On Rangelands: Progress And Plans For An Indicator Framework In The Ltar Network, S. Spiegal, N. P. Webb, E. H. Boughton, R. K. Boughton, A. Bentley Brymer, P. E. Clark, C. D. Holifield Collins, D. L. Hoover Et. Al
School of Natural Resources: Faculty Publications
No abstract provided.
Network Science: Genealogy, Worlds Of Connections Sepa
Network Science: Genealogy, Worlds Of Connections Sepa
Worlds of Connections Resources
Remember that family trees are a type of network. The network we create helps us understand which traits were passed down and who they came from. While humans can inherit traits like hair color and eye shape, sometimes they can inherit genetic diseases or be more likely to develop health issues because of their genetics. In most cases, inherited traits are based on probability, so tracing family networks can tell us how likely people are to have these types of diseases. When tracing the genealogical flow of relatedness from one generation to the next one or two generations, it is …
Research At Nebraska, 2021-2022 Report, University Of Nebraska-Lincoln
Research At Nebraska, 2021-2022 Report, University Of Nebraska-Lincoln
Office of Research and Economic Development: Publications
This publication is a snapshot of the fiscal year’s activities. To read more stories about research and creativity at Nebraska, visit the online edition at https://research.unl.edu/annualreport/2022. Additional multimedia are available for many stories.
Expanding Graduate Education And Career Placement Through Cer, Julia Mcquillan, Patricia Wonch Hill, Meghan Leadabrand
Expanding Graduate Education And Career Placement Through Cer, Julia Mcquillan, Patricia Wonch Hill, Meghan Leadabrand
Worlds of Connections Resources
The University of Nebraska-Lincoln (UNL) is an R1 (doctoral granting and high research activity) institution with decades of experience with community-engaged research (CER). The UNL Sociology Department has long emphasized research methods, particularly survey methodology and social network analyses, in academic and practice settings. The department offers many opportunities to conduct CER, as well as general applied sociology, and encourages faculty to publish with students out of those opportunities. In part through insights gained through ASA efforts (e.g., leadership development about careers in practice settings), and in part learning from graduate students who perceived discouragement from considering jobs in applied …
Ferrihydrite Enrichment In The Rhizosphere Of Unsaturated Soil Improves Nutrient Retention While Limiting Arsenic And Uranium Plant Uptake, Arindam Malakar, Daniel D. Snow, Michael Kaiser, Jordan Shields, Bijesh Maharjan, Harkamal Walia, Daran Rudnick, Chittaranjan Ray
Ferrihydrite Enrichment In The Rhizosphere Of Unsaturated Soil Improves Nutrient Retention While Limiting Arsenic And Uranium Plant Uptake, Arindam Malakar, Daniel D. Snow, Michael Kaiser, Jordan Shields, Bijesh Maharjan, Harkamal Walia, Daran Rudnick, Chittaranjan Ray
Nebraska Water Center: Faculty Publications
Improvement of nutrient use efficiency and limiting trace elements such as arsenic and uranium bioavailability is critical for sustainable agriculture and food safety. Arsenic and uranium possess different properties and mobility in soils, which complicates the effort to reduce their uptake by plants. Here, we postulate that unsaturated soil amended with ferrihydrite nanominerals leads to improved nutrient retention and helps reduce uptake of these geogenic contaminants. Unsaturated soil is primarily oxic and can provide a stable environment for ferrihydrite nanominerals. To demonstrate the utility of ferrihydrite soil amendment, maize was grown in an unsaturated agricultural soil that is known to …
Web-Based Platform For Analysis Of Rna Folding From High Throughput Chemical Probing Data, Christopher Jurich, Amir Brivanlou, Silvi Rouskin, Joseph D. Yesselman
Web-Based Platform For Analysis Of Rna Folding From High Throughput Chemical Probing Data, Christopher Jurich, Amir Brivanlou, Silvi Rouskin, Joseph D. Yesselman
Department of Chemistry: Faculty Publications
RNA structures play critical roles in regulating gene expression across all domains of life and viruses. Chemical probing methods coupled with massively parallel sequencing have revolutionized the RNA structure field by enabling the assessment of many structures in their native, physiological context. Previously, we developed Dimethyl-Sulfate-based Mutational Profiling and Sequencing (DMS-MaPseq), which uses DMS to label the Watson-Crick face of open and accessible adenine and cytosine bases in the RNA. We used this approach to determine the genome-wide structures of HIV-1 and SARS-CoV-2 in infected cells, which permitted uncovering new biology and identifying therapeutic targets. Due to the simplicity and …
Impacts Of The Covid-19 Pandemic On Elementary School Teachers’ Practices And Perceptions Across The Spring And Fall 2020 Semesters, J. Marc Goodrich, Michael Hebert, Jessica M. Namkung
Impacts Of The Covid-19 Pandemic On Elementary School Teachers’ Practices And Perceptions Across The Spring And Fall 2020 Semesters, J. Marc Goodrich, Michael Hebert, Jessica M. Namkung
Department of Special Education and Communication Disorders: Faculty Publications
Following the closure of schools in the spring 2020 semester due to the COVID-19 pandemic, we developed two surveys to understand how the pandemic affected elementary education in the U.S. First, we distributed a survey at the end of the spring 2020 semester to understand how school closures impacted delivery of instruction. Second, we conducted a follow up survey in November 2020 to determine the nature of instruction provided to students when schools did or did not re-open in Fall 2020 and understand teachers’ perceptions of student learning and achievement during the pandemic. Each survey was sent to a sample …
Peptidomics Analysis Reveals Changes In Small Urinary Peptides In Patients With Interstitial Cystitis/Bladder Pain Syndrome, Md Shadman Ridwan Abid, Haowen Qiu, Bridget Tripp, Aline De Lima Leite, Heidi E. Roth, Jiri Adamec, Robert Powers, James W. Checco
Peptidomics Analysis Reveals Changes In Small Urinary Peptides In Patients With Interstitial Cystitis/Bladder Pain Syndrome, Md Shadman Ridwan Abid, Haowen Qiu, Bridget Tripp, Aline De Lima Leite, Heidi E. Roth, Jiri Adamec, Robert Powers, James W. Checco
Department of Chemistry: Faculty Publications
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic and debilitating pain disorder of the bladder and urinary tract with poorly understood etiology. A definitive diagnosis of IC/BPS can be challenging because many symptoms are shared with other urological disorders. An analysis of urine presents an attractive and non-invasive resource for monitoring and diagnosing IC/BPS. The antiproliferative factor (APF) peptide has been previously identified in the urine of IC/BPS patients and is a proposed biomarker for the disorder. Nevertheless, other small urinary peptides have remained uninvestigated in IC/BPS primarily because protein biomarker discovery efforts employ protocols that remove small endogenous peptides. …
Oxide Two-Dimensional Electron Gas With High Mobility At Room-Temperature, K. Eom, H. Paik, J. Seo, N. Campbell, Evgeny Y. Tsymbal, S. H. Oh, M. Rzchowski, D. G. Schlom, Chang-Beom Eom
Oxide Two-Dimensional Electron Gas With High Mobility At Room-Temperature, K. Eom, H. Paik, J. Seo, N. Campbell, Evgeny Y. Tsymbal, S. H. Oh, M. Rzchowski, D. G. Schlom, Chang-Beom Eom
Evgeny Tsymbal Publications
No abstract provided.
Ferroelectric Control Of Magnetic Skyrmions In Two-Dimensional Van Der Waals Heterostructures, K. Huang, Ding-Fu Shao, Evgeny Y. Tsymbal
Ferroelectric Control Of Magnetic Skyrmions In Two-Dimensional Van Der Waals Heterostructures, K. Huang, Ding-Fu Shao, Evgeny Y. Tsymbal
Evgeny Tsymbal Publications
No abstract provided.
Tilted Spin Current Generated By The Collinear Antiferromagnet Ruo2, A. Bose, N. J. Schreiber, R. Jain, Ding-Fu Shao, H. P. Nair, J. Sun, X. S. Zhang, D. A. Muller, D. A. Muller, Evgeny Y. Tsymbal, D. G. Schlom, D. C. Ralph
Tilted Spin Current Generated By The Collinear Antiferromagnet Ruo2, A. Bose, N. J. Schreiber, R. Jain, Ding-Fu Shao, H. P. Nair, J. Sun, X. S. Zhang, D. A. Muller, D. A. Muller, Evgeny Y. Tsymbal, D. G. Schlom, D. C. Ralph
Evgeny Tsymbal Publications
No abstract provided.
Evaluating The Effectiveness Of Readiness Assurance Testing As Part Of Team-Based Ecology Instruction, Danielle Berger, Larkin Powell
Evaluating The Effectiveness Of Readiness Assurance Testing As Part Of Team-Based Ecology Instruction, Danielle Berger, Larkin Powell
School of Natural Resources: Faculty Publications
Readiness Assurance Testing (RAT) incorporates content recall, immediate feedback and peer instruction, three strategies known to enhance student learning, into a single classroom activity. While iRAT and tRAT assessments are promising instructional tools, they are time-intensive to administer.
1.Do iRAT/tRAT tests promote student retention of content better than other in-class activities, justifying the investment of instructional time? 2.Are iRAT/tRAT tests beneficial across the spectrum of academic performance?
• Students get a larger proportion of RAT questions correct on exams than other multiple choice questions (Table 1, RAT~MC Intercept), supporting the claim that this instructional technique provides better content-retention than other …
Natural Resource System Size Can Be Used For Managing Recreational Use, D. S. Kane, K. L. Pope, K. D. Koupal, M. A. Pegg, C. Chizinski, M. Kaemingk
Natural Resource System Size Can Be Used For Managing Recreational Use, D. S. Kane, K. L. Pope, K. D. Koupal, M. A. Pegg, C. Chizinski, M. Kaemingk
School of Natural Resources: Faculty Publications
No abstract provided.
Developing A New Treatment For Superficial Fungal Infection Using Antifungal Collagen-Hsaf Dressing, Jing Zhong, Xiayi Yan, Xin Zuo, Xuan Zhao, Jiahui Yang, Qin Dou, Lulu Peng, Yuxiang Zhu, Yichen Xiao, Zeran Bian, Dalian He, Qiushuang Xu, Stephen Wright, Yaoyao Li, Liangcheng Du, Yan Wang, Jin Yuan
Developing A New Treatment For Superficial Fungal Infection Using Antifungal Collagen-Hsaf Dressing, Jing Zhong, Xiayi Yan, Xin Zuo, Xuan Zhao, Jiahui Yang, Qin Dou, Lulu Peng, Yuxiang Zhu, Yichen Xiao, Zeran Bian, Dalian He, Qiushuang Xu, Stephen Wright, Yaoyao Li, Liangcheng Du, Yan Wang, Jin Yuan
Department of Chemistry: Faculty Publications
Fungal pathogens are common causes of superficial clinical infection. Their increasing drug resistance gradually makes existing antifungal drugs ineffective. Heat stable antifungal factor (HSAF) is a novel antifungal natural product with a unique structure. However, the application of HSAF has been hampered by very low yield in the current microbial producers and from extremely poor solubility in water and common solvents. In this study, we developed an effective mode of treatment applying HSAF to superficial fungal infections. The marine-derived Lysobacter enzymogenes YC36 contains the HSAF biosynthetic gene cluster, which we activated by the interspecific signaling molecule indole. An efficient extraction …