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An Educational Framework For Equity And Inclusion In Planning, Jacob Schlange
An Educational Framework For Equity And Inclusion In Planning, Jacob Schlange
Community and Regional Planning Program: Theses
As societal discourse about equity has increased, so has the need for planning practitioners to be educated about equity-related issues. This study examines the planning curricula of the 22 land-grant institutions accredited by the Planning Accreditation Board (PAB) to assess whether these programs align with the new emphasis on equity in the most recent PAB accreditation standards. Finding a notable lack of required courses explicitly addressing the topic among most of the programs surveyed, this thesis goes on to propose a framework for developing a course on equity in planning, using existing literature on planning education and guidance from the …
Embracing A Pedagogy Of Care In The Infant And Toddler Classroom, Paige D. Wernick
Embracing A Pedagogy Of Care In The Infant And Toddler Classroom, Paige D. Wernick
College of Education and Human Sciences: Dissertations, Theses, and Student Research
Care is a universal concept which connects us all as humans. Everyone comes into this world needing care and most of us will exit this world in need of care. Care is necessary throughout the span of our lives and should be considered a human right. Everyone is entitled to quality care, no matter their age or social status. The U.S. society has been entrenched in a decades long division between education and care which has historically prioritized education over care. This division has contributed to care being hidden and undervalued within the context of early childhood (EC) as a …
Creating An Inclusive And Accessible Culture: Supportive Management For People With Disabilities, Sammy Peter, Katie Quirin Manwiller, Kiyomi D. Deards
Creating An Inclusive And Accessible Culture: Supportive Management For People With Disabilities, Sammy Peter, Katie Quirin Manwiller, Kiyomi D. Deards
University of Nebraska-Lincoln Libraries: Presentations
From the perspective of disabled academic librarians, covers the ways academic library managers can be inclusive and support disabled library workers.
Accompanies the article: Sally Lindsay and Kristina Fuentes. 2022. It is time to address ableism in academia: A systematic review of the experiences and impact of ableism among faculty and staff. Disabilities 2(2): 178-203. doi: 10.3390/disabilities2020014
Covid‑19 Vaccine Distribution: Exploring Strategic Alternatives For The Greater Good, Arben Asllani, Silvana Trimi
Covid‑19 Vaccine Distribution: Exploring Strategic Alternatives For The Greater Good, Arben Asllani, Silvana Trimi
Department of Supply Chain Management and Analytics: Faculty Publications
The dire state of the COVID-19 pandemic crisis symbolized the urgency for efficient distribution and administration of vaccines to combat the virus as the most urgent public health service. This paper presents a prototype multi-criteria decision support model based on goal programming that can effectively support vaccination plans for the greater good of society. The optimization goals of the model include minimizing the number of fatalities and risk of spreading the disease, while complying with government health agency’s priority guidelines for vaccination. This study applied the model to a real-world dataset to demonstrate how it can be effectively applied as …
Relational Trust In Group Coaching With First-Grade Teachers: A Single Case Study, Jentry Stoneman Barrett
Relational Trust In Group Coaching With First-Grade Teachers: A Single Case Study, Jentry Stoneman Barrett
College of Education and Human Sciences: Dissertations, Theses, and Student Research
Coaching has become a prominent professional development tool for helping early childhood teachers implement curriculum and research-based practices in their classrooms. One of the coaching strategies found to create positive changes in teacher practice and child outcomes is building trust between the coach and teacher(s). Despite what is known in terms of the benefits of these positive relationships, there is limited understanding of the nature of trust-building between coach and teachers, in general, and particularly in group coaching configurations. There is also scant literature exploring the nature of trust between teachers participating in group coaching sessions. Researchers call these two …
Individual Trophic Niche Specialization In American Beaver (Castor Canadensis), Jimmy Taylor, Robert Francis, Scott Rush, Bronson Strickland, Guiming Wang
Individual Trophic Niche Specialization In American Beaver (Castor Canadensis), Jimmy Taylor, Robert Francis, Scott Rush, Bronson Strickland, Guiming Wang
United States Department of Agriculture Wildlife Services: Staff Publications
The American beaver (Castor canadensis) has been described as a choosy generalist at the species/population scale, yet observational studies have shown little variation in diet among individuals. We compared isotopic values of δ13C or δ15N taken from hair of 32 beaver, representing seven colonies in northern Alabama, USA to determine 1) if colonies of beaver show overlap in isotopic niche width as a result of the similar use of food resources and 2) if individual trophic niche specialization occurs within colonies. Total Trophic Niche Width varied across the wetland with the widest being twice …
Estimation Of Methane Emissions From Beef Cattle Manure In Nebraska, Noe Hernandez
Estimation Of Methane Emissions From Beef Cattle Manure In Nebraska, Noe Hernandez
Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research
The emission of methane from livestock production contributes to climate change. Cattle manure accounts for one-third of the total methane emission over the lifecycle of beef and dairy production and represents an opportunity to lower the environmental footprint of the beef industry. While models have been developed to estimate methane emissions from manure under certain types of manure storage methods, there is a lack of a user-friendly interface that agricultural or environmental engineers can use to estimate the methane emission from manure for specific regions. Therefore, the goal of this study was to build an interface to estimate methane emissions …
Does A Hypertrophying Muscle Fibre Reprogramme Its Metabolism Similar To A Cancer Cell?, Henning Wackerhage, Ivan J. Vechetti, Philipp Baumert, Sebastian Gehlert, Lore Becker, Richard T. Jaspers, Martin Hrabě De Angelis
Does A Hypertrophying Muscle Fibre Reprogramme Its Metabolism Similar To A Cancer Cell?, Henning Wackerhage, Ivan J. Vechetti, Philipp Baumert, Sebastian Gehlert, Lore Becker, Richard T. Jaspers, Martin Hrabě De Angelis
Department of Nutrition and Health Sciences: Faculty Publications
In 1924, Otto Warburg asked “How does the metabolism of a growing tissue differ from that of a non-growing tissue?” Currently, we know that proliferating healthy and cancer cells reprogramme their metabolism. This typically includes increased glucose uptake, glycolytic flux and lactate synthesis. A key function of this reprogramming is to channel glycolytic intermediates and other metabolites into anabolic reactions such as nucleotide-RNA/DNA synthesis, amino acid-protein synthesis and the synthesis of, for example, acetyl and methyl groups for epigenetic modification. In this review, we discuss evidence that a hypertrophying muscle similarly takes up more glucose and reprogrammes its metabolism to …
Differential Associations Of Conduct Disorder, Callous‑Unemotional Traits And Irritability With Outcome Expectations And Values Regarding The Consequences Of Aggression, J. Elowsky, S. Bajaj, J. Bashford‑Largo, R. Zhang, A. Mathur, A. Schwartz, M. Dobbertin, K. S. Blair, E. Leibenluft, D. Pardini, R. J.R. Blair
Differential Associations Of Conduct Disorder, Callous‑Unemotional Traits And Irritability With Outcome Expectations And Values Regarding The Consequences Of Aggression, J. Elowsky, S. Bajaj, J. Bashford‑Largo, R. Zhang, A. Mathur, A. Schwartz, M. Dobbertin, K. S. Blair, E. Leibenluft, D. Pardini, R. J.R. Blair
Center for Brain, Biology, and Behavior: Faculty Publications
Background: Previous work has examined the association of aggression levels and callous-unemotional traits with outcome expectations and values regarding the consequences of aggression. Less work has examined the outcome expectations and values regarding the consequences of aggression of adolescents with Conduct Disorder (CD). Also, no studies have examined links between irritability (a second socio-affective trait associated with CD) and these social cognitive processes despite the core function of anger in retaliatory aggression and establishing dominance.
Method: The current study, investigating these issues, involved 193 adolescents (typically developing [TD; N = 106], 87 cases with CD [N = 87]). Participants completed …
Program And Proceedings: Nebraska Academy Of Sciences 1880–2022, 142nd Anniversary Year, One Hundred-Thirty-Second Annual Meeting, April 22, 2022
Nebraska Academy of Sciences: Programs and Proceedings
Program
Aeronautics and Space Science
Anthropology
Applied Science and Technology
Biological Sciences
Biomedical Sciences
Chemistry
Earth Sciences
Environmental Sciences
Physics
2022 Maiben Lecture: Dan Sitzman
2022 Friend of Science Award: Julie Sigmon and Chris Schaben
Europium-Doped Cerium Oxide Nanoparticles For Microglial Aβ Clearance And Homeostasis, Jatin Machhi, Pravin Yeapuri, Milica Markovic, Milankumar Patel, Wenhui Yan, Yaman Lu, Jacob D. Cohen, Mahmudul Hasan, Mai Mohamed Abdelmoaty, You Zhou, Huangui Xiong, Xinglong Wang, R. Lee Mosley, Howard E. Gendelman, Bhavesh D. Kevadiya
Europium-Doped Cerium Oxide Nanoparticles For Microglial Aβ Clearance And Homeostasis, Jatin Machhi, Pravin Yeapuri, Milica Markovic, Milankumar Patel, Wenhui Yan, Yaman Lu, Jacob D. Cohen, Mahmudul Hasan, Mai Mohamed Abdelmoaty, You Zhou, Huangui Xiong, Xinglong Wang, R. Lee Mosley, Howard E. Gendelman, Bhavesh D. Kevadiya
Nebraska Center for Biotechnology: Faculty and Staff Publications
Alzheimer’s disease (AD) is the most common neurodegenerative disorder. Pathologically, it is characterized by the deposition of amyloid beta (Aβ) plaques and presence of neurofibrillary tangles. These drive microglia neuroinflammation and consequent neurodegeneration. While the means to affect Aβ plaque accumulation was achieved how it affects disease outcomes remains uncertain. Cerium oxide (CeO2) reduces Aβ plaques, oxidative stress, inflammation, and Alzheimer’s disease (AD) signs and symptoms. Specifically, CeO2 nanoparticles (CeO2NPs) induces free radical scavenging and cell protective intracellular signaling. This can ameliorate the pathobiology of an AD-affected brain. In order to investigate, CeO2NPs …
Transforming The “Great Resignation” Into The “Great Attraction”, Cheryl A. Burkhart-Kriesel
Transforming The “Great Resignation” Into The “Great Attraction”, Cheryl A. Burkhart-Kriesel
Cornhusker Economics
Businesses of all types are scrambling to hire people, especially those that work on the frontline with customers - from healthcare to hospitality to retail and everything in between. This is resulting in an incredibly tight labor market across the nation. Some are calling this time “The Great Resignation” which refers to the more than 19 million workers - and counting - that have quit their jobs since April 2021. Logic would say that if people are resigning in record numbers that there should be a lot of employees out there to hire, but that is not the case. It …
Systemic Stress In Mid-Century American Military Service Members: The Impact Of Socioeconomic Status And Military Service Length On The Human Skeleton, Brianna L. Petersen
Systemic Stress In Mid-Century American Military Service Members: The Impact Of Socioeconomic Status And Military Service Length On The Human Skeleton, Brianna L. Petersen
Department of Anthropology: Theses and Student Research
The purpose of this study is to identify how socioeconomic status (SES) and, separately, length of military service, may affect the human skeleton. Specifically, this study considers non-specific indicators of skeletal stress such as periosteal reactions, enamel defects, and skeletal porosity in a sample of World War II decedents. The Exact Logistic Regression test was used to examine the possible association between military service length and the presence of skeletal porosity and periosteal reaction, and Fisher’s Exact Test of Independence was used to evaluate the relationship between SES and presence of enamel defects, skeletal porosity, and periosteal reaction. In total, …
Examining The Impact Of Political Identification And Morality On Compliance With Covid-19 Public Health Measures, Jessica Stump
Examining The Impact Of Political Identification And Morality On Compliance With Covid-19 Public Health Measures, Jessica Stump
Honors Program: Senior Projects (Public)
COVID-19 provides a unique opportunity to study the influence of individual and group differences on beliefs and behavior. In the present work, we examine COVID beliefs and behavior as a function of morality, ideology, and emotion. Data were collected in the spring of 2021 and the fall of 2021, allowing for distinct snapshots of an undergraduate sample at two periods of the pandemic. Of primary interest was the relationship between political ideology, moral foundation endorsement, and COVID-19 behaviors and beliefs. The results reveal that ideology drives COVID-19-related beliefs and behaviors. The results from Study 2 suggest that political liberals were …
Editorial: Special Issue “Innovative Techniques And Approaches In The Control And Prevention Of Rabies Virus”, Amy T. Gilbert, Ryan M. Wallace, Charles E. Rupprecht
Editorial: Special Issue “Innovative Techniques And Approaches In The Control And Prevention Of Rabies Virus”, Amy T. Gilbert, Ryan M. Wallace, Charles E. Rupprecht
United States Department of Agriculture Wildlife Services: Staff Publications
Rabies is an ancient lethal scourge that has plagued humankind for centuries. Globally, 60,000 human deaths are estimated to occur each year from rabies virus (RABV) transmission in domestic dogs, mostly affecting children. While rabies is recognized as a neglected disease, there is cause for optimism in the context of growing global recognition, collaboration and commitment to advance a tripartite agenda to eliminate human deaths transmitted from rabid dogs by 2030, also known as “Zero By Thirty” (ZBT). Nevertheless, the ZBT goal must also confront competing challenge(s) of tracking and mitigating human morbidity and mortality during a global pandemic caused …
The Impact Of China's Environmental And Trade Policies On U.S. Plastic And Paper Waste Exports, Savant Nzayiramya, John C. Beghin
The Impact Of China's Environmental And Trade Policies On U.S. Plastic And Paper Waste Exports, Savant Nzayiramya, John C. Beghin
Honors Program: Senior Projects (Public)
This article documents major environmental and trade policy changes in China and their impact on plastic and paper waste trade between the U.S. and China and other trade partners. The article explains how U.S. plastic waste exports have been nearly annihilated by these policies. Paper waste trade is more resilient and has survived the policy shifts in China, although quite diminished.
Redfin Strategic Analysis, Steffanie Hitz
Redfin Strategic Analysis, Steffanie Hitz
Honors Program: Senior Projects (Public)
No abstract provided.
A Cookbook For The Trendy Chef, Katja Roberts
A Cookbook For The Trendy Chef, Katja Roberts
Honors Program: Senior Projects (Public)
A Cookbook for the Trendy Chef contains a compilation of recipes which fall under 8 major food trends for 2021. These trends were determined to be vegan, keto, and gluten-free diets, along with “viral foods”, easy recipes, functional foods, international flavors, and comfort foods. These trends were selected based on predictions made by the Institute of Food Technologists (IFT) and the Washington Post.
Something Fishy In Seafood Trade?, Kathy Baylis, Lia Nogueira, Linlin Fan, Kathryn Pace
Something Fishy In Seafood Trade?, Kathy Baylis, Lia Nogueira, Linlin Fan, Kathryn Pace
Cornhusker Economics
The safety of food imports continues to be in the spotlight. Globally, each year, contaminated food causes almost 1 in 10 people to fall ill and 420 thousand people to die (WHO, 2017). Protecting consumers from unsafe foods is complicated by the increased role of international trade in our food system. The U.S. Centers for Disease Control and Prevention found that disease outbreaks associated with imported food increased from 1996 to 2014, with fish and produce being the main culprits (Gould et al., 2017). For example, in 2019, two separate cases of tuna from Vietnam were found to have sickened …
The Impact Of Afghan Opium Cultivation On The U.S. Opioid Epidemic, Zachary Wahab Cheek
The Impact Of Afghan Opium Cultivation On The U.S. Opioid Epidemic, Zachary Wahab Cheek
UNL Student Research Days Posters, Undergraduate
I argue here that increases in Afghan opium cultivation, the most prolific in the world, has depressed American prescription opioid and heroin prices, thereby increasing abuse risk in U.S. addict populations and increasing death rates. Utilizing a two-stage regression model with a sparse dataset from several national and international sources, I find evidence that a one percent increase in Afghan opium production is associated with a 0.122 percent increase in prescription opioid overdose deaths, and a 0.367 percent increase in heroin overdose deaths. Assessing the 2001-2002 Taliban opium ban with an identification strategy, I find that in this timeframe prescription …
Can We Use Antipredator Behavior Theory To Predict Wildlife Responses To High-Speed Vehicles?, Ryan B. Lunn, Bradley Blackwell, Travis L. Devault, Esteban Fernández-Juricic
Can We Use Antipredator Behavior Theory To Predict Wildlife Responses To High-Speed Vehicles?, Ryan B. Lunn, Bradley Blackwell, Travis L. Devault, Esteban Fernández-Juricic
United States Department of Agriculture Wildlife Services: Staff Publications
Animals seem to rely on antipredator behavior to avoid vehicle collisions. There is an extensive body of antipredator behavior theory that have been used to predict the distance/time animals should escape from predators. These models have also been used to guide empirical research on escape behavior from vehicles. However, little is known as to whether antipredator behavior models are appropriate to apply to an approaching high-speed vehicle scenario. We addressed this gap by (a) providing an overview of the main hypotheses and predictions of different antipredator behavior models via a literature review, (b) exploring whether these models can generate quantitative …
Peptidomics Analysis Reveals Changes In Small Urinary Peptides In Patients With Interstitial Cystitis/Bladder Pain Syndrome, Md Shadman Ridwan Abid, Haowen Qiu, Bridget A. Tripp, Aline De Lima Leite, Heidi Roth, Jiri Adamec, Robert Powers, James W. Checco
Peptidomics Analysis Reveals Changes In Small Urinary Peptides In Patients With Interstitial Cystitis/Bladder Pain Syndrome, Md Shadman Ridwan Abid, Haowen Qiu, Bridget A. Tripp, Aline De Lima Leite, Heidi Roth, Jiri Adamec, Robert Powers, James W. Checco
UNL Student Research Days Posters, Graduate
Interstitial cystitis or bladder pain syndrome (IC/BPS) is a chronic and debilitating pain disorder of the bladder and urinary tract with poorly understood etiology. Symptomatic criteria to aid in the diagnosis of IC/BPS includes bladder pain, an increase in urinary urgency or Hunner’s ulcers on the bladder wall.
Our study revealed differences in the profiles of small urinary peptides for IC/BPS patients compared to age-matched controls which is consistent with increased protease activity in IC/BPS. Our study also enabled the direct measurement of APF peptide abundance in IC/BPS and control urine. Our results indicate that the full-length APF peptide was …
Asymmetric Synthesis Of 𝜸-Borylated Amines Via Rhodium-Catalyzed Hydroboration Of Allylamine Derivatives, Rukshani Wickrama Arachchi, Shekhar Kc, Arun Suneja, James Takacs
Asymmetric Synthesis Of 𝜸-Borylated Amines Via Rhodium-Catalyzed Hydroboration Of Allylamine Derivatives, Rukshani Wickrama Arachchi, Shekhar Kc, Arun Suneja, James Takacs
UNL Student Research Days Posters, Graduate
The Takacs group has explored different dimensions of Catalytic Asymmetric Hydroboration (CAHB) reaction mainly focusing on variety of amide, oxime ether and phosphonate directing groups. Inspired by the results obtained with BINOL- and TADDOL- derived chiral catalysts along with pinacolborane, we explored the potential of acyclic N-acyl allylamines as substrates for direct-hydroboration to prepare chiral amine derivatives bearing g-boronic ester functionality, yields up to 90% with 98:2 enantioselectivity. The major enantiomer obtained is independent of starting alkene geometry, revealing that rhodium-catalyzed cis/trans-alkene isomerization occurs prior to hydroboration. In this poster, we will discuss the generation of active catalysts …
“Many People Have No Idea”: A Qualitative Analysis Of Healthcare Barriers Among Yazidi Refugees In The Midwestern United States, Falah Rashoka, Megan S. Kelley, Jeong‑Kyun Choi, Marc A. Garcia, Weiwen Chai, Hazim N. Rashawka
“Many People Have No Idea”: A Qualitative Analysis Of Healthcare Barriers Among Yazidi Refugees In The Midwestern United States, Falah Rashoka, Megan S. Kelley, Jeong‑Kyun Choi, Marc A. Garcia, Weiwen Chai, Hazim N. Rashawka
Department of Nutrition and Health Sciences: Faculty Publications
Background: The COVID-19 pandemic has shed new light on inequities in healthcare access faced by immigrant and refugee communities. To address ongoing disparities, there is an urgent need for ecological approaches to better understand the barriers that hinder and resources that facilitate access to healthcare. This study investigates barriers to healthcare system access faced by Yazidi refugees in the Midwestern United States.
Methods: Informed by the Interpretative Phenomenological Approach, three focus group meetings with a community advisory board were conducted between September 2019 and January 2020. The nine-member focus group included social workers, healthcare providers, and members of …
The Chromosome-Level Rambutan Genome Reveals A Significant Role Of Segmental Duplication In The Expansion Of Resistance Genes, Jinfang Zheng1, Lyndel W. Meinhardt, Ricardo Goenaga, Tracie Matsumoto, Dapeng Zhang, Yanbin Yin
The Chromosome-Level Rambutan Genome Reveals A Significant Role Of Segmental Duplication In The Expansion Of Resistance Genes, Jinfang Zheng1, Lyndel W. Meinhardt, Ricardo Goenaga, Tracie Matsumoto, Dapeng Zhang, Yanbin Yin
Food for Health: Publications
Rambutan (Nephelium lappaceum var. lappaceum), a tropical fruit tree native to southeastern Asia, belongs to the family Sapindaceae. Rambutan is a popular table fruit and is also processed into preserves, juices, wines, and sorbets [1]. At present, only three Sapindaceae genomes are publicly available: Xanthoceras sorbifolium [2], Dimocarpus longan (longan) [3], and Acer yangbiense [4]. During the process of submitting this manuscript, the genome paper for the rambutan cultivar Baoyan7 became available online, but its genome sequence has not yet been released [5].
Influence Of Acute Water Ingestion And Prolonged Standing On Raw Bioimpedance And Subsequent Body Fluid And Composition Estimates, Grant M. Tinsley, Matthew T. Stratton, Patrick S. Harty, Abegale D. Williams, Sarah J. White, Christian Rodriguez, Jacob R. Dellinger, Baylor A. Johnson, Robert W. Smith, Eric T. Trexler
Influence Of Acute Water Ingestion And Prolonged Standing On Raw Bioimpedance And Subsequent Body Fluid And Composition Estimates, Grant M. Tinsley, Matthew T. Stratton, Patrick S. Harty, Abegale D. Williams, Sarah J. White, Christian Rodriguez, Jacob R. Dellinger, Baylor A. Johnson, Robert W. Smith, Eric T. Trexler
Department of Nutrition and Health Sciences: Faculty Publications
This study evaluated the influence of acute water ingestion and maintaining an upright posture on raw bioimpedance and subsequent estimates of body fluids and composition. Twenty healthy adults participated in a randomized crossover study. In both conditions, an overnight food and fluid fast was followed by an initial multi-frequency bioimpedance assessment (InBody 770). Participants then ingested 11 mL/kg of water (water condition) or did not (control condition) during a 5-minute period. Thereafter, bioimpedance assessments were performed every 10 minutes for one hour with participants remaining upright throughout. Linear mixed effects models were used to examine the influence of condition and …
Auditory Experience Modulates Frontoparietal Theta Activity Serving Fluid Intelligence, Elizabeth Heinrichs-Graham, Elizabeth A. Walker, Brittany K. Taylor, Sophia C. Menting
Auditory Experience Modulates Frontoparietal Theta Activity Serving Fluid Intelligence, Elizabeth Heinrichs-Graham, Elizabeth A. Walker, Brittany K. Taylor, Sophia C. Menting
Department of Psychology: Faculty Publications
Children who are hard of hearing are at risk for developmental language and academic delays compared with children with normal hearing. Some work suggests that high-order cognitive function, including fluid intelligence, may relate to language and academic outcomes in children with hearing loss, but findings in these studies have been mixed and to date, there have been no studies of the wholebrain neural dynamics serving fluid intelligence in the context of hearing loss. To this end, this study sought to identify the impact of hearing loss and subsequent hearing aid use on the neural dynamics serving abstract reasoning in children …
Antibody Dependent Enhancement Of Infectious Bronchitis Virus In Poultry, Zachary Hamilton, Barry Simpson, Donald L. Reynolds
Antibody Dependent Enhancement Of Infectious Bronchitis Virus In Poultry, Zachary Hamilton, Barry Simpson, Donald L. Reynolds
UCARE: Research Products
Avian infectious bronchitis (IB) is a coronavirus infection of chickens that causes respiratory disease and reproductive problems in chickens. Currently, there are vaccines that are effective against IB. However, new variants and strains of avian infectious bronchitis virus (IBV) routinely emerge. A vaccine that is not the same strain as the virus is not completely effective in protecting against other variants because the vaccine will not allow the host antibodies to completely neutralize the strain. This is a problem because it makes IB difficult to control and diagnose.
Antibody-dependent enhancement (ADE) is a phenomenon whereby non-neutralizing antibodies, or low levels …
Als-Associated Kif5a Mutations Abolish Autoinhibition Resulting In A Toxic Gain Of Function, Desiree M. Barron, Adam R. Fenton, Sara Saez-Atienzar, Anthony Giampetruzzi, Aparna Sreeram, Shankaracharya, Pamela J. Keagle, Victoria R. Doocy, Nathan J. Smith, Eric W. Danielson, Megan Andresano, Mary C. Mccormack, Jaqueline Garcia, Valérie Bercier, Ludo Van Den Bosch, Jonathan R. Brent, Claudia Fallini, Brian J. Traynor, Erica L.F. Holzbaur, John E. Landers
Als-Associated Kif5a Mutations Abolish Autoinhibition Resulting In A Toxic Gain Of Function, Desiree M. Barron, Adam R. Fenton, Sara Saez-Atienzar, Anthony Giampetruzzi, Aparna Sreeram, Shankaracharya, Pamela J. Keagle, Victoria R. Doocy, Nathan J. Smith, Eric W. Danielson, Megan Andresano, Mary C. Mccormack, Jaqueline Garcia, Valérie Bercier, Ludo Van Den Bosch, Jonathan R. Brent, Claudia Fallini, Brian J. Traynor, Erica L.F. Holzbaur, John E. Landers
Biochemistry -- Faculty Publications
Understandingthepathogenicmechanismsof diseasemutations is critical toadvancingtreatments.ALS-associated mutations in the gene encoding the microtubulemotor KIF5A result in skipping of exon 27 (KIF5ADExon27) and the encoding of a protein with a novel 39 amino acid residue C-terminal sequence. Here, we report that expression of ALS-linked mutant KIF5A results in dysregulated motor activity, cellular mislocalization, altered axonal transport, and decreased neuronal survival. Single-molecule analysis revealed that the altered C terminus of mutant KIF5A results in a constitutively active state. Furthermore,mutant KIF5A possesses altered protein and RNA interactions and its expression results in altered gene expression/splicing. Taken together, our data support the hypothesis that causative …
Variation In Bacterial Community Structure Under Long-Term Fertilization, Tillage, And Cover Cropping In Continuous Cotton Production, Ning Duan, Lidong Li, Xiaolong Liang, Aubrey Fine, Jie Zhuang, Mark Radosevich, Sean M. Schaeffer
Variation In Bacterial Community Structure Under Long-Term Fertilization, Tillage, And Cover Cropping In Continuous Cotton Production, Ning Duan, Lidong Li, Xiaolong Liang, Aubrey Fine, Jie Zhuang, Mark Radosevich, Sean M. Schaeffer
Department of Agronomy and Horticulture: Faculty Publications
Agricultural practices alter the structure and functions of soil microbial community. However, few studies have documented the alterations of bacterial communities in soils under long-term conservation management practices for continuous crop production. In this study, we evaluated soil bacterial diversity using 16S rRNA gene sequencing and soil physical and chemical properties within 12 combinations of inorganic N fertilization, cover cropping, and tillage throughout a cotton production cycle. Soil was collected from field plots of the West Tennessee Agriculture Research and Education Center in Jackson, TN, United States. The site has been under continuous cotton production for 38 years. A total …