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Mapping Injustice: The World Is Witness, Place-Framing, And The Politics Of Viewing On Google Earth, Joshua P. Ewalt
Mapping Injustice: The World Is Witness, Place-Framing, And The Politics Of Viewing On Google Earth, Joshua P. Ewalt
Department of Communication Studies: Faculty Publications
Working from assumptions that inequality is often spatially informed, a set of interactive cartographies has recently proliferated on Google Earth. In this essay, I analyze one of those interactive cartographies: The World is Witness produced by the United States Holocaust Memorial Museum (USHMM). I read the map as an organizational rhetoric that frames place as "embedded injustice." I also argue that thorough analysis of the framing of local place on Google Earth must inherently question whether the map can create a disruption in the viewing subject. While the map presents vital information on excruciatingly despicable acts of injustice, and the …
Student Perceptions Of Public Relations And Journalism: A Pilot Study Of Attitude Shifts Through Curriculum Innovation, Bernard R. Mccoy, Jerry Renaud, Adam Wagler, Amy Struthers, John Baker
Student Perceptions Of Public Relations And Journalism: A Pilot Study Of Attitude Shifts Through Curriculum Innovation, Bernard R. Mccoy, Jerry Renaud, Adam Wagler, Amy Struthers, John Baker
College of Journalism and Mass Communications: Faculty Publications
Journalism and public relations have had a long and often contentious relationship. It is rare when journalists and advertising/PR specialists work well together in the real world. It is equally rare when advertising, public relations and journalism students work together as part of their classroom education. This mixed methods pilot study explored the perceptions journalism and public relations majors had about each other’s professions. The experimental group was comprised of 40 journalism and public relations majors who worked together covering a national event in an experimental college class. The control group included 68 students who participated in a more traditional …
Review Of Generous Man - Ahxs-I-Tapina: Essays In Memory Of Colin Taylor, Plains Indian Ethnologist. Edited By Arni Brownstone And Hugh Dempsey., Daniel C. Swan
Review Of Generous Man - Ahxs-I-Tapina: Essays In Memory Of Colin Taylor, Plains Indian Ethnologist. Edited By Arni Brownstone And Hugh Dempsey., Daniel C. Swan
Great Plains Research: A Journal of Natural and Social Sciences (through 2013)
This volume celebrates Colin Taylor's contributions to North American ethnology through the presentation 251 of 14 research articles that reflect the diversity and vigor of Taylor's scholarship. Taylor spent his entire life in the Sussex region of southeastern England and the majority of his career teaching at the University of Hastings. His interest in Native Americans began with a boyhood fascination that matured into a disciplined and enduring passion for research and scholarly discourse. Arni Brownstone and Hugh Dempsey, two respected scholars and close friends and colleagues of Taylor, edited the volume. The three of them, along with John C. …
Blood-Speak: Ward Churchill And The Racialization Of American Indian Identity, Casey Ryan Kelly
Blood-Speak: Ward Churchill And The Racialization Of American Indian Identity, Casey Ryan Kelly
Department of Communication Studies: Faculty Publications
After publishing a controversial essay on 9/11, Professor Ward Churchill’s scholarship and personal identity were subjected to a hostile public investigation. Evidence that Churchill had invented his American Indian identity created vehemence among many professors and tribal leaders who dismissed Churchill because he was not a “real Indian.” This essay examines the discourses of racial authenticity employed to distance Churchill from tribal communities and American Indian scholarship. Responses to Churchill’s academic and ethnic self-identification have retrenched a racialized definition of tribal identity defined by a narrow concept of blood. Employing what I term blood-speak, Churchill’s opponents harness a biological concept …
Navigating Socio-Spatial Difference, Constructing Counter-Space: Insights From Transnational Feminist Praxis, Sarah E. Dempsey, Patricia S. Parker, Kathleen J. Krone
Navigating Socio-Spatial Difference, Constructing Counter-Space: Insights From Transnational Feminist Praxis, Sarah E. Dempsey, Patricia S. Parker, Kathleen J. Krone
Department of Communication Studies: Faculty Publications
In recent years, feminist activists have increasingly transnationalized their struggle against local forms of oppression. Our study explores the contentious nature of feminist transnationalism, asking how transnational feminist networks (TFNs) navigate socio-spatial inequalities within their own practices and as a wider social movement. We argue that: (1) TFNs make socio-spatial differences meaningful in part through their constructions of regional, international, and trans-local imaginaries; and (2) TFNs construct resistant feminist counter-spaces through dialogue and strategies aimed at destabilizing dominant structures. Our findings highlight the central role of spatial praxis within transnational feminism.
Networked Expertise In The Era Of Many-To-Many Communication: On Wikipedia And Invention, Damien S. Pfister
Networked Expertise In The Era Of Many-To-Many Communication: On Wikipedia And Invention, Damien S. Pfister
Department of Communication Studies: Faculty Publications
This essay extends the observations made in E. Johanna Hartelius’ The Rhetoric of Expertise about the nature of expertise in digital contexts. I argue that digital media introduce a scale of communication—many-to-many—that reshapes how the invention of knowledge occurs. By examining how knowledge production on Wikipedia occurs, I illustrate how many-to-many communication introduces a new model of “participatory expertise.” This model of participatory expertise challenges traditional information routines by elevating procedural expertise over subject matter expertise and opening up knowledge production to the many. Additionally, by hosting multiperspectival conversations on Wikipedia, the participatory model of expertise introduces epistemic turbulence into …
Environmental And Taxonomic Bacterial Diversity Of Anaerobic Uranium(Iv) Bio-Oxidation, Karrie A. Weber, J. Cameron Thrash, J. Ian Van Trump, Laurie A. Achenbach, John D. Coates
Environmental And Taxonomic Bacterial Diversity Of Anaerobic Uranium(Iv) Bio-Oxidation, Karrie A. Weber, J. Cameron Thrash, J. Ian Van Trump, Laurie A. Achenbach, John D. Coates
School of Biological Sciences: Faculty Publications
Microorganisms in diverse terrestrial surface and subsurface environments can anaerobically catalyze the oxidative dissolution of uraninite. While a limited quantity (~5 to 12 μmol liter-1) of uranium is oxidatively dissolved in pure culture studies, the metabolism is coupled to electron transport, providing the potential of uraninite to support indigenous microbial populations and to solubilize uranium.
Supplementary files (zip folder) attached (below).
Tucked In: American Quilts And The Beds They Cover, 1790-1939, Madeleine Roberg
Tucked In: American Quilts And The Beds They Cover, 1790-1939, Madeleine Roberg
College of Education and Human Sciences: Dissertations, Theses, and Student Research
This study examines the size of quilts to determine if changes in quilt size are a reflection of changes in bedstead size. To conduct this study 118 quilt publications and 304 furniture publications (including Sears, Roebuck and Co. retail catalogues). were examined for data on quilts and bedsteads. Using these sources the dimensions of 3299 surviving quilts and 1651 bedsteads were examined to determine whether or not changes in quilts sizes correlate with changes in bedstead dimensions. The study found that quilt size (mean area) steadily declined between 1800 and 1910 and increased in the 1920s and 1930s. The most …
When Knowing Just Isn't Enough: Examining The Role Of Moral Emotions In Health Decision Making Using The Theory Of Planned Behavior, Kate Duangdao
When Knowing Just Isn't Enough: Examining The Role Of Moral Emotions In Health Decision Making Using The Theory Of Planned Behavior, Kate Duangdao
Department of Psychology: Dissertations, Theses, and Student Research
A proposed integrated Theory of Planned Behavior (TPB) model aimed to examine the role of moral emotions and two health outcomes: prosocial behaviors and smoking outcomes. Based on Tangney’s work with shame and guilt-proneness, it was expected that those more prone to guilt would engage in more prosocial behaviors and those more prone to shame would engage in more smoking behaviors. Prosocial behaviors were found to be negatively associated with smoking outcomes. However, results suggested that guilt and shame-proneness seem to function similarly in predicting behavioral outcomes. Components within the TPB were generally positively correlated with each health outcome, however …
Mobilizing Sentiment: Popular American Women's Fiction Of The Great War, 1914–1922, Sabrina Ehmke Sergeant
Mobilizing Sentiment: Popular American Women's Fiction Of The Great War, 1914–1922, Sabrina Ehmke Sergeant
Department of English: Dissertations, Theses, and Student Research
This dissertation examines American women’s popular novels about the Great War published between 1914 and 1922, and offers a perspective that complicates our understanding of the American experience of WWI. Drawing on a historical framework that illuminates the subtleties of the nation’s the ever-shifting political stance in response to the European War, this study demonstrates how American response to the war was neither monolithic nor static. This study contributes to current efforts to recover women’s voices in the male-dominated terrain of war writing, and promotes the value of studying noncanonical texts. Rarely considered in scholarship of American war literature, women’s …
Towards A Theory Of Comic Book Adaptation, Colin Beineke
Towards A Theory Of Comic Book Adaptation, Colin Beineke
Department of English: Dissertations, Theses, and Student Research
Contemporary adaptation studies/theories have tended to focus singularly on the movement from the novel/short story to film – largely ignoring mediums such as the theater, music, visual art, video games, and the comic book. Such a limited view of adaptation has led to an underdeveloped and misplaced understanding of the adaptation process, which has in turn culminated in a convoluted perception of the products of artistic adaptation. The necessity of combating the consequences of these limited outlooks – particularly in the field of comics studies – is as vital as the difficulties are manifold. In opposition to this current stream …
Learning Style Differentiation Between Hispanic And Non-Hispanic College Students In Selected Institutions In The North Carolina Public University System, Robert C. Tripp
Learning Style Differentiation Between Hispanic And Non-Hispanic College Students In Selected Institutions In The North Carolina Public University System, Robert C. Tripp
Department of Educational Administration: Dissertations, Theses, and Student Research
As the Hispanic population increases in North Carolina the number of college graduates of Hispanic descent should follow. Although a gradual increase in Hispanic students attending state universities has been seen, the increase has not kept pace with the increases seen in the general population. Additionally, the numbers of those achieving the baccalaureate degree have not increased. There have been a number of research projects in recent years that have documented qualitative reasons why Hispanic students have been reluctant to go to college and the factors that contribute to their success and failure at institutions of high education. Cultural influences …
Piracy, Slavery, And Assimilation: Women In Early Modern Captivity Literature, David C. Moberly
Piracy, Slavery, And Assimilation: Women In Early Modern Captivity Literature, David C. Moberly
Department of English: Dissertations, Theses, and Student Research
This thesis examines a hitherto neglected body of works featuring female characters enslaved in Islamicate lands. During the sixteenth and seventeenth centuries, many Englishmen and women were taken captive by pirates and enslaved in what is now the Middle East and North Africa. Several writers of the time created narratives and dramas about the experiences of such captives. Recent scholarship has brought to light many of these works and pointed out their importance in establishing what was still a young, unsure, and developing English identity in this early period. Most of this scholarship, however, has dealt with narratives of the …
“Instead Of Growing Under Her Heart, I Grew In It”: The Relationship Between Adoption Entrance Narratives And Adoptees’ Self-Concept, Haley Kranstruber, Jody Koenig Kellas
“Instead Of Growing Under Her Heart, I Grew In It”: The Relationship Between Adoption Entrance Narratives And Adoptees’ Self-Concept, Haley Kranstruber, Jody Koenig Kellas
Department of Communication Studies: Faculty Publications
Adoptees are partially or entirely disconnected from those involved in their birth stories, so adoptive families create adoption entrance narratives to fill that void. Scholars assert that these narratives impact adopted child well-being later in life, but that assumption has yet to be empirically tested. The goal of this study was to examine themes emerging from adoption entrance narratives (n = 105), and to then determine the impact of story content on adoptees’ self-concept. Seven themes emerged: openness, deception, chosen child, fate, difference, rescue, and reconnection. Results indicate the salience of the chosen child, negative reconnection, and difference themes …
Agricultural Leadership, Education, And Communication (Aglec) Collection Development Policy, Judith Wolfe
Agricultural Leadership, Education, And Communication (Aglec) Collection Development Policy, Judith Wolfe
University of Nebraska-Lincoln Libraries: Collection Development Policies
The ALEC collection supports the teaching, research and service activities of the entire university community. Its primary audience is the faculty, staff, and students of the ALEC department. The collections primary focus is support for the undergraduate and graduate curricula for agricultural education, tourism in agriculture, industrial technology education, leadership and communication. Specific and transient research needs of ALEC faculty and graduate students are supplemented through Interlibrary Loan. The focus of the ALEC collection is diverse in nature as it encompasses disciplines that are well established within colleges and departments in the university structure. The collection is multifaceted and is …
Low Levels Of Hydrogen Peroxide Stimulate Corneal Epithelial Cell Adhesion, Migration, And Wound Healing, Qing Pan, Wen-Ya Qiu, Ya-Nan Huo, Yu-Feng Yao, Marjorie F. Lou
Low Levels Of Hydrogen Peroxide Stimulate Corneal Epithelial Cell Adhesion, Migration, And Wound Healing, Qing Pan, Wen-Ya Qiu, Ya-Nan Huo, Yu-Feng Yao, Marjorie F. Lou
School of Veterinary and Biomedical Sciences: Faculty Publications
PURPOSE. Intracellular reactive oxygen species have been reported to associate with growth factor and integrin signalings in promoting cell adhesion in many cell types. This study is to explore if exogenous H2O2 at low levels can be beneficial to cell adhesion, migration, and wound healing.
METHODS. Primary rabbit corneal epithelial cells treated with 0–70 M H2O2 were tested for viability by MTT assay, adhesion by centrifugation assay, focal contacts of vinculin and F-actin by immunofluorescence, activated Src(pY416), EGF receptor (pY845), vinculin(pY1065), FAK(pY397), and FAK(pY576) by immunoblotting. Cell migration was examined with 0–50 M H2O2 using the scratch wound technique. Corneal …
Effect Of Brown Midrib Corn Silage And Dried Distillers Grains Plus Solubles On Lactational Performance And Nitrogen Utilization By Dairy Cows, Hugo A. Ramirez
Effect Of Brown Midrib Corn Silage And Dried Distillers Grains Plus Solubles On Lactational Performance And Nitrogen Utilization By Dairy Cows, Hugo A. Ramirez
Department of Animal Science: Dissertations, Theses, and Student Research
Thirty six Holstein cows, four ruminally cannulated, (mean ± SD, 111 ± 35 DIM; 664 ± 76.5 kg BW) were used in replicated 4×4 Latin squares to investigate the effects of brown midrib (bm3) and conventional (DP) corn silages, and the inclusion of dried distillers grains plus solubles (DDGS) on milk production and N utilization. In each 28 d period cows were assigned to one of four treatments: DP plus 0% DDGS (CON); bm3 plus 0% DDGS (BMR); DP corn silage plus 30% DDGS (DP+DG); and bm3 plus 30% DDGS (BMR+DG). Dry matter intake was greater (P < 0.01) for cows consuming bm3 (25.8 VS 24.4 ± 0.47 kg), likewise for DDGS (24.3 and 25.9 ± 0.47 kg/d for 0 and 30%). Compared to DP hybrid, NDFD was higher (P < 0.01) for bm3 (32.5 VS 38.1 ± 1.79%). There was a hybrid × DDGS interaction (P < 0.01) for total concentration of volatile fatty acids (VFA) and rumen pH as the highly digestible treatment BMR+DG resulted in the highest VFA and the lowest pH. Milk yield was not affected by treatment and averaged 30.6 ± 1.09 kg/d. Milk protein yield (MPY) was greater (P < 0.01) for bm3 and DDGS treatments. There was a hybrid by DDGS interaction (P = 0.02) for milk fat yield (MFY) resulting in 1.03, 1.08, 0.84 and 0.78 ± 0.045 kg/d for DP, BMR, DP+DG and BMR+DG. Fat corrected milk (FCM) was affected by DDGS (P < 0.01) and averaged 30.0 and 26.4 ± 1.0kg/d (0% and 30% inclusions). Urinary N excretion was similar among treatments; however fecal N was lower (P = 0.03) for diets containing bm3 corn silage which caused lower (P = 0.02) manure N. These results indicate that bm3 corn silage and DDGS increase DMI, NDFD and MPY; however high inclusion of corn silage with 30% DDGS reduces FCM. Nitrogen excretion was reduced when cows consumed bm3.
Baby Boomers At Work: Growing Older And Working More, Eve M. Brank
Baby Boomers At Work: Growing Older And Working More, Eve M. Brank
Nebraska College of Law: Faculty Publications
In the current chapter, I will first detail the legal framework for workplace age discrimination and court case examples that have largely mirrored race and gender discrimination law. Next, I will discuss the psychological research that details the consequences of age discrimination with a particular focus on the combined effects of stereotype assimilation and notions of deservingness of respect. Last, I will suggest that until we know the causes of age discrimination, we cannot legitimately address its consequences the same way we have addressed other forms of discrimination. Specifically, I will argue that legislating against age discrimination is inherently different …
Risk Maps For Targeting Exotic Plant Pest Detection Programs In The United States, R Magarey, D Borchert, J S. Engle, M Colunga-Garcia Michigan State University, F Koch, D Yemshanov Canadian Forest Service, Great Lakes Forestry Centre
Risk Maps For Targeting Exotic Plant Pest Detection Programs In The United States, R Magarey, D Borchert, J S. Engle, M Colunga-Garcia Michigan State University, F Koch, D Yemshanov Canadian Forest Service, Great Lakes Forestry Centre
United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications
In the United States, pest risk maps are used by the Cooperative Agricultural Pest Survey for spatial and temporal targeting of exotic plant pest detection programs. Methods are described to create standardized host distribution, climate and pathway risk maps for the top nationally ranked exotic pest targets. Two examples are provided to illustrate the risk mapping process: late wilt of corn (Harpophora-maydis) and the giant African land snail (Achatina fulica). Host risk maps were made from county-level crop census and USDA Forest Inventory and Analysis data, respectively. Climate risk maps were made using the North Carolina …
Regulation Of C-Type Natriuretic Peptide Expression, Donald F. Sellitti, Nancy Koles, Maria C. Mendonça
Regulation Of C-Type Natriuretic Peptide Expression, Donald F. Sellitti, Nancy Koles, Maria C. Mendonça
Uniformed Services University of the Health Sciences
C-type natriuretic peptide (CNP) is a member of the small family of natriuretic peptides that also includes atrial natriuretic peptide (ANP) and brain, or B-type natriuretic peptide (BNP). Unlike them, it performs its major functions in an autocrine or paracrine manner. Those functions, mediated through binding to the membrane guanylyl cyclase natriuretic peptide receptor B (NPR-B), or by signaling through the non-enzyme natriuretic peptide receptor C (NPR-C), include the regulation of endochondral ossification, reproduction, nervous system development, and the maintenance of cardiovascular health. To date, the regulation of CNP gene expression has not received the attention that has been paid …
Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated By Association Of The Catalytic And Regulatory Subunits, Melanie Neely Willis, Yilin Liu, Ekaterina I. Biterova, Melanie A. Simpson, Heejeong Kim, Jaekwon Lee, Joseph J. Barycki
Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated By Association Of The Catalytic And Regulatory Subunits, Melanie Neely Willis, Yilin Liu, Ekaterina I. Biterova, Melanie A. Simpson, Heejeong Kim, Jaekwon Lee, Joseph J. Barycki
Department of Biochemistry: Faculty Publications
Glutamate cysteine ligase (GCL) deficiency is a rare autosomal recessive trait that compromises
production of glutathione, a critical redox buffer and enzymatic cofactor. Patients have markedly
reduced levels of erythrocyte glutathione, leading to hemolytic anemia and in some cases,
impaired neurological function. Human glutamate cysteine ligase is a heterodimer comprised of a
catalytic (GCLC) and a regulatory subunit (GCLM), which catalyzes the initial rate limiting step
in glutathione production. Four clinical missense mutations have been identified within GCLC:
Arg127Cys, Pro158Leu, His370Leu, and Pro414Leu. Here, we have evaluated the impacts of
these mutations on enzymatic function in vivo and in vitro …
Some Multidisciplinary Practices, Kathleen Black
Some Multidisciplinary Practices, Kathleen Black
Honors in Practice Online Archive
From the beginning of the Northwestern College Honors Program in 2002, we have operated with several underlying principles, three of which relate to our goal of being multidisciplinary. Based upon our recognition of multiple intelligences and our acknowledgment of scholarship in all academic disciplines, we have made it our goal that a single definition of either intelligence or giftedness should not suffice as a strategic design concept for the program or as a selection criterion for the students who participate in it.
In creating our program, the Faculty Honors Program Committee decided that our honors program would not include only …
Rethinking Asian Studies In The Interdisciplinary Honors Setting, Adam D. Frank
Rethinking Asian Studies In The Interdisciplinary Honors Setting, Adam D. Frank
Honors in Practice Online Archive
In an interdisciplinary honors setting, especially at colleges and universities with minimal Asian studies offerings, teaching interdisciplinary Asian studies courses can present a particularly difficult challenge. The problem, as Charles Holcombe notes, is that “Asia is simply too enormous, spanning the better part of the entire Old World, and too diverse, to serve as a very meaningful label” (9). Unless students already have a background in Asian studies, have studied Asian languages and cultures, or are themselves from Asian countries, they often lack the basic, macro-level knowledge of geography, history, and politics necessary to address complex issues, particularly Orientalist stereotypes …
Rethinking Digital Editing Practices To Better Address Non-Canonical Texts, Amanda A Gailey
Rethinking Digital Editing Practices To Better Address Non-Canonical Texts, Amanda A Gailey
Documentary Editing: Journal of the Association for Documentary Editing (1979–2011)
This article stems from my recent work on Race and Children’s Literature of the Gilded Age (RCLGA),1 a digital archive that aims to provide a heavily annotated resource for scholars and students of literature, history, African American studies, visual communication, and education to examine how adults wanted children to think about race during the era of Jim Crow. I edit the archive with Gerald Early, Professor of Modern letters, English, African studies, and African American studies at Washington University in St. Louis, and D. B. Dowd, Professor of Communication Design and American Culture Studies, also at Washington University. When complete, …
The Honors Differential: At Home And Abroad, Neil H. Donahue
The Honors Differential: At Home And Abroad, Neil H. Donahue
Journal of the National Collegiate Honors Council Online Archive
Study abroad constitutes already the kind of enrichment that defines honors education at home. The honors component of instruction at home in the U.S. emerges from the differential between the regular course of instruction and the extension, or rather qualitative enrichment, of the same through various types of added conceptual complexity, scope of detail, depth of inquiry, or level of skill. That honors differential can be tracked visibly and explicitly onto a syllabus in a regular course through highlighted assignments for eligible students; or can be embedded invisibly and implicitly in a designated honors course the syllabus for which makes …
About The Authors
Journal of the National Collegiate Honors Council Online Archive
Contents
Larry Andrews
Jaclyn Bankert
Sister Edith Bogue
Bernice Braid
Marian Bruce
Scott Carnicom
James J. Clauss
Craig T. Cobane
Theodore Coladarci
Kevin L. Dooley
Richard England
Linda Frost
Annmarie Guzy
Mark Haggerty
Nathan Hilberg
Mimi Killinger
Kenneth Oswald
Benjamin Moritz
Gladys Palma de Schrynemakers
Debra S. Schroeder
Charlie Slavin
Ernest Smith
Becky L. Spritz
Cross-Domain Collaborative Learning And The Transformation Of Faculty Identity, James B. Young
Cross-Domain Collaborative Learning And The Transformation Of Faculty Identity, James B. Young
To Improve the Academy: A Journal of Educational Development
This chapter addresses how faculty from disparate backgrounds collaborate in interdisciplinary learning communities and how this cross-domain collaboration leads to a tangible change in identity. Faculty enter learning communities playing the more common roles of expert and teacher, but they leave taking on the additional roles of novice, learner, and knowledge integrator. The experience of cross-domain interaction is both rewarding and transformative for faculty as they are well equipped to communicate across the disciplinary landscape and gain a rhetorical awareness that is an invaluable ingredient for learning community participation.
Introduction To Willa Cather And Modern Cultures [Cather Studies 9], Melissa J. Homestead
Introduction To Willa Cather And Modern Cultures [Cather Studies 9], Melissa J. Homestead
Department of English: Faculty Publications
To some, linking Willa Cather to "the modern" or more narrowly to literary modernism still seems an eccentric proposition. As Richard Millington has pointed out, "one will look in vain for Cather's name in the index of most accounts, whether new or old, of the nature and history of Anglo-American modernism" (52). Perhaps she fails to feature in these accounts because in her public pronouncements and certain recurring motifs in her fiction, she appeared to turn her back on modernity. Cather was skeptical about many aspects of the culture that took shape around her in the early decades of the …
Roles Of The 15-Kda Selenoprotein (Sep15) In Redox Homeostasis And Cataract Development Revealed By The Analysis Of Sep 15 Knockout Mice, Marina V. Kasaikina, Dmitri E. Fomenko, Vyacheslav M. Labunskyy, Salil A. Lachke, Wenya Qiu, Juliet A. Moncaster, Jie Zhang, Mark W. Wojnarowicz, Sathish Kumar Natarajan, Mikalai I. Malinouski, Ulrich Schweizer, Petra A. Tsuji, Bradley A. Carlson, Richard L. Maas, Marjorie F. Lou, Lee E. Goldstein, Dolph L. Hatfield, Vadim N. Gladyshev
Roles Of The 15-Kda Selenoprotein (Sep15) In Redox Homeostasis And Cataract Development Revealed By The Analysis Of Sep 15 Knockout Mice, Marina V. Kasaikina, Dmitri E. Fomenko, Vyacheslav M. Labunskyy, Salil A. Lachke, Wenya Qiu, Juliet A. Moncaster, Jie Zhang, Mark W. Wojnarowicz, Sathish Kumar Natarajan, Mikalai I. Malinouski, Ulrich Schweizer, Petra A. Tsuji, Bradley A. Carlson, Richard L. Maas, Marjorie F. Lou, Lee E. Goldstein, Dolph L. Hatfield, Vadim N. Gladyshev
School of Veterinary and Biomedical Sciences: Faculty Publications
The 15-kDa selenoprotein (Sep15) is a thioredoxin-like, endoplasmic reticulum-resident protein involved in the quality control of glycoprotein folding through its interaction with UDP-glucose:glycoprotein glucosyltransferase. Expression of Sep15 is regulated by dietary selenium and the unfolded protein response, but its specific function is not known. In this study, we developed and characterized Sep15 KO mice by targeted removal of exon 2 of the Sep15 gene coding for the cysteinerich UDP-glucose:glycoprotein glucosyltransferase-binding domain. These KO mice synthesized a mutant mRNA, but the shortened protein product could be detected neither in tissues nor in Sep15 KO embryonic fibroblasts. Sep15 KO mice were viable …
Another Really, Really Big Virus, James L. Van Etten
Another Really, Really Big Virus, James L. Van Etten
Department of Plant Pathology: Faculty Publications
Viruses with genomes larger than 300 kb and up to 1.2 Mb, which encode hundreds of proteins, are being discovered and characterized with increasing frequency. Most, but not all, of these large viruses (often referred to as giruses) infect protists that live in aqueous environments. Bioinformatic analyses of metagenomes of aqueous samples indicate that large DNA viruses are quite common in nature and await discovery. One issue that is perhaps not appreciated by the virology community is that large viruses, even those classified in the same family, can differ significantly in morphology, lifestyle, and gene complement. This brief commentary, which …