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Investigating Programming Behaviors To Understand Student Engagement And Experience In Introductory Programming Courses, Marcus Eugene Gubanyi Dec 2025

Investigating Programming Behaviors To Understand Student Engagement And Experience In Introductory Programming Courses, Marcus Eugene Gubanyi

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Introductory programming courses are foundational to developing students’ problem-solving abilities and shaping their persistence in computing pathways. Engagement with programming tasks plays a central role in student learning and experience. Many research measures, including self-reports and code submissions, offer only a limited view of student engagement with programming tasks. This dissertation leverages programming process data, consisting of keystrokes and compilation events, to capture the programming process as it unfolds and to investigate observable programming behaviors. Guided by educational theories, three studies examine how students’ programming behaviors vary across instructional and assessment contexts, how they relate to motivational profiles, and how …


Making Deep Neural Networks Trustworthy: Intelligibility And Safety Through Symbolic Methods, Eleanor Catherine Quint Dec 2025

Making Deep Neural Networks Trustworthy: Intelligibility And Safety Through Symbolic Methods, Eleanor Catherine Quint

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The rapid adoption of deep learning has come at the cost of properties long valued in artificial intelligence: intelligibility and safety. This dissertation develops methods that restore these properties by coupling neural networks with symbolic structure.

First, for supervised classification, I propose a differentiable decision tree integrated with a supervised variational autoencoder. The resulting model maintains competitive accuracy and generative performance while exposing clear macro-features in its latent space, improving interpretability.

Second, for reinforcement learning, I extend constrained Markov decision processes by specifying constraints in formal languages. This formal language constrained MDP enables the use of automata for state augmentation, …


Amplifying Mother Leaders’ Voices: A Feminist Inquiry Into Gender Inequity In Higher Education Leadership, Katherine Bard Dec 2025

Amplifying Mother Leaders’ Voices: A Feminist Inquiry Into Gender Inequity In Higher Education Leadership, Katherine Bard

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Women now comprise more than half of mid- and upper-level administrators in higher education, yet they remain underrepresented in the most senior leadership roles. For mothers in leadership, this underrepresentation is compounded by gendered structures, expectations, and norms that shape their personal and professional lives in distinct ways. While scholarship has examined working motherhood broadly and gender inequity in higher education separately, little research has focused on how mother leaders experience and interpret gender inequity in higher education leadership. This study sought to address that gap by exploring the lived experiences of ten mother leaders working at research-intensive (R1) universities …


Ethical Decision-Making Processes In Authentic Environmental Engineering Contexts Through Systems Thinking And Team Collaboration Lenses: An Embedded Single Case Study, Toluwalase Eniola Brower Dec 2025

Ethical Decision-Making Processes In Authentic Environmental Engineering Contexts Through Systems Thinking And Team Collaboration Lenses: An Embedded Single Case Study, Toluwalase Eniola Brower

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Ethical and professional responsibility is a critical learning outcome emphasized in ABET accreditation. However, ethics instruction in engineering education often lacks integration of system-level considerations such as economic, environmental, and societal contexts, that are essential for developing engineering solutions that ensure the safety and welfare of diverse stakeholders. This embedded single-case study investigated the integration of authentic ethics instruction within a junior-level environmental engineering course at a Midwestern U.S. university during spring 2025 and explores how civil engineering student teams within the course engage in ethical decision-making process during authentic problem-solving.

The instructional intervention consisted of four problem-based ethics modules, …


Changepoint Detection As Model Selection: A General Framework, Michael A. Grantham Dec 2025

Changepoint Detection As Model Selection: A General Framework, Michael A. Grantham

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation presents a general framework for changepoint detection based on ℓ0 model selection. The core method, Iteratively Reweighted Fused Lasso (IRFL), improves upon the generalized lasso by adaptively reweighting penalties to enhance support recovery and minimize criteria such as the Bayesian Information Criterion (BIC). The approach allows for flexible modeling of seasonal patterns, linear and quadratic trends, and autoregressive dependence in the presence of changepoints.

Simulation studies demonstrate that IRFL achieves accurate changepoint detection across a wide range of challenging scenarios, including those involving nuisance factors such as trends, seasonal patterns, and serially correlated errors. The framework is …


In-Field Tractor Operational Load Profile Generation In Support Of Advanced Tractor Testing In Mixedmode Power, Andrew Donesky Dec 2025

In-Field Tractor Operational Load Profile Generation In Support Of Advanced Tractor Testing In Mixedmode Power, Andrew Donesky

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation addresses the need to better characterize real-world tractor power requirements across drawbar, power take-off (PTO), and hydraulic modes to support more representative tractor testing. Conventional testing protocols, such as OECD Code 2, emphasize steady-state performance under controlled high-load conditions, which do not reflect the mixed and dynamic demands of modern field operations. To address this gap, a Tractor Instrumentation System (TIS) was developed, validated, and deployed to collect high-resolution, mixed-mode power data during planting, anhydrous ammonia application, and grain cart operations. The TIS integrates physical sensors, including custom load pins, hydraulic pressure/flow sensors, and a redesigned PTO torque …


A Strategic Audit Of Live Nation Entertainment: Industry Position, Competitive Dynamics, And Long-Term Growth Outlook, William H. Wooden Iv, Owen B. Crone, Reece L. Flores, Grace A. Schaefer, Eric M. Jacob, Sydney A. Beck Dec 2025

A Strategic Audit Of Live Nation Entertainment: Industry Position, Competitive Dynamics, And Long-Term Growth Outlook, William H. Wooden Iv, Owen B. Crone, Reece L. Flores, Grace A. Schaefer, Eric M. Jacob, Sydney A. Beck

Honors Program: Senior Projects (Public)

Live Nation Entertainment is the dominant global leader in the concert and live events industry, supported by a vertically integrated model that spans artist management, concert promotion, venue operations, ticketing, and sponsorship. This strategic audit evaluates Live Nation’s internal strengths, external threats, competitive position, corporate governance, and long-term strategic prospects based on comprehensive analysis of company reports, industry dynamics, and market trends. Live Nation benefits from unmatched scale, global venue ownership, exclusive artist relationships, and the substantial network effects generated by Ticketmaster, which collectively create high barriers to entry and sustained competitive advantage. The audit also examines significant challenges such …


Evaluation Of Ramp Instead Of Forage During Grain Adaptation And Different Sorghum Varieties On Enteric Methane Production From Cattle, Jack T. Fort Dec 2025

Evaluation Of Ramp Instead Of Forage During Grain Adaptation And Different Sorghum Varieties On Enteric Methane Production From Cattle, Jack T. Fort

Department of Animal Science: Dissertations, Theses, and Student Research

Two experiments were conducted to evaluate the use of RAMP (Cargill Corn Milling, Blair, Nebraska) compared with traditional forage-based adaptations on methane (CH4) and carbon dioxide (CO2) emissions, performance, and carcass characteristics. Experiment 1, 64 yearling British × Continental steers (initial BW = 423 ± 6 kg) were adapted using 100% RAMP (RAMP) or a traditional forage diet (CON; 43% forage) before transitioning 22 d to a common finishing diet containing 65.6% steam-flaked corn. Emissions were measured in paired replications using a two-chamber indirect calorimetry barn. During adaptation RAMP did not affect CH4 production (g/d; …


Further Evaluation Of Speed Tables On Roadway Curves: Simulation And Expeditionary Deployments, Nathan Reineke Dec 2025

Further Evaluation Of Speed Tables On Roadway Curves: Simulation And Expeditionary Deployments, Nathan Reineke

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

The road network leading up to a United States military base is known as an Entry Control Facility, or ECF. Entry control facilities are used to shield military installations by monitoring vehicles and refusing access to unauthorized vehicles. Passive control devices, including speed tables, are used to disrupt or delay threat vehicles attempting to navigate ECFs at high speeds. The purpose of this research was to recommend optimized configurations of speed tables in combination with roadway curves which allow safe, efficient traversal for authorized vehicles and disruption or delay for threat vehicles.

First, an analytical model of a Tesla Model …


Two Essays On Agricultural Trade Policy And Total Factor Productivity, Hanifi Otgun Dec 2025

Two Essays On Agricultural Trade Policy And Total Factor Productivity, Hanifi Otgun

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation consists of two essays: the first examines the welfare and trade implications of the 2016–2017 drought in Brazil and the subsequent temporary import ban on Robusta coffee; the second examines how trade openness influences agricultural total factor productivity across 26 NUTS-2 regions in Türkiye from 2013 to 2020.

The first essay focuses on Brazil, a major Robusta coffee producer and exporter that faced a significant drought in 2016–17, reducing Robusta output. In response, the government initially allowed one million 60-kg bags of Robusta coffee to be imported. An import ban was imposed shortly afterward due to lobbying by …


Detecting Prescribed Fire, Haying And Grazing Events Via Remote Sensing To Create Grassland Disturbance Landcovers For The Ring-Necked Pheasant (Phasianus Colchicus), Megan Amy Baldissara Dec 2025

Detecting Prescribed Fire, Haying And Grazing Events Via Remote Sensing To Create Grassland Disturbance Landcovers For The Ring-Necked Pheasant (Phasianus Colchicus), Megan Amy Baldissara

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation developed disturbance detection models to fulfill the need for remote sensing landcover products describing grassland structure. The use of landcover products derived from remote sensing is increasing over time in pheasant (Phasianus colchicus) research. Such landcover, however, does not provide relevant pheasant structural habitat information (Chapter 1). Pheasants require tall, high-density grassland for nesting, tall grassland with medium density for brood rearing, and tall grassland for wintering. Time since disturbance can serve as a proxy for structure, as it shapes vegetation by removing biomass and resetting succession. Disturbance is easier to detect than structure with current …


Real-Time, Co-Regulated Design For Cyber-Physical, Multi-Rotor Uas Swarms, Grant Simon Phillips Dec 2025

Real-Time, Co-Regulated Design For Cyber-Physical, Multi-Rotor Uas Swarms, Grant Simon Phillips

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Uncrewed Aerial Systems (UAS) have been integrated into a wide range of research and industrial applications, with growing interest in extending mission duration and spatial coverage through coordinated multi-UAS systems, or swarms. While swarming offers the potential for extended mission endurance and robustness through advanced path-planning, control, and estimation algorithms, significant challenges arise when implementing these methods on decentralized platforms composed of size, weight, and power-constrained (SWaP) vehicles. Limitations in onboard computational capacity and congested communication channels can break critical design-time assumptions, which at best, will degrade application quality of service, and at worst, destabilize the fleet through excessive delays …


Determination Of Steroid Hormones And ⍺-Zeranol In Beef Products In East Tennessee, W. Colby Huffman, S. Ellie Jaynes, Nathan C. Duncan, D. Andrew Crain Nov 2025

Determination Of Steroid Hormones And ⍺-Zeranol In Beef Products In East Tennessee, W. Colby Huffman, S. Ellie Jaynes, Nathan C. Duncan, D. Andrew Crain

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Hormone growth implants are commonly used in cattle to increase growth and there is some concern that these implants may result in altered hormone concentrations in the beef from implanted cattle. This study aims to (1) develop a simple, standard, cost-effective method to measure hormones in beef and (2) compare hormones in meat from cattle not exposed to growth implants (negative controls), cattle exposed to growth implants (positive controls), and from a commercial retail store. Extraction and measurement using LCMS/MS was successful in detecting 17b-estradiol, progesterone, testosterone, and a-zeranol in meat, with a trend to lower concentrations in meat not …


Examining Microbial Biomass And Soil Organic Carbon In Annual Vs. Perennial Agricultural Ecosystem Soils, Paige Kenyon, Jacob Rutz, Kelsey S. Bitting Nov 2025

Examining Microbial Biomass And Soil Organic Carbon In Annual Vs. Perennial Agricultural Ecosystem Soils, Paige Kenyon, Jacob Rutz, Kelsey S. Bitting

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Soil systems have the ability to store large amounts of carbon for both short and long periods of time, much like other carbon pools such as oceans and forests. As increased amounts of carbon dioxide are released into the atmosphere via anthropogenic means, including the agricultural industry, scientists have been researching how to increase the amount of carbon cycled from the atmosphere and into soils as a climate change mitigation strategy. Soil systems have the capacity to sequester carbon in part due to fungal and bacterial community activity. Differences in soil microbial biomass levels between annual and perennial agricultural systems …


New Butterfly Taxa And Findings From Genomic Analyses, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin Nov 2025

New Butterfly Taxa And Findings From Genomic Analyses, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Continuing our genomics-driven exploration of butterfly taxonomy, we integrate phylogenetic trees from all protein-coding genes with existing taxonomic and phenotypic knowledge and uncover further insights into butterfly systematics. As a result, one subgenus, 44 species, and 11 subspecies are proposed as new (type species in original combinations or type localities are listed in parentheses): Porphaurea Grishin, subgen. n. (Phoenicops porphyropis Meyrick & Lower, 1902) of Chaetocneme C. Felder, 1860 in Hesperiidae Latreille, 1809; Dione (Agraulis) lamasi Grishin, sp. n. (Peru: Cuzco) in Nymphalidae Rafinesque, 1815; Lasaia (Lasaia) chiapis Grishin, sp. n. (Mexico: Chiapas), Lasaia …


Fraggin’ The Superhero Genre: Parody And Carnival In Dc’S Lobo, Ryan L. Johnson Nov 2025

Fraggin’ The Superhero Genre: Parody And Carnival In Dc’S Lobo, Ryan L. Johnson

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This essay examines the DC anti-hero Lobo as an ideal example of the constructive, creative power of parody and Bakhtinian carnival. Unlike Bakhtin’s assertion that carnival since the Renaissance has lost its spirit of play and become purely destructive, Lobo uses grotesque violence to create just as much as he destroys social norms. Ultimately, the mini-series under consideration provide a valuable tool for students to understand carnival, parody, and its power as criticism.


Parenting Under Constraint: How Histories Of Abuse And Sexual Violence Shape Mothers' Caregiving In A Homeless Shelter, Kiera P. Irvin Nov 2025

Parenting Under Constraint: How Histories Of Abuse And Sexual Violence Shape Mothers' Caregiving In A Homeless Shelter, Kiera P. Irvin

Honors Program: Senior Projects (Public)

Background: Mothers experiencing homelessness often carry extensive trauma histories, yet little work examines how abuse and sexual violence shape day-to-day parenting inside communal shelter settings. This study explored how trauma histories intersect with shelter structures to influence caregiving and feelings surrounding parenting among homeless mothers.

Method: Using a qualitative design, four mothers (ages 30–51) residing in a large Midwestern homeless shelter completed approximately 30-minute, semi-structured interviews in a private room onsite. Data were audio-recorded, transcribed verbatim, and analyzed with inductive reflexive thematic analysis in Dedoose.

Results: Three interrelated themes were identified. (1) Parenting Under Constraint, in which communal living, limited …


Flea News 96 (November 2025), R. L. Bossard Nov 2025

Flea News 96 (November 2025), R. L. Bossard

Flea News

Flea News is a twice-yearly newsletter about fleas (Siphonaptera). Before including in publications any of the citations given here, please review for accuracy and correct formatting. Many of our sources are abstracting journals and current literature sources, and editors have not necessarily checked citations.

Announcements

Obituary: Lane Douglas Foil (June 16, 1949 - June 22, 2025)

Siphonaptera Literature (2025): Taxonomy, Conservation, Hosts and Distributions, Physiology and Morphology, Evolution, Ecology, Pathology and Control, Microbial Symbionts


Stable Isotope Paleoecology In The Bridgerian (Early Eocene): Investigation Of The Bridgerian Crash And The Canopy Effect, Aaron M. English Nov 2025

Stable Isotope Paleoecology In The Bridgerian (Early Eocene): Investigation Of The Bridgerian Crash And The Canopy Effect, Aaron M. English

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

The Early Eocene Climatic Optimum (EECO) was the warmest sustained interval of the Cenozoic. Its waning stages coincided with a marked decline in mammalian biodiversity known as the Bridgerian Crash, which was likely driven by increasingly cooler and drier conditions. Paleobotanical evidence suggests the early Eocene supported wet, subtropical to tropical forests at mid-latitudes, however the structure of these forests at the close of the EECO remains poorly understood. In this study, I measure carbon isotope values (d13CE) from the enamel of early Bridgerian (~52.2 – 48.3 Ma) herbivorous mammals from the Greater Green River …


The Impact Of Relative Bridge Width On Highway Crashes In Nebraska, Mujahid Ali Bahadur Nov 2025

The Impact Of Relative Bridge Width On Highway Crashes In Nebraska, Mujahid Ali Bahadur

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

This research examines how bridge width relative to the approach roadway affects crash occurrence on Nebraska highways. The Nebraska Department of Transportation-(NDOT) Bridge Design Manual sets minimum bridge widths based on roadway classification, traffic projections, and the American Association of State Highway and Transportation Officials’ (AASHTO) Load and Resistance Factor Design (LRFD) criteria. While these guidelines ensure structural and functional adequacy, they do not incorporate safety performance analyses based on crash data. This leaves an important gap in understanding how bridge and approach roadway width decisions influence safety outcomes.

This research has four objectives: (1) evaluate crash frequency across different …


A Practice-Based Framework For Teaching Geography At The Secondary Level, Kyle F. Tredinnick Nov 2025

A Practice-Based Framework For Teaching Geography At The Secondary Level, Kyle F. Tredinnick

Department of Geography: Dissertations, Theses, and Student Research

Further work is necessary to carry out the goals set forth in geography education initiatives like the Geography for Life: National Geography Standards and Road Map for 21st Century Geography Education Project. Methods to communicate the focus of geographic lessons at the secondary level can help guide teachers who are otherwise unaware of the ability for geography to answer questions and develop solutions to problems. Research and development of effective instructional tools to teach geography is needed. This research aims to provide a practice-based model for lesson-development in geography, as supported in academic literature. Input from higher-education faculty …


Erratum Of "Temporal Variability In Grassland Leaf Water Content Is Strongly And Similarly Dependent On Soil Moisture Among Dominant Grasses", Henry K. Joniak, Andrew Felton Oct 2025

Erratum Of "Temporal Variability In Grassland Leaf Water Content Is Strongly And Similarly Dependent On Soil Moisture Among Dominant Grasses", Henry K. Joniak, Andrew Felton

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

In this erratum, we correct a typographical error in “Temporal variability in grassland leaf water content is strongly and similarly dependent on soil moisture among dominant grasses.” In this correction, we strengthen our findings that leaf water content in the dominant grasses of grasslands in the Northern Great Plains is directly tied to changes in soil moisture. Consequently, this soil moisture is non-linearly correlated with time since rainfall events, showcasing a relationship between precipitation and leaf water content. Our results indicate a strong and nearly identical vulnerability of two key forage grasses to fine-scale fluctuations in soil water availability, suggesting …


The Big Bang Theory’S Blurred (Tele)Vision Of Scientific Ethics: Some Thoughts For Educators Who Want To Change The Channel, Lee-Anne Broadhead, Sean J. Howard Oct 2025

The Big Bang Theory’S Blurred (Tele)Vision Of Scientific Ethics: Some Thoughts For Educators Who Want To Change The Channel, Lee-Anne Broadhead, Sean J. Howard

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This article investigates the way the popular American television program The Big Bang Theory represents the pursuit of scientific knowledge and reflects on the cultural and educational implications of the show’s contradictory problematization and valorization of the reductionist method at the core of modern Eurocentric science. Drawing on story-lines relating to military research, animal experimentation, and pharmaceutical drug trials, we consider the show’s precarious balance of implicit critique (the consistent exposé of systematically violent, often unethical research) and overt celebration (the presentation of science as “cool,” and its practitioners as flawed but endearing). This tension, we argue, enhances the show’s …


Interview With Orca Award Winner Donald Weeks; Unl Biochemistry; Biotechnology, Mark Griep, Donald Weeks Oct 2025

Interview With Orca Award Winner Donald Weeks; Unl Biochemistry; Biotechnology, Mark Griep, Donald Weeks

UNL ORCA Interview Series

Emeritus Professor Donald Paul Weeks was awarded the ORCA in 2014, a year before he retired. He grew up in a small farm south of Terre Haute, Indiana. In his youth, he participated in 4-H programs that must have sparked an interest in science because he earned his bachelor's degree from Purdue University in 1963. Purdue is about 90 miles north of Terre Haute. Don's doctoral work was at the University of Illinois in Champaign-Urbana for a project about protein synthesis during maize germination. Next, he did postdoctoral work at the Fox Chase Cancer Center in Philadelphia, where his research …


Nebline, October 2025 Oct 2025

Nebline, October 2025

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Contents

4-H super fair helps youth become beyond ready

What's popping? by Natalie Sehi

Recipes of the month, by Kayla Colgrove: Fish bait snack mix, kicked up popcorn, and cinnamon crunch snack mix

Are your trees for the next storm? by Rachel Anderson

Garden guide: Things to do this month by Mary Jane Frogge

GRO Big Red virtual learning series

Composting demonstration

Promoting language development in young children by Hayley Jackson

Tip sheet for harvest 2025 by John Nelson

Rogers Memorial Day farm field day, September 2025

Heart of 4-H volunteer award: Rachel Wells

Join 4-H to become beyond ready …


Course Syllabus For Entomology: Introduction To Acarology, Andrew Prescott Oct 2025

Course Syllabus For Entomology: Introduction To Acarology, Andrew Prescott

Department of Entomology: Distance Master of Science Projects

Includes an outline and syllabus for an introductory college-level class on acarology, covering both ticks and mites.


Mini Movie Master Of Science Project, Nicole Pruess Oct 2025

Mini Movie Master Of Science Project, Nicole Pruess

Department of Entomology: Distance Master of Science Projects

Contents

Educational Video Creative Process

Host Plants

Fruit Trays/Nectar Plants

Butterfly vs Moth

Longevity/Lifespan

Includes videos:
Butterfly vs Moth.mp4 (2623912 kB)
Fruit Trays and Nectar Plants.mp4 (1742827 kB)
Host Plants.mp4 (1721714 kB)
Lifespan and Longevity.mp4 (2528704 kB)


Insect Biodiversity Of Prairie Land Based On Prescribed Fire Plans In Central Iowa, Katelyn Rodriguez Oct 2025

Insect Biodiversity Of Prairie Land Based On Prescribed Fire Plans In Central Iowa, Katelyn Rodriguez

Department of Entomology: Distance Master of Science Projects

Introduction

Insects play a crucial role in the prairie ecosystems by helping to maintain a healthy balance in various aspects of human life. They play vital roles in assisting with pest control, waste decomposition, and the pollination of plants and crops (The Nature Conservancy, 2021). Additionally, they can serve as indicators of an environment's health, such as nutrient cycling in water and soil formation in crop fields (The Nature Conservancy, 2021). Insect biodiversity is a crucial component in ensuring our environment is adequately cared for, and in turn, other aspects of life that rely on insect relationships.

In some states, …


The Inimitable And Neologistical Dickens, Peter J. Capuano Oct 2025

The Inimitable And Neologistical Dickens, Peter J. Capuano

Department of English: Faculty Publications

This article traces the provenance of the adjective Dickensian and argues that Dickens both inaugurated new words, phrases, and idioms, and also popularized many obscure ones that are part of our common lexicon today.


Use Of Modified Z-Domain Peptides To Specifically Label The Constant Region Of Immunoglobulin G And Vegf, Madeline Allen Oct 2025

Use Of Modified Z-Domain Peptides To Specifically Label The Constant Region Of Immunoglobulin G And Vegf, Madeline Allen

Department of Chemistry: Dissertations, Theses, and Student Research

Antibodies are increasingly being used in medicinal therapies due to their ability to specifically bind to a target antigen. This fundamental behavior of antibodies has been used as a key component in drug development to address common problems with traditional drug molecules such as off-targeting, fast drug clearance, and low efficacy. This thesis provides some background into how antibodies can be used as potential treatments for a few diseases. Chapter 1 begins with an overview of the human immune system, and the role antibodies play within it. Then, the variety of ways in which antibodies can be used as medicinal …