Digital Commons Network^™

Mechanism Of Sphingolipid Homeostasis Revealed By Structural Analysis Of Arabidopsis Spt-Orm1 Complex, Peng Liu, Tian Xie, Xinyue Wu, Gongshe Han, Sita D. Gupta, Zike Zhang, Jian Yue, Feitong Dong, Kenneth Gable, Somashekarappa Niranjanakumari, Wanyuan Li, Lin Wang, Wenchen Liu, Ruifeng Yao, Edgar B. Cahoon, Teresa M. Dunn, Xin Gong

Center for Plant Science Innovation: Faculty Publications

The serine palmitoyltransferase (SPT) complex catalyzes the first and rate-limiting step in sphingolipid biosynthesis in all eukaryotes. ORM/ORMDL proteins are negative regulators of SPT that respond to cellular sphingolipid levels. However, the molecular basis underlying ORM/ORMDL-dependent homeostatic regulation of SPT is not well understood.We determined the cryo–electron microscopy structure of Arabidopsis SPT-ORM1 complex, composed of LCB1, LCB2a, SPTssa, and ORM1, in an inhibited state. A ceramide molecule is sandwiched between ORM1 and LCB2a in the cytosolic membrane leaflet. Ceramide binding is critical for the ORM1-dependent SPT repression, and dihydroceramides and phytoceramides differentially affect this repression. A hybrid β sheet, formed …

Diverse Portfolios: Investing In Tributaries For Restoration Of Large River Fishes In The Anthropocene, Kristen L. Bouska, Brian D. Healy, Michael J. Moore, Corey G. Dunn, Jonathan J. Spurgeon, Craig P. Paukert

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Rehabilitation of large Anthropocene rivers requires engagement of diverse stakeholders across a broad range of sociopolitical boundaries. Competing objectives often constrain options for ecological restoration of large rivers whereas fewer competing objectives may exist in a subset of tributaries. Further, tributaries contribute toward building a “portfolio” of river ecosystem assets through physical and biological processes that may present opportunities to enhance the resilience of large river fishes. Our goal is to review roles of tributaries in enhancing mainstem large river fish populations. We present case histories from two greatly altered and distinct large-river tributary systems that highlight how tributaries contribute …

From Laboratory To Field: Unsupervised Domain Adaptation For Plant Disease Recognition In The Wild, Xinlu Wu, Xijian Fan, Peng Luo, Sruti Das Choudhury, Tardi Tjahjadi, Chunhua Hu

School of Computing: Faculty Publications

Plant disease recognition is of vital importance to monitor plant development and predicting crop production. However, due to data degradation caused by different conditions of image acquisition, e.g., laboratory vs. field environment, machine learning-based recognition models generated within a specific dataset (source domain) tend to lose their validity when generalized to a novel dataset (target domain). To this end, domain adaptation methods can be leveraged for the recognition by learning invariant representations across domains. In this paper, we aim at addressing the issues of domain shift existing in plant disease recognition and propose a novel unsupervised domain adaptation method via …

Spatial And Temporal Patterns Of Red Foxes And Coyotes Through Camera Traps And Citizen Science, Nadia Wojcik

Honors Program: Senior Projects (Public)

Wildlife may change their temporal activity patterns or spatial distribution in response to human activity in developed landscapes. Citizen science and camera trap approaches have both been used to study wildlife in urban areas, though both methods have their strengths and weaknesses. I studied the temporal activity and spatial occurrence of red foxes (Vulpes vulpes) and coyotes (Canis latrans) in Lincoln, Nebraska to test ecological and methodological hypotheses. Specifically, I compared camera trap detections of red foxes and coyotes to observations of red foxes made by residents of Lincoln. Using these two data streams, I evaluated temporal activity patterns and …

Analysis And Design Of Lateral Framing Systems For Multi-Story Steel Buildings, Husam Al Dughaishi, Jawad Al Lawati, Moad Alosta, Shaker Mahmood, Mohamed Faisal Al-Kazee, Nur Izzi Md Yusoff, Abdalrhman Milad

Durham School of Architectural Engineering and Construction: Faculty Publications

This study focused on identifying the most appropriate structural system for multi-story buildings and analyzing its response to lateral loads. The study analyzed and compared the different structural systems to determine the most suitable option. The study aims to utilize three lateral framing systems (moment, braced, and diagrid) in order to investigate which system needs the least amount of steel to meet the design requirements. Thus, in order to determine the estimated steel savings of this system as compared to the moment and braced frames, the four-story and eight-story buildings that are 96' × 96' in the plane and utilize …

Soil Depth And Geographic Distance Modulate Bacterial Β-Diversity In Deep Soil Profiles Throughout The U.S. Corn Belt, Lucas Dantas Lopes, Stephanie L. Futrell, Emily E. Wright, Gerasimos J. Danalatos, Michael J. Castellano, Tony J. Vyn, Sotirios V. Archontoulis, Daniel P. Schachtman

Department of Agronomy and Horticulture: Faculty Publications

Understanding how microbial communities are shaped across spatial dimensions is of fundamental importance in microbial ecology. However, most studies on soil biogeography have focused on the topsoil microbiome, while the factors driving the subsoil microbiome distribution are largely unknown. Here we used 16S rRNA amplicon sequencing to analyse the factors underlying the bacterial β-diversity along vertical (0–240 cm of soil depth) and horizontal spatial dimensions (~500,000 km²) in the U.S. Corn Belt. With these data we tested whether the horizontal or vertical spatial variation had stronger impacts on the taxonomic (Bray-Curtis) and phylogenetic (weighted Unifrac) β-diversity. Additionally, we …

An Annotated Checklist Of The Dung Beetles (Coleoptera: Geotrupidae And Scarabaeidae, Subfamilies Aphodiinae And Scarabaeinae) Of Oaxaca, Mexico, Burt Kohlmann, Alfonsina Arriaga-Jiménez, Eder F. Mora-Aguilar

Insecta Mundi

Abstract. A checklist of the dung beetles (Coleoptera: Geotrupidae; Scarabaeidae: Aphodiinae and Scara­baeinae) of Oaxaca, Mexico, is presented for the first time. The checklist contains 252 taxa, 15 Geotrupidae, 77 Aphodiinae, and 160 Scarabaeinae. The state includes 58 genera and 15 tribes, where Onthophagus is the most species-rich genus with 49 taxa, followed by Ataenius with 22, Canthon with 17 and Phanaeus with 15 taxa. Valid names, as well as synonyms, are provided. First records, notes on presently recognized spe­cies, nomenclatural problems, and biodiversity comparisons are included. Phanaeus dionysius Kohlmann, Arriaga-Jiménez and Rös, 2018 (Coleoptera: Scarabaeidae: Scarabaeinae) is re-established as …

Taxonomic Placement And Nomenclatural Revisions For Five Species Of Neotropical Buprestidae (Coleoptera), Norman E. Woodley

Insecta Mundi

Autarcontes lopezi Fisher, 1925 (Coleoptera: Buprestidae), is transferred to the genus Agrilus Curtis, 1825 (new combination). Colobogaster bella Kirsch, 1873, is transferred to the genus Chrysobothris Eschscholtz, 1829 (new combination). Ectinogonia isamarae Moore, 1994, is resurrected as the valid name for the species previously called E. obscuripennis Cobos, 1954, as the latter is unavailable as infrasubspecific. Conognatha jakobsoni Obenberger, 1928, is resurrected over C. germaini Théry in Hoscheck, 1934, as the for­mer name has priority. Callimicra lucida Waterhouse, 1889, is resurrected as the valid name over C. hoscheki Obenberger, 1922, which has been used due to …

A Role For Heritable Transcriptomic Variation In Maize Adaptation To Temperate Environments, Guangchao Sun, Huihui Yu, Peng Wang, Martha Lopez‑Guerrero, Ravi V. Mural, Olivier N. Mizero, Marcin Grzybowski, Baoxing Song, Karin V. Van Dijk, Daniel P. Schachtman, Chi Zhang, James C. Schnable

Center for Plant Science Innovation: Faculty Publications

Background: Transcription bridges genetic information and phenotypes. Here, we evaluated how changes in transcriptional regulation enable maize (Zea mays), a crop originally domesticated in the tropics, to adapt to temperate environments.

Result: We generated 572 unique RNA-seq datasets from the roots of 340 maize genotypes. Genes involved in core processes such as cell division, chromosome organization and cytoskeleton organization showed lower heritability of gene expression, while genes involved in anti-oxidation activity exhibited higher expression heritability. An expression genome-wide association study (eGWAS) identified 19,602 expression quantitative trait loci (eQTLs) associated with the expression of 11,444 genes. A GWAS …

Graphene Twistronics: Tuning The Absorption Spectrum And Achieving Metamaterial Properties, Ammar Armghan, Meshari Alsharari, Khaled Aliqab, Osamah Alsalman, Juveriya Parmar, Shobhit K. Patel

Department of Mechanical and Materials Engineering: Faculty Publications

Graphene twistronics using multilayer graphene is presented in such a way that it provides a metamaterial effect. This manuscript also analyzes the prediction of behavior using machine learning. The metamaterial effect is achieved by twisting the graphene layers. Graphene twistronics is a new concept for changing the electrical and optical properties of bilayer graphene by applying a small angle twist between the layers. The angle twists of 5^o, 10^o, and 15^o are analyzed for the proposed graphene twistronics design. Tuning in the absorption spectrum is achieved by applying small twists to the angles of the …

Differentiating Between Urban Flood Risk As A Unitary Problem And As A Strand In A Braided Problem Set: Implications For Administrative Coordination, Sarah Michaels

Department of Political Science: Faculty Publications

Flood protection is a leading priority for urban water sustainability. Making cities more resilient to flooding has become urgent as the climate changes and as cities increasingly become the loci of human population and resources. Reducing the risk of future flooding in cities often necessitates different jurisdictions working together. They may do so because they confront a shared problem. This was the case in the City of Lincoln, Nebraska, USA, when partnering agencies shared a single focus on reducing flood risk from Beal Slough to the Nebraska State Penitentiary. In contrast, entities may band together to confront braided problems, intertwined …

A Role For Heritable Transcriptomic Variation In Maize Adaptation To Temperate Environments, Guangchao Sun, Huihui Yu, Peng Wang, Martha Lopez‑Guerrero, Ravi V. Mural, Olivier N. Mizero, Marcin Grzybowski, Baoxing Song, Karin V. Van Dijk, Daniel P. Schachtman, Chi Zhang, James C. Schnable

Department of Agronomy and Horticulture: Faculty Publications

Background: Transcription bridges genetic information and phenotypes. Here, we evaluated how changes in transcriptional regulation enable maize (Zea mays), a crop originally domesticated in the tropics, to adapt to temperate environments.

Result: We generated 572 unique RNA-seq datasets from the roots of 340 maize genotypes. Genes involved in core processes such as cell division, chromosome organization and cytoskeleton organization showed lower heritability of gene expression, while genes involved in anti-oxidation activity exhibited higher expression heritability. An expression genome-wide association study (eGWAS) identified 19,602 expression quantitative trait loci (eQTLs) associated with the expression of 11,444 genes. A …

Prominent Size Effects Without A Depolarization Field Observed In Ultrathin Ferroelectric Oxide Membranes, Haoying Sun, Jiahui Gu, Yongqiang Li, Tula R. Paudel, Di Liu, Jierong Wang, Yipeng Zang, Chengyi Gu, Jiangfeng Yang, Wenjie Sun, Zhengbin Gu, Evgeny Y. Tsymbal, Junming Liu, Houbing Huang, Di Wu, Yuefeng Nie

Department of Physics and Astronomy: Faculty Publications

The increasing miniaturization of electronics requires a better understanding of material properties at the nanoscale. Many studies have shown that there is a ferroelectric size limit in oxides, below which the ferroelectricity will be strongly suppressed due to the depolarization field, and whether such a limit still exists in the absence of the depolarization field remains unclear. Here, by applying uniaxial strain, we obtain pure in-plane polarized ferroelectricity in ultrathin SrTiO₃ membranes, providing a clean system with high tunability to explore ferroelectric size effects especially the thickness-dependent ferroelectric instability with no depolarization field. Surprisingly, the domain size, ferroelectric transition …

Federated Learning Framework Integrating Refined Cnn And Deep Regression Forests, Daniel Nolte, Omid Bazgir, Souparno Ghosh, Ranadip Pal

Department of Statistics: Faculty Publications

Predictive learning from medical data incurs additional challenge due to concerns over privacy and security of personal data. Federated learning, intentionally structured to preserve high level of privacy, is emerging to be an attractive way to generate cross-silo predictions in medical scenarios. However, the impact of severe population-level heterogeneity on federated learners is not well explored. In this article, we propose a methodology to detect presence of population heterogeneity in federated settings and propose a solution to handle such heterogeneity by developing a federated version of Deep Regression Forests. Additionally, we demonstrate that the recently conceptualized REpresentation of Features as …

Federated Learning Framework Integrating Refined Cnn And Deep Regression Forests, Daniel Nolte, Omid Bazgir, Souparno Ghosh, Ranadip Pal

Department of Statistics: Faculty Publications

Predictive learning from medical data incurs additional challenge due to concerns over privacy and security of personal data. Federated learning, intentionally structured to preserve high level of privacy, is emerging to be an attractive way to generate cross-silo predictions in medical scenarios. However, the impact of severe population-level heterogeneity on federated learners is not well explored. In this article, we propose a methodology to detect presence of population heterogeneity in federated settings and propose a solution to handle such heterogeneity by developing a federated version of Deep Regression Forests. Additionally, we demonstrate that the recently conceptualized REpresentation of Features as …

Projected Long-Term Climate Trends Reveal The Critical Role Of Vapor Pressure Deficit For Soybean Yields In The Us Midwest, Wenguang Sun, David Fleisher, Dennis Timlin, Chittaranjan Ray, Zhuangji Wang, Sahila Beegum, Vangimalla Reddy

Nebraska Water Center: Faculty Publications

Extreme climate events including heat waves and droughts are projected to become more frequent under future climate change conditions. However, the mechanisms between soybean yields and climate factors, specifically involving variable rainfall and high heat episodes, are still unclear, particularly with respect to spatial trends in the United States (US) Midwest. A recently modified version of the model GLYCIM was used to evaluate rainfed soybean production across 12 states at a 10 km spatial resolution for three time periods (2011–2020, 2051–2060, 2091–2099) under Representative Concentration Pathway (RCP) scenarios 4.5 and 8.5. Results showed that except for the northernmost Midwest counties, …

Protocol To Engineer Nanofilms Embedded Lipid Nanoparticles For Controlled And Targeted Drug Delivery (Nectar), Rashi Porwal, Stephen L. Hayward, Srivatsan Kidambi

Department of Chemical and Biomolecular Engineering: Faculty Publications

We present a protocol to engineer a substrate-mediated delivery platform comprising hyaluronic acid-coated lipid nanoparticles (HALNPs) embedded into polyelectrolyte multilayer (PEM) films. This platform allows controlled spatiotemporal release of lipid nanoparticles (LNP) by embedding them within the polyelectrolyte multilayer films matrix. HALNP conjugate with antibodies also adds the ability for targeted delivery. The use of LNP enables this platform to encapsulate both hydrophobic and hydrophilic drugs. This platform can easily be reproduced and utilized for various biomedical drug delivery applications. For complete details on the use and execution of this protocol, please refer to Hayward et al. (2015, 2016a, 2016b), …

Computational Discovery Of Active And Selective Metal- Nitrogen-Graphene Catalysts For Electrooxidation Of Water To H2O2, Payal Chaudhary, Iman Evazzade, Rodion Belosludov,, Vitaly Alexandrov

Department of Chemical and Biomolecular Engineering: Faculty Publications

A direct electrosynthesis of H₂O₂ from either O₂ or H₂O is an attractive strategy to replace the energy-intensive industrial anthraquinone process. Two-electron water oxidation reaction (2e-WOR) offers several advantages over the oxygen reduction reaction such as better mass transfer due to the absence of gasphase reactants. However, 2e-WOR is a more challenging and less studied process with only a handful of metal oxides exhibiting reasonable activity/selectivity properties. Herein, we employ density-functional-theory calculations to screen a variety of metal-nitrogen-graphene structures for 2e-WOR. As a consequence of scaling between the adsorption energies of reaction intermediates, we …

Dwarfism And Gigantism Drive Human-Mediated Extinctions On Islands, Roberto Rozzi, Mark V. Lomolino, Alexandra A.E. Van Der Geer, Daniele Silvestro, S. Kathleen Lyons, Pere Bover, Josep A. Alcover, Ana Benítez-López, Cheng-Hsiu Tsai, Masaki Fujita, Mugino O. Kubo, Janinie Ochoa, Matthew E, Scarborough, Samuel T. Turvey, Alexander Zizka, Jonathan M. Chase

School of Biological Sciences: Faculty Publications

Islands have long been recognized as distinctive evolutionary arenas leading to morphologically divergent species, such as dwarfs and giants. We assessed how body size evolution in island mammals may have exacerbated their vulnerability, as well as how human arrival has contributed to their past and ongoing extinctions, by integrating data on 1231 extant and 350 extinct species from islands and paleo islands worldwide spanning the past 23 million years. We found that the likelihood of extinction and of endangerment are highest in the most extreme island dwarfs and giants. Extinction risk of insular mammals was compounded by the arrival of …

Large And Stable Genome Edits At The Sorghum Alpha Kafirin Locus Result In Changes In Chromatin Accessibility And Globally Increased Expression Of Genes Encoding Lysine Enrichment, J. Preston Hurst, Abou Yobi, Aixia Li, Shirley Sato, Thomas E. Clemente, Ruthie Angelovici

Department of Agronomy and Horticulture: Faculty Publications

Introduction: Sorghum is a resilient and widely cultivated grain crop used for feed and food. However, it’s grain is deficient in lysine, an essential amino acid. This is due to the primary seed storage proteins, the alpha-kafirins, lacking lysine. It has been observed that reductions in alpha-kafirin protein results in rebalancing of the seed proteome and a corresponding increase in non-kafirin proteins which leads to an increased lysine content. However, the mechanisms underlying proteome rebalancing are unclear. This study characterizes a previously developed gene edited sorghum line, with deletions at the alpha kafirin locus.

Methods: A single consensus …

Genome Assembly Of The Brassicaceae Diploid Orychophragmus Violaceus Reveals Complex Whole-Genome Duplication And Evolution Of Dihydroxy Fatty Acid Metabolism, Fan Huang, Peng Chen, Xinyu Tang, Ting Zhong, Taihua Yang, Chinedu Charles Nwafor, Chao Yang, Xianhong Ge, Hong An, Zaiyun Li, Edgar B. Cahoon, Chunyu Zhang

Center for Plant Science Innovation: Faculty Publications

Orychophragmus violaceus is a Brassicaceae species widely cultivated in China, particularly as a winter cover crop in northern China because of its low-temperature tolerance and low water demand. Recently, O. violaceus has also been cultivated as a potential industrial oilseed crop because of its abundant 24- carbon dihydroxy fatty acids (diOH-FAs), which contribute to superior high-temperature lubricant properties. In this study, we performed de novo assembly of the O. violaceus genome. Whole-genome synteny analysis of the genomes of its relatives demonstrated that O. violaceus is a diploid that has undergone an extra whole-genome duplication (WGD) after the Brassicaceae-specific α-WGD event, …

Plant Breeding Advancements With “Crispr-Cas” Genome Editing Technologies Will Assist Future Food Security, M. Ahmad

Center for Plant Science Innovation: Faculty Publications

Genome editing techniques are being used to modify plant breeding, which might increase food production sustainably by 2050. A product made feasible by genome editing is becoming better known, because of looser regulation and widespread acceptance. The world’s population and food supply would never have increased proportionally under current farming practices. The development of plants and food production has been greatly impacted by global warming and climate change. Therefore, minimizing these effects is crucial for agricultural production that is sustainable. Crops are becoming more resilient to abiotic stress because of sophisticated agricultural practices and a better understanding of the abiotic …

Inherent Envelope Fluctuations In Forward Masking: Effects Of Age And Hearing Loss, Marc A. Brennan, Adam Svec, Afagh Farhadi, Braden N. Maxwell, Laurel H. Carney

Department of Special Education and Communication Disorders: Faculty Publications

Forward masking is generally greater for Gaussian noise (GN) than for low-fluctuation noise maskers, i.e., GN disruption. Because the minimal hearing loss that is associated with older age may affect GN disruption differently than more significant hearing loss, the current study explored the contribution of minimal hearing loss associated with older age to GN disruption. GN disruption was measured using three masker-signal delays (25, 75, and 150 ms) for three adult groups: younger participants with normal hearing (NH), older participants with minimal hearing loss, and older participants with sensorineural hearing loss. The role of underlying mechanisms was tested using a …

Perspectives On Adaptive Functioning And Intellectual Functioning Measures For Intellectual Disabilities Behavioral Research, Laura J. Mattie, Susan J. Loveall, Marie Moore Channell, Derek B. Rodgers

Department of Special Education and Communication Disorders: Faculty Publications

Introduction: Intellectual disability (ID) is a significant limitation in both intellectual ability and adaptive functioning, but many studies of participants with ID only include a measure of overall intellectual functioning when describing their samples. The purpose of this perspective article was to provide a starting point for future research regarding the utility of including measures of both intellectual and adaptive functioning in research focused on ID. In this article, we discuss the differences and similarities between the constructs of intellectual and adaptive functioning, how they are measured, and the benefits of using both measures to describe participant abilities. Data …

The Role Of Religious Contexts On Hate Crimes, 2003–2017, Shawn Ratcliff, Philip Schwadel

Department of Sociology: Faculty Publications

Objective: Combining insights from socio-criminological theories of (hate) crimes and the moral communities perspective, this article examines how the religious makeup of a county— evangelical Protestant, mainline Protestant, and Catholic adherence rates—affects county-level hate crime patterns.

Methods: Zero-inflated negative binomial regressions were conducted on a unique county-level data set that included reported hate crimes, religious adherence rates, and related correlates of hate crimes for three distinct temporal periods: 2003–2007, 2008–2012, and 2013–2017.

Results: Results demonstrate that a county’s total adherence rate, mainline Protestant rate and, to a lesser degree, Catholic adherence rate are associated with fewer hate …

Male Hormonal Contraceptives: Associations Between Students’ Perception Of And Trust In Usage And Endorsement Of Gender Norms, Zoe Keese

Honors Program: Senior Projects (Public)

As clinical trials continue to test the safety and efficacy of new male contraceptive options, evaluating attitudes towards them is critical in expanding access to reproductive healthcare. The present study sought to investigate the relationship of endorsement of traditional masculine and feminine gender norms with attitudes towards male hormonal contraceptive pills. Using a Qualtrics survey, 45 participants rated their attitudes towards different measures, including attitude towards the male contraceptive pill, willingness to use male hormonal contraception, and endorsement of traditional masculine and feminine gender norms. The results of the survey indicated that there was a significant positive correlation between endorsing …

Using Game Theory To Model Tripolar Deterrence And Escalation Dynamics, Grace Farson

Honors Program: Senior Projects (Public)

The study investigated how game theory can been utilized to model multipolar escalation dynamics between Russia, China, and the United States. In addition, the study focused on analyzing various parameters that affected potential conflict outcomes to further new deterrence thought in a tripolar environment.

A preliminary game theoretic model was created to model and analyze escalation dynamics. The model was built upon framework presented by Zagare and Kilgour in their work ‘Perfect Deterrence’. The model is based on assumptions and rules set prior to game play. The model was then analyzed based upon these assumptions using a form of mathematical …

Association Of Excessive Precipitation And Agricultural Land Use With Honey Bee Colony Performance, Gabriela M. Quinlan, Rufus Isaacs, Clint R. V. Otto, Autumn H. Smart, Meghan O. Milbrath

Department of Entomology: Faculty Publications

Context From landscape variables to weather, multiple environmental factors affect honey bees and other pollinators. Detailed honey bee colony assessments in a variety of landscape and weather conditions offer the opportunity to develop a mechanistic understanding of how landscape composition, configuration, and weather are associated with colony nutrition, demography, and productivity.

Objectives Our objective was to test if weather and landscape characteristics (e.g., agricultural versus forested land use) are associated with different honey bee colony outcomes (foraged nectar mass, foraged pollen mass, pupal population size, and adult population size change).

Methods We collected detailed colony measurements on over 450 honey …

Disturbances In Primary Visual Processing As A Function Of Healthy Aging, Seth D. Springer, Tara D. Erker, Mikki Schantell, Hallie J. Johnson, Madelyn P. Willett, Hannah J. Okelberry, Maggie P. Rempe, Anthony Wilson

Department of Agricultural and Biological Systems Engineering: Faculty Publications

For decades, visual entrainment paradigms have been widely used to investigate basic visual processing in healthy individuals and those with neurological disorders. While healthy aging is known to be associated with alterations in visual processing, whether this extends to visual entrainment responses and the precise cortical regions involved is not fully understood. Such knowledge is imperative given the recent surge in interest surrounding the use of flicker stimulation and entrainment in the context of identifying and treating Alzheimer’s disease (AD). In the current study, we examined visual entrainment in eighty healthy aging adults using magnetoencephalography (MEG) and a 15 Hz …

Spectral Features Of Non-Nutritive Suck Dynamics In Extremely Preterm Infants, Steven M. Barlow, Chunxiao Liao, Jaehoon Lee, Seungman Kim, Jill L. Maron, Dongli Song, Priya Jegatheesan, Balaji Govindaswami, Bernard J. Wilson, Kushal Bhakta, John P. Cleary

United States Public Health Resources

Background: Non-nutritive suck (NNS) is used to promote ororhythmic patterning and assess oral feeding readiness in preterm infants in the neonatal intensive care unit (NICU). While time domain measures of NNS are available in real time at cribside, our understanding of suck pattern generation in the frequency domain is limited. The aim of this study is to model the development of NNS in the frequency domain using Fourier and machine learning (ML) techniques in extremely preterm infants (EPIs).

Methods: A total of 117 EPIs were randomized to a pulsed or sham orocutaneous intervention during tube feedings 3 times/day …