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Correcting The Record: Subspecific Identification Of Nebraska’S Lone Common Eider (Somateria Mollissima), Sam Manning, Joel G. Jorgensen, Stephen J. Brenner, W. Ross Silcock Sep 2024

Correcting The Record: Subspecific Identification Of Nebraska’S Lone Common Eider (Somateria Mollissima), Sam Manning, Joel G. Jorgensen, Stephen J. Brenner, W. Ross Silcock

Nebraska Bird Review

In late November or early December 1967, Roger Guenther harvested a Common Eider (Somateria mollissima) on Maloney Canal between Maloney and Sutherland in Lincoln County, Nebraska. The head and a single foot from the carcass were deposited at the University of Nebraska State Museum via the University of Nebraska–Lincoln and the Nebraska Fish and Game Department (now the Game and Parks Commission). Dr. Jean Tate prepared the parts, which were inventoried as specimen #ZM-12341 in the UNSM. Dr. Paul Johnsgard purportedly took this specimen to the Field Museum of Natural History in Chicago for identification purposes, and concluded …


Unl Emeriti And Retirees Association Newsletter, September 2024 Sep 2024

Unl Emeriti And Retirees Association Newsletter, September 2024

UNL Emeriti and Retirees Association: Newsletters and Other Materials

University of Nebraska-Lincoln Emeriti and Retirees Association Newsletter, September 2024


High-Mast Tower Foundation – Phase Ii, Ammar Al Maabreh, Abdelrahman Awawdeh, Marc Maguire, Jay Puckett, Brandon Kreiling Sep 2024

High-Mast Tower Foundation – Phase Ii, Ammar Al Maabreh, Abdelrahman Awawdeh, Marc Maguire, Jay Puckett, Brandon Kreiling

Nebraska Department of Transportation: Research Reports

Challenge: High-mast luminaire supports used in the US transportation sector are typically steel poles that are attached to a baseplate via a butt or socket weld. Many have failed primarily due to fatigue cracking at the weld toe. Significant research in the US improved the fatigue performance of these structures; however, failures still occur due to high-cycle cracking at the weld toes, or at other fatigue-prone details. Additionally, poles are failing in moderate winds that create galloping. Galloping is an aerodynamic phenomenon where the wind excitation frequency matches the pole’s natural frequency creating resonance. The top amplitudes are many times …


Technical Note: Assessing Gps Sensor Accuracy Using Real-Time Kinematic Device For Livestock Tracking, Biquan Zhao, Rebecca Mcdermott, Galen E. Erickson, Yijie Xiong Aug 2024

Technical Note: Assessing Gps Sensor Accuracy Using Real-Time Kinematic Device For Livestock Tracking, Biquan Zhao, Rebecca Mcdermott, Galen E. Erickson, Yijie Xiong

Department of Animal Science: Faculty Publications

The technical aspects of global positioning system (GPS) sensors have been improved substantially over the years, making them valuable and popular tools for livestock tracking. Using GPS sensors allows producers and researchers to locate grazing livestock, monitor their behavior and distribution, and gather referencing information about the health status of the animals and pastures. However, interpreting the behavior of grazing livestock, such as cattle, from GPS data can be difficult due to positioning inaccuracies. Without knowing the positioning accuracy range of GPS sensors, achieving high-level confidence in determining grazing densities and identifying abnormal livestock movement patterns is challenging. …


Conservation Decision Making And Agricultural Land Leasing - An Experimental Investigation Of The Role Of Gender, Diya Ganguly, Simanti Banerjee, Christopher Gustafson Aug 2024

Conservation Decision Making And Agricultural Land Leasing - An Experimental Investigation Of The Role Of Gender, Diya Ganguly, Simanti Banerjee, Christopher Gustafson

Cornhusker Economics

This research investigated the impact of landowner gender and of the different types of contract leases offered by them to a male tenant, on the conservation (or non-conservation) choice made by the tenant. Specifically, we investigate if a) female and male landowners offer different rental contracts and b) whether tenants choose different actions based on the landowner’s gender. For this purpose, we implemented a controlled, gender-context-loaded economic experiment with university students, in which we tested contract and land use choice under different treatments for three types of rental contracts – fixed rent, fixed rent with penalty, and fixed rent with …


Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Applications For Metabolomics, Darcy Cochran, Robert Powers Aug 2024

Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Applications For Metabolomics, Darcy Cochran, Robert Powers

Robert Powers Publications

Metabolomics is an interdisciplinary field that aims to study all metabolites < 1500 Da that are ubiquitously found within all organisms. Metabolomics is experiencing exponential growth and commonly relies on high-resolution mass spectrometry (HRMS). Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) is a form of HRMS that is particularly well suited for metabolomics research due to its exceptionally high resolution (105–106) and sensitivity with a mass accuracy in parts per billion (ppb). In this regard, FT-ICR-MS can provide valuable insights into the metabolomics analysis of complex biological systems due to unique capabilities such as the easy separation of isobaric and isomeric species, isotopic fine structure analysis, spatial resolution of metabolites in cells and tissues, and a high confidence (error) in metabolite identification. Alternatively, the large and complex data sets, long acquisition times, high cost, and limited access mainly through national mass spectrometry facilities may impede the …


Psychosocial Well-Being Facilitation Of Leader Identity Transitions For Retirees, Brooke Wells Aug 2024

Psychosocial Well-Being Facilitation Of Leader Identity Transitions For Retirees, Brooke Wells

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Leadership scholars have worked to advance the knowledge of leader identity—how one views oneself as a leader—across many age groups. However, there is still little known about leader identity in older adults. This study explored how older adults identified as leaders after exiting the workforce and in retirement. The retirement process often indicates a transition in which one plans to navigate life post-workforce. For some, retirement may be a signal of growing older. Social identity theory scholars argue that retirees do not always embrace this aging identity. Individuals’ thoughts regarding aging are complex. For those able to embrace and navigate …


Research Report: Well-Being, Heather Akin, Cheryl A. Burkhart-Kriesel, Mary Emery, Katelyn Larson, Bradley Lubben, L. J. Mcelravy, Rebecca J. Vogt Aug 2024

Research Report: Well-Being, Heather Akin, Cheryl A. Burkhart-Kriesel, Mary Emery, Katelyn Larson, Bradley Lubben, L. J. Mcelravy, Rebecca J. Vogt

Nebraska Rural Poll

This year, rural Nebraskans are more pessimistic about their current situation than they’ve been since this study began. The proportion believing they are worse off than they were five years ago was 33 percent, up from 27 percent last year and 21 percent in 2022. This is the highest level across all years of the study. This increase in pessimism was matched with a sharp decrease in optimism. This year, just over one-third (36%) of rural Nebraskans believe they are better off compared to five years ago, down from 45 percent last year.

This trend continued when looking to the …


Nebline, August/September 2024 Aug 2024

Nebline, August/September 2024

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Preserving the Harvest: Canning, Freezing and Drying Tips, Kayla Colgrove

How Savvy are YOU with Home Canning?

Recipe of the Month: Freezing Onions, Kayla Colgrove

Deep, Infrequent Irrigation Makes Lawns and Trees Healthier, Sarah Browning

Garden Guide: Things to Do This Month, Mary Jane Frogge

Get the Jump on Jumping Worms, Kait Jumpman

Preparing Water for Use in an Emergency, Becky Schuerman

Heart of 4-H Volunteer Award: Nicole Miller and Cole Meador

4-H Teen Council Invites New Members

4-H Announcements

Lancaster County Super Fair, August 1-10, 2024

4-H Premiere Communication Event Top Results

4-H Clover College: 55 Hands-on Workshops

4-H …


Leavers And Movers: Turnover Of Music Teachers In Nebraska, Christian G. Schuerman Aug 2024

Leavers And Movers: Turnover Of Music Teachers In Nebraska, Christian G. Schuerman

Glenn Korff School of Music: Dissertations, Theses, Student Creative Work, and Performances

The purpose of this study was to determine if the rates of music teachers leaving the teaching profession and changing schools were significantly different than those of teachers of other content areas in the state of Nebraska. This study used data from the previous nine years of the Nebraska Department of Education’s Education Directory in order to find results for the entire population. Results indicated that music teachers leave the profession at similar rates as teachers of other content areas, but move schools at significantly higher rates.

Advisor: Robert H. Woody


Online Course Development With University Extension And Industry Experts, Kelsey L. Mccullough Aug 2024

Online Course Development With University Extension And Industry Experts, Kelsey L. Mccullough

Applied Science Program: Theses

Project Background

While pursuing my college degrees, the highest impact classes have been filled with applications that I understood as being relevant at the time and have used within my career, had hands-on experiences, and included influential interactions with professionals. Taking this idea forward to course development as an online instructor, I know that creating and adapting college classes to be centered on key aspects of the agricultural industry will add to the education quality of the program and the college experience. This paper will describe my first attempt at this model of partnering with academic and industry experts to …


Dancing With Identity: How Women In It Navigate Leadership Construction, Amy Barry Aug 2024

Dancing With Identity: How Women In It Navigate Leadership Construction, Amy Barry

Instructional Leadership Abstracts

Women are underrepresented in the information technology sector and experience pervasive gender bias in the typically male-dominated organizations. Barry explores how women navigate and shape their leadership identities within such an environment.


Real-Time Cerebral Oximetry During Cognition, Sensorimotor Control, And Pneumotactile Perception In Neurotypical Adults, David J. Sanchez Aug 2024

Real-Time Cerebral Oximetry During Cognition, Sensorimotor Control, And Pneumotactile Perception In Neurotypical Adults, David J. Sanchez

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Continuous-wave functional near-infrared spectroscopy (cw-fNIRS) is a non-invasive brain imaging methodology designed to measure neural activity by detecting hemodynamic responses i.e., adjustments in blood flow and oxygenation to meet the brain’s metabolic needs. Findings on the use of cw-fNIRS by speech-language pathologists (SLP) and neuroscientists to assess cerebral hemodynamic responses during communication assessment and treatment are limited. This study aims to explore the brain’s metabolic response to various sensory processing tasks in neurotypical adults.

This research examines the relationship between cognitive load, sensorimotor control, and somatosensory processing, and hemodynamic modulation in the prefrontal cortex of 18 right-handed neurotypical adults. The …


Further Developing Drought Early Warning Information Systems Using Mixed-Methods And Multiple Streams Of Data, Caily Claire Schwartz Aug 2024

Further Developing Drought Early Warning Information Systems Using Mixed-Methods And Multiple Streams Of Data, Caily Claire Schwartz

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Drought is a complex phenomenon with varying degrees of impacts and monitoring methods. No drought is alike, creating a challenge for both water managers and communities. No area is immune to a drought. Due to the cyclical nature of drought events, clear information to those impacted is necessary to reduce risk and move towards proactive responses, as opposed to reactive responses. To better provide communication and mitigation tools, Drought Early Warning Information Systems (DEWIS) have been developed in various regions and contexts. To improve early warning, an understanding of the end user’s perceptions of risk, and the applicability of data …


Development Of An Egg-Specific Mass Spectrometry Targeted Method For Processed Food Matrices, Liyun Zhang Aug 2024

Development Of An Egg-Specific Mass Spectrometry Targeted Method For Processed Food Matrices, Liyun Zhang

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Egg is a major food allergen in the United States, causing symptoms from mild reactions to severe anaphylaxis. An egg-free diet remains the only management approach for egg allergy. Therefore, individuals and families living with egg allergies rely heavily on allergen statements on packaged food products for informed food choices. Currently, no labeling regulations exist for unintentionally introduced allergens, posing risks to consumers with egg allergies. Therefore, it is critical to have an accurate and reliable detection method in allergen control and management to determine the concentration of total protein from allergenic food sources. Traditional enzyme-linked immunosorbent assays are routinely …


Investigation Of Faults In Air-Conditioning Systems In Commercial Buildings: Occurrence, Diagnostic Validation, And Energy Impacts, Yuxuan Chen Aug 2024

Investigation Of Faults In Air-Conditioning Systems In Commercial Buildings: Occurrence, Diagnostic Validation, And Energy Impacts, Yuxuan Chen

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

In commercial buildings, fault detection and diagnosis (FDD) tools have been developed for detecting and diagnosing faults in building systems, which can provide useful information regarding fault locations and potential causes of faults, so that building operators and facility staff can be notified in time and quickly respond as problems arise. Nowadays, there are many commercial FDD tools available in the market, and these tools have been widely adopted in large- and medium-scale commercial buildings in the United States. Several studies have demonstrated the energy saving potential with the use of FDD in commercial HVAC systems, and one critical aspect …


A Data-Driven Discovery System For Studying Extracellular Microrna Sorting And Rna-Protein Interactions, Sasan Azizian Aug 2024

A Data-Driven Discovery System For Studying Extracellular Microrna Sorting And Rna-Protein Interactions, Sasan Azizian

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Interactions between microRNAs (miRNAs) and RNA-binding proteins (RBPs) are pivotal in miRNA-mediated sorting, yet the molecular mechanisms underlying these interactions remain largely understudied. Few miRNA-binding proteins have been verified, typically requiring extensive laboratory work. This study introduces DeepMiRBP, a novel hybrid deep learning model designed to predict microRNA-binding proteins. The model integrates Bidirectional Long Short-Term Memory (Bi-LSTM) networks with attention mechanisms, transfer learning, and cosine similarity to offer a robust computational approach for inferring miRNA-protein interactions.

DeepMiRBP is implemented through two distinct architectures. The first architecture employs a Y-shaped model that uses Bi-LSTM networks and transfer learning to extract contextual …


The Value Of Knowledge And Its Problems, Kevin Patton Aug 2024

The Value Of Knowledge And Its Problems, Kevin Patton

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation answers the three value problems in epistemology. These three problems require an answer as to how knowledge is more valuable 1) than mere true belief, 2) any of the proper subsets of knowledge, and 3) in kind than that which falls short of knowledge. The methodology used to provide an answer to these problems relies on the arguments put forth in a rarely discussed paper from Ward Jones. In short, the Jonesian approach can be summed up as the view that epistemic axiology and analysis ought to be kept separate. The Jonesian framework instead looks outside of the …


Role Of The Malate Dehydrogenase-Citrate Synthase Metabolon In Metabolic Flux Regulation, Joy John Omini Aug 2024

Role Of The Malate Dehydrogenase-Citrate Synthase Metabolon In Metabolic Flux Regulation, Joy John Omini

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The TCA cycle enzymes- malate dehydrogenase (MDH) and citrate synthase (CS)- interact to transfer oxaloacetate from the active site of MDH to the active site of CS, through an electropositive channel. The MDH-CS metabolon is highly conserved across different domains of life, and it has been associated with many advantages. Some of these advantages include protecting oxaloacetate from competing enzymes like aspartate aminotransferase, allowing the thermodynamically unfavorable MDH forward reaction to occur and increasing the local concentration of oxaloacetate within the active site of CS. These advantages and conservativeness of the MDH-CS metabolon indicate that it is highly important to …


Teacher-Child Interaction Quality In Free Choice And Associations With Child Peer-Related Social Competence, Yuenjung Joo Aug 2024

Teacher-Child Interaction Quality In Free Choice And Associations With Child Peer-Related Social Competence, Yuenjung Joo

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Children’s peer-related social skills in early childhood set the stage for school readiness, social competence, and lifelong well-being. Preschoolers spend most of their classroom time in free choice, offering substantial opportunities for learning experiences that facilitate peer interactions that support social development. Yet, little is known about how early childhood teachers can best optimize children’s social learning without disrupting the benefits of play during this time. The purpose of this study is to investigate how preschool teachers’ social support behaviors during free choice align with children’s social needs (i.e., fit of teacher-child social interaction) and the association between the fit …


Emergent Phenomena In Ferroelectric-Dielectric And Ferroelectric-Graphene Heterostructures, Tianlin Li Aug 2024

Emergent Phenomena In Ferroelectric-Dielectric And Ferroelectric-Graphene Heterostructures, Tianlin Li

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation explores the emergent phenomena in epitaxial ferroelectric oxide-based heterostructures, including the negative capacitance (NC) effect in ferroelectric-dielectric systems, ferroelectric gate imposed mobility limit in graphene field-effect transistors, and ferroelectric domain-induced graphene-superlattices.

We carry out a phenomenological study of the NC effect in PbZr0.2Ti0.8O3/SrTiO3 capacitors. The Landau free-energy profile predicts a critical thickness ratio for the ferroelectric-dielectric phase transition, consistent with the observed abrupt change in remnant polarization. A static NC state is observed in the low thickness ratio region, which is compromised by the emergence of multidomain in the moderate ratio …


Laser Surface Processing For Enhanced Adhesion Between Diamond Coatings And Metallic Substrates, Zhipeng Wu Aug 2024

Laser Surface Processing For Enhanced Adhesion Between Diamond Coatings And Metallic Substrates, Zhipeng Wu

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Application of diamond coatings on metallic substrates endows them with superior properties including mechanical robustness and corrosion resistance, rendering them highly adaptable for diverse industrial and technological applications. However, significant disparities in coefficients of thermal expansion (CTEs) result in pronounced residual stress near interfaces, causing delamination of the diamond coatings. Moreover, weak chemical bonding poses a concern for certain metallic substrates. Laser surface processing techniques show promise in enhancing adhesion by altering stress distribution and improving mechanical bonding. Therefore, the research efforts described in this dissertation mainly focus on femtosecond (fs) laser texturing for enhanced adhesion of diamond coatings on …


Dynamics Of Soybean Seed Protein And Oil Content With Depth In The Canopy, Hafith Furqoni Aug 2024

Dynamics Of Soybean Seed Protein And Oil Content With Depth In The Canopy, Hafith Furqoni

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Understanding the physiological basis of variation in seed composition is critical for optimizing soybean seed composition. Also, studying dry matter accumulation and nitrogen uptake, partitioning, and redistribution in soybeans is crucial due to its direct impact on seed yield levels and overall plant productivity. This study aimed to test the primary proxy influencing seed protein and oil content, which is their accumulation rate determined by the assimilate supply per seed. The second objective was to comprehensively understand soybean dry matter (DM) accumulation and nitrogen (N) uptake, partitioning, and removal patterns within the canopy. Field experiments were conducted using two soybean …


Remotely Sensed Early Warning Of Algal Blooms In An Eastern Nebraska Reservoir: A Comparison Of Temporal And Spatial Indicators, Mercy Kipenda Aug 2024

Remotely Sensed Early Warning Of Algal Blooms In An Eastern Nebraska Reservoir: A Comparison Of Temporal And Spatial Indicators, Mercy Kipenda

School of Natural Resources: Dissertations, Theses, and Student Research

Cyanobacterial harmful algal blooms (CyanoHABs) detrimentally affect human, animal, and ecosystem health. Remotely sensed early warning systems for cyanoHABs in inland lakes could contribute to more proactive water quality monitoring and help mitigate negative impacts. Advances in freely available remote sensing imagery, with finer spatial, temporal, and spectral resolutions, present new opportunities for the development and comparative analysis of methods to detect sudden deterioration in lake water quality. In this thesis, I compared and tested for temporal and spatial early warning signals of cyanoHABs in field-based and remotely sensed datasets from 2019 to 2023 in Pawnee Lake in southeast Nebraska, …


Assessing, Restoring, And Centering Social–Ecological Relationships For Advancing Social–Ecological Resilience In The Northern Great Plains Grasslands, Katia Pilar Carranza Bernal Aug 2024

Assessing, Restoring, And Centering Social–Ecological Relationships For Advancing Social–Ecological Resilience In The Northern Great Plains Grasslands, Katia Pilar Carranza Bernal

School of Natural Resources: Dissertations, Theses, and Student Research

The Northern Great Plains grasslands are social-ecological systems that were shaped by evolutionary and Indigenous social-ecological relationships. European colonization disrupted many of these interactions, including the coupling of fire and grazing, and degraded social-ecological resilience, shifting these grasslands to a new state. For those reasons, my research focused on assessing, restoring, and centering evolutionary and Indigenous social-ecological relationships for advancing social-ecological resilience in the Northern Great Plains grasslands. I first performed a study in the Nebraska Sandhillls assessing the potential of patch-burn grazing to support grassland resilience by comparing its effects to those of rotational grazing. Through vegetation and bird …


We're Swarming Again! Swarming, Collectivity, And Trope: The Case Of Extinction Rebellion, Tyler J. Behymer Aug 2024

We're Swarming Again! Swarming, Collectivity, And Trope: The Case Of Extinction Rebellion, Tyler J. Behymer

Department of Communication Studies: Dissertations, Theses, and Student Research

This thesis explores the rhetoric of the eco-movement Extinction Rebellion, focusing on the use of swarming and nature tropes to mobilize collective action and revivify contemporary notions of collectivity. Drawing on rhetoric of social movement scholarship, cultural studies, and psychoanalysis, this essay theorizes swarming as a tropological economy that expands the conditions of propriety in the context of collectivity. Through an analysis of Extinction Rebellion’s discourse, this study demonstrates how the naturalization of swarming tropes works in various ways to rewild conventional political discourse, galvanize disruptive collective assembly, and challenge green neoliberalism.

Advisor: Casey Ryan Kelly


Integration Of Matlab And Machine Learning To Accelerate Evaluation Of Biological Activity In Agricultural Soils And Promote Soil Health Improvement Goals, Andrew Stiven Ortiz Balsero Aug 2024

Integration Of Matlab And Machine Learning To Accelerate Evaluation Of Biological Activity In Agricultural Soils And Promote Soil Health Improvement Goals, Andrew Stiven Ortiz Balsero

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Traditionally, assessments of soil biological activity have been confined to laboratory settings, creating a disconnect with practical in-field methods. To bridge this gap, cotton fabric degradation has been used to illustrate soil microbial activity under different management practices. While effective, these demonstrations are subjective and labor-intensive.

Researchers have explored using image processing software like ImageJ and Adobe Photoshop to streamline this process. Although these tools accurately quantified fabric degradation under varying soil conditions, the methods remained labor-intensive and complex. Consequently, these methods were still not ideal for on-farm use by agricultural practitioners.

To further address labor and complexity limitations, the …


Applications Of Artificial Intelligence On Drought Impact Monitoring And Assessment, Beichen Zhang Aug 2024

Applications Of Artificial Intelligence On Drought Impact Monitoring And Assessment, Beichen Zhang

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Drought, a prevalent and consequential natural disaster, poses widespread, indirect challenges across environmental and societal dimensions. Despite considerable focus on monitoring meteorological and hydrological drought and studying their characteristics, there is a gap in assessing its multifaceted impacts, especially on societal sectors. The dissertation comprises three research essays utilizing artificial intelligence to quantitatively study multi-dimensional drought impacts. The first essay leveraged deep learning and natural language processing to predict multi-dimensional drought impacts from textual datasets, including social media, news media, and citizen scientist reports. The findings demonstrate superior performance over traditional methods and unveil the spatial and temporal heterogeneity of …


The Value Of Knowledge And Its Problems, Kevin Patton Aug 2024

The Value Of Knowledge And Its Problems, Kevin Patton

Department of Philosophy: Dissertations, Theses, and Student Research

This dissertation answers the three value problems in epistemology. These three problems require an answer as to how knowledge is more valuable 1) than mere true belief, 2) any of the proper subsets of knowledge, and 3) in kind than that which falls short of knowledge. The methodology used to provide an answer to these problems relies on the arguments put forth in a rarely discussed paper from Ward Jones. In short, the Jonesian approach can be summed up as the view that epistemic axiology and analysis ought to be kept separate. The Jonesian framework instead looks outside of the …


Candida Albicans Farnesol Synthesis And Secretion, Daniel J. Gutzmann Aug 2024

Candida Albicans Farnesol Synthesis And Secretion, Daniel J. Gutzmann

School of Biological Sciences: Dissertations, Theses, and Student Research

Candida albicans is a polymorphic fungus and opportunistic commensal found primarily in the gastrointestinal and skin of healthy individuals. Several barriers prevent C. albicans from causing disease including a healthy immune system and microbiome. When these barriers become comprised, C. albicans can transition to a pathogen and disseminate through the intestinal mucosa leading to life-threatening bloodstream and invasive infections with mortality rates of up to 64%. Morphogenic plasticity is key to this transition and impacts virulence, adaptation to different host environments, and evasion of host immune responses. One regulator of morphogenesis is farnesol. Farnesol is a secondary metabolite of …