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Articles 301 - 330 of 594
Full-Text Articles in Entire DC Network
A Unique Group I Intron In Coxiella Burnetii Is A Natural Splice Mutant, Rahul Raghavan, Linda D. Hicks, Michael F. Minnick
A Unique Group I Intron In Coxiella Burnetii Is A Natural Splice Mutant, Rahul Raghavan, Linda D. Hicks, Michael F. Minnick
Biological Sciences Faculty Publications
Cbu.L1917, a group I intron present in the 23S rRNA gene of Coxiella burnetii, possesses a unique 3'-terminal adenine in place of a conserved guanine. Here, we show that, unlike all other group I introns, Cbu.L1917 utilizes a different cofactor for each splicing step and has a decreased self-splicing rate in vitro.
Pubh 580.01: Rural Health Issues In Global Context, Peter Koehn
Pubh 580.01: Rural Health Issues In Global Context, Peter Koehn
University of Montana Course Syllabi, 1990-2010
No abstract provided.
Terrestrial Ecosystem Adaptation, Steven W. Running, L. Scott Mills
Terrestrial Ecosystem Adaptation, Steven W. Running, L. Scott Mills
Numerical Terradynamic Simulation Group Publications
In this report we evaluate adaptation issues for natural ecosystems. We will specifically focus on the interactions with the abiotic environment of plants and animals, along with other organisms with which they interact (e.g., disease-causing bacteria and viruses). We further limit ourselves to natural ecosystems in which the predominant vegetation has developed without having been planted, irrigated, or fertilized. Most of the natural lands in the United States are managed by federal or state governments. Agricultural lands— including range grazing lands — are dealt with in a related adaptation report. This will evaluate the potential magnitudes and challenges facing terrestrial …
Empirical Testing Of 16s Rrna Gene Pcr Primer Pairs Reveals Variance In Target Specificity And Efficacy Not Suggested By In Silico Analysis, Sergio E. Morales, William E. Holben
Empirical Testing Of 16s Rrna Gene Pcr Primer Pairs Reveals Variance In Target Specificity And Efficacy Not Suggested By In Silico Analysis, Sergio E. Morales, William E. Holben
Biological Sciences Faculty Publications
Phylogenetic and "fingerprinting" analyses of the 16S rRNA genes of prokaryotes have been a mainstay of microbial ecology during the last two decades. However, many methods and results from studies that rely on the 16S rRNA gene for detection and quantification of specific microbial taxa have seemingly received only cursory or even no validation. To directly examine the efficacy and specificity of 16S rRNA gene-based primers for phylum-, class-, and operational taxonomic unit-specific target amplification in quantitative PCR, we created a collection of primers based solely on an extensive soil bacterial 16S rRNA gene clone library containing similar to 5,000 …
Intersubunit Interactions Modulate Ph-Induced Activation Of Membrane Fusion By The Junín Virus Envelope Glycoprotein Gpc, Joanne York, Jack H. Nunberg
Intersubunit Interactions Modulate Ph-Induced Activation Of Membrane Fusion By The Junín Virus Envelope Glycoprotein Gpc, Joanne York, Jack H. Nunberg
Biological Sciences Faculty Publications
The mature arenavirus envelope glycoprotein GPC is a tripartite complex comprising a stable signal peptide (SSP) in addition to the receptor-binding (G1) and transmembrane fusion (G2) subunits. We have shown previously that SSP is a key element in GPC-mediated membrane fusion, and that GPC sensitivity to acidic pH is modulated in part through the lysine residue at position 33 in the ectodomain loop of SSP (J. York and J. H. Nunberg, J. Virol. 80: 7775-7780, 2006). A glutamine substitution at this position stabilizes the native GPC complex and thereby prevents the induction of pH-dependent membrane fusion. In efforts to identify …
Department Of Mathematical Sciences Newsletter, Spring 2009, University Of Montana--Missoula. Department Of Mathematical Sciences
Department Of Mathematical Sciences Newsletter, Spring 2009, University Of Montana--Missoula. Department Of Mathematical Sciences
Newsletters from the Department of Mathematical Sciences at UM
An Interview with a Graduate Student from Finland -- AISES Conference 2008: A Universe of Opportunities / Nicole Jefferson -- Graduate Student Does Research in New Zealand / Erin Landguth -- Notes from the Chair / David Patterson -- My Summer Adventure / Marylesa Wilde -- Undergraduate Research: An Eye Opening Experience / Jade Roskam -- Alumni News -- 2009 Spring Scholarship and Award Winners -- Degree Recipients of 2008-2009 -- Department News -- Honor Roll of Donors -- Math Club Corner / Nikolaus Vonessen
Um Brings Climate Change Discussions To Classrooms, University Of Montana--Missoula. Office Of University Relations
Um Brings Climate Change Discussions To Classrooms, University Of Montana--Missoula. Office Of University Relations
University of Montana News Releases, 1928, 1956-present
No abstract provided.
Extensive Phylogenetic Analysis Of A Soil Bacterial Community Illustrates Extreme Taxon Evenness And The Effects Of Amplicon Length, Degree Of Coverage, And Dna Fractionation On Classification And Ecological Parameters, Sergio E. Morales, Theodore F. Cosart, Jesse Johnson, William Holben
Extensive Phylogenetic Analysis Of A Soil Bacterial Community Illustrates Extreme Taxon Evenness And The Effects Of Amplicon Length, Degree Of Coverage, And Dna Fractionation On Classification And Ecological Parameters, Sergio E. Morales, Theodore F. Cosart, Jesse Johnson, William Holben
Computer Science Faculty Publications
To thoroughly investigate the bacterial community diversity present in a single composite sample from an agricultural soil and to examine potential biases resulting from data acquisition and analytical approaches, we examined the effects of percent G+C DNA fractionation, sequence length, and degree of coverage of bacterial diversity on several commonly used ecological parameters (species estimation, diversity indices, and evenness). We also examined variation in phylogenetic placement based on multiple commonly used approaches (ARB alignments and multiple RDP tools). The results demonstrate that this soil bacterial community is highly diverse, with 1,714 operational taxonomic units demonstrated and 3,555 estimated (based on …
Pubh 595.52: The Practice Of International Health, Lisa Pascopella, Craig A. Molgaard
Pubh 595.52: The Practice Of International Health, Lisa Pascopella, Craig A. Molgaard
University of Montana Course Syllabi, 1990-2010
No abstract provided.
Phar 452.01: Therapeutics Ii: Clinical Use Of Antimicrobials, Doug Allington
Phar 452.01: Therapeutics Ii: Clinical Use Of Antimicrobials, Doug Allington
University of Montana Course Syllabi, 1990-2010
No abstract provided.
Montana Business Quarterly, Winter 2009, University Of Montana--Missoula. Bureau Of Business And Economic Research
Montana Business Quarterly, Winter 2009, University Of Montana--Missoula. Bureau Of Business And Economic Research
Montana Business Quarterly, 1949-2021
This is an academic publication produced by the Bureau of Business and Economic Research (BBER) at the University of Montana’s College of Business. This is volume 47, number 4.
Consequences Of Aryl Hydrocarbon Receptor Activation In Dendritic Cells, Jaishree Bankoti
Consequences Of Aryl Hydrocarbon Receptor Activation In Dendritic Cells, Jaishree Bankoti
Graduate Student Theses, Dissertations, & Professional Papers
TCDD (dioxin) causes immunosuppression via activation of the Aryl hydrocarbon receptor (AhR). Dendritic cells (DCs), the professional antigen-presenting cells in the immune system, are adversely affected by TCDD. However, limited information exists regarding the effects of AhR activation on DCs. We evaluated the consequences of AhR activation by TCDD on both steady-state and inflammatory DCs using in vivo and in vitro approaches, respectively. We hypothesized that AhR activation alters DC homeostasis and differentiation leading to generation of immunosuppression. C57Bl/6 mice gavaged with an immunosuppressive dose of TCDD (15 ug/kg) displayed decreased frequency and number of splenic CD11chigh DCs on …
Injury Rates, Severity Of Injury, And Access To Specialty Health Care Of American Indian High School Athletes In Montana, Drew Anthony Babcock
Injury Rates, Severity Of Injury, And Access To Specialty Health Care Of American Indian High School Athletes In Montana, Drew Anthony Babcock
Graduate Student Theses, Dissertations, & Professional Papers
Introduction: Athletics are an integral part of American Indian (AI) life and culture. However, with participation there is a risk of receiving an injury. Sustaining an injury can be devastating to AI athletes that live on or near a reservation due to the rural location and disparities in health care. Objective: To determine Montana’s AI high school athletes’ injury rates, severity of injury, the current level of medical supervision, and type of health care they seek/receive. Methods: The procedure for collecting data consisted of sending out surveys to head coaches at 11 high schools that met the inclusion criteria. Analysis: …
Randomness In Tree Ensemble Methods, Joran Elias
Randomness In Tree Ensemble Methods, Joran Elias
Graduate Student Theses, Dissertations, & Professional Papers
Tree ensembles have proven to be a popular and powerful tool for predictive modeling tasks. The theory behind several of these methods (e.g. boosting) has received considerable attention. However, other tree ensemble techniques (e.g. bagging, random forests) have attracted limited theoretical treatment. Specifically, it has remained somewhat unclear as to why the simple act of randomizing the tree growing algorithm should lead to such dramatic improvements in performance. It has been suggested that a specific type of tree ensemble acts by forming a locally adaptive distance metric [Lin and Jeon, 2006]. We generalize this claim to include all tree ensembles …
The Effects Of Grazing On Deer Mice Movements Into Peridomestic Settings With Implications To Human Exposure To Sin Nombre Virus, Abigail Jean Leary
The Effects Of Grazing On Deer Mice Movements Into Peridomestic Settings With Implications To Human Exposure To Sin Nombre Virus, Abigail Jean Leary
Graduate Student Theses, Dissertations, & Professional Papers
The effects of deer mouse immigration into buildings in response to horse grazing were examined during this study. Treatment (grazing) and control (no grazing) pastures were created to simulate interactions between peridomestic (in or around buildings or structures in close proximity to humans) and sylvan settings. Each pasture was 0.6 ha in size and contained two small buildings. Twelve experimental trials were conducted from April through June 2005; October through November 2005; February 2006; June through August 2007; and May through July 2008. During these trials, mouse movements into buildings were monitored using a passive integrated transponder (PIT) tag transceiver …
Ph-Induced Activation Of Arenavirus Membrane Fusion Is Antagonized By Small-Molecule Inhibitors, Joanne York, Dongcheng Dai, Sean M. Amberg, Jack H. Nunberg
Ph-Induced Activation Of Arenavirus Membrane Fusion Is Antagonized By Small-Molecule Inhibitors, Joanne York, Dongcheng Dai, Sean M. Amberg, Jack H. Nunberg
Biological Sciences Faculty Publications
The arenavirus envelope glycoprotein (GPC) mediates viral entry through pH-induced membrane fusion in the endosome. This crucial process in the viral life cycle can be specifically inhibited in the New World arenaviruses by the small-molecule compound ST-294. Here, we show that ST-294 interferes with GPC-mediated membrane fusion by targeting the interaction of the G2 fusion subunit with the stable signal peptide (SSP). We demonstrate that amino acid substitutions at lysine-33 of the Junin virus SSP confer resistance to ST-294 and engender de novo sensitivity to ST-161, a chemically distinct inhibitor of the Old World Lassa fever virus. These compounds, as …
Neurovirulence Of Polytropic Murine Retrovirus Is Influenced By Two Separate Regions On Opposite Sides Of The Envelope Protein Receptor Binding Domain, Karin E. Peterson, Susan Pourciau, Min Du, Rachel Lacasse, Melissa Pathmajeyan, David J. Poulsen, Mavis Agbandje-Mckenna, Kathy Wehrly, Bruce Chesebro
Neurovirulence Of Polytropic Murine Retrovirus Is Influenced By Two Separate Regions On Opposite Sides Of The Envelope Protein Receptor Binding Domain, Karin E. Peterson, Susan Pourciau, Min Du, Rachel Lacasse, Melissa Pathmajeyan, David J. Poulsen, Mavis Agbandje-Mckenna, Kathy Wehrly, Bruce Chesebro
Biomedical and Pharmaceutical Sciences Faculty Publications
Changes in the envelope proteins of retroviruses can alter the ability of these viruses to infect the central nervous system (CNS) and induce neurological disease. In the present study, nine envelope residues were found to influence neurovirulence of the Friend murine polytropic retrovirus Fr98. When projected on a three-dimensional model, these residues were clustered in two spatially separated groups, one in variable region B of the receptor binding site and the other on the opposite side of the envelope. Further studies indicated a role for these residues in virus replication in the CNS, although the residues did not affect viral …
Toxic Introns And Parasitic Intein In Coxiella Burnetii: Legacies Of A Promiscuous Past, Rahul Raghavan, Linda D. Hicks, Michael F. Minnick
Toxic Introns And Parasitic Intein In Coxiella Burnetii: Legacies Of A Promiscuous Past, Rahul Raghavan, Linda D. Hicks, Michael F. Minnick
Biological Sciences Faculty Publications
The genome of the obligate intracellular pathogen Coxiella burnetii contains a large number of selfish genetic elements, including two group I introns (Cbu.L1917 and Cbu.L1951) and an intervening sequence that interrupts the 23S rRNA gene, an intein (Cbu.DnaB) within dnaB and 29 insertion sequences. Here, we describe the ability of the intron-encoded RNAs (ribozymes) to retard bacterial growth rate (toxicity) and examine the functionality and phylogenetic history of Cbu.DnaB. When expressed in Escherichia coli, both introns repressed growth, with Cbu.L1917 being more inhibitory. Both ribozymes were found to associate with ribosomes of Coxiella and E. coli. In addition, ribozymes significantly …
Phar 557.00: Public Health In Pharmacy, Curtis Noonan, Donna G. Beall, Jean Carter, William J. Docktor, David Forbes, Kari Harris, Gayle A. Hudgins, Kendra Keeley, Ellen Leahy, Craig A. Molgaard
Phar 557.00: Public Health In Pharmacy, Curtis Noonan, Donna G. Beall, Jean Carter, William J. Docktor, David Forbes, Kari Harris, Gayle A. Hudgins, Kendra Keeley, Ellen Leahy, Craig A. Molgaard
University of Montana Course Syllabi
No abstract provided.
Pt 525.01: Clinical Medicine And Pharmacology, Steven Fehrer
Pt 525.01: Clinical Medicine And Pharmacology, Steven Fehrer
University of Montana Course Syllabi
No abstract provided.
Pubh 535.50: Health Policy, Craig A. Molgaard
Pubh 535.50: Health Policy, Craig A. Molgaard
University of Montana Course Syllabi
No abstract provided.
Pubh 510.50: Introduction To Epidemiology, Curtis Noonan
Pubh 510.50: Introduction To Epidemiology, Curtis Noonan
University of Montana Course Syllabi
No abstract provided.
University Of Montana Events Monday, July 14, Through Monday, July 28, 2008, University Of Montana--Missoula. Office Of University Relations
University Of Montana Events Monday, July 14, Through Monday, July 28, 2008, University Of Montana--Missoula. Office Of University Relations
University of Montana News Releases, 1928, 1956-present
No abstract provided.
Pubh 580.50: Rural Health Issues In Global Context, Peter Koehn
Pubh 580.50: Rural Health Issues In Global Context, Peter Koehn
University of Montana Course Syllabi, 1990-2010
No abstract provided.
Montana Kaimin, April 15, 2008, Students Of The University Of Montana, Missoula
Montana Kaimin, April 15, 2008, Students Of The University Of Montana, Missoula
Montana Kaimin, 1898-present
Student newspaper of the University of Montana, Missoula.
University Of Montana Events Monday, April 14, Through Monday, April 21, 2008, University Of Montana--Missoula. Office Of University Relations
University Of Montana Events Monday, April 14, Through Monday, April 21, 2008, University Of Montana--Missoula. Office Of University Relations
University of Montana News Releases, 1928, 1956-present
No abstract provided.
University Of Montana Events Monday, April 7, Through Monday, April 14, 2008, University Of Montana--Missoula. Office Of University Relations
University Of Montana Events Monday, April 7, Through Monday, April 14, 2008, University Of Montana--Missoula. Office Of University Relations
University of Montana News Releases, 1928, 1956-present
No abstract provided.
Montana Kaimin, April 2, 2008, Students Of The University Of Montana, Missoula
Montana Kaimin, April 2, 2008, Students Of The University Of Montana, Missoula
Montana Kaimin, 1898-present
Student newspaper of the University of Montana, Missoula.
Lecture Examines Climate Change, Disease Relationship, University Of Montana--Missoula. Office Of University Relations
Lecture Examines Climate Change, Disease Relationship, University Of Montana--Missoula. Office Of University Relations
University of Montana News Releases, 1928, 1956-present
No abstract provided.
Montana Kaimin, February 28, 2008, Students Of The University Of Montana, Missoula
Montana Kaimin, February 28, 2008, Students Of The University Of Montana, Missoula
Montana Kaimin, 1898-present
Student newspaper of the University of Montana, Missoula.