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Biological Effects Of Trogocytosis On Cd4+ T Lymphocytes, Douglas Grant Osborne
Biological Effects Of Trogocytosis On Cd4+ T Lymphocytes, Douglas Grant Osborne
Graduate Student Theses, Dissertations, & Professional Papers
Antigen recognition by CD4+ T cells leads to large-scale spatial and temporal molecular redistributions, forming the immunological synapse. We have previously shown that upon dissociation, T cells capture large membrane fragments from antigen-presenting cells directly from the immunological synapse. The mechanism and biological significance of this process, termed trogocytosis, is still unclear. In this thesis I examined the impact that trogocytosis has on the individual T cell after capturing molecules from the antigen presenting cell. I employed murine fibroblast cell lines expressing an I-Ek molecule loaded with a covalently attached antigenic peptide (moth cytochrome C 88-103) and with or without …
A Molecular Genetic Investigation Of The Regulation Of Outer Surface Protein C In Borrelia Burgdorferi: Identification And Characterization Of The Novel Regulatory Protein Bbd18, Beth Hayes
Graduate Student Theses, Dissertations, & Professional Papers
Lyme disease, caused by Borrelia burgdorferi, is the most prevalent arthropod-borne disease in the U.S. In nature, B. burgdorferi is maintained in an enzootic cycle between Ixodes ticks and mammalian hosts. In order to cause infection in mammals, B. burgdorferi spirochetes within a feeding tick sense environmental changes and subsequently alter their gene expression and protein profiles. As part of this adaptation, spirochetes within the tick midgut downregulate outer surface protein (Osp) A and upregulate OspC. Although OspC is an essential B. burgdorferi virulence factor needed for early mammalian infection, it is also a target for the mammalian acquired immune …
Modeling Connectivity In Landscape Genetics: Applications, Optimization And Assessing Uncertainty, Brian Kevin Hand
Modeling Connectivity In Landscape Genetics: Applications, Optimization And Assessing Uncertainty, Brian Kevin Hand
Graduate Student Theses, Dissertations, & Professional Papers
Connectivity modeling and corridor identification are an essential part of landscape genetics and important tools for the future of conservation biology. The previous decade has shown a steadily increasing interest and rise in publications in landscape genetics. This enthusiasm has led to advances in the methods and theoretical background of the field; however, there remain important, yet unresolved, challenges. Many of these are related to validation and uncertainty testing for resistance surfaces (hypotheses of connectivity). These fundamental issues need to be addressed before landscape genetics can gain the full recognition of a scientific discipline such as population genetics or landscape …
A Chicken In Every Lot: The 2007 Chicken Ordinance In Missoula, Montana, Kate Margaret Sheridan
A Chicken In Every Lot: The 2007 Chicken Ordinance In Missoula, Montana, Kate Margaret Sheridan
Graduate Student Theses, Dissertations, & Professional Papers
In 2007, the City Council of Missoula, Montana passed an ordinance allowing six chickens per urban lot. Missoula followed the lead of many other cities seeking to expand urban agriculture and food security opportunities through microlivestock. This paper gives context to the implementation of a specific ordinance, investigates the benefits and challenges experienced by twenty households in Missoula, and connects it back to the food system as a whole.
Acceptance Of Wildlife Crossing Structures On Us Highway 93 Missoula, Montana, Jeremiah P. Purdum
Acceptance Of Wildlife Crossing Structures On Us Highway 93 Missoula, Montana, Jeremiah P. Purdum
Graduate Student Theses, Dissertations, & Professional Papers
Wildlife and humans have always interacted on the landscape. However, growing transportation infrastructure and its associated use are causing a large increase in direct and indirect effects on wildlife populations. Humans can also directly be affected, for example, through wildlife-vehicle collisions that impact human safety and lead to economic costs for individuals and society. In some cases transportation and wildlife agencies have implemented substantial mitigation measures along roadways in an attempt to reduce wildlife-vehicle collisions and to provide for safe crossing opportunities for wildlife. Wildlife-specific crossing structures are now increasingly considered in road construction. Reconstruction projects and a range of …
Climate As Assemblage: Imagining An Ecological Metaphysic, Andrea Rae Gammon
Climate As Assemblage: Imagining An Ecological Metaphysic, Andrea Rae Gammon
Graduate Student Theses, Dissertations, & Professional Papers
Human interventions have resulted in striking changes to the global climate. I work from the understanding of anthropogenic climate change as the product of 250 years of emissions brought about through industrialization and continued by our fossil fuel economies and lifestyles. The instrumentalism of such activities can be traced back to our modern metaphysic, where inanimate matter becomes object and falls away from ‘man,’ the knowing, active subject. In this thesis, I specifically address how this division of passive object from active subject pervades our understanding of climate and conditions the ethics of our human responses to climate change. I …
Nearing The End: Reef Building Corals And Bivalves In The Late Triassic And Comparing Corals And Bivalves Before And After The End-Triassic Mass Extinction Using A Taxonomic Database, Hannah Morgan Elliott Shepherd
Nearing The End: Reef Building Corals And Bivalves In The Late Triassic And Comparing Corals And Bivalves Before And After The End-Triassic Mass Extinction Using A Taxonomic Database, Hannah Morgan Elliott Shepherd
Graduate Student Theses, Dissertations, & Professional Papers
One of the most important tenants in geology is that the present is the key to the past, but it can also be said that the past is the key to the present. The five great extinction events are some of the key events that can help us to understand how changes in climate and sea chemistry can cause great changes in the ecology of our planet. Today the increase in atmospheric CO2 is causing ocean acidification, which has also been proposed as part of the system that caused the end-Triassic mass extinction. Ocean acidification can be greatly detrimental to …
Pristine Places And Passive People? Responses To Neoliberal Development And Maoist Conflict In Nepal's Northwest Himalayas, Catherine Lee Sanders
Pristine Places And Passive People? Responses To Neoliberal Development And Maoist Conflict In Nepal's Northwest Himalayas, Catherine Lee Sanders
Graduate Student Theses, Dissertations, & Professional Papers
In Humla District, Nepal, agro-pastoralists' confrontations with forces of change in the last generation have altered villagers' abilities to gain access to scarce resources. Development efforts and Nepal's recent armed conflict, in particular, introduced novel technologies and ideologies that affected Humli vulnerabilities. This dissertation is based on field research comparing two Hindu villages in northwest Nepal during 2009 and 2010. One village had more extensive ties to development than the other, and these villagers and other change agents co-created transitional contexts of vulnerability in the post-conflict setting of rural Nepal. An armed conflict dominated the political landscape in Nepal for …
Effects Of Local And Landscape Processes On Animal Distribution And Abundance, Aaron David Flesch
Effects Of Local And Landscape Processes On Animal Distribution And Abundance, Aaron David Flesch
Graduate Student Theses, Dissertations, & Professional Papers
Investigations of processes that drive animal distribution and abundance are often approached at one of two different scales and therefore focus on different processes. At local scales, animals are thought to select home ranges or territory patches in an ideal manner by occupying them in order of their fitness potential, but a variety of processes can decouple choices from their fitness consequences and create non-ideal patterns of distribution. At landscape scales, the spatial arrangement of habitat patches and their size and isolation are thought to influence distribution patterns because extinction probability declines with increasing patch area and colonization probability declines …
Opportunities And Constraints To Community Forest User Groups Participating In Redd+ Payment Programs In Nepal, Alexander Cuthbert Smith
Opportunities And Constraints To Community Forest User Groups Participating In Redd+ Payment Programs In Nepal, Alexander Cuthbert Smith
Graduate Student Theses, Dissertations, & Professional Papers
In response to global concern for the consequences of climate change, the United Nations’ Reducing Emissions from Deforestation and Forest Degradation (REDD+) program was developed to support greenhouse gas emission reduction and carbon sequestration in developing countries. While still being developed around the world, in Nepal a REDD+ pilot project is being conducted with the involvement of the Nepali government’s Department of Forestry (DoF) and its community forestry program. The pilot project is called “REDD+ in Community Managed Forests in Nepal” (RCMFN). The commitment of Nepal’s government to carry out this project makes it an ideal location to study carbon …
Here For Life: A Chapter & Stories, Gil Filar
Here For Life: A Chapter & Stories, Gil Filar
Graduate Student Theses, Dissertations, & Professional Papers
Four short stories and a novel chapter.
Imagining Boundaries: (Post) Humanist Understandings And Ecological Ethics In The Fiction Of Margaret Atwood, Megan Kathleen Telligman
Imagining Boundaries: (Post) Humanist Understandings And Ecological Ethics In The Fiction Of Margaret Atwood, Megan Kathleen Telligman
Graduate Student Theses, Dissertations, & Professional Papers
Atwood’s concern for the environment has spanned nearly the entirety of her career, informing her fears about the future and providing the grounding for her speculative fiction. In Atwood’s understanding, ecological ruin stems from human estrangement from the natural environment, an estrangement fortified by capitalism and consumerism in contemporary societies. Instead, she strives to situate the creative, imaginative human species within a larger natural order that inspires ethical treatment of the more-than-human world. Atwood attempts to provide us with a model of interconnection and respect for nature that we must imagine if we desire to avoid the apocalyptic future she …
Getting On Nicely In The Dark: The Perils And Rewards Of Annotating Ulysses, Barbara Nelson
Getting On Nicely In The Dark: The Perils And Rewards Of Annotating Ulysses, Barbara Nelson
Graduate Student Theses, Dissertations, & Professional Papers
The problem of how to provide useful contextual and extra-textual information to readers of Ulysses has vexed Joyceans for years. The debate has generated lively and opinionated discussions in print and at Joyce meetings, forums and listservs. On one side are scholars who argue for scaled-down annotations that present only basic information as simply as possible, minimizing the amount of interpretation involved. On the other side are the actual first-time readers, struggling to make sense of Joyce’s complex, highly allusive text, and willing to accept help wherever it may be found. The work of annotation is both complicated and enriched …
Liars Like Him, Samantha Lynne Duncan
Liars Like Him, Samantha Lynne Duncan
Graduate Student Theses, Dissertations, & Professional Papers
This is a collection of short stories, which fall somewhere between the realist and absurdist genres of fiction. Most of them take place in or around Ohio. Birds and humans often appear side by side.
Performing At The Block: Scripting Early Modern Executions, Jennifer Lillian Lodine-Chaffey
Performing At The Block: Scripting Early Modern Executions, Jennifer Lillian Lodine-Chaffey
Graduate Student Theses, Dissertations, & Professional Papers
This thesis explores the executions of noble men and women in Tudor and early Jacobean England and the theatrical representations of executions that mirrored real life spectacles of deadly punishment. Historical scaffold confessions followed a formulaic pattern and condemned traitors performed their final moments before a crowd of witnesses with the power to judge the quality of the actor’s deportment, costuming and words. As a public stage, the scaffold allowed the traitor a chance to assert and define his or her own individuality in the face of death and formulaic requirements, which I outline in the first chapter. Dramatic representations …
Narrative Reflection And Anatomical Introspection In Thomas Carlyle's Sartor Resartus And Herman Melville's Moby Dick, Torey Elizabeth Davie
Narrative Reflection And Anatomical Introspection In Thomas Carlyle's Sartor Resartus And Herman Melville's Moby Dick, Torey Elizabeth Davie
Graduate Student Theses, Dissertations, & Professional Papers
Thomas Carlyle’s Sartor Resartus (1831) and Herman Melville’s Moby Dick or, the Whale (1851) combine the novel and the anatomy, creating a plot as well as a reflection on the human condition. The result of this combination produces a narrator whose single-minded focus on an object both propels events forward while at the same time stalling the progress of a traditional plot. The aspects of the text that connect to the novel, such as character and plot, offer a reflection of the effect truth and society have on character. Aspects that connect to the anatomy, such as the exhaustive knowledge …
Queer Panic In Native American Literature, Theodore Cecil Decelles
Queer Panic In Native American Literature, Theodore Cecil Decelles
Graduate Student Theses, Dissertations, & Professional Papers
Indigenous American sexual minorities and alternatively gendered voices went underground due to Eurowestern sexual colonization from the time of the conquistador invasions of the early 16th century to the political campaigns of cultural homogenization of the mid-20th century. A cultural distortion still exists in the postcolonial era. In the past many North American indigenous nations had culturally specific sexualities and genders that reflected the cultural heterogeneity of the Americas. Today cultural assimilation negatively affects queer Native Americans, and culturally imported attitudes of homophobia are reflected in Native American literature. An interdisciplinary approach must be used to study the cultural distortion …
Touch-Screan Mss, Colin Post
Touch-Screan Mss, Colin Post
Graduate Student Theses, Dissertations, & Professional Papers
This is a poetry manuscript that examines the epic form, concrete poetic techniques, and science fiction concepts so as to posit a created world of surfaces.
City On The “River Of Awe”: An Historical & Observational Study Of Missoula’S Urban River Greenway, Sandra Burch
City On The “River Of Awe”: An Historical & Observational Study Of Missoula’S Urban River Greenway, Sandra Burch
Undergraduate Theses, Professional Papers, and Capstone Artifacts
Urban river greenways have the potential to serve as landscapes of civic environmentalism in the American West. Missoula’s urban river corridor is such a landscape. This study seeks to assess the history of Missoula’s urban river corridor, and the degree to which the city’s current urban river greenway meets social and environmental goals. The urban river greenway in Missoula is a successful social undertaking, and its history shows a positive change in the treatment of the river as a healthy landscape feature. In order to explore this concept, historical data was gathered on Missoula’s past relationship to the river, and …
Wrigg V. Junkermier, Clark, Campanella, Stevens, P.C.: The Effect Of Involuntary Termination On Post-Employment Non-Compete Agreements, Michelle H. Vanisko
Wrigg V. Junkermier, Clark, Campanella, Stevens, P.C.: The Effect Of Involuntary Termination On Post-Employment Non-Compete Agreements, Michelle H. Vanisko
Montana Law Review
While this author agrees with the Wrigg Court’s ultimate decision, the Court’s overall discussion was lacking on three points. First, before determining whether an agreement has the requirements of an enforceable noncompete clause, the Court should have addressed the contract issues involved in Wrigg. In particular, the Court should have addressed the question of consideration and the potential ambiguity surrounding the terms of the shareholder agreement. If the agreement is an unenforceable contract, enforceability of the non-compete clause becomes irrelevant. Next, even if a contract is enforceable, a non-compete clause within it is not automatically enforceable. As a general rule, …
The Damage Done, Kelly Beth Conde
The Damage Done, Kelly Beth Conde
Graduate Student Theses, Dissertations, & Professional Papers
Conde, Kelly, M.A., Spring 2013 Journalism The Damage Done Chairperson: Dennis Swibold The water that ran from Helen Ricker’s faucet stank of rotten eggs and of chemicals. It ran orange and greasy. It stained her clothes and clung to her skin. Ricker lives on the Fort Peck Indian Reservation, three miles north of Poplar, Mont. From Ricker’s home, the oil wells from the East Poplar oilfields can be seen in the distance. Her water started to change in the early 1970’s, twenty years after the first oil well was drilled. It took about that long for the contamination from poorly …
The Archaeological Investigation Of Cedar Bark Basket Trees In Western Montana: Background, Methods, And Trial Study Of Culturally Modified Trees, Dean Sonneah Nicolai
The Archaeological Investigation Of Cedar Bark Basket Trees In Western Montana: Background, Methods, And Trial Study Of Culturally Modified Trees, Dean Sonneah Nicolai
Graduate Student Theses, Dissertations, & Professional Papers
This thesis explores the potential for archaeological investigations of culturally modified trees (CMTs) in the northern Rocky Mountain region of Western Montana. Culturally modified trees are considered to be living artifacts, representations of traditional culture, and a lasting physical manifestation of long term use by inhabitants. The goal of this thesis is to offer an archaeological perspective for investigation of cultural modifications of the cedar basket tree (Thuja plicata), and to contribute to the development of a method for inquiry and analysis. Two primary research questions were posed: How does the study of behavioral archaeology and the methodological approach presented …
Salmon & Steelhead Hatcheries: Conservation Or Condemnation?, Samuel Hunter Lungren
Salmon & Steelhead Hatcheries: Conservation Or Condemnation?, Samuel Hunter Lungren
Graduate Student Theses, Dissertations, & Professional Papers
Wild salmon and steelhead are as fundamental to the Pacific Northwest as evergreen trees and rain. For thousands of years ecosystems and economies have relied on the bountiful marine nutrients annually running inland from the Pacific Ocean in the form of large, silver fish. Even today, the chance to tangle with one of these wild gems is one of the greatest gifts the Northwest has to offer. Early settlers of the West Coast witnessed seemingly infinite salmon abundance. But as time passed and humans increasingly exploited both salmon and their ecosystems, they found out just how finite salmon really were. …
Women’S Water, Women’S Work: Evaluating Decentralized Management Of Deep Borehole Wells For Improved Rural Water Access In Tawa Fall Village, Senegal, Tenly Elizabeth Snow
Women’S Water, Women’S Work: Evaluating Decentralized Management Of Deep Borehole Wells For Improved Rural Water Access In Tawa Fall Village, Senegal, Tenly Elizabeth Snow
Graduate Student Theses, Dissertations, & Professional Papers
Throughout the developing world, countries face a number of issues regarding the health and welfare of their populations. One issue that stands out with critical and growing importance is the availability-and accessibility-of water. Across the Sahel, access to potable water for domestic use, as well as contaminant-free water for agricultural and animal husbandry purposes is of growing concern. This study evaluates Government of Senegal efforts at improving rural water access through public-private operation contracts to manage deep groundwater resources. In West Africa, Senegal currently counts itself among the few Sahelian countries having sufficient freshwater supplies to support its population’s growing …
Color/Shape/Form/Space, Brett James Hargesheimer
Color/Shape/Form/Space, Brett James Hargesheimer
Graduate Student Theses, Dissertations, & Professional Papers
Color/Shape/Form/Space begins at its title. The show is named with the same directness that I want the work to have: accessible, ready for consumption. Stripped of unnecessary information, the exhibition’s title needed to match the work itself, which expresses minimalistic tendencies, avoiding the superfluous. Everything needed to be consciously put together to operate as a well-designed whole. Simple and clear. It is the age that we live in that prompts me to be so forthright. Our present is defined by attention deficit digital connectivity. Accessibility and information sharing are rampant. With the possibilities being seemingly endless, it is an exciting …
Silent Sentinels: Archaeology, Magic, And The Gendered Control Of Domestic Boundaries In New England, 1620-1725, C. Riley Auge
Silent Sentinels: Archaeology, Magic, And The Gendered Control Of Domestic Boundaries In New England, 1620-1725, C. Riley Auge
Graduate Student Theses, Dissertations, & Professional Papers
The following dissertation is an historical archaeological study of the material culture of gendered protective magic used by Anglo-Europeans in seventeenth-century New England as a tactic to construct boundaries that mitigated perceived personal, social, spiritual, and environmental dangers. Such boundary construction was paramount in the seventeenth-century battle between good and evil epitomized by the belief in and struggle against witchcraft. This dissertation sought to answer three interrelated research questions: 1) What constitutes protective magical material culture in seventeenth-century contexts and how is it recognizable in the archaeological record? 2) What signifies gender specific protective magical practices and what can these …
Paying To Play: Supply Management In Montana's Dairy Industry, Laura Ginsburg
Paying To Play: Supply Management In Montana's Dairy Industry, Laura Ginsburg
Graduate Student Theses, Dissertations, & Professional Papers
Montana’s dairy industry is unique among US states because of its supply management program, which allocates quota to limit how much fluid milk can be produced and sold within the state. The amount of quota is set and price varies with market conditions; therefore, quota adds to a farm’s production costs. This paper presents findings from in-depth interviews with 17 dairy farmers to learn how quota has affected on-farm decision-making and how they perceive the impacts of quota on the statewide industry. Farmers tend to be spilt between those who think it affected their on-farm decisions and those who felt …
Measuring Visual Literacy Ability In Graduate Level Pre-Service Teachers, Teresa Farrell
Measuring Visual Literacy Ability In Graduate Level Pre-Service Teachers, Teresa Farrell
Graduate Student Theses, Dissertations, & Professional Papers
Farrell, Teresa, Ed.D., August 2013 Curriculum and Instruction Measuring Visual Literacy Ability in Graduate Level Pre-service Teachers Chairperson: Dr. Marian J. McKenna The field of visual literacy has been active since its inception in 1969 by John Debes and members of various fields of study such as science, mathematics, psychology, education, and the arts forming the International Visual Literacy Association (IVLA). Recognizing that modern society is increasingly visual by nature, and with the advances in digital technologies, visual literacy is becoming an area of critical importance in education. Although much work has been done within the field to define it …
4-Isoxazolyl-1,4-Dihydropyrirines Bind The Multidrug-Resistance Transporter, Scott Steiger
4-Isoxazolyl-1,4-Dihydropyrirines Bind The Multidrug-Resistance Transporter, Scott Steiger
Graduate Student Theses, Dissertations, & Professional Papers
The development of multidrug resistance in tumor cells has been recognized as a major obstacle to successful cancer treatment. Tumor cells in vitro and in vivo can develop multidrug resistance (MDR) to the lethal effects of a variety of cytotoxic drugs used to treat cancerous tumor cells. The over expression of multiple drug resistance gene 1 has been correlated with the expression of multi drug resistance protein 1(MDR1, also known as P-glycoprotein or P-gp). MDR1's role in altering uptake, distribution and bioavailability is considered a significant factor when examining drugs for clinical administration, and represents a viable drug target for …
Costs And Benefits Of An Extended Phenotype: Chambers Made By Manduca Sexta Larvae, Jonathan Cooley Sprague
Costs And Benefits Of An Extended Phenotype: Chambers Made By Manduca Sexta Larvae, Jonathan Cooley Sprague
Graduate Student Theses, Dissertations, & Professional Papers
Extended phenotypes can serve interesting physiological functions and their externality provides ready opportunity to manipulate and examine their functions and costs. One such set of extended phenotypes are below-ground pupation chambers made by a wide range of insects and whose function is unknown and costs unquantified. We use a series of lab and field experiments to examine the cost and benefit of chambers made by the hawkmoth, Manduca sexta (Sphingidae), whose larvae lose up to 60% of their body mass during chamber construction. Our study shows that these chambers provide critically important free space in which individuals transition from larvae …