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Exploration Of Chemical Transformations Of Pentafluoro-Gem-Diols And Their Utility In Drug Discovery, Baharul Islam

Electronic Theses and Dissertations

Methods for creating fluorinated organic molecules are highly valuable in drug discovery and synthetic organic chemistry. Fluorine has been found to enhance desirable properties of organic molecules, leading to an increasing number of pharmaceuticals containing fluorine. The research studies in this dissertation center around the synthetic utility of pentafluoro-gem-diols, which are precursors of fluorinated building blocks. Using pentafluoro-gem-diols, we have discovered new synthetic methods to create valuable fluorinated molecules such as difluoro-β-amino ketones, difluoroethanols, pentafluorohemiketals, and pentafluoroisopropanols. Prior methods for making α,α-difluoro-β-amino ketones required multiple steps and the use of an unstable starting material. We have developed a one-step method …

Development And Characterization Of An Intravenous Formulation Containing Paclitaxel-Loaded Lipid Nanoparticles And Doxycycline, Navya Nalajala

Electronic Theses and Dissertations

Ovarian cancer (OC) is the fifth-most common cause of cancer-related deaths among women. It is often difficult to detect in its early stages, leading to a higher mortality rate. There are several types of ovarian cancer, including epithelial ovarian cancer, germ cell ovarian cancer, and stromal ovarian cancer, which is the most common type among all of them. The exact causes of ovarian cancer are not fully understood. Paclitaxel (PTX), a chemotherapeutic agent, is currently used as the first-line agent in combined therapy for epithelial OC. Doxycycline (DOX) is a Tetracycline class of antibiotics, currently emerging as a chemotherapeutic agent …

Leadership Matters: An Assessment Of The Mpower Leadership Program At The University Of Mississippi, Ryan Upshaw

Electronic Theses and Dissertations

The purpose of this manuscript is to examine the importance of student leadership development programs on undergraduate students using the framework of the Social Change Leadership Model. This document will specifically examine the MPower Leadership program held at the University of Mississippi. Student engagement and leadership is extremely important to college campuses as universities seek to prepare their students for the world of work and to become engaged citizens. Student leadership and engagement also has ties to academic success and persistence. A concrete plan that is focused on leadership development also benefits student affairs administrators who are responsible for coordinating, …

Social Anxiety And Engagement In Risky Behaviors: Exploring The Role Of Emotion Regulation, Carey J. Sevier

Electronic Theses and Dissertations

Social anxiety disorder (SAD) is a chronic, prevalent disorder that is characterized by persistent and marked fear of social situations when there is potential for negative evaluation from others. Although SAD is typically characterized by inhibition and escape behaviors, some research suggests some individuals with SAD display approach-oriented behaviors wherein individuals engage in greater risky behaviors (e.g., aggression, sexual impulsivity, substance use). This approach-oriented presentation appears to have an earlier onset, greater symptoms severity and greater functional impairment. Emotion regulation (ER) is the ability to use strategies to engage in goal directed behavior. ER difficulties have been shown to be …

Project Grit: An Applied Research Study Conducted In An Alternative School Program To Promote Alternative Behaviors To Violence, James Ray Howington

Electronic Theses and Dissertations

Students in the Anniston School District are placed in the alternative setting (i.e., the Avery Alternative Center) for fighting and violence more than any other disciplinary infraction. The disproportionality of students of color and minority groups enrolled in the alternative setting for fighting is also alarming. Why is this happening? Why does student conflict often end in physical aggression and violence, especially disputes involving minorities? What can stop the violence? Stakeholders in the Avery Alternative Center created Project GRIT to help answer these questions by incorporating research-based practices and interventions designed to strengthen conflict resolution skills in participants and support …

Harness Therapeutic Potential Of Immune Responses: Molecular Characterization And Targeted Delivery, Nan Ji

Electronic Theses and Dissertations

The immune system plays a crucial role in protecting the body from harmful pathogens and cancer cells and maintaining tissue homeostasis. Immunotherapy has shown significant potential in treating various diseases by harnessing the therapeutic potential of immune responses through the targeting of different immune cells, receptors, and signaling pathways. This dissertation investigated two immune modulators for their immune-enhancing potential.In the first chapter, the components of innate immunity are introduced. In the second chapter, Immulina, a commercially available extract of Arthrospira platensis enriched with Braun-type proteins, was studied for its immunostimulatory effect in mouse bone marrow-derived dendritic cells and macrophages. The …

Sustained And Improved Ophthalmic Formulations Of Gatifloxacin For Better Therapeutic Outcomes During Topical Ocular Applications, Poorva Hemant Joshi

Electronic Theses and Dissertations

Gatifloxacin (GTX) is a broad-spectrum 4th generation antimicrobial fluroquinolone used in the treatment of ocular infections such as conjunctivitis, keratitis and keratoconjuctivitis. GTX (as a sesquihydrate) is commercially available as aqueous eyedrops for the treatment of bacterial conjunctivitis (BC) which requires frequent administration due to low residence time on the conjunctival surface. The eye is a highly specialized photoreceptive organ, which is protected by a continuous tear flow containing antibacterial components. However, inflammation or scarring of the eye may be difficult to resolve once having occurred. Furthermore, initial infections if ignored are likely to invade the inner portions of the …

Understanding Financial Toxicity Among Adult Cancer Survivors In The Us, Siddhi Korgaonkar

Electronic Theses and Dissertations

The term ‘financial toxicity’ (FT) has been used to describe cancer-related financial hardship and psychological distress experienced by cancer survivors. FT can be detrimental to the health and wellbeing of cancer survivors due to its multifarious adverse effects.

This dissertation strives to advance extant knowledge on cancer-related FT research by investigating three key questions: 1. How have the trends in the direct total and out-of-pocket (OOP) healthcare expenditures, and OOP financial burden of US cancer survivors aged 18-64 years evolved between 2008 – 2019? 2. What are the self-reported HIL levels among adult cancer survivors aged 27-64 years in the …

Effects Of Pictorial And Imagery Encoding On False Memories, Paul D. Loprinzi

Electronic Theses and Dissertations

Prior research demonstrates that viewing matched pictures is ineffective in reducing false memories for related lures that have not been previously externally presented during the experiment. However, other types of visual processing, such imagery encoding, have been shown to reduce false memories when evaluated from paradigms where the critical item is also thought to be internally activated, such as when using DRM lists. The prior work showing that imagery encoding can reduce false memories when using DRM lists may be confounded by a potential mismatch between the mentally-generated image and the visual word. Using a category associate procedure, as opposed …

Evaluation Of Quality Ratings In Healthcare: Is There Evidence Of Disparities In Their Applications?, Irene B. Nsiah

Electronic Theses and Dissertations

This dissertation examined racial and ethnic disparities in: (1) the impact of the Centers for Medicare and Medicaid Services (CMS) policy and payment changes to the Medicare Part D Star Ratings Program on adherence to diabetes, renin-angiotensin system antagonists (RASA) and statin medications, (2) the spillover effect of this program onto nontargeted therapies used to treat hypertension (calcium channel blockers and beta blockers), and (3) insulin non-persistence among Medicare beneficiaries, and quantified the contribution of sociodemographic, clinical and cost factors associated with the racial and ethnic disparities.

For objectives 1 and 2, interrupted time series (ITS) analyses were conducted using …

Determining Background Deep-Time Critical Zone Conditions In Mississippi Preceding The Onset Of Paleocene-Eocene Hyperthermals, Savannah Reese Rathbun

Electronic Theses and Dissertations

Hyperthermals are periods of extremely rapid global warming. In order to understand the magnitude of hyperthermals, a more complete understanding of background conditions must be established. My goal is to study the paleoclimatic conditions that existed prior to the onset of Paleocene- Eocene hyperthermal events in order to establish background conditions. Relatively thick Paleocene and Eocene sedimentary units ideal for this study are present in the Mississippi Embayment (MSE), a major southwest- dipping sedimentary basin in the Gulf of Mexico coastal region of North America. The MSE contains an extensive record of Paleocene strata that were deposited prior to the …

Exploration Of Student Success Programs For Freshmen Students On Academic Warning/Academic Probation At The University Of Mississippi, Jeremy Roberts

Electronic Theses and Dissertations

Nearly ten percent of the first-year class at the University of Mississippi go on Academic Warning or Academic Probation each semester after their first-full semester at the University. During this time, the student's GPA is below a 2.0, which requires them to take the EDHE 101: Academic Skills for College course, if they plan to return to the University that following Spring or Fall semester (depending on which was their first-full semester). Academic Support Programs, under the Center for Student Success and First-Year Experience oversees this course and several other programs to assist students as they look to return to …

Formulation And Development Of Curcumin Implants For Treatment Of Colorectal Cancer: Application Of Hme And 3d Printing, Neha Rajendra Sali

Electronic Theses and Dissertations

Targeted drug delivery for preventing colorectal cancer (CRC) reoccurrence after surgery can be one of the potent tumor reduction methods among other therapies, such as chemotherapy, ablation, embolization, and radiation therapy. Curcumin has been reported to target the growth factors in carcinoma cells and thereby reducing the proliferation and accelerating the apoptosis of the cancerous cells. Due to its poor bioavailability, it has several limitations for its use in anti-cancer therapy. Piperine has increased the solubility and bioavailability of curcumin and acts synergistically to suppress cancer cell growth. The current study intended to develop novel curcumin implants by coupling hot …

Entrepreneurs Want More Than Just Money: The Role Of Subjective Entrepreneurial Success In Predicting Entrepreneur’S Grief Following Venture Failure, Joseph Richard Schaefer

Electronic Theses and Dissertations

The focal topics of this dissertation are subjective entrepreneurial success (SES) and grief. Over the past three decades, the budding SES literature has seen accelerating growth since its conceptual inception in 1987, with 2016 marking a key event in the literature – the formal naming and definition of the SES construct. Research on the SES construct is of interest to scholars because it complements the objective economic conceptualizations of success often seen in the entrepreneurship literature, highlighting the idiosyncratic ways that entrepreneurs conceptualize and evaluate their success.

To contribute to the SES literature, Essay One of my three-essay dissertation, I …

Lipid Based Ophthalmic Nanoformulations For Ciprofloxacin, Moxifloxacin, And Cannabidiol, Ahmed Adel Ali Youssef

Electronic Theses and Dissertations

Ocular drug delivery faces many challenges due to the unique anatomy and physiology of the human eye. The development of ocular drug delivery systems is subjected to a gradual shift from an empirical to a rational base due to a better understanding of the ocular barriers that control drug disposition in the eyeball as well as new approaches in clinical testing. Most of the topically applied actives are lipophilic with low aqueous solubility, and the ocular delivery of these drugs is posing a challenging task. Lipid-based drug delivery systems are well reported to improve solubility and enhance both bioavailability and …

Pharmacy Matters - December 2022/January 2023, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "Partnership Expands Health Care in Union County," "Graduate Students Shine in 3MT Competition"

Directory Of Accounting Faculty, Academic Year 2023-2024, 50th Year, James R. Hasselback

Individual and Corporate Publications

No abstract provided.

Customer Experience With Service Robots In Hospitality And Tourism: Scale Development, Olena Ciftci

Electronic Theses and Dissertations

Purpose: This study aims to create a measurement scale of customer experience with service delivered by robots in hospitality and tourism settings to address the industry need and gap in the academic literature.

Methods: This study follows a widely accepted psychometric procedure for scale development. The scale development consists of four stages: item generation, item purification, item reduction and dimensionality, and scale validation. The items for the scale are generated from the literature on customer experience with and perception of service robots in hospitality and tourism and semi-structured interviews with customers who experienced service from robots in hospitality and tourism …

Hotel Staycationers' Well-Being Perception, Satisfaction, And Loyalty: The Role Of Restorative Qualities And Service Quality, Chanmi Hong

Electronic Theses and Dissertations

During the COVID-19 pandemic, a rising trend for travelers is to stay at a local hotel, known as "hotel staycations," rather than traveling outside of their area. Despite the increasing popularity, empirical studies on customer behavior in the hotel staycation context are limited. Furthermore, existing studies have largely overlooked restorative qualities and service quality of hotel staycations, which can significantly influence customer well-being and satisfaction. To address these gaps, this study aims to examine the impact of restorative qualities and service quality on customers' perception of well-being and satisfaction with the hotel staycation experience by extending Kaplan's (1995) attention restorative …

The Crisis Of White Supremacy In The Antebellum South: Poor Whites, Slavery, And The Coming Of The Civil War, Jeffrey Glossner

Electronic Theses and Dissertations

The so-called “poor whites” of the antebellum South have often been overlooked by historians due to their perceived insignificance to the political and cultural development of the South. However, within the context of the sectional debate over slavery, poor whites represented a disturbing presence for elite southerners who sought to defend slavery on the basis of white supremacy, a political platform built on the promise of universal white superiority. In order to defend the slave labor system from northern promises of white supremacy under free labor and to justify widespread southern white poverty, the architects of the antebellum southern cultural …

Combating Teacher Turnover Through Teacher Development In A Collaborative Culture Of Teacher Leadership, Nina M. Johnson

Electronic Theses and Dissertations

This applied action research with program evaluation aimed to determine if teacher-led professional development and empowerment initiatives such as the Teacher Leader Collaborative (TLC) contributed to a group of teachers' efficacy and professional growth to reduce teacher turnover of English Language Arts (ELA) teachers at Bernard Williams Middle School (BWMS). Each year the middle school has a turnover trend in the ELA department. As a result, sustainable school improvement efforts have waned, and teachers have had limited access to professional growth initiatives because of these transitions. The outcome has led to student achievement challenges. Therefore, this applied research study comprises …

A Content Analysis Of State-Level Restorative Justice Statutes, Mason Karlyn Myers

Electronic Theses and Dissertations

Restorative justice programs have garnered attention as a potential policy solution to address critical issues within the criminal justice system, such as mass incarceration, re-victimization, and costliness. However, effective implementation of these programs faces various challenges, including communication gaps, inadequate program design, and implementation issues. These challenges may be further exacerbated by the lack of consistent policies at the state level guiding restorative justice practices. Surprisingly, limited research has been conducted to examine restorative justice statutes at the state level. In response to this gap in the literature, this study analyzes the restorative justice policies of all fifty states, including …

A Review Of Mental Health Intake Assessments In Mississippi Jails, Sierra Molina

Electronic Theses and Dissertations

Over 64 percent of jail inmates report mental health concerns in the United States. Limited research, however, has explored the guidelines provided by jail facilities for screening and assessing mental illness. To address this gap in the literature, this study used a qualitative design to examine the intake policy guidelines for mental health screening in Mississippi jails. Furthermore, it explored the following questions to discover themes relating to correctional mental health: how many facilities have policies relating to screening for mental health symptoms; how are these guidelines defined by correctional officials; is there variation across location and facility; and are …

Plot Twist: Vomiting Is Good! Online Psychoeducational Intervention Among Internet Support Group Users, Jennifer Petell

Electronic Theses and Dissertations

Emetophobia is a specific phobia of vomit (SPOV) characterized by persistent and chronic symptoms with severe impairment across domains. Research on emetophobia is limited, with even fewer studies examining the impact of intervention. Available treatment studies have broadly been examined through behavioral interventions, such as cognitive behavioral therapy (CBT) of which psychoeducation is an important foundational component. The positive role of psychoeducation on symptom reduction has been examined among a variety of psychopathology, including anxiety disorders. However, to date, research has not examined the role of psychoeducation itself (psychoeducational intervention, PI) among specific phobias broadly or emetophobia specifically. Therefore, the …

Dark Personality, Sexual Satisfaction And Sexual Perceptions: An Event-Contingent Study, Jasmine Whitney Rios

Electronic Theses and Dissertations

Research has consistently linked Dark Personality (DP) to one’s mating tendencies (e.g., mating strategy, sexual behavior, sociosexual orientation) and sexual motivation. However, DP researchers have failed to expand the association between DP and sex beyond these common sexual dimensions. As such, there is little to no research linking DP to people’s sexual satisfaction and sexual perceptions. Additionally, personality research has predominantly investigated sexuality at the global-level (e.g., average/general report of sexual satisfaction) when studying aspects of sexual interaction at the interaction-level (i.e., soon after the interaction) can reduce various issues that accompany global measures. Thus, one purpose of this current …

Development Of A Novel Psychological Screening Tool For Young Children In Educational And Childcare Settings, Diana Tinsley

Electronic Theses and Dissertations

Young children experience psychological difficulties at comparable rates to school-aged children (Egger & Angold, 2006; Bufferd et al., 2011; Fuchs et al., 2013), yet few screening tools are available for this age range. Childcare and preschool settings present a unique opportunity to increase early screening efforts, particularly in terms of observing children among their peers. The current study presents initial steps toward the development of a new psychological screening tool for young children ages 1.5 – 5 years in childcare and educational settings. The aim of the study was to develop a brief and broad psychological screening tool that can …

Enhancing Student Engagement: Regional Campus Students’ Access To High Impact Practices And Co-Curricular Organizations, Angela Kristina Austin

Electronic Theses and Dissertations

Regional campuses serve a vital role in today's higher education landscape, extending access to college education for underserved locations and populations. The University of Mississippi’s university system has five regional campuses. The students at a regional campus, like their traditional main campus counterparts, aspire to attain bachelor's or graduate degrees. However, regional campus students often exhibit characteristics more akin to community college or non-traditional students.

While literature on regional campuses is limited, ample research supports the positive impact of student involvement in higher education. Even more limited is research on participation levels of non-traditional students in co-curricular organizations and high-impact …

Saudi Perspective On Using Efl Resources To Improve Their English Pronunciation In Saudi Public Institutions, Khadija Abdullah Alzahrani

Electronic Theses and Dissertations

Due to the lack of a pronunciation curriculum and materials in Saudi universities, EFL students individually select use different resources to help with their English pronunciation difficulties. Therefore, this study aims to describe (a) Saudi students' perspectives and attitudes toward pronunciation resources that may help with their pronunciation (b) if they use them to help with their weaknesses, and (c) the teachers’ perspectives on their students' pronunciation difficulties, their knowledge of the resources the universities provide, and what they use to help the students' pronunciation learning and development. This study investigates what Saudi students think they need to learn pronunciation, …

Formulation Development And Targeted Delivery For Bcs Ii Drugs Using Hot Melt Extrusion Technology, Ahmed Almotairy

Electronic Theses and Dissertations

Hot-melt extrusion (HME) is one of the approaches to formulate an amorphous solid dispersion (ASD) and has gained popularity within the pharmaceutical industry over the past three decades. Additionally, HME has the ability to produce several versatile formulations and its ability to tailor processing materials through modifications in the screw design and mixing and shearing forces or by controlling the material feed rate; additionally, HME allows processing at multiple temperatures and screw speeds. HME has advantages over traditional pharmaceutical processing techniques, including its ability for continuous operation and ability to implement quality by design (QbD) and process analytical technology (PAT) …

Solubility Enhancement Of Atorvastatin Calcium Using Cyclodextrin, Karthik Abburi

Electronic Theses and Dissertations

The present study is intended to increase the solubility and dissolution rate of Atorvastatin calcium (ATN Ca) by formulating the drug- hydroxy-propyl-beta cyclodextrin (HPBCD) complexes using solvent-assisted extrusion (SAE) using a twin-screw extruder. Various studies on ATN Ca saturation solubility in water and other pH mediums revealed a pH-dependent solubility with a difference. Thus, the saturation solubility for ATN Ca and Solvent Assisted Extruded complex was conducted in water and different pH mediums in this study. Phase solubility studies between ATN Ca and CDs revealed an AL-type solubility profile exhibiting a linear increase with HPBCD. Drug-HPBCD complexes were made using …