Digital Commons Network^™

Design Of Topical Ocular Drug Delivery Systems For Management Of Eye Keratitis, Chuntian Cai

Electronic Theses and Dissertations

Due to the complexity of the anatomical and physiological barriers in the eye, ocular drug delivery presents significant challenges. The poor solubility of many drugs and short retention times on the ocular surface results in low bioavailability from traditional topical dosage forms. Various types of eye infections, such as bacterial keratitis (BK) and fungal keratitis (FK), can become critical and lead to serious visual disabilities. Therefore, this research study aims to enhance the solubility and corneal permeation of two drugs, Ciprofloxacin (CIP) for BK and the antifungal agent Natamycin (NT) for FK, using nanoemulsion (NE) and cyclodextrin (CD) based technologies.

"A Transient Veil": Appropriation Of Exclusionary Form In Eighteenth-Century Women's Writing, Andrea Ferniany

Electronic Theses and Dissertations

“’A Transient Veil’ : Appropriation of Exclusionary Form in Eighteenth-Century Women’s Writing” is an exploration of how women writers of the eighteenth century strategically and subversively appropriated patriarchal, often misogynistic, literary idioms to expand literary discourse and craft flexible, alternative, and feminine literary forms. It emerges from the desire to underscore what rhetorical features of women’s writing can tell us about the creative agency of women writers. By exclusionary form, I mean to reference both rhetorical conventions and aesthetic traditions that excluded women writers by assuming a male subject position or by the explicit objectification of feminine figures. This dissertation …

Community Engagement/Involvement In School Life: Connecting The Missing Pieces Between School And Community, Shanika Hardy-Hickmon

Electronic Theses and Dissertations

Long Creek Elementary School is a small, rural school with approximately 292 students in Sallis, Mississippi. Long Creek Elementary School has historically struggled with stronger parent involvement in their children’s school life. To address this concern, the administration, faculty, and staff at Long Creek Elementary School targeted barriers to parental involvement/engagement to increase community engagement/involvement in school life and connect the missing pieces between school and community. This has led to discussions of the creation of a parent center to provide parents with daily support and needed resources to contribute to their child/children’s academic success.

The purpose of this study …

Crosscultural Backchannelling Responses Among Second Language Learners, Chien-Hui Hsu

Electronic Theses and Dissertations

Backchannel responses (Yngve, 1970) have always been an essential component of conversational interactions that facilitate speaker-listener engagement and mutual shaping of narratives (Bavelas et al., 2000). This study aims to investigate the cross-linguistic difference in backchannelling responses between Taiwan Mandarin and English (General American) second language (L2) learners, and how those differences might impact communication in a cross-cultural classroom. The current study examines 20 participants, ten each from Taiwan Mandarin speakers and American English speakers. Each speaker was observed in an online conversation to eliminate the influence of non-verbal cues such as gestures and facial expressions. The backchannelling responses they …

The Metaphysics Of Creaturely Love In The Philosophy Of Anne Conway, Jeremiah Joseph Langer

Electronic Theses and Dissertations

A common belief during the early modern period held that humans bear ethical relations only to creatures with whom we share the right kinds of similarity. A tradition attributed to René Descartes holds speciesist and anthropocentric views according to which nonhuman animals are mere automata who lack rational minds. Even Baruch Spinoza, who was much more radical in his Ethics, suggests creaturely similarity is restricted to beings with rationality. As such, Descartes and Spinoza conclude that lower beings cannot be morally evaluated for their actions and humans cannot be morally evaluated for their treatment of lower creatures. In her sole …

Examining Institutional Effectiveness Planning As A Tool To Advance Student Success Outcomes For Underrepresented Males, Jazmine Kelley

Electronic Theses and Dissertations

Higher education should operate as a tool by which democratic equality is enhanced for the betterment of society and its occupants; however, there are systemic inequities as it pertains to educational attainment for different groups when considering race, ethnicity, and sex (Anthony et al., 2021a). More often than not, male collegiates that hold racial and ethnic identities outside of the cultural majority have less than satisfactory student success outcomes when compared to their female as well as White counterparts. As scholars have noted, the burden of improvement and advancement of these outcomes should be placed on the institutions rather than …

Bigger Than Bees: Victorian England’S Relationship To The Bee – Considering Symbolism And Understanding, Grace Jacqueline Kaim

Electronic Theses and Dissertations

The complex and beautiful relationship the people in Victorian England had to the bee is one that goes beyond ideas of politics and religion. This thesis will explore this relationship by utilizing print, ephemera, jewelry, and household items, to demonstrate how the representation and symbolism of the bee was recognized and cherished by Victorians. While bees did certainly have an intimate relationship to the areas of politics and religion, one that is acknowledged throughout this work, their connection to grander themes of introspection, industrialism, folklore, morality, and status helps us understand the Victorians on a deeper level.

Examining The Impact Of Mississippi's Early Learning Collaboratives In Supporting Children From Low Socioeconomic Backgrounds With Autism, Lisa Suzanne Ryals

Electronic Theses and Dissertations

Mississippi established the Early Learning Collaborative Act, MS Code § 37-21-51 (2023), in 2013 to expand pre-k opportunities statewide. This study examined the processes within Mississippi’s Early Learning Collaboratives that support school readiness for children from low socioeconomic backgrounds with autism. Improving access, participation, and supports for children from low socioeconomic backgrounds with autism by increasing the components of high-quality inclusive settings allows children to gain the necessary readiness skills for kindergarten. A policy analysis of the Mississippi Early Learning Act (2023) established the first phase of the research, followed by focus groups from the Mississippi Department of Education Office …

A Qualitative Examination Of The Interplay Of Attachment Styles, The Supervisory Relationship & Counseling Self-Efficacy, Kamiron Ball Tran

Electronic Theses and Dissertations

This phenomenological qualitative study explores the intricate dynamics between attachment styles, the supervisory relationship, and counseling self-efficacy among supervisory dyads in counseling. The findings reveal five themes: supervision is relational, supervision is a therapeutic space, security within supervision bolsters self-efficacy, supervision is a mirror for clinical practice, and the nuanced "both/and" nature of attachment and self-efficacy dynamics. This study addresses a gap in the literature by offering qualitative insights into the interplay of attachment styles, supervisory relationship, and counselor self-efficacy, thus contributing to a deeper understanding of the complexities within supervisory practices in counseling.

The Microbial Communities Of Freshwater Invertebrates And Their Influence On Biogeochemical Cycling, Stephanie Nicole Vaughn

Electronic Theses and Dissertations

Nutrient cycling in freshwater systems is primarily performed by microorganisms, however the interactions between microorganisms and other aquatic organisms such as macroinvertebrates is poorly understood. Interactions between macroinvertebrates and their associated microbial community, their microbiome, are important to understanding ecosystem functioning and guiding conservation efforts for imperiled macroinvertebrate species. In this study, I characterized the microbiomes of various freshwater macroinvertebrates and investigated the influence of sample storage methods and environmental parameters on these microbial communities. I first evaluated the impact of different sample preservation methods on the gut microbiome of two crayfish species, Procambarus vioscai paynei collected in the field …

The Value Of Empathy For Teachers In Nontraditional Classrooms, Mindy Clair Waldrop

Electronic Theses and Dissertations

Little is known about the experience of teachers in nontraditional classrooms, particularly those in Juvenile Detention Centers (JDCs). Using the tenets of hermeneutic phenomenology this study interpreted the lived experience of teachers in nontraditional classrooms. Hermeneutic principles involve using texts, including interview transcripts, to develop understanding and interpret meaning. Following interviews with teachers currently practicing in the JDC nontraditional classroom setting, the researcher engaged in the hermeneutic circle of understanding, which requires an ongoing commitment to the attitude of hermeneutic phenomenology and reflection (Alsaigh & Coyne, 2021). Four themes emerged as significant to the experience of teachers and their use …

Essays On Monetary Policy And Financial Frictions, David Agyeman-Duodu

Electronic Theses and Dissertations

This dissertation examines the implications of monetary policy in two interconnected frameworks. The first chapter investigates the impact of paying interest on reserves on the effectiveness of open market operations via the portfolio balance channel. Using a structural vector autoregression (SVAR) model, I find that responses of output and price levels are muted and uncertain in the post-interest-on-reserves regime, suggesting that open market operations have become less effective in transmitting monetary policy. A corollary to this is that the portfolio balance channel may have been sufficiently weakened after the introduction of interest on reserves policy. The second chapter revisits Alchian …

Dixieland Do Sul: Brazilian Racial Democracy And The Recontextualization Of Transnational Confederate Symbols (Vol. 1), Maximilian Xavier Conrad

Electronic Theses and Dissertations

Following their defeat in the American Civil War, tens of thousands of American Southerners, many of them former Confederates, fled the United States to seek out new homelands in Latin America. Thousands would set their sights on Brazil, encouraged by the promise of arable land and the prospect of a new society in one of the hemisphere’s last slaveholding societies. Though many of these Confederados returned to the United States after Reconstruction, their influential presence in Brazil has remained a persistent factor. What has been the resulting impact of this nineteenth century Confederate immigration? This thesis volume will argue that …

Dixieland Do Sul: Brazilian Racial Democracy And The Recontextualization Of Transnational Confederate Symbols (Vol. 2), Maximilian Xavier Conrad

Electronic Theses and Dissertations

Following their defeat in the American Civil War, tens of thousands of American Southerners, many of them former Confederates, fled the United States to seek out new homelands in Latin America. Thousands would set their sights on Brazil, encouraged by the promise of arable land and the prospect of a new society in one of the hemisphere’s last slaveholding societies. Though many of these Confederados returned to the United States after Reconstruction, their influential presence in Brazil has remained a persistent factor. This thesis volume will focus on a semiotic struggle over the role of transnational Confederate symbols in the …

Topics In Quantitative Symplectic Topology And Rigidity In Circle Dynamics, Joseph Paul Lopez

Electronic Theses and Dissertations

This dissertation has two parts.

Using The Disc Personality Assessment To Enhance Organizational Climate And Culture At A Mississippi University, Brian Carlyle Grizzell

Electronic Theses and Dissertations

Employee turnover presents a costly challenge for institutions of higher learning. This includes significant financial burdens, diminished productivity, and disruptions in business operations. Moreover, high employee turnover erodes morale and negatively influences organizational climate and culture. According to the literature, many organizations have incorporated tools such as the DiSC, a personality assessment tool that measures individuals’ behavioral styles based on four key traits: Dominance (D), Influence (I), Steadiness (S), and Conscientiousness (C), to enhance team cohesion and improve person-environment fit (PE-Fit). However, limited research exists on whether the DiSC assessment is effective in addressing these issues in a higher education …

Spatial Variation Of Microbial Communities In Aquatic Ecosystems In The Southeastern United States, Jordan Heiman

Electronic Theses and Dissertations

Spatial variation in bacterial communities, or bacterial biogeography, is important for understanding the role of microorganisms in biogeochemical cycles. In the Southeastern United States, aquatic ecosystems are highly biodiverse and imperiled, yet few studies have investigated bacterial biodiversity and biogeography in this region. In this dissertation, I aimed to understand the bacterial biogeography in aquatic ecosystems in the Southeastern United States and how this spatial variation relates to abiotic factors in these ecosystems. To do this, I analyzed biogeographic patterns in bacterial communities from three distinct types of aquatic ecosystems (rivers, a lake, and beaches) and conducted a microcosm experiment …

Quality & Credibility Ff Adhd Information On Social Media And Adhd Help-Seeking Intentions, Saara Zakkiya Nasruddin

Electronic Theses and Dissertations

Background: There is an increased prevalence of adult Attention-deficit/hyperactivity disorder (ADHD), and stimulant prescription use in the United States, especially when compared to years prior to 2020. Due to accessibility and popularity of ADHD on social media, many individuals gain information on ADHD from these sources. People may view information on social media as credible due to its ability to provide connection, community, and empowerment. However, content analyses of ADHD information on social media show the quality of content on social media is poor. These content analyses utilized outdated quality evaluation tools that are not specific for social media. Principles …

Open-Source Frameworks For Groundwater Analytics: Advancing Machine Learning Workflow Development And Deployment, Sarva Pulla

Electronic Theses and Dissertations

This dissertation introduces three innovative tools to advance groundwater analytics: the GRACE Downscaler, Synthetic Timeseries Generator, and a lightweight web-based service for deploying machine learning and physical models. These tools address critical challenges in groundwater management by enhancing the local applicability of GRACE satellite data, overcoming data scarcity through synthetic generation, and simplifying the deployment of complex hydrological models. The GRACE Downscaler provides a reproducible workflow for regional groundwater analysis, while the Synthetic Timeseries Generator creates opportunities for model development in data-poor regions. The web-based service demonstrates how advanced models like MODFLOW can be made accessible for rapid simulations and …

Breaking Barriers: Ben Williams Integrates Ole Miss Football, Fredderick Nettles

Electronic Theses and Dissertations

Breaking Barriers: Ben Williams Integrates Ole Miss Football is a written and visual thesis that explores the life and cultural legacy of Robert Jerry “Ben” Williams — the first Black football player at the University of Mississippi — while tracing a broader lineage of Black pioneers in American football. Structured through a multi-chapter analysis, this work examines the significance of Williams’s quiet leadership during a time of racial unrest in Mississippi, alongside historical figures like Fritz Pollard and Woody Strode, who first paved the way for racial integration in football.

Through archival research, interviews, and narrative storytelling, the thesis also …

Substance Use Amongst Veterans Following Post-Deployment Reintegration: An Examination Through The Lens Of Acculturation, Brittany Hampton

Electronic Theses and Dissertations

Each year, approximately 46.3 million Americans are diagnosed with substance use disorder (SUD), which costs the United States healthcare system approximately $13 billion in annual costs. One group particularly at risk for SUD is veterans due to the unique stressors that veterans face (e.g., being apart from loved ones, exposure to life threatening events, transitioning between military and civilian life) and a military culture that often reinforces maladaptive patterns of substance use. Little research has been done to examine substance use as a negative outcome associated with the acculturative experience veterans face when transitioning from military life back to civilian …

Regional Differences In The Adoption Of Automated License Plate Readers Among Police Departments, Dalton Lee Massingill

Electronic Theses and Dissertations

Since the 2000s, the adoption of License Plate Readers (LPRs) in the United States has steadily increased. Prior research has shown that agency characteristics (mainly size) strongly impact the likelihood of LPR usage. However, researchers have primarily examined larger police departments and used smaller samples in examining the adoption of LPRs. This study uses recent data from a nationally represented sample of law enforcement agencies to examine the relationship between agency geographical location and LPR usage. The current study extends past literature by examining the impact an agency’s geographical location has on LPR usage. Research has not studied if LPR …

The Impact Of A First-Year Experience Course On The Persistence And Retention Of Community College Students, Edward Campbell Mclaughlin

Electronic Theses and Dissertations

This study aimed to explore the connections between student persistence and retention and students who participated in a First Year Seminar (FYS) called the First-Year Experience Course at a Mississippi community college during the 2022 fall semester and students who were enrolled at the college in the fall of 2018 and took the traditional orientation course. By gathering and utilizing archival data from the community college student database, this study sought to determine if taking the First-Year Experience Course is positively related to students’ persistence into the spring semester of 2023 and their retention into the fall of 2023.

Chi-square …

Pi3k Signaling And Its Role In Cardiac Morphogenesis, Rabina Shrestha

Electronic Theses and Dissertations

The formation of the heart tube in vertebrates involves the coordinated movement of bilateral myocardial precursors to the midline, where they merge in a process known as cardiac fusion to form the primitive heart tube. While external influences from the anterior endoderm and the endocardium are known to be essential for cardiac fusion, intrinsic myocardial mechanisms are less understood. Here, we identify an intrinsic PI3K-dependent mechanism directing myocardial cells toward the midline during cardiac fusion. We found that inhibiting the PI3K pathway throughout the embryo using chemical inhibitors and injection of dnPI3K mRNA results in cardiac fusion defects. PI3K-inhibited embryos …

Isolation Of Novel Myxobacteria And Progress Towards Heterologous Expression Of Uncharacterized Secondary Metabolites, Andrew Ahearne

Electronic Theses and Dissertations

Myxobacteria, first observed by Roland Thaxter in the late 19th century, are known for their unique swarming behavior, complex fruiting body formation and biosynthetic potential. Myxobacteria are noted for their large genomes and the presence of numerous biosynthetic gene clusters (BGCs) that hint at their potential to produce novel metabolites with therapeutic properties. Isolation of myxobacteria utilizing E. coli and filter paper baiting yielded 20 myxobacteria isolated from rhizospheric soil samples in North America. Among these isolates, nine were identified as novel species, representing the genera Archangium, Myxococcus, Nannocystis, Polyangium, Pyxidicoccus, Sorangium, and Stigmatella. Comprehensive growth profiles, biochemical assays, and …

Essays On Institutions And Growth, Fouzia Zafar Awan

Electronic Theses and Dissertations

This dissertation comprises two projects, one focusing on the IMF and economicgrowth, and the other on Economic Freedom of the World (EFW) and economic growth.

Make It Funny! Developing A Novel Humor-Based Digital Positive Psychology Intervention To Investigate The Influence Of Duchenne Laughter And Mirth On Psychological Distress In Daily Life, Joshua Semko

Electronic Theses and Dissertations

The aim of the present research was to develop a novel digital humor-based PPI (Make it Funny!) to investigate the influence of Duchenne laughter and mirth on psychological distress in daily life. Participants (N = 159; Agemedian = 39 years; 47.77% biologically female; 68.15% White) were tasked with completing Make it Funny! or a placebo activity every day for 7 days. Duchenne laughter frequency had a small negative cross-sectional moderation effect on the relationship between the occurrence of stressful events and psychological distress (t(79.71) = -2.33, b = -10.89, p = .022). Within participants, Duchenne laughter frequency slightly increased the …

Formulation Development Of Simvastatin Self-Emulsifying Drug Delivery System Using Hot Melt Extrusion, Srikanth Chilamula

Electronic Theses and Dissertations

Simvastatin, a potent HMG-CoA reductase inhibitor, lowers cholesterol levels. It prevents cardiovascular events like heart attacks and strokes in patients with high cholesterol and heart disease. However, its oral bioavailability is limited due to its poor aqueous solubility The current study aims to enhance the solubility of the poorly water-soluble drug simvastatin through the development of self-emulsifying drug delivery systems (SEDDS). Gelucire® 48/16 (oil), Gelucire 44/14 (surfactant), and Cremophor RH40 (co-surfactant) were assessed as potential excipients for SEDDS formulation. Initial SEDDS (Before adsorption) formulations were created based on the solubility of simvastatin in solid lipid excipients, as determined by a …

Imaginative Play In The Inculcation Of Creativity As An Intellectual Virtue, Annie Elisabet Gustafsson

Electronic Theses and Dissertations

Creativity, defined as the ability to generate original and innovative ideas and products, is widely valued yet not explicitly taught. This largely stems from the understanding that creativity cannot be cultivated through traditional methods like imitation or direct instruction, as such approaches contradict the essence of creativity itself. However, we must not write it off as unteachable. To help us better understand what can be done to teach creativity effectively, we must consider its character.

This paper offers a theory of creativity as an intellectual virtue, drawing on Linda Zagzebki’s components of virtue and aligning creativity with Aristotle’s phronesis and …

Infrasound From Tornadoes: Theory And Experiment, Bin Liang

Electronic Theses and Dissertations

Previous field experiments support the claim that a tornado can radiate discernible infrasound between 0.5−10 Hz. The physical mechanisms of tornado sound generation are still not fully understood although several potential mechanisms have been proposed. In this dissertation, a new mechanism based on vortex sound theory is examined analytically and numerically. Basically, rotation of the non-axisymmetric vorticity field in tornadoes can produce dominant low-frequency infrasound less than 2.0 Hz. This finding is based on a detailed analysis of calculating infrasound emitted from two numerical models of tornadoes using large eddy simulation (LES), called the baseline model and the eddy injection …