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Articles 5461 - 5490 of 94725
Full-Text Articles in Entire DC Network
Opera Performances Themed Around Suspense, Supernatural, Erin Garrett
Opera Performances Themed Around Suspense, Supernatural, Erin Garrett
University of Mississippi News
OXFORD, Miss. – The University of Mississippi Opera Theatre's annual spring production aims to transport audiences to a ghostly world of psychological suspense.
Beyond Appearance: Nmr Metabolomics For Mushroom Quality Assurance And Authenticity, Arun Krishna Murthy, Amber Thelen
Beyond Appearance: Nmr Metabolomics For Mushroom Quality Assurance And Authenticity, Arun Krishna Murthy, Amber Thelen
Oxford ICSB
Driven by their prominent health benefits, mushrooms are extremely popular in food and nutraceutical sectors, incidentally attracting food fraud such as species mislabeling and substitution, adulteration, and contamination with synthetic and cheaper substitutes, severely affecting the supply chain and raising concerns among consumers about product safety and quality. Untargeted chemical profiling using Nuclear Magnetic Resonance (U-NMR) spectroscopy, in conjunction with Multivariate Statistical Analysis (MSA) proves to be a superior and universally recognized analytical method in simultaneously addressing these concerns and inadequacies of conventional analytical methods. A comprehensive and robust 1H NMR spectral library is built using validated mushroom samples of …
Metabolite Profiling Of Functional Fungi Strains Of Hericium Erinaceus & Cordyceps Militaris: Using Phenotypes, Untargeted Metabolomics By Mass Spectrometry And Cell-Based Assays, Julie Daoust
Oxford ICSB
Mushrooms have a long tradition of use as medicinal and functional ingredients however the lack of development in testing methods currently limits our ability to characterize these products. Selecting the right strain or processing method is currently challenging given the lack of commercially available analytical methods to detect or quantify secondary metabolites with therapeutic endpoints. Very little is known about the variability of these metabolites between strains of the same species and between identical strains grown in different conditions therefore an untargeted analytical method was needed to adequately assess impact of strain genetics and growing methods for M2 Ingredients cultures …
Re-Discovery Of Fungi, Christopher Hobbs
Re-Discovery Of Fungi, Christopher Hobbs
Oxford ICSB
This will be a very concise overview of the laboratory and clinical work that has been published on the health and medical benefits of medicinal mushrooms and mycelium. Medicinal mushroom and mycelium-based products currently on the market will be critically reviewed, specifically focusing on identifying the 5 most important constituent groups intensive world-wide research has identified as providing the intended benefits of these products, and what leading companies as well as startups are doing to insure their products contain them in meaningful amounts.
Evaluation Of Botanical Extracts For Cytochrome P450 Inhibition Mediated Drug Interactions, Angela I. Calderón, Zarna Raichura, Kabre Heck, Jaewoo Choi, Mikah Brandes, Cody Neff, Claudia Maier, Amala Soumyanath, Robert Arnold
Evaluation Of Botanical Extracts For Cytochrome P450 Inhibition Mediated Drug Interactions, Angela I. Calderón, Zarna Raichura, Kabre Heck, Jaewoo Choi, Mikah Brandes, Cody Neff, Claudia Maier, Amala Soumyanath, Robert Arnold
Oxford ICSB
There has been remarkable growth in consumption of botanical dietary supplements (BDS), making it important to understand the safety profile of BDS with respect to the pharmacokinetic properties for any potential of botanical-drug interactions. One such botanical interactions which has gained significant attention involves inhibition of cytochrome P450 (CYP450) enzymes by co-administered drugs. Our study involved examining two widely used botanicals, ashwagandha and açaí for any potential inhibition of CYP450. Four different ashwagandha extracts were tested, resulting in inhibition of CYP2B6 with IC50 < 100 µg/ml of extract and showed potential of time-dependent inhibition for CYP2C9 and CYP2D6 with an IC50 ~ 200 µg/ml of extract. In the case of açaí, seven different extracts were tested and only CYP2C9 was inhibited. The acidic methanol extract of açaí formulation showed an IC50 of 0.3 µg/ml of extract indicating potent inhibition of CYP2C9, while the methanol (IC50 ~ 91.75 µg/ml) & ethanol extracts of Mountain Rose açaí powder showed weak inhibitory effect with an IC50 < 100 µg/ml of extract for CYP2C9. The results reflect that both botanical extracts showed potential of CYP450 inhibition, suggesting that compounds in BDS can prolong the half-lives of medications leading to extended action or toxicity. Next step involves, testing subfractions of these extracts to identify the compounds responsible for the observed inhibition.
Multifaced Factors To Cause Conflicting Outcomes In Drug-Herb Interactions Mainly Focusing On Reverse Pharmacokinetics, Young Hee Choi
Multifaced Factors To Cause Conflicting Outcomes In Drug-Herb Interactions Mainly Focusing On Reverse Pharmacokinetics, Young Hee Choi
Oxford ICSB
Metabolic enzyme and/or transporter-mediated pharmacokinetic (PK) changes in a drug caused by concomitant herbal products have been a primary issue of herb and drug interactions (HDIs), because PK changes of a drug may result in the alternation of efficacy and toxicity. Studies on HDIs have been carried out by predictive in vitro and in vivo preclinical studies, and clinical trials. Nevertheless, the discrepancies between predictive data and the clinical significance on HDIs still exist, and different reports of HDIs add to rather than clarify the confusion regarding the use of herbal products and drug combinations. Here, the underlying mechanisms causing …
Screening Of Medicinal Herbs To Predict The Potential Perpetrators Of Herb-Drug Interaction, Ikhlas A. Khan, Amar G. Chittiboyina, Shabana Khan, Bill Gurley, Islam Husain
Screening Of Medicinal Herbs To Predict The Potential Perpetrators Of Herb-Drug Interaction, Ikhlas A. Khan, Amar G. Chittiboyina, Shabana Khan, Bill Gurley, Islam Husain
Oxford ICSB
Over time, the popularity and consumption of herbal medicine and its products like nutraceuticals, botanical drugs, and dietary supplements have increased immensely. Parallelly, several health issues associated with the overconsumption of these products have also been raised, which has attracted enormous attention. Herb-drug interaction (HDI) is a health issue caused by herbs or phytochemicals that modulate the homeostasis of drug-metabolizing enzymes (CYPs) and transporters, thus altering the pharmacokinetic of clinical drugs. To date, only a few medicinal herbs, such as Hypericum perforatum, Hydrastis canadensis, Glycyrrhiza glabra, and Camellia sinensis etc., were recognized as HDI perpetrators. However, many need to be …
New Natural Product Certified Reference Material Resources Supported By The Nih Office Of Dietary Supplements, Adam Kuszak, Zoe Ruan, Linda Smith, Sarah Ajaz, Uma Srennivasan, Sabrina Giddings, Daniel Beach, Pearse Mccarron, Stephen Wise
New Natural Product Certified Reference Material Resources Supported By The Nih Office Of Dietary Supplements, Adam Kuszak, Zoe Ruan, Linda Smith, Sarah Ajaz, Uma Srennivasan, Sabrina Giddings, Daniel Beach, Pearse Mccarron, Stephen Wise
Oxford ICSB
The NIH Office of Dietary Supplements (ODS) Analytical Methods and Reference Materials (AMRM) Program supports the development of tools that promote and facilitate rigorous and reliable characterization of dietary supplement (DS) identity, composition, and purity, as well as assessments of authenticity and contamination of botanical and other natural product raw materials and finished products. AMRM goals are accomplished through development and validation of quantitative and qualitative methods, production of certified reference materials (CRMs), and support of dietary supplement focused laboratory quality assurance programs. Recent advances in DS analytical resources supported by AMRM include an expanded availability of CRM calibration solutions …
The Botanical Safety Consortium: Collaborative Effort To Improve Botanical Safety Testing Methods, Connie Mitchell, Cynthia Rider, Julie Kzykwa
The Botanical Safety Consortium: Collaborative Effort To Improve Botanical Safety Testing Methods, Connie Mitchell, Cynthia Rider, Julie Kzykwa
Oxford ICSB
The use of botanical dietary supplements is increasing, making their safety a crucial issue for public health. This article discusses the role and goals of the Botanical Safety Consortium (BSC), a collaborative effort between the US FDA, the National Institute of Environmental Health Sciences, and the Health and Environmental Sciences Institute. Formed through a Memorandum of Understanding, the BSC aims to improve safety evaluation methods for botanicals. It operates as an international platform where experts from various sectors, including government, academia, industry, and non-profits, collaborate to advance and apply new approach methodologies (NAMs) for the safety assessment of botanical products. …
Issue 441: April 18-May 2, 2024, The Local Voice
Issue 441: April 18-May 2, 2024, The Local Voice
The Local Voice
No abstract provided.
University Celebrates Community, Employee Service, Edwin Smith
University Celebrates Community, Employee Service, Edwin Smith
University of Mississippi News
OXFORD, Miss. – The University of Mississippi recognized accomplishments in community-engaged research, learning, service and scholarship by its students, faculty and staff members on Tuesday (April 16) during the annual Celebration of Service Awards.
The French Divorcee And Her Evolution, Mackenzie Bialzik
The French Divorcee And Her Evolution, Mackenzie Bialzik
Honors Theses
This thesis serves to explore the greater questions concerning patterns of divorce in France and how women, through divorce, experienced greater liberties within the law. The evidence used in this paper stems mainly from demographic data, opinion pieces on divorce, and legal journals. While I had hoped to access specific divorce hearings, privacy laws in France and the language barrier prevented me from this type of research. Through my research I have found that divorce did not follow typical trends in feminist movements as expected in France. Instead, divorce was reactionary of the social perceptions of marriage and gender. Additionally, …
April 18, 2024, The Daily Mississippian
April 18, 2024, The Daily Mississippian
Daily Mississippian (all digitized issues)
No abstract provided.
Mocra And The New Cosmetics Gmps, Brandi Reinbold
Mocra And The New Cosmetics Gmps, Brandi Reinbold
Oxford ICSB
The Modernization of Cosmetics Regulation Act (MoCRA) enacted by Congress December 29th, 2022, includes provisions for the FDA to publish proposed Good Manufacturing Practice (GMP) regulations by the end of 2024 and a final rule by the end of 2025. In this talk we will explore what the language of MoCRA tells us about what GMPs are likely to be promulgated with a focus on GMPs related to ingredient and finished product identity and purity. MoCRA exempts small cosmetics manufacturers from GMP compliance requirements and directs FDA to “take it easy” on other not-quite-so-small manufacturers. Despite these exemptions, most cosmetics …
Session E Overview Of The U.S. Cosmetics Regulatory Framework, Jannavi Srinivasan
Session E Overview Of The U.S. Cosmetics Regulatory Framework, Jannavi Srinivasan
Oxford ICSB
Cosmetic products in the U.S. has been regulated by the Food and Drug Administration (FDA) according to the Federal Food, Drug, and Cosmetic Act which has provided for FDA’s regulation of cosmetics since 1938. The Modernization of Cosmetics Regulation Act (MoCRA), enacted in December of 2022, significantly expanded and reformed regulations overseeing cosmetics in the U.S. Included in MoCRA among other provisions, are facility registration and product listing, reporting of serious adverse events, and a requirement that FDA propose a rule for good manufacturing practices. This presentation will provide an overview of cosmetics regulations including the major provisions of MoCRA …
Impact Of Mocra When Assessing Botanical Safety, Rick Kingston
Impact Of Mocra When Assessing Botanical Safety, Rick Kingston
Oxford ICSB
The Modernization of Cosmetics Regulation Act of 2022 (MoCRA) became effective December 29th, 2023. MoCRA is the most significant expansion of FDA’s authority to regulate cosmetics since the Federal Food, Drug, and Cosmetic (FD&C) Act was enacted in 1938. MoCRA expands the FDA's rulemaking and enforcement authority over cosmetics and creates new compliance obligations for manufacturers. There are six key areas of the legislation including Facility Registration, Product & Ingredient Listing, Safety Substantiation, Cosmetics Labeling, and Adverse Event Reporting and Record Keeping. Each of these areas has significant implications for manufacturers and the ingredients commonly found in cosmetics. Given the …
Short & Long-Term Consequences Of Cannabis Intake & Differences Between Occasional & Chronic Frequent Cannabis Use, Marilyn Huestis
Short & Long-Term Consequences Of Cannabis Intake & Differences Between Occasional & Chronic Frequent Cannabis Use, Marilyn Huestis
Oxford ICSB
As the medicalization and legalization of the United States continues to increase it is important to understand the short- and long-term consequences of cannabis use. The endogenous cannabinoid neurotransmitter system is critical for the appropriate functioning of survival functions including hunger, body temperature control, memory and reproduction. When individuals use cannabis, they hijack the normal functioning of the system that attempts to maintain homeostasis. The most important short-term consequence of cannabis use is the morbidity and mortality of driving under the influence of cannabis. Also, legalization reduced the perception of risk of using cannabis that leads to higher adolescent and …
A New Way Forward For Cannabidiol (Cbd) And Other Hemp Products, Patrick Cournoyer
A New Way Forward For Cannabidiol (Cbd) And Other Hemp Products, Patrick Cournoyer
Oxford ICSB
The FDA announced that existing regulatory frameworks for foods and supplements are not appropriate for cannabidiol (CBD). Given the available evidence, it is not apparent how CBD products could meet safety standards for dietary supplements or food additives. A new regulatory pathway for CBD is needed that balances individuals’ desire for access to CBD products with the regulatory oversight needed to manage risks.
Opening Remarks For “Cannabis: Current Status And Future Outlook”, Cassandra Taylor
Opening Remarks For “Cannabis: Current Status And Future Outlook”, Cassandra Taylor
Oxford ICSB
No abstract provided.
A Disputed Reading In The Codex Veronensis Lx (58): Revisiting The Imperial Rescript On The Communion Of Damasus And Meletius., Lester L. Field Jr.
A Disputed Reading In The Codex Veronensis Lx (58): Revisiting The Imperial Rescript On The Communion Of Damasus And Meletius., Lester L. Field Jr.
Faculty and Student Open Access Publications
No abstract provided.
Researchers Review Reasoning For Nordic Ashwagandha Ban, Clara Turnage
Researchers Review Reasoning For Nordic Ashwagandha Ban, Clara Turnage
University of Mississippi News
OXFORD, Miss. – Two University of Mississippi researchers are seeking to find out why three Nordic countries are attempting to ban ashwagandha.
Mechanical Engineering Professor Receives Nsf Career Award, Clara Turnage
Mechanical Engineering Professor Receives Nsf Career Award, Clara Turnage
University of Mississippi News
OXFORD, Miss. – A University of Mississippi engineering professor has won the National Science Foundation's most prestigious award for early career researchers for his upcoming work in 4D printing.
Biological Activity Of Essential Oils – Focus On Antibiotic Resistance, Gyorgyi Horvath
Biological Activity Of Essential Oils – Focus On Antibiotic Resistance, Gyorgyi Horvath
Oxford ICSB
No abstract provided.
Natural Products Ireland: From Bioactives To The Bioeconomy - A Systems-Based Approach, Gaia Scalabrino
Natural Products Ireland: From Bioactives To The Bioeconomy - A Systems-Based Approach, Gaia Scalabrino
Oxford ICSB
Natural Products (NP) are on the rise across the world, driven by economic, environmental, health and societal needs. An increasing focus has been placed on the role of boglands within climate change as peatlands store 1/3 of the world’s soil carbon and provide water storage. With our project ‘Unlocking Nature’s Pharmacy’ we aim to increase public awareness and drive Ireland towards a bioeconomy where Natural Product Science (NPS) plays a key role. At the NatPro Centre, the Trinity Centre for Natural Products Research, we use systems-based approaches (SBA), for example looking at the bogs of Ireland, to identify innovative bio-based …
Cold-Water Extract Of Nerium Oleander Leaves Inhibits Cancer: From Bench To Bedside, Thomas Efferth, Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Katrin, Ioannis Ioannis, Ludger A. Wessjohann, Heinz-Herbert Fiebig
Cold-Water Extract Of Nerium Oleander Leaves Inhibits Cancer: From Bench To Bedside, Thomas Efferth, Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Katrin, Ioannis Ioannis, Ludger A. Wessjohann, Heinz-Herbert Fiebig
Oxford ICSB
Nerium oleander is a well-known medicinal plant used in the Mediterranean region and traditional Indian medicine (Ayurveda) against a variety of diseases, including cancer. We investigated a cold-water extract of N. oleander leaves for their anticancer activities in vitro and in vivo. The cytotoxicity testing in the Oncotest panel of tumor cell lines and concomitant COMPARE analysis showed a high degree of similarity to mitosis-inhibiting compounds. We verified this hypothesis by treating tumor cells transfected with a tubulin-GFP fusion cDNA construct and confocal microscopy as well as a biochemical tubulin polymerization assay. N. oleander showed a similar inhibition of tubulin …
African Plants In Jamaican Farms And Gardens, Thera Edwards
African Plants In Jamaican Farms And Gardens, Thera Edwards
Oxford ICSB
Plants of all growth forms and regeneration strategies were introduced to Jamaica by European slavers and by Enslaved Africans. Some species such as Tamarind used to purify drinking water on ships arrived through purposes of practicality while others that such as yam and plantain were transported as food supplies on the ships or by the Enslaved Africans as tubers for planting in their countries of destination. Tuber crops proved to be invaluable in hurricane prone islands such as Jamaica as the underground tuber was left undamaged by the high winds of the storms. Other crops such as Plantain while not …
Fda Investigational New Drug (Ind) Applications, Cassandra Taylor
Fda Investigational New Drug (Ind) Applications, Cassandra Taylor
Oxford ICSB
Current Federal law requires that a drug be the subject of an approved marketing application before it is transported or distributed across state lines. Because a sponsor will probably want to ship the investigational drug to clinical investigators in many states, it must seek an exemption from that legal requirement. The IND is the means through which the sponsor technically obtains this exemption from the FDA. During a new drug's early preclinical development, the sponsor's primary goal is to determine if the product is reasonably safe for initial use in humans, and if the compound exhibits pharmacological activity that justifies …
Introduction To The Premarket Review Of Human Food Ingredients In The United States And Concepts In The Safety Assessment Of Novel Plant-Derived Ingredients, Troy Hubbard
Oxford ICSB
Premarket regulation of ingredients added to food is a key pillar ensuring the safety of food as it allows the opportunity to address potential safety concerns prior to consumer exposure. In the United States, food and color additives are substances that are intentionally added to food and are subject to pre-market approval by the Food and Drug Administration (FDA) and require a listing in the Code of Federal Regulations, unless the intended use of the substance is generally recognized as safe (GRAS), among qualified experts. GRAS is not an inherent property of a substance, as is often misunderstood; rather, it …
Past Meets Present For Museum Project Manager, Rebecca Lauck Cleary
Past Meets Present For Museum Project Manager, Rebecca Lauck Cleary
Blog Posts
Greta Koshenina combines passions for ancient Rome and the modern South Like most 18-year-olds, Greta Koshenina came to the University of Mississippi unclear of what she wanted to do with her life. But through her studies in the College of Liberal Arts and at the Center for the Study of Southern Culture, she discovered her
Lee County Educator Takes Lead At Um Tupelo, Booneville Campuses, Pam Starling
Lee County Educator Takes Lead At Um Tupelo, Booneville Campuses, Pam Starling
University of Mississippi News
TUPELO, Miss. – Leigh Anne Newton, a Tupelo native and faculty member at the University of Mississippi at Tupelo, is helping the university continue its commitment to workforce development in the area as the new director of its Booneville and Tupelo regional campuses.