Digital Commons Network^™

Combined In Silico And Experimental Approaches Of Pharmacognosy To Resolve Complex Natural Product Issues, William Michael Neal

Electronic Theses and Dissertations

Since the identification of useful bioactive natural products can often involve tedious dereplication measures to decipher complex mixtures, much emphasis is placed on methods that can effectively characterize natural products. Several in silico methods, such as quantitative structure-activity relationships (QSARs), molecular docking, and quantum calculations, provide researchers with valuable tools to overcome the challenge of complex natural product mixtures. To exemplify the abilities of computational methodologies to further the field of pharmacognosy, this dissertation elaborates on several research projects involving computational approaches in pharmacognosy, including: (1) global assessment of pregnane X receptor (PXR) agonism via multiple QSAR models, (2) differentiation …

The Effects Of Multimodal Communication With Discourse In People With Chronic Aphasia, Elizabeth Grace Peeler

Electronic Theses and Dissertations

Purpose

Individuals with aphasia often experience communication breakdowns. One strategy that has been shown to be useful is switching communication modalities when a breakdown occurs. While many researchers have incorporated and shown positive effects of multimodality in aphasia treatment, few studies have utilized a discourse task to generalize the methods trained during the structured tasks to everyday life. The purpose of Multimodal Communication Treatment + Discourse and Group (MCT+DG) is to train various communication modalities in both structured and unstructured settings, which include a discourse and group therapy to help generalizing the skills in daily communication.

Method

Two participants with …

The Trading Dynamics Of Corporate Bonds And Bond Etfs, Cindy Pan

Electronic Theses and Dissertations

We find trading dynamics in bond ETFs and equity ETFs to be different. Although lit trading activity in equity ETFs is greater than bond ETFs, hidden liquidity in bond ETFs is significantly higher than in equity ETFs. Dark trading volume in bond ETFs is also greater than dark trading volume in equity ETFs. Results are robust to an out-of-sample test and is not driven by a specific exchange or specific types of bond ETFs. The extensive use of hidden and dark liquidity for bond ETFs relative to equity ETFs indicates that demand for opaquely trading bond ETFs has value to …

Grace Satellite Spatial Resolution Downscaling Using Machine Learning: Methods And Applications, Abdel Rahman M. Awawdeh

Electronic Theses and Dissertations

The Gravity Recovery and Climate Experiment (GRACE) satellite mission has been instrumental in advancing our understanding of global water dynamics, providing unprecedented insights into terrestrial water storage (TWS). Despite its revolutionary contributions, the coarse spatial resolution of GRACE data (~300 km² grids) limits its utility for local-scale water resource management, particularly in regions requiring detailed hydrological analysis such as the Mississippi Delta. This dissertation addresses this limitation by developing and validating machine learning models to enhance the spatial resolution of GRACE data, thereby facilitating more precise and effective local water management strategies.

This research first establishes a comprehensive background in …

Godspeed: American Evangelicals And The Space Race, Kari Edwards

Electronic Theses and Dissertations

When the Space Race between the United States and the Soviet Union erupted in 1957 with the launch of the Sputnik 1 satellite by the Soviets, Americans were forced to face a disturbing new reality: the world had changed, humanity had reached into space, and the United States had not been the first nation to accomplish such a feat. In a Cold War climate dominated by religious concepts of good versus evil, American evangelicals approached the birth of space exploration with some reluctance, unsure whether such magnificent feats were truly blessed by God and struggling to come to terms with …

The Effects Of Technology-Enhanced Learning On Radiologic Sciences Student Engagement, Zack Gray

Electronic Theses and Dissertations

This dissertation investigates the multifaceted connection between technology-enhanced learning (TEL) and student engagement, with a specific emphasis on student perceptions, attitudes, and distractions associated with technology usage in the classroom. Recognizing the increasing prevalence of technology in educational settings, this study seeks to understand how students perceive technology in the learning environment and how these perceptions influence their attitudes toward its use. The research framework is anchored in the Theory of Planned Behavior (TPB), providing a theoretical lens to assess the cognitive factors influencing student behavior.The study employs a mixed-methods approach, combining surveys and observations to gather comprehensive insights into …

Trait Forgiveness And Trait Anger: Links With 24-Hour Ambulatory Blood Pressure, Bianca Kirsch

Electronic Theses and Dissertations

Hypertension is a leading risk factor for cardiovascular disease. Higher levels of trait anger and unforgiveness are linked with elevations in blood pressure, which increases one’s risk for hypertension. Most of the research examining the association between trait anger, trait forgiveness, and blood pressure (BP) uses single-time point assessment of BP and thus, is not able to capture day-to-day BP variability. Further, existing research has primarily focused on the forgiveness of others. The purpose of this study is to address these gaps in the literature. This is a preliminary analysis using about one-fourth of the target sample. Sixteen community-dwelling adults …

Team Origins: Leveraging Network Utilization And Leadership To Explain Team Assembly, Pol Solanelles

Electronic Theses and Dissertations

Drawing from social networks and leadership perspectives, I advance our understanding of team assembly – which I define as the goal-motivated, multi-step, and iterative process by which two or more potential team members interact to organize into nascent teams via formal and/or informal influence. Across three essays, I aim to redirect the conversation from who will become part of a team to how individuals assemble teams, placing leaders assembling teams and potential team members at the forefront of this research.

In Essay 1, my interdisciplinary integrative conceptual review revealed four opportunities to clarify how people assemble teams. First, I use …

Indirect And Direct Pathways Of Migratory Shorebird Effects On Nitrogen Cycling Within Temporarily Flooded Agricultural Fields, Victoria Blocker

Electronic Theses and Dissertations

The global human population continues to grow exponentially, and agriculture will need to become more productive to meet growing food demands. Humans also need clean water and other services that ecosystems provide. This requires future agriculture production to reduce environmental and wildlife impacts through improved efficiencies and best management practices. Migratory shorebirds rely on wetlands throughout North and South America as stopover habitat for rest and refueling during migration. Temporarily flooded farmlands in the Mississippi Delta have proven to be beneficial locations for shorebirds during migrations along the central flyway. This conservation practice also enhances wetland properties that promote excess …

Application Of Hot-Melt Extrusion Technology For The Preparation Of Carbamazepine Extended-Release Tablets, Chamundeswara Srinivasa Akash Kalla

Electronic Theses and Dissertations

Carbamazepine (CBZ) is an anti-convulsant and specific analgesic for trigeminal neuralgia that reduces polysynaptic responses and blocks post titanic potentiation. Moreover, CBZ is effective in partial and generalized convulsions and mixed types. It is not effective in petit mal seizures. Carbamazepine extended-release tablets are used to treat episodes of mania (or) mixed episodes i.e., symptoms of mania and depression that happen at the same time, in patients with bipolar disorder. The present study was designed to develop CBZ extended-release tablets with acrylic acid-based polymer (Eudragit® RL PO) using a melt granulation and to match the USP dissolution test specification. Thermal …

Title Character: A Novel, Di Bei

Electronic Theses and Dissertations

Inspired by true events, Title Character: A Novel tells the intimate and fraught relationships of Asian female artists during a pandemic in Idaho: Jade, a rebellious girl born amid the one-child policy in Beijing, writes her love story into a script; Pearl, an ambitious actress raised in rural China, stars in Jade’s film and dates the method actor who plays her lover. Strung together by one film, young women of the Asian diaspora mirror and maneuver each other, while playing out their performances of self with art as their arena.

More Than A Feeling: Materializing Sympathy In Nineteenth-Century American Literature, Kathleen Downes

Electronic Theses and Dissertations

“More than a Feeling: Materializing Sympathy in Nineteenth-Century American Literature” breaks from a long tradition of criticism that only considers the nineteenth-century belief that sympathy was a benevolent, voluntary, imaginative act of feeling that maintains moral rectitude through the identification of suffering with others. In this context, sympathy is primarily defined as identificatory sympathy. “More than a Feeling” expands the definition of sympathy in the nineteenth century as also something that could be atmospherically communicated, transmitting good or bad feeling, and thus affecting and infecting those around them. This other form of sympathy, which for this project I term “effluvial …

Exploring The Habits And Perceptions Of True Crime Podcast Listeners, Remy Heinen

Electronic Theses and Dissertations

Although podcasts as a whole are growing in popularity, the true crime genre of podcasts continues to be especially popular, particularly with female listeners. The unique intersection of informational and entertainment goals associated with true crime podcasts raises ethical questions about how these priorities should be balanced. This study focused on learning more about listeners’ motivations, habits, and perceptions via an online survey. Additionally, it explored the gendered nature of true crime podcast consumption. A total of N = 657 participants completed the survey providing information about why they listen to true crime podcasts, how often they listen, and how …

A Case Study Of The Mississippi Teacher Corps (Mtc) Program Graduate School Experience As It Relates To Mtc Postgraduate Teacher Retention, Sandra Evelyn Carver Hubbard

Electronic Theses and Dissertations

The purpose of this dissertation in practice (DiP) is to explore the relationship, if any, between the Mississippi Teacher Corps Graduate School experience and the expressed reasons of some of its teachers to either leave their placement school; teach in another critical-needs school in Mississippi, but not remain long-term; teach in another state; or exit the profession of classroom teaching after completion of the program. This study will only focus on teachers who left their placement school, another critical-needs school in Mississippi, or classroom teaching after 5 years. These five years include the two years while participants were in the …

Magnolia State Of Mind: Memory And Memorialisation In Mississippi, Cosmo Mcgee

Electronic Theses and Dissertations

This thesis explores the ways Mississippi has historically and contemporaneously crafted its collective memory through symbolism. Confederate memorial groups endeavoured to create a “Lost Cause” memory of the state’s Antebellum past, validating its White supremacist systems into the 1960s. With the violence of the Civil Rights era failing to stop integration, Mississippians would spend the next sixty years debating the best ways to represent the state’s history.

This work looks at three distinct manifestations of Mississippi’s memorial culture: the discussions around and changes to the state flag, the cultural and sporting atmosphere of the University of Mississippi (“Ole Miss”), and …

Evaluation Of Process Parameters For Continuous Manufacturing Of Quetiapine Fumarate Immediate Release Tablets Using Twin Screw Wet Granulation, Tejaswini Naguboyina

Electronic Theses and Dissertations

Granulation is one of the important unit operations in the manufacturing of solid dosage forms like tablets and capsules that regulate the quality of end products. It is a process of particle enlargement by agglomeration technique, which improves flow properties, compressibility, reduction of dust formation, drug content uniformity, dissolution rates, and overall product stability. Traditionally, it has been a batch process due to a better understanding. However, there has been a shift towards continuous manufacturing using a Twin-screw granulator, which is more robust, scalable, and versatile for various applications. This work presents the use of Twin screw wet granulation (TSWG) …

Montesquieu: The Nature Of L’Esprit Des Lois, Christian Jax Murray

Electronic Theses and Dissertations

When Baron de Montesquieu received a copy of his L’Esprit des lois, he was horrified by the total removal and reorganization of critical parts of his text, changed ideas, and an abnormal amount of printing errors in his work. While he saw these issues hindering the reception of his work, this thesis argues that the chaos of the text, in both its style and publication, made the book more popular instead of hindering it. Montesquieu, his editor, and his publisher constructed a new kind of text that was broad in its subject matter and ambiguous in its meaning where its …

Moving Minds: Examining The Potential Effects Of Movement On Executive Function Among 3-Year-Olds, Zubie Reagan Pearce

Electronic Theses and Dissertations

This study aimed to examine the effect of movement on the conscious control of behavior (i.e., executive function or EF) in three-year-old children. Two questions were addressed regarding the role of movement in preschoolers' EF. First, the study investigated how altering movement within EF tasks influenced children's EF performance by manipulating relevant motor patterns (i.e., arm movement within EF searching and sorting tasks) in 3-year-olds. Children wore slightly weighted armbands while engaging in two distinct EF tasks, one focusing on motor control (i.e., reaching for an object) and the other on cognitive control (i.e., sorting objects based on rules). Second, …

From Likes To Looks: The Relationship Between Tiktok Use And Body Satisfaction In A Young Adult Population, Madeline Pruett

Electronic Theses and Dissertations

Body dissatisfaction is becoming an increasingly pervasive problem among young adults, presenting severe implications including the onset of eating disorders and related behaviors. This alarming trend can be attributed, at least in part, to the ubiquity and influence of social media platforms, which serve as a modern catalyst for appearance pressures. While there is a substantial body of research establishing the connection between body dissatisfaction and traditional social media, the examination of newer platforms like TikTok, which have become highly popular among young adults, remains limited. As such, the present study aimed to bridge this gap by investigating the relationship …

Utilizing Embedded Mathematics Instructional Coaching When Implementing High-Quality Instructional Materials, Shannon E. Priest

Electronic Theses and Dissertations

Professional development is essential for teachers to grow in their profession. However, often professional development is a one size fits all approach, and it occurs outside of the teachers’ classroom. This causes teachers to not fully implement new strategies when they return to their classroom. One way to overcome this is to utilize instructional coaching. As our school district began implementing new high-quality instructional materials without guidance, I took on the role of serving as an embedded mathematics instructional coach.

For this qualitative self-study, I acted as an embedded mathematics instructional coach and provided research-based teaching activities to peer teachers …

Modeling The Relationship Between Protein Sequence And Structure Using Triangular Spatial Relationship-Based Keys, Arianna Nicole Swensen

Electronic Theses and Dissertations

Protein structure comparison and our understanding of protein sequence and structure relationships are intertwined. In this work, I use the TSR-based key generation algorithm to develop a model for relating sequence and structure. I develop embeddings for the sequence-based keys and the structure-based keys as the basis for a translation model between the two sets of keys, evaluating the efficacy of local and global embedding generation techniques in the context of the TSR-based comparison method.

Molecular Modeling Of Inhibitors Of Severe Acute Respiratory Syndrome Coronavirus 2 And Urinary Tract Infections, Priyanka Samanta

Electronic Theses and Dissertations

Infectious diseases are the leading cause of disability-adjusted life years worldwide. Glycans initiate host–pathogen interactions in two particular infectious diseases, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and urinary tract infections (UTIs). In this work, recent advances of computational tools in drug design are utilized to target these glycanspecific host–pathogen interactions for the potential prevention of SARS-CoV-2 or UTIs.

SARS-CoV-2 viral entry into the host cell is mediated by the viral S-protein. Carbohydrate molecules bind to the receptor-binding domain (RBD) of the S-protein which interacts with angiotensin-converting enzyme 2 and leads to host cell invasion. Here we report computational studies …

Branching Fraction Measurements Of Ξc + → Σ+H+H− And Λc + → P+H+H− Using Belle Ii Monte Carlo, Azwad Adnan

Electronic Theses and Dissertations

Charmed baryon decays are a great place to probe and search for physics beyond the Standard Model. The Belle II experiment is equipped to explore this area with high statistics datasets to shed light on any potential anomalies. In addition to searches for new physics, the Belle II data samples can be used to make SM measurements that are either missing, statistics limited, or require confirmation.

English Language Teachers’ Perspective On The Applicability Of The Language Assessment Frameworks Used In Saudi Arabian Universities, Asmahan Ghazi Alqahtani

Electronic Theses and Dissertations

This study investigates English language assessment practices in Saudi Arabian universities from the perspectives of English language teachers. It explores how ESL teachers perceive the applicability of assessment frameworks provided by policymakers in higher education. Guided by concepts of Language Assessment Literacy, the study examines the roles and practices of various stakeholders in language assessment, the principles and concepts guiding these practices, and the awareness of the social contexts in which language assessment takes place. In Saudi Arabia, research on language assessment is needed due to the limited attention given to assessment and testing issues, and the minimal involvement of …

North Ms Foodrx Farm-To-Farmacy: A Home Delivery Local Food Prescription Model, Cameron De'cal Brown

Electronic Theses and Dissertations

This portfolio presents a comprehensive overview of my contributions and involvement in the Farm-to-Farmacy (FTF) program model. Farm-to-Farmacy is an extension of the FoodRx program which aims to address food insecurity in rural parts of North Mississippi. This program was inspired by the 2019 FoodRx program in the Mississippi Delta that assisted in delivering fresh produce to the doorsteps of the elderly and homebound. Farm-to-Farmacy incorporates a unique approach by soliciting the support of local farmers which assists in sustainability for a program of this stature but also supports community engagement and involvement. The Farm-to-Farmacy program relies on local farmers …

Advancing Diversity, Equity, And Inclusion: A Graduate Portfolio On Lebonheur Children's Hospital Initiatives, James Lee Hawkins

Electronic Theses and Dissertations

In every facet of life, diversity finds a way to play a role. By advocating for, acknowledging, and drawing attention to the disparities that emerge within the various spaces people may encounter, we consciously strive to bridge the gap, aiming for a future that is more equitable and inclusive. Diversity, equity, and inclusion (DEI) have not only become personal moral imperatives but also essential pillars at the forefront for companies, healthcare, educational institutions, and businesses alike.

Small Organic Molecules Absorbing Low Energy Photons For Dye Sensitized Solar Cells And Biological Imaging, Ravinder Kaur

Electronic Theses and Dissertations

Small organic molecules with the ability to access photons at longer wavelengths are greatly needed in the fields of dye sensitized solar cells and biological imaging. Firstly, an urgent challenge limiting the improvement in photocurrent of dye-sensitized solar cell (DSC) technology is the availability of chromophores capable of harvesting the full spectrum of solar irradiation and the judicious employment of these chromophores with other components of the DSC device in order to achieve higher efficiencies. Therefore, strategies are put forward to fabricate and optimize the DSC devices by using novel cross conjugated organic photosensitizers based on benzo[b]thiophene and fused dibenzosilin …

A Quantitative Study Of The Effectiveness Of The University Of Mississippi's Biology Bootcamp, Nicole Lewis

Electronic Theses and Dissertations

There is a growing demand for a Science, Technology, Engineering, and Mathematics (STEM) trained workforce in the United States. In order to remain globally competitive, the US needs to increase the STEM workforce not only in numbers but also diversity. Colleges and universities throughout the US need to not only gain STEM majors but retain them through graduation. Research has shown that the majority of STEM students struggle their first year in college for a variety of reasons. Many academics agree that incoming freshman need to integrate both socially and academically to prevent attrition. This has led to the creation …

Inclusive Measurement Of Upsilon(4s) To Upsilon(1s) Decays With Belle Ii Data, John Wilson Stacy

Electronic Theses and Dissertations

An inclusive measurement of ϒ(4S) decays to ϒ(1S) is reported. Using 364.5 fb−1 of Belle II data collected at the ϒ(4S) center-of-mass energy, ϒ(4S) → ϒ(1S) decays are identified via a fit to the μ+μ− invariant mass spectrum. Backgrounds from initial state radiation production of ϒ(1S) are subtracted using a fit to 42.6 fb−1 of data collected below the ϒ(4S) center-of-mass energy. Using our models and values taken from literature, the inclusive branching ratio for inclusive ϒ(4S) decays to ϒ(1S) can be measured with a statistical uncertainty of 5.1% and a systematic uncertainty of 14.8%.

Evolving To Abstraction - Seclusion Of Efik And Ibibio Women From The Precolonial Era To The Present, Itunuoluwa Williams

Electronic Theses and Dissertations

Female seclusion was an important cultural practice to the Efik and Ibibio peoples in southernmost Nigeria. Before the advent of Western education in the precolonial and colonial eras, it was particularly essential to the development of the girl child as she received a first-rate education and preparation for maturity, marriage, and motherhood. However, despite its crucial role in both cultural societies, studies on the Efik and Ibibio female seclusion cultures are far and in-between. Furthermore, the nkuho and mbopo – as they are called in Efik and Ibibio respectively – are often analyzed and presented as one singular entity, in …