Digital Commons Network^™

Biological And Phytochemical Studies On Six Astragalus Taxa From Anatolia, Sophie Fadime Aydoğan, Zulfiqar Ali, Shabana I. Khan, Jianping Zhao, Ikhlas A. Khan

Annual Poster Session 2022

Corresponding author (NCNPR): Fadime Aydoğan, [email protected]

Utility Of Fatty Acid Profile And In Vitro Immune Cell Activation For Chemical And Biological Standardization Of Arthrospira/Limnospira, Jungmoo Huh, Jin Zhang, Radka Hauerová, Joseph Lee, Saqlain Haider, Mei Wang, Tomáš Hauer, Ikhlas A. Khan, Amar G. Chittiboyina, Nirmal D. Pugh

Annual Poster Session 2022

Corresponding author (NCNPR): Jin Zhang, [email protected]

Department Of Biomolecular Sciences, Candace Lowstuter

Annual Poster Session 2022

Department/Unit poster (BioMolecular Sciences). Corresponding author: Candace Lowstuter ([email protected])

Improved Topical Ophthalmic Natamycin Suspension For The Treatment Of Fungal Keratitis, Chuntian Cai, Poorva Joshi, Ahmed Adel Ali Youssef, Narendar Dudhipala, Soumyajit Majumdar

Annual Poster Session 2022

Corresponding author (Pharmaceutics and Drug Delivery): Chuntian Cai, [email protected]

Effect Of Ploidy On Early Oyster Life Stage Tolerance Of Salinity And Temperature, Christian Boudreaux, Alexz Carpenter, Jessica Pruett, Kristine Willett, Deborah Gochfeld

Annual Poster Session 2022

Corresponding author (BioMolecular Sciences): Christian Boudreaux, [email protected]

Effects Of Chemical Inducers On Larval Oyster Settlement In Suboptimal Conditions, Alexz Carpenter, Christian Boudreaux, Jessica Pruett, Kristine Willett, Deborah Gochfeld

Annual Poster Session 2022

Corresponding author (Biological Science): Alexz Carpenter, [email protected]

Oxford Blues Festival Highlights Local, Regional Talent, Clara Turnage

University of Mississippi News

UM Professors, Local and National Artists to Perform at Blues Festival

Dominant Frequency Extraction For Operational Underwater Sound Of Offshore Wind Turbines Using Adaptive Stochastic Resonance, Rongxin Wang, Xiaomei Xu, Zheguang Zou, Longfei Huang, Yi Tao

Faculty and Student Publications

Underwater sound generated by the rapidly increasing offshore wind farms worldwide greatly affects the underwater soundscape and may cause long-term cumulative effects on sound-sensitive marine organisms. However, its analysis and impact assessment are heavily interfered with by underwater ambient noise. In this study, an adaptive stochastic resonance method is proposed to extract the dominant frequency of wind turbine operational sound when heavy noise is present. In particular, a time–frequency–amplitude fusion index was proposed to guide the parameter tuning of an adaptive stochastic resonance system, and an equilibrium optimizer based on the physical dynamic source–sink principle was adopted to optimize the …

Bioassay-Guided Isolation Of Iridoid Glucosides From Stenaria Nigricans, Their Biting Deterrence Against Aedes Aegypti (Diptera: Culicidae), And Repellency Assessment Against Imported Fire Ants (Hymenoptera: Formicidae), Fazila Zulfiqar, Abbas Ali, Zulfiqar Ali, Ikhlas A. Khan

Faculty and Student Publications

In our natural product screening program, we screened natural products for their repellency and toxicity against insect vectors. Methanolic extract of aerial parts of Stenaria nigricans (Lam.), with no published chemistry, was tested for repellency against mosquitoes and imported hybrid fire ants. Methanolic extracts showed biting deterrence similar to DEET (N,N-diethyl-3-methylbenzamide) against Aedes aegypti L. Based on this activity, the crude extract was fractionated into chloroform, ethyl acetate, and methanol subfractions. The active methanolic subfraction was further fractionated into 13 subfractions. These fractions were tested for their biting deterrence against Ae. Aegypti. Active subfractions were further characterized to identify the …

Synthesis And Inhibitory Activity Of Machaeridiol-Based Novel Anti-Mrsa And Anti-Vre Compounds And Their Profiling For Cancer-Related Signaling Pathways, Mallika Kumarihamy, Siddharth Tripathi, Premalatha Balachandran, Bharathi Avula

Faculty and Student Publications

Three unique 5,6-seco-hexahydrodibenzopyrans (seco-HHDBP) machaeridiols A–C, reported previously from Machaerium Pers., have displayed potent activities against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium, and E. faecalis (VRE). In order to enrich the pipeline of natural product-derived antimicrobial compounds, a series of novel machaeridiol-based analogs (1–17) were prepared by coupling stemofuran, pinosylvin, and resveratrol legends with monoterpene units R-(−)-α-phellandrene, (−)-p-mentha-2,8-diene-1-ol, and geraniol, and their inhibitory activities were profiled against MRSA ATCC 1708, VRE ATCC 700221, and cancer signaling pathways. Compounds 5 and 11 showed strong in vitro activities with MIC values of 2.5 μg/mL and 1.25 μg/mL against MRSA, respectively, and …

Immunomodulatory Effects Of Plant Extracts From Salvia Deserta Schang. And Salvia Sclarea L., Aizhan Zhussupova, Gaziza Zhumaliyeva, Vyacheslav Ogay, Assel Issabekova

Faculty and Student Publications

Medicines, their safety, effectiveness and quality are indispensable factors of national security, important on a global scale. The COVID-19 pandemic has once again emphasized the importance of improving the immune response of the body in the face of severe viral infections. Plants from the Salvia L. genus have long been used in traditional medicine for treatment of inflammatory processes, parasitic diseases, bacterial and viral infections. The aim of the current study was to evaluate the immunomodulatory effects of plant extracts LS-1, LS-2 from Salvia deserta Schang. and LS-3, LS-4 from Salvia sclarea L. plants growing in southern Kazakhstan by conventional …

Phytochemical Investigation Of Egyptian Spinach Leaves, A Potential Source For Antileukemic Metabolites: In Vitro And In Silico Study, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran

Faculty and Student Publications

Spinacia oleracea L., Amaranthaceae, leaves cultivated in Egypt demonstrated a potential antileukemic activity against the chronic myeloid leukemia, K562 cell line. Thus, the aim of this study is to carry out a phytochemical investigation of S. oleracea leaves as well as the isolation of its antileukemic phytoconstituents. Phytochemical investigation of S. oleracea leaves resulted in the isolation of seventeen known compounds. The biological study revealed that compounds hexaprenol, phytol, and 18-[(1-oxohexadecyl) oxy]-9-octadecenoic acid exhibited a remarkable antiproliferative activity against K562 cells in vitro. A mechanistic in silico study showed that hexaprenol, phytol, and 18-[(1-oxohexadecyl) oxy]-9-octadecenoic acid exhibited a strong binding …

Bisc 504: Biometry, Jason Hoeksema

GMAS Course Syllabi

No abstract provided.

Genome-Wide Identification And Salt Stress Response Analysis Of The Bzip Transcription Factor Family In Sugar Beet, Yongyong Gong, Xin Liu, Sixue Chen, Hongli Li, Huizi Duanmu

Faculty and Student Publications

As one of the largest transcription factor families in plants, bZIP transcription factors play important regulatory roles in different biological processes, especially in the process of stress response. Salt stress inhibits the growth and yield of sugar beet. However, bZIP-related studies in sugar beet (Beta vulgaris L.) have not been reported. This study aimed to identify the bZIP transcription factors in sugar beet and analyze their biological functions and response patterns to salt stress. Using bioinformatics, 48 BvbZIP genes were identified in the genome of sugar beet, encoding 77 proteins with large structural differences. Collinearity analysis showed that three pairs …

Undergraduate Student Publishes Sleep Research Paper, Erin Garrett

University of Mississippi News

UM senior studies correlation between brain anatomy and sleep duration

Issue 403: September 22-October 6, 2022, The Local Voice

The Local Voice

No abstract provided.

Interactions Of Marine Sulfated Glycans With Antithrombin And Platelet Factor 4, Wenjing Zhang, Weihua Jin, Vitor H. Pomin, Fuming Zhang

Faculty and Student Publications

The molecular interactions of sulfated glycans, such as heparin, with antithrombin (AT) and platelet factor 4 (PF4) are essential for certain biological events such as anticoagulation and heparin induced thrombocytopenia (HIT). In this study, a library including 84 sulfated glycans (polymers and oligomers) extracted from marine algae along with several animal-originated polysaccharides were subjected to a structure-activity relationship (SAR) study regarding their specific molecular interactions with AT and PF4 using surface plasmon resonance. In this SAR study, multiple characteristics were considered including different algal species, different methods of extraction, molecular weight, monosaccharide composition, sulfate content and pattern and branching vs. …

Inhibition Of Sars-Cov-2 Wild-Type (Wuhan-Hu-1) And Delta (B.1.617.2) Strains By Marine Sulfated Glycans, Rohini Dwivedi, Poonam Sharma, Marwa Farrag, Seon Beom Kim

Faculty and Student Publications

The Coronavirus disease pandemic has steered the global therapeutic research efforts toward the discovery of potential anti-severe acute respiratory syndrome coronavirus (SARS-CoV-2) molecules. The role of the viral spike glycoprotein (S-protein) has been clearly established in SARS-CoV-2 infection through its capacity to bind to the host cell surface heparan sulfate proteoglycan (HSPG) and angiotensin-converting enzyme-2. The antiviral strategies targeting these 2 virus receptors are currently under intense investigation. However, the rapid evolution of the SARS-CoV-2 genome has resulted in numerous mutations in the S-protein posing a significant challenge for the design of S-protein-targeted inhibitors. As an example, the 2 key …

Faculty Senate Subcommittees, 2022-2023, University Of Mississippi. Faculty Senate

Membership

A list of the University of Mississippi Faculty Senate subcommittees and their members for the 2021-2022 academic year.

Faculty Senate Membership, 2022-2023, University Of Mississippi. Faculty Senate

Membership

A list of officers, committee chairs, and senators of the University of Mississippi Faculty Senate for the 2022-2023 academic year.

Nsf Grfp Information Session, Sept 7, 2022, Jason Hale, Robert Doerksen, Vivian Ibrahim

ORSP Presentations

NSF Graduate Research Fellowship Program (GRFP) Information Sessions

• Jason Hale, M.S., Director of Research Development, ORSP
• Robert Doerksen, Ph.D., Associate Dean of the Graduate School
• Vivian Ibrahim, Ph.D., Associate Professor of History; Director of the Office of National Scholarship Advisement

UM Faculty members Nikki Reinemann-Gross (Biomedical Engineering), Rachel Greenspan (Criminal Justice and Legal Studies), Donald Dyer (Associate Dean for Faculty & Academic Affairs, College of Liberal Arts), and Claire Mischker (Writing and Rhetoric) also participated.

Biologist, Students Promote Research On Sustainable Ecotourism, Erin Garrett

University of Mississippi News

Team leads workshop for international scientists, industry experts

Using The Capabilities-Opportunity-Motivation-Behavior (Com-B) System To Conceptualize The Legalization Of Sunday Migratory Game Bird Hunting, Elena C. Rubino, Christopher Serenari

Journal of Rural Social Sciences

Recent wildlife agency efforts aimed at hunter recruitment, retention, and reactivation (R3) are examples of behavior change interventions. Therefore, these R3 programs and policies should be strategically designed to meet hunters’ goals and motivations. We analyzed survey responses (n=808) from North Carolina resident migratory bird hunters regarding potential Sunday hunting legalization to serve as an illustrative case demonstrating how the capabilities-opportunity-motivation-behavior (COM-B) system can be used to conceptualize and more effectively test potential hunter behavior changes prompted by debated R3 strategies. Findings provide decision-makers and land managers with an understanding of the potential implications of migratory game bird Sunday hunting …

College Of Liberal Arts Viewbook 2022, University Of Mississippi. College Of Liberal Arts

Liberal Arts Publications

Eight-page brochure with an overview of the University of Mississippi College of Liberal Arts. A brief history of the college is provided, along with a description of majors, minors, centers, and multi-disciplinary programs.

Preparation, Characterization And Pharmacokinetics Of Tolfenamic Acid-Loaded Solid Lipid Nanoparticles, Wei Xu, Zhaoyou Deng, Yifei Xiang, Dujuan Zhu

Faculty and Student Publications

The clinical use of nonsteroidal anti-inflammatory drugs is limited by their poor water solubility, unstable absorption, and low bioavailability. Solid lipid nanoparticles (SLNs) exhibit high biocompatibility and the ability to improve the bioavailability of drugs with low water solubility. Therefore, in this study, a tolfenamic acid solid lipid nanoparticle (TA-SLN) suspension was prepared by a hot melt–emulsification ultrasonication method to improve the sustained release and bioavailability of TA. The encapsulation efficiency (EE), loading capacity (LC), particle size, polydispersity index (PDI), and zeta potential of the TA-SLN suspension were 82.50 ± 0.63%, 25.13 ± 0.28%, 492 ± 6.51 nm, 0.309 ± …

Physical, Chemical, And Mineralogical Controls On Retardation Of Anatoxin-A Migration By Sorption To Natural Soils With Implications For Groundwater Protection, Justin L. Hobart, Andrew M. O’Reilly, Jennifer N. Gifford

Faculty and Student Publications

Increasing prevalence of cyanotoxins in surface water bodies worldwide threatens groundwater quality when contaminated water recharges an aquifer through natural or artificial means. The subsurface fate of anatoxin-a (ATX) is not well studied. Laboratory batch experiments were performed to expand the current knowledge of ATX sorption affinities to geologic media, with a focus on natural soil (Vertisol, Ultisol, Alfisol, and Inceptisol) and physical, chemical, and mineralogical characteristics. For a range of aqueous ATX concentrations (0.3–14 μg/L), linear, Freundlich, and Langmuir isotherms fit observed data well (r2 = 0.92–1.00, RMSE = 0.4–6.3 μg/kg). Distribution coefficient (Kd) and retardation factor (Rf) values …

Arabidopsis Shoot Gravitropism Requires The Mediator Coactivator Complex, Gabriella Newton

Honors Theses

Gravitropism is a plant response to gravity in directing the growth of its organs, such as the root and the stem. Gravity is sensed by statocytes, unique cells that contain starch-filled amyloplasts, which trigger gravitropic growth response by modulating the distribution of growth hormone auxin in the elongation zone of the stem and root. Despite the fact that multiple factors have been identified as key regulators of shoot negative gravitropism, how these factors are regulated at the transcriptional level is largely unknown. In this study, we explore the role of transcriptional machinery in regulating shoot gravity sensing and responses by …

Blood-Flow-Restriction-Training-Induced Hormonal Response Is Not Associated With Gains In Muscle Size And Strength, Gilberto C. Laurentino, Jeremy P. Loenneke, Carlos Ugrinowitsch, Marcelo S. Aoki, Antonio G. Soares, Hamilton Roschel, Valmor Tricoli

Faculty and Student Publications

The aim of this study was to determine whether increases in post-exercise endocrine response to low-load resistance exercise with blood flow restriction and high-load resistance exercise would have association with increases in muscle size and strength after an 8-week training period. Twenty-nine untrained men were randomly allocated into three groups: low-load resistance exercise with (LL-BFR) or without blood flow restriction (LL), and high-load resistance exercise (HL). Participants from LL-BFR and LL groups performed leg extension exercise at 20% of one repetition maximum (1RM), four sets of 15 repetitions and the HL group performed four sets of eight repetitions at 80% …

New Faculty, 2022-2023, University Of Mississippi. Provost

New Faculty

No abstract provided.

The Transcriptional Regulator Ctra Controls Gene Expression In Alphaproteobacteria Phages: Evidence For A Lytic Deferment Pathway, Elia Mascolo, Satish Adhikari, Steven M. Caruso, Tagide Decarvalho, Anna Folch Salvador, Joan Serra-Sagristà, Ry Young, Ivan Erill, Patrick D. Curtis

Faculty and Student Publications

Pilitropic and flagellotropic phages adsorb to bacterial pili and flagella. These phages have long been used to investigate multiple aspects of bacterial physiology, such as the cell cycle control in the Caulobacterales. Targeting cellular appendages for adsorption effectively constrains the population of infectable hosts, suggesting that phages may have developed strategies to maximize their infective yield. Brevundimonas phage vB_BsubS-Delta is a recently characterized pilitropic phage infecting the Alphaproteobacterium Brevundimonas subvibrioides. Like other Caulobacterales, B. subvibrioides divides asymmetrically and its cell cycle is governed by multiple transcriptional regulators, including the master regulator CtrA. Genomic characterization of phage vB_BsubS-Delta identified the presence …