Digital Commons Network^™

Naturally Derived Kratom Extracts: Toxicological Evaluation In Humans And Rodents, Sibyl Swift

Oxford ICSB

Peer-reviewed literature provides limited toxicological data on the consumption of naturally derived kratom extracts. Given the increasing use of kratom products, understanding their safety profile is critical for public health and regulatory decision-making. To address this gap, we conducted a rodent toxicology assessment and a controlled human clinical study. Human Clinical Study: Healthy male and female participants consumed specified kratom extracts daily for 14 consecutive days under controlled conditions. Clinical observations and biochemical markers were monitored throughout the study. Rodent Toxicology Study: Equivalent extract doses were administered to rodents for 90 days to evaluate subchronic exposure. Assessments included body weight, …

Natural Products As Multi Drug-Multi Target Therapeutics - From The Pharmacological Proof To New Approaches For Quantitative Quality Control, Olaf Kelber

Oxford ICSB

In the two decades since the mode of action of herbal medicinal products has been characterized as the Multi Target action of Multi Drug combinations [1,2, 3], the body of evidence supporting the general applicability of this principle to herbal health products has been exponentially increasing.  Key studies describing this principle, based on a wide range of pharmacological models, have been conducted in STW 5 and STW 5-II, herbal combinations used in the treatment of disturbances of the gut-brain interaction (DGBIs) as e.g. upset stomach and irritable bowel syndrome [2, 4]. They allow to characterize the contribution of each combination …

Medicinal Plants And One Health Drug Discovery: Plectranthus Abietanes As P-Glycoprotein Modulators, Patricia Rijo

Oxford ICSB

Cancer remains a major global health challenge, with multidrug resistance (MDR)—frequently driven by P-glycoprotein (P-gp) overexpression—significantly limiting the effectiveness of chemotherapy. Within a One Health perspective, Africa, home to five major medicinal biodiversity hotspots, represents an underexplored reservoir for natural products–based drug discovery. Among this rich flora, the genus Plectranthus (Lamiaceae) emerges as a particularly promising source of bioactive abietane diterpenes. In this work, the abietane diterpene 7α-acetoxy-6β-hydroxyroyleanone (Roy), isolated from Plectranthus grandidentatus Gürke, exhibited pronounced cytotoxic activity against several cancer cell lines. To enhance its pharmacological profile, a series of Roy ester derivatives was synthesized and evaluated for their …

Jtc 26: The Journey Of Risk To Reward, Grace Landry

University of Mississippi News

This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

April 23, 2026, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Mycotoxin Trends In Cannabis Flower And Concentrates In The United States, Kyle Boyar, Yasha Kahn, Michael Esposito, Sukhikh Pavel

Oxford ICSB

Mycotoxins are toxic fungal metabolites that may pose potential health risks in cannabis products, yet limited data exists on their prevalence in regulated markets. This study analyzed multi-state compliance testing data for cannabis flower and concentrates across eleven U.S. states to evaluate detection and failure rates for aflatoxins (B1, B2, G1, and G2) and ochratoxin A. Ochratoxin A was the most frequently detected mycotoxin in both flower and concentrates; however, detections rarely exceeded regulatory action limits, with overall failure rates remaining low at 0.016% for flower and 0.017% for concentrates. After excluding outlier laboratories with unusually high detection rates, true …

Real World Fertility: From Participatory Research To Clinical Trial, Belinda Tan, Azure Grant, Ayla Barmmer

Oxford ICSB

Nutritional supplements are widely popular for female reproductive health, but their ingredients are typically studied in isolation in the laboratory. Finished products make claims based on these isolated studies, creating a gap in which impact of multi-nutrient formulas in the real world are not investigated, largely due to high research costs. Decentralized clinical research methods are modernizing clinical trials, leading to affordable, efficient evidence generation in large representative populations. Utilizing a decentralized research platform, we tested the hypothesis that specific supplement protocols would be associated with improved female health and fertility in a real world cohort. We present a novel …

Frankincense (Boswellia Spp.) Essential Oils: Chemistry-Driven Authentication, Chemotype Discovery, And Sustainability Insights Across My Published Studies, Prabodh Satyal

Oxford ICSB

Frankincense, which comes from the oleo-gum resins of Boswellia species, is one of the most important botanicals in global trade. However, its essential oils often face issues like variations in chemical makeup, mislabeling, and adulteration. This presentation summarizes findings from ten peer-reviewed studies conducted between 2016 and 2023. These studies create a chemistry-based framework for authenticating frankincense and ensuring sustainable sourcing.  Research on various Boswellia species, including B. sacra, B. carteri, B. papyrifera, B. frereana, B. occulta, B. ogadensis, and B. rivae, shows strong patterns in volatile profiles at both the species and tree levels. This supports distinguishing between species …

In Vitro Vs. In Vivo Studies On The Interaction Of Natural Products With The Gut Microbiota: The Example Of Stw 5, Olaf Kelber

Oxford ICSB

Background: Recent evidence suggests that natural products can modulate microbiome composition, offering health benefits. This study evaluates the effects of STW 5 (Iberogast) on microbiota in functional dyspepsia (FD) and Irritable Bowel Syndrome (IBS) through a comparison of in vitro and in vivo data. Methods: A comprehensive literature review was conducted using PubMed and other scientific databases to collate data on STW 5's impact on the gut microbiome at phyla and genera levels. Results: In vitro studies demonstrated an increase in Enterococcus and a decrease in Clostridium and Bacteroides. Further in vitro research confirmed an increase in Firmicutes and a …

Jtc 26: Two Degrees And A Commission, Staff Report

University of Mississippi News

This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

The Evolution And Impact Of Fashion Marketing In The Age Of Social Media, Lillie L. Warrington

Honors Theses

This research paper aims to analyze the effect of social media on consumer behavior in fashion marketing by investigating how fashion brands have adapted their strategies to leverage social media platforms effectively and exploring the role of social media influencers in shaping brand perception and consumer loyalty. By addressing these objectives, this research seeks to contribute to the growing body of knowledge on digital marketing in the fashion industry, offering valuable insights.

The study will be conducted through a comprehensive review of existing research and primary research, including a survey of 143 participants, to better understand how social media affects …

Icsb Poster Session, Ikhlas Khan

Oxford ICSB

Poster abstracts from the ICSB 2026 poster session.

Botanical Safety Consortium: Overview And Progress, Connie Mitchell

Oxford ICSB

No abstract provided.

Determination Of Kratom Alkaloids In Botanical Products Using Multi-Criteria Lc–Ms Analysis, Mengliang Zhang

Oxford ICSB

Kratom (Mitragyna speciosa) is a botanical product widely sold in the United States as powders, capsules, tablets, gummies, and beverages. Natural kratom leaves primarily contain mitragynine (MG) as the dominant alkaloid. However, an increasing number of commercial products contain elevated levels of the more potent opioid alkaloid 7-hydroxymitragynine (7-OH) and the semi-synthetic compound mitragynine pseudoindoxyl (MGP). Reliable analytical identification of these compounds is critical for dietary supplement testing, regulatory monitoring, and public health protection. However, kratom matrices contain numerous structurally related alkaloids and isomeric compounds that complicate mass spectrometric identification and may lead to false positive assignments. The objective of …

Efficacy And Safety Of Red Ginseng Extract Powder (Kgc05pg) In Achieving Glycemic Control In Prediabetes Korean Subjects: A 12-Week, Single-Center, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study, Namhan Cho

Oxford ICSB

Background: This study was conducted to evaluate the efficacy and safety of Red Ginseng Extract Powder (RGEP) in achieving glycemic control in prediabetic Korean subjects. Methods: The study consisted of 49 subjects in the RGEP group and 49 in the placebo group.  The participants were orally given 2 tablets of RGEP and placebo (500 mg/day twice daily in the morning and the evening within 30 min after meal), respectively.  The subjects were followed duration of 12-week.  The participants glycemic control parameters, such as fasting blood glucose levels, 30-, 60-, 90-, and 120-min blood glucose levels at 75gm oral glucose tolerance …

Ginsenoside-Based Theranostic Agents For Alzheimer's Disease: Implications For Brain Penetration, Cellular Uptake, And Anti-Aging Effects, Hak Soo Choi

Oxford ICSB

Red ginseng and its bioactive constituents, ginsenosides, have long been associated with neuroprotection and anti-aging effects, yet their limited ability to cross the blood-brain barrier (BBB) and poorly characterized biodistribution have hindered therapeutic translation. To address this, we developed a library of “ginsenoprobes” by conjugating major red ginseng components (Rg1, Rg3, Rb1, Rh2, Rk1, Rg5) and red ginseng extract (RGE) to a zwitterionic near-infrared (NIR) fluorophore (ZW800-1C), enabling real-time tracking of their fate in vitro and in vivo. All ginsenoprobes were purified to >95% homogeneity via preparative HPLC and rigorously characterized for optical properties, including molar extinction coefficients and dye-to-ginsenoside …

Hptlc: The New Front Line Of Global Botanical Surveillance, Tiên Do, Ilona Trettin, Ehab Mahran, Sonja Drobnjak

Oxford ICSB

Quality control of botanicals is approaching a breaking point. Regulators, industry, and pharmacists are now forced to answer questions faster and at larger scale than ever before: What plant is actually in the product? Is it the right species—or a look-alike? Is it pure or adulterated? Is it safe? Is the chemistry consistent? And how can labs make confident decisions when analytical capacity and staffing are finite? This presentation demonstrates how modern HPTLC— far beyond its historical role as a simple identity test— now provides clear, interpretable chemical evidence that supports analyst with a practical tool for risk-based surveillance of …

Advancements In Extraction And Co-Extraction Of Botanicals For Standardization And Efficacy, Rory Coleman

Oxford ICSB

Historically, botanicals have served human health in traditional medicine and supplementation due to their bioactive components. Efficient, clean extractions and clinical validation have become fundamental technologies, rendering access to libraries of efficacious products. However, cost, regulatory status, and speed to market have kept many botanicals in single or simple form. Mixtures of such single botanical extracts often require large quantities for effect, influenced by chemical composition, concentration, and delivery format. During the extraction and concentration process, exogenous "bioenhancers," e.g. piperine or oil blends for hydrophilic molecules, often become a necessity, exasperating the problem.   Here, we will delve into the development …

Yeast As A "Microbial Factory", Kaila Fuller, Betsy Jean Yakes

Oxford ICSB

Yeast are eukaryotic, single-celled microorganisms that are members of Kingdom Fungi, and in the world of dietary supplements, yeast qualify as a dietary ingredient as a botanical. During fermentation, yeast naturally produce byproducts that can be harvested, purified, and sold in a dietary supplement. Advances in biotechnology have allowed for genetic modification of yeast so that yeast can produce large quantities of native or non-native constituents during fermentation, effectively making yeast a “microbial factory” for various chemicals. Chemicals produced this way can qualify as a dietary ingredient as a constituent of a botanical. Relevant examples of past submitted notifications (public …

Jtc 26: A Community Builder With A Cause, Staff Report

University of Mississippi News

This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Jtc 26: Reading, Research And A Road To Medicine, Staff Report

University of Mississippi News

This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Application Of Aqbd Principles To Build A Robust Compendial Analytical Method For The Quantification Of Phytochemicals In Mate And Guayusa Leaf Dietary Ingredients, Maria Monagas, Salika Jeelani, Greg Winter, Natalia Kouznetsova

Oxford ICSB

Mate (Ilex paraguariensis) and Guayusa (Ilex guayusa), both members of the Aquifoliaceae family, have traditionally been consumed as herbal teas in South America. Their leaves are rich in methylxanthines and hydroxycinnamoylquinic acids—quinic acid derivatives of caffeic and gregrferulic acids—which provide stimulant and antioxidant properties. These compounds make them valuable for use in health and energy beverages as well as dietary supplements. We applied the Analytical Quality-by-Design (AQbD) approach to develop a robust UHPLC method for simultaneous quantification of methylxanthines and hydroxycinnamoylquinic acids. The method and sample preparation were designed in alignment with USP General Chapter < 1220> Analytical Procedure Life Cycle and …

A Joint Effort: Accomplishments Of The Resource Center For Cannabis And Cannabinoids Research, Patrick Still, Don Stanford, Mary Paine, Nandakumara Sarma

Oxford ICSB

No abstract provided.

Jtc 26: Transfer Student Discovers Full Potential At Ole Miss, Emerson Penny

University of Mississippi News

This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Math In Melody: How Music Strikes A Chord With Memory And Learning, Aidan V. Waters

Honors Theses

As a result of personal curiosity, this thesis seeks to understand the current status of music integration within educational settings, discussing its importance and potential impact. By considering existing literature, it analyzes music’s effectiveness in K-12 education, particularly within the mathematics classroom. Based on the current body of research, the study identifies three key features of music integration: its effectiveness as an energizer, a memory tool, and a means of creating structure within the classroom. Building on these findings, a proposed ten-day, music-integrated Algebra I unit on functions is presented, applying the research in a variety of ways. The unit …

Ole Miss Honors Sharyn Alfonsi With 2026 Silver Em Award, Mackenzie Ross

University of Mississippi News

OXFORD, Miss. – The University of Mississippi School of Journalism and New Media honored Sharyn Alfonsi with the 2026 Samuel Talbert Silver Em Award, recognizing her distinguished career in journalism and her contributions to the profession.

Causes, Effects, And Solutions Of Wrongful Convictions, Allison B. Gobuzzi

Honors Theses

This study examines the wrongful conviction of Anthony Hinton and other examples that illustrate the causes of wrongful convictions in the United States and the effects that wrongful convictions have on the wrongfully accused and their families. This study uses research from scholarly articles and legal cases to analyze the factors that contribute to wrongful convictions and the impact on the wrongfully accused and their families. The research concludes that wrongful convictions are frequently the result of both evidentiary and procedural issues within the criminal justice system.

Ole Miss Names Political Science Department For Ray Mabus, Tina H. Hahn

University of Mississippi News

OXFORD, Miss. – Former Mississippi Gov. Ray Mabus has been called "one of the outstanding public servants of our time." Now his legacy at the University of Mississippi is being acknowledged with the naming of its Department of Political Science in his honor.

Green And Clean: Case Studies Featuring The Shift Toward Healthier Consumption, Mckay Orwig

Honors Theses

This thesis is composed of eight accounting case studies investigating the impact of the “Make America Healthy Again” (MAHA) movement on corporate operations, and other narratives. Dr. Dickenson assigned and advised the case studies throughout the course of Honors Accountancy 420. During the fall semester, we were assigned several individual case studies that broadened our background knowledge on legislation and the MAHA movement, as well as having the opportunity to hear from professionals from leading firms.  During the spring semester, Dr. Dickenson placed us in groups to research our assigned companies, my group ultimately assigned the international snacking company, Kellanova. …

April 16, 2026, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.