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Formulation Development Of Natamycin Loaded Nanoemulsion For Ocular Drug Delivery, Kanika Goel Jan 2019

Formulation Development Of Natamycin Loaded Nanoemulsion For Ocular Drug Delivery, Kanika Goel

Electronic Theses and Dissertations

Natamycin (NT), also known as Pimaricin, is predominantly used as an anti-fungal medication for the treatment of fungal infections around the eye. The goal of the present study was to formulate and optimize NT loaded nanoemulsion (NT-NE) and examine its potential application in ophthalmic drug delivery. Placebos were evaluated with respect to particle size, PDI and ZP to identify the aqueous phase and lipid phase concentrations to be carried forward with NT-NE development. NT-NE were prepared by hot homogenization and ultra-probe sonication method, using Castor oil (CO) and Miglyol 812 as liquid lipids, Tween®80 and Poloxomer 188 as surfactants. NT-NE …

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Formulation Strategies To Address Physiological And Anatomical Constraints For Improved Topical Ocular Drug Delivery, Karthik Yadav Janga Jan 2019

Formulation Strategies To Address Physiological And Anatomical Constraints For Improved Topical Ocular Drug Delivery, Karthik Yadav Janga

Electronic Theses and Dissertations

Delivery of therapeutic molecules to the eye has been a complicated task owing to its anatomical and physiological barriers. This dissertation delineates several formulation strategies to circumvent dynamic and static constraints hampering the ocular drug delivery. Advanced vesicular systems, bilosomes and transfersomes, were prepared to improve the ocular pharmacotherapy of natamycin (NT). NT bilosomes and transfersomes were further loaded into in situ gel systems which transformed immediately to hydrogel, in the simulated tear fluid, with good viscoelastic and mucoadhesive properties.In vitro corneal transport studies confirmed the superior permeability characteristics of NT from the optimized bilosome and transfersome in situ gel …

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Development Of Continuous Manufacturing Process Of Acyclovir Ointment Using Hot-Melt Extrusion, Rui Wang Jan 2019

Development Of Continuous Manufacturing Process Of Acyclovir Ointment Using Hot-Melt Extrusion, Rui Wang

Electronic Theses and Dissertations

Hot-melt extrusion is a viable technology in preparing the pharmaceutical delivery system and has been considered as an attractive alternative to conventional processing methods. The objective of this study was to utilize the advantage of continuous manufacturing in HME to design and evaluate a formulation of topical semisolid ointment. Melt fusion ointments containing 5% of acyclovir (ACV) in water-soluble base with PEG 400, PEG 1500, and PEG 3350 polymers at various ratio were prepared. A design of experiment using I-optimal design was conducted. This design was used to study the influence of polymer ratio on the physicochemical properties of the …

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Empirical Support For Multidimensional Treatment Foster Care (Mtfc): A Critical Review, Jennifer Marie Ladner-Graham Jan 2019

Empirical Support For Multidimensional Treatment Foster Care (Mtfc): A Critical Review, Jennifer Marie Ladner-Graham

Electronic Theses and Dissertations

Multidimensional Treatment Foster Care (MTFC), initially intended as a treatment for chronic juvenile offenders (adolescents having multiple contacts with the juvenile justice system), was designed as an alternative to placement within group facilities. MTFC allows the adolescent to remain in the community while receiving individual and family-based interventions. These interventions are dedicated to decreasing risk factors associated with offending (e.g., poor parental supervision, association with delinquent peers, poor academic performance) and increasing protective factors (e.g., effective parenting practices, healthy relationships with supportive peers, increased school involvement). MTFC has been utilized to meet the needs of a variety of populations (e.g., …

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Validating Military Culture: The Factor Analysis Of A Military-Related Adaptation Of Acculturation, Mathew A. Tkachuck Jan 2019

Validating Military Culture: The Factor Analysis Of A Military-Related Adaptation Of Acculturation, Mathew A. Tkachuck

Electronic Theses and Dissertations

The concept of acculturation has a long history, and measures of the construct attempt to assess the degree to which attitudes and behaviors reflect the interaction between different cultures. Berry’s acculturation framework (1997) is arguably the most empirically-supported and well-known model of acculturation. Berry’s model posits that an individual may have difficulty appropriately adapting to a culture different than his or her own depending on how much they are oriented to either culture. Moreover, Searle and Ward (1990) hypothesized that an individual’s acculturation orientation, in addition to how different the dominant and non-dominant cultures are from one another, impacts psychological …

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Nonmedical Use Of Prescription Drugs Among Young Adults: An Examination Of Anxiety Sensitivity, Distress Tolerance, And Emotion-Driven Impulse Control Difficulties, Sara Michelle Witcraft Jan 2019

Nonmedical Use Of Prescription Drugs Among Young Adults: An Examination Of Anxiety Sensitivity, Distress Tolerance, And Emotion-Driven Impulse Control Difficulties, Sara Michelle Witcraft

Electronic Theses and Dissertations

Individuals with anxiety disorders are significantly more likely to develop substance use disorders than those without anxiety disorders (Kessler & Greenberg, 2002). Despite a sizeable body of literature focused on etiological and maintenance factors underlying the co-occurrence of substance use and anxiety pathology, this relationship remains poorly understood. Transdiagnostic factors, specifically distress tolerance, anxiety sensitivity, and emotion-driven impulse control difficulties, have been posited to contribute to the relationship of anxiety and substance abuse, and in particular, nonmedical use of prescription drugs (NMUPD; Dennhardt & Murphy, 2013; Wolitzky-Taylor et al., 2015). The current study examined group differences among the aforementioned transdiagnostic …

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African American Students In Physical Therapy: Enhancing Diversity, Sherry T. Colson Jan 2019

African American Students In Physical Therapy: Enhancing Diversity, Sherry T. Colson

Electronic Theses and Dissertations

African Americans are motivated by early exposure to the profession and future expectations for their personal career path including stability work-life balance and helping others. The elimination of barriers such as finances lack of support and cultural microaggressions influences their career path. Following statistical analysis of admissions data conclusions were made that the current admissions criteria does not successfully predict first year success for any students including African American students. Lastly African American physical therapy graduates from UMMC reported excitement upon admission concerns over quotas lack of African American faculty students and physical therapists and the presence of microaggressions while …

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On The Relationship Between Resilience, Meaning, And Hardiness: A Bi-Factor Exploratory And Confirmatory Analysis, Lauren Weathers Jan 2019

On The Relationship Between Resilience, Meaning, And Hardiness: A Bi-Factor Exploratory And Confirmatory Analysis, Lauren Weathers

Electronic Theses and Dissertations

Meaning in life, resilience, and hardiness have been conceptualized in a variety of ways. Some researchers theorize that these constructs share significant overlap. The goal of the current study was to examine how much overlap exists between these concepts. Three thousand and ten participants from a university in the Midwest and a university in the South completed measures of meaning in life, resilience, and hardiness. It was hypothesized that some items from these measures would create a unidimensional model while some items would create multidimensionality. Hypotheses that incorporated both models were important as there is disagreement within the literature with …

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A Balm For The Times: The Origins And Evolution Of The Lost Cause In The South Carolina Low Country, 1830-1876, Andrew Patrick Davis Jan 2019

A Balm For The Times: The Origins And Evolution Of The Lost Cause In The South Carolina Low Country, 1830-1876, Andrew Patrick Davis

Electronic Theses and Dissertations

This study uses the concept of civil religion as a framework through which to examine the origins and early development of the Lost Cause in the South Carolina Low country. In the late eighteenth and early nineteenth centuries as American colonists severed their ties with Great Britain and established an independent republic they likewise began forming a civil religion or a set of beliefs regarding the relationship between God and their incipient polity. Prophetic in nature the central tenets of this civil religion held that the Almighty proved actively involved in human history and that Americans represented an especially chosen …

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Decolonial Resistance In Latinx Writings From Peru To The United States: A Portfolio, Isabel Norwood Jan 2019

Decolonial Resistance In Latinx Writings From Peru To The United States: A Portfolio, Isabel Norwood

Electronic Theses and Dissertations

This collection begins with the premise that colonial relationships manifest in ways beyond exploitation of one nation by another. It relies on the decolonial theory of Walter D. Mignolo in its assumption that imbalances of power in the realms of race gender sexuality and class are fundamentally colonial. With this more expansive understanding of coloniality in mind I examine resistance to colonial exploitation in a range of texts from across the Americas. The first essay in this collection explores the role of the guinea pig in Andean food culture arguing that the continued consumption of guinea pig represents a form …

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African American Students In Physical Therapy: Enhancing Diversity, Melanie H. Lauderdale Jan 2019

African American Students In Physical Therapy: Enhancing Diversity, Melanie H. Lauderdale

Electronic Theses and Dissertations

African Americans are motivated by early exposure to the profession and future expectations for their personal career path including stability work-life balance and helping others. The elimination of barriers such as finances lack of support and cultural microaggressions influences their career path. Following statistical analysis of admissions data conclusions were made that the current admissions criteria does not successfully predict first year success for any students including African American students. Lastly African American physical therapy graduates from UMMC reported excitement upon admission concerns over quotas lack of African American faculty students and physical therapists and the presence of microaggressions while …

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A Computational Approach To Predicting And Understanding New Psychoactive Substances (Nps) For Developing A Database For State And Federal Crime Laboratories, Caroline Amelia Spencer Jan 2019

A Computational Approach To Predicting And Understanding New Psychoactive Substances (Nps) For Developing A Database For State And Federal Crime Laboratories, Caroline Amelia Spencer

Electronic Theses and Dissertations

The object of this dissertation was to use a computational approach to predict and understand new psychoactive substances (NPS) to develop a database for state and federal crime. The primary scope of the dissertation was to better understand the interactions that take place between new psychoactive substances and their corresponding receptors. Through analysis of the interactions between the amino acids within the receptors and the NPS an understanding into the pharmacology and toxicology of these drugs can be gained. NPS such as synthetic cannabinoids fentanyl and its analogs and kratom have become more problematic for both state and federal crime …

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Subverting The Patriarchal Panopticon: Challenges To Eugenics Rhetoric In The Novels Of Mccullers And Welty, Regina Marie Young Jan 2019

Subverting The Patriarchal Panopticon: Challenges To Eugenics Rhetoric In The Novels Of Mccullers And Welty, Regina Marie Young

Electronic Theses and Dissertations

My thesis takes into consideration the scope of eugenics ideologies and their influence on literature specifically two mid-twentieth century authors from the U.S. South Carson McCullers and Eudora Welty. I contend that both writers engage with eugenics rhetoric challenging and subverting the prevailing ideology of the day albeit in differing ways. McCullers and Welty address different facets of eugenics rhetoric in their novels— namely the nature of “defect” and the criteria for “fitness” for “citizenship.” This thesis interrogates the ways in which these writers develop rhetorical strategies for resisting eugenics ideologies in their respective novels Reflections in a Golden Eye …

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Development Of Topical Oil/Peg Creams Of Voriconazole, Abhishek Shivashankar Shettar Jan 2019

Development Of Topical Oil/Peg Creams Of Voriconazole, Abhishek Shivashankar Shettar

Electronic Theses and Dissertations

Voriconazole (VRC) was selected as a model drug for preparation of Oil/PEG cream consisting of PEG 2000, PEG 400 and propylene glycol after performing drug-excipient compatibility studies. Twin screw processor with a 10 mm co-rotating twin screw configuration was used for preparation of oil/PEG creams. Creams prepared using twin-screw processor were characterized for the following: Differential Scanning Calorimetry (DSC), pH, Solvent activity (as)), viscosity, drug content uniformity, in vitro drug release testing (IVRT) and in vitro permeation testing (IVPT) using human cadaver skin. Creams are heterogenous biphasic semi-solid preparations consisting of oil and aqueous phases, wherein one phase is dispersed …

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Implementing Mass Spectrometry For The Structural And Compositional Analysis Of Proteins, Mohammad Riaz Jan 2019

Implementing Mass Spectrometry For The Structural And Compositional Analysis Of Proteins, Mohammad Riaz

Electronic Theses and Dissertations

Lectins are sugar-binding proteins that perform various biological functions such as cellular recognition attachments etc. Pulses the dried edible seeds of certain plants are great sources of lectins and a proteomics approach directed at lectins identification would bring substantial improvement in the lectin identification process. Lectins from nine different plant species were analyzed through SDS-PAGE and proteomics analysis. After LC-MS/MS analysis proteins were identified with protein database searches using Uniprot. Functionally uncharacterized proteins were identified with database searches were annotated with the Pfam and NCBI-CCD databases. In-vitro pharmacological screening will be carried out to assess the pharmacological effects of these …

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General Accounting And Auditing Developments, 2019/20; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa) Jan 2019

General Accounting And Auditing Developments, 2019/20; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

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Not-For-Profit Entities Industry Developments - 2019; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa) Jan 2019

Not-For-Profit Entities Industry Developments - 2019; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

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Employee Benefit Plans Industry Developments - 2019; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa) Jan 2019

Employee Benefit Plans Industry Developments - 2019; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

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Employee Benefit Plans, January 1, 2019; Audit And Accounting Guide, American Institute Of Certified Public Accountants (Aicpa) Jan 2019

Employee Benefit Plans, January 1, 2019; Audit And Accounting Guide, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

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Revenue Recognition, January 1, 2019; Audit And Accounting Guide, American Institute Of Certified Public Accountants (Aicpa) Jan 2019

Revenue Recognition, January 1, 2019; Audit And Accounting Guide, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

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Spatio-Temporal Distribution Of Spiroplasma Infections In The Tsetse Fly (Glossina Fuscipes Fuscipes) In Northern Uganda, Daniela I. Schneider, Norah Saarman, Maria G. Onyango, Chaz Hyseni, Robert Opiro, Richard Echodu, Michelle O'Neill, Danielle Bloch, Aurélien Vigneron, T. J. Johnson, Kirstin Dion, Brian L. Weiss, Elizabeth Opiyo, Adalgisa Caccone, Serap Aksoy Jan 2019

Spatio-Temporal Distribution Of Spiroplasma Infections In The Tsetse Fly (Glossina Fuscipes Fuscipes) In Northern Uganda, Daniela I. Schneider, Norah Saarman, Maria G. Onyango, Chaz Hyseni, Robert Opiro, Richard Echodu, Michelle O'Neill, Danielle Bloch, Aurélien Vigneron, T. J. Johnson, Kirstin Dion, Brian L. Weiss, Elizabeth Opiyo, Adalgisa Caccone, Serap Aksoy

Faculty and Student Publications

Copyright: © 2019 Schneider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Tsetse flies (Glossina spp.) are vectors of parasitic trypanosomes, which cause human (HAT) and animal African trypanosomiasis (AAT) in sub-Saharan Africa. In Uganda, Glossina fuscipes fuscipes (Gff) is the main vector of HAT, where it transmits Gambiense disease in the northwest and Rhodesiense disease in central, southeast and western regions. Endosymbionts can influence transmission efficiency of parasites through their insect …

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Effects Of Vertical Transmission Of Maternal Antibodies To Mycoplasma Gallisepticum On Growth And Condition Of Eastern Bluebird Nestlings (Sialia Sialis), Mckenzie Xiang Denton Jan 2019

Effects Of Vertical Transmission Of Maternal Antibodies To Mycoplasma Gallisepticum On Growth And Condition Of Eastern Bluebird Nestlings (Sialia Sialis), Mckenzie Xiang Denton

Honors Theses

Mothers display maternal effects to influence the development and success of offspring through processes such as resource allocation. In birds, this occurs largely through the egg yolk with the vertical transmission of antibodies to offspring to protect the vulnerable young from disease. Specifically, poultry and eastern bluebirds across the eastern United States are commonly infected by the bacteria Mycoplasma gallisepticum (MG), for which mothers may produce antibodies against. To test for the vertical transmission of MG-specific antibodies from mothers to nestlings in eastern bluebirds and the associated fitness effects, bluebird boxes were set up and monitored during the field season. …

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State And Regional Comparisons Of Breastfeeding Policies And Rates: A National Study, Erin Johnson Jan 2019

State And Regional Comparisons Of Breastfeeding Policies And Rates: A National Study, Erin Johnson

Honors Theses

State legislation focused on promoting and supporting breastfeeding is relatively new, beginning in the 1990s. The purpose of this study is to determine if there is an association between state breastfeeding rates and state breastfeeding legislation and other institutional policies. The Centers for Disease Control and Prevention releases breastfeeding report cards with the most up-to-date state breastfeeding rates. These reports are used to examine the relationship between state breastfeeding rates and number of breastfeeding policies passed by a state. Government initiatives, such as Healthy People Initiative, and organizational practices, such as Baby-Friendly USA Inc., are also studied to determine their …

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Fungal-Algal Speed Dating: Exploring Symbiotic Potential Of Fungal-Algal Cocultures, Natalie S. Williams Jan 2019

Fungal-Algal Speed Dating: Exploring Symbiotic Potential Of Fungal-Algal Cocultures, Natalie S. Williams

Honors Theses

Symbiotic relationships are widely studied phenomena in the biological world. Of particular interest are the ubiquitous relationships that exist between fungi and photoautotrophs. While much is known about the commonly occurring interactions that persist between fungi and a wide range of terrestrial plants, we are interested in exploring the symbiotic capacity between fungi and earlier diverging lineages of the plant kingdom, notably green algae. We developed an experiment to allow for a medium-throughput analysis of fungal-algal interactions using three model green algae: Chlamydomonas reinhardtii, Chlorella vulgaris, and Penium margaritaceum. With numerous replicated assays, these algae were individually paired with a …

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Assessing The Effects Of Antioxidants On Oxidative Stress In Triple-Negative Breast Cancer Cells Via Protein Carbonylation, Dalton Sheffield Jan 2019

Assessing The Effects Of Antioxidants On Oxidative Stress In Triple-Negative Breast Cancer Cells Via Protein Carbonylation, Dalton Sheffield

Honors Theses

Breast cancer is a highly complex, heterogeneous disease, and potential effective treatment options are being continuously researched in order to provide a method of halting cancer growth and metastasis. One area in particular involves alleviating oxidative stress within cancer cells. Oxidative stress is generally defined as an imbalance between oxidant and antioxidant species in favor of the oxidants. Cancer cells use this oxidative stress to initiate carcinogenesis in cells through different mechanisms, and protein carbonylation is a primary biomarker used to quantify oxidative stress levels. Antioxidant compounds are those used to alleviate oxidative stress within cells. Here breast cancer cells …

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The Economic Effects Of National Marijuana Legalization, Alexander Lee Robison Jan 2019

The Economic Effects Of National Marijuana Legalization, Alexander Lee Robison

Honors Theses

In today’s political and social climate, the legalization of marijuana has been a major topic of discussion across the nation. As more states pass legislation to legalize marijuana, whether it be for medicinal or recreational purposes, a market is being created that has economically beneficial possibilities that can be harnessed on a national level. This thesis seeks to highlight the economic effect marijuana legalization could possibly have on the national economy by examining the states that have legalized marijuana. States who have already passed such legislation provide a framework for state-level economic impact of marijuana legalization that can be projected …

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Measurements Of The Primary Bjerknes Force In A Cavitating Ultrasonic Field, Mason Smith Jan 2019

Measurements Of The Primary Bjerknes Force In A Cavitating Ultrasonic Field, Mason Smith

Honors Theses

Cavitation is the result when there are rapid changes in pressure in a liquid. These vapor-filled cavities can occur when ultrasound propagates through water at sufficient power. The volumes of these cavities can pulsate and can even couple with the radiation pressure from the ultrasound. The result is a translational force on the bubbles. This translational force on the bubble is called the primary Bjerknes force. The secondary Bjerknes force is the result of two pulsating cavities, but this force is ignored since the buoyant force and the primary Bjerknes force are the dominant forces. Immediately before a bubble begins …

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A Study Of The Kratom Alkaloids And Their Binding To The Μ-Opioid Receptor, Reba Elizabeth Ann Chamblee Jan 2019

A Study Of The Kratom Alkaloids And Their Binding To The Μ-Opioid Receptor, Reba Elizabeth Ann Chamblee

Honors Theses

Kratom, a plant commonly found in southeast Asia, has traditionally been used for medicinal treatments. Recently, however, the popularity of the drug has significantly increased due to its euphoric effects, leading to it being used as an alternative to illegal opioids. Several alkaloid compounds have been isolated from the leaves of the plant. The main alkaloids seen are the following five alkaloids: mitragynine, 7-hydroxymitragynine, speciociliatine, speciogynine, and paynantheine. Two alkaloids, mitragynine and 7-hydroxymitragynine, have exhibited high potencies and are potentially even more potent than morphine. Previous studies have indicated that the main mediator of the psychoactive effects is the opioid …

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Institutional Divides: How Democracy Affects Economic Complexity In The Transition Economies Of Eastern Europe And Central Asia, Mary Frances Holland Jan 2019

Institutional Divides: How Democracy Affects Economic Complexity In The Transition Economies Of Eastern Europe And Central Asia, Mary Frances Holland

Honors Theses

The transition economies, in making their way from a command economy to an integrated market economy, experience vastly different levels of development. This work proposes an influence of inclusive, democratic institutions on increased economic complexity. This project reviews the history of diverging political and economic policy decisions across the region. Case studies for Poland, Ukraine, and Kazakhstan review trade data and democratic policies to better understand groups of development across the region. This paper utilizes Daron Acemoglu and James A. Robinson’s institutional developmental theory as a basis for the creation and sustainability of democratic and economically diverse structures.

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Renewables & Refugees: A Solution For Jordan, Lauren Burns Jan 2019

Renewables & Refugees: A Solution For Jordan, Lauren Burns

Honors Theses

As the Hashemite Kingdom of Jordan continues to host the third largest Syrian refugee population in the world, the state’s infrastructure and its people are taking a toll. Before the war in Syria began, Jordan was already suffering from a weak economy, resource scarcity, and an enormous population boom. Since accepting nearly 2.5 million refugees, these issues have compounded year after year—nearly reaching a breaking point. I propose an unconventional solution to some aspects of the refugee crisis: renewable energy. Renewables are cheaper than fossil fuels, consume less water in electricity generation, emit fewer greenhouse gases, and promote job creation …

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