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Senior Named To Time Magazine's "30 For 2030", Michael Newsom Jan 2022

Senior Named To Time Magazine's "30 For 2030", Michael Newsom

University of Mississippi News

Bobby Hudson III, a public policy major from Gulfport, makes list of 'a generation creating change'


Researchers Study Cannabis Pain Relief With $1.37 Million Grant, Whitney Tarpy Jan 2022

Researchers Study Cannabis Pain Relief With $1.37 Million Grant, Whitney Tarpy

University of Mississippi News

Pharmacy faculty use NIDA support to examine reducing HIV-related pain and inflammation


Improving The Well-Being Of Mississippi Children, Shea Stewart Jan 2022

Improving The Well-Being Of Mississippi Children, Shea Stewart

University of Mississippi News

University receives grant to expand preschool curriculum


Major And Minor Flyer, University Of Mississippi. College Of Liberal Arts Jan 2022

Major And Minor Flyer, University Of Mississippi. College Of Liberal Arts

Liberal Arts Publications

A pamphlet listing the 35 majors and 52 minors available through the College of Liberal Arts.


School Of Pharmacy Intellectual Property Report, Fy22, Second Quarter Report, Soumyajit Majumdar Jan 2022

School Of Pharmacy Intellectual Property Report, Fy22, Second Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

No abstract provided.


Phytochemical Investigation Of Egyptian Riverhemp: A Potential Source Of Antileukemic Metabolites, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran Jan 2022

Phytochemical Investigation Of Egyptian Riverhemp: A Potential Source Of Antileukemic Metabolites, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran

Faculty and Student Publications

As part of our research group's continuous efforts to find alternative treatments for cancer, the aqueous ethanol extract of Sesbania sesban L. Merr. (SS, Egyptian riverhemp) demonstrated an antileukemic activity against K562 cell line. Bioguided fractionation of SS leaves hydroethanolic extract resulted in the isolation of one new compound (33) named as hederatriol 3-O-β-D-glucuronic acid methyl ester as well as 34 known compounds. Seven compounds ((34), (22), (20), (24), (21), (19), and (35)) showed high antiproliferative effects (IC50 = 22.3, 30.8, 31.3, 33.7, 36.6, 37.5, and 41.5 μM, respectively), while four compounds ((32), (5), (29), and (1)) showed milder activities …


Cryptococcosis In A Patient With Multiple Myeloma Receiving Pomalidomide: A Case Report And Literature Review, Daniel B. Chastain, Sahand Golpayegany, Andrés F. Henao-Martínez, Brittany T. Jackson Jan 2022

Cryptococcosis In A Patient With Multiple Myeloma Receiving Pomalidomide: A Case Report And Literature Review, Daniel B. Chastain, Sahand Golpayegany, Andrés F. Henao-Martínez, Brittany T. Jackson

Faculty and Student Publications

While overall survival with multiple myeloma (MM) has improved, patients suffer from overwhelming tumor burden, MM-associated comorbidities, and frequent relapses requiring administration of salvage therapies. As a result, this vicious cycle is often characterized by cumulative immunodeficiency stemming from a combination of disease- and treatment-related factors leading to neutropenia, T-cell deficiency, and hypogammaglobulinemia. Infectious etiologies differ based on the duration of MM and treatment-related factors, such as number of previous treatments and cumulative dose of corticosteroids. Herein, we present the case of a patient who was receiving pomalidomide without concomitant corticosteroids for MM and was later found to have cryptococcosis, …


Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa N. Qrareya, Fakhri Mahdi, Marc J. Kaufman, Nicole M. Ashpole Jan 2022

Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa N. Qrareya, Fakhri Mahdi, Marc J. Kaufman, Nicole M. Ashpole

Faculty and Student Publications

In the U.S. about half of the HIV-infected individuals are aged 50 and older. In men living with HIV, secondary hypogonadism is common and occurs earlier than in seronegative men, and its prevalence increases with age. While the mechanisms(s) are unknown, the HIV-1 trans-activator of transcription (Tat) protein disrupts neuroendocrine function in mice partly by dysregulating mitochondria and neurosteroidogenesis. We hypothesized that conditional Tat expression in middle-aged male transgenic mice [Tat(+)] would promote age-related comorbidities compared to age-matched controls [Tat(−)]. We expected Tat to alter steroid hormone milieu consistent with behavioral deficits. Middle-aged Tat(+) mice had lower circulating testosterone and …


Synthesis Of 3,4,5-Trisubstituted Isoxazoles In Water Via A [3 + 2]-Cycloaddition Of Nitrile Oxides And 1,3-Diketones, Β-Ketoesters, Or Β-Ketoamides, Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le Jan 2022

Synthesis Of 3,4,5-Trisubstituted Isoxazoles In Water Via A [3 + 2]-Cycloaddition Of Nitrile Oxides And 1,3-Diketones, Β-Ketoesters, Or Β-Ketoamides, Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le

Faculty and Student Publications

Herein we report a method for the synthesis of 3,4,5-trisubstituted isoxazoles in water under mild basic conditions at room temperature via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides. We optimized the reaction conditions to control the selectivity of the production of isoxazoles and circumvent other competing reactions, such as O-imidoylation or hetero [3 + 2]-cycloaddition. The reaction happens fast in water and completes within 1-2 hours, which provides an environmentally friendly access to 3,4,5-trisubstituted isoxazoles, an important class of structures found in numerous bioactive natural products and pharmaceuticals. Additionally, we optimized the reaction conditions to …


Identification Of An Orally Bioavailable, Brain-Penetrant Compound With Selectivity For The Cannabinoid Type 2 Receptor, Meirambek Ospanov, Suresh P. Sulochana, Jason J. Paris, John M. Rimoldi Jan 2022

Identification Of An Orally Bioavailable, Brain-Penetrant Compound With Selectivity For The Cannabinoid Type 2 Receptor, Meirambek Ospanov, Suresh P. Sulochana, Jason J. Paris, John M. Rimoldi

Faculty and Student Publications

Modulation of the endocannabinoid system (ECS) is of great interest for its therapeutic relevance in several pathophysiological processes. The CB2 subtype is largely localized to immune effectors, including microglia within the central nervous system, where it promotes anti-inflammation. Recently, a rational drug design toward precise modulation of the CB2 active site revealed the novelty of Pyrrolo[2,1-c][1,4]benzodiazepines tricyclic chemotype with a high conformational similarity in comparison to the existing leads. These compounds are structurally unique, confirming their chemo-type novelty. In our continuing search for new chemotypes as selective CB2 regulatory molecules, following SAR approaches, a total of 17 selected (S,E)-11-[2-(arylmethylene)hydrazono]-PBD analogs …


1,2,3-Triazole Derivatives As Highly Selective Cannabinoid Receptor Type 2 (Cb2) Agonists, Amer H. Tarawneh, Pankaj Pandey, Lo'ay A. Al-Momani, Anastassiya V. Gadetskaya Jan 2022

1,2,3-Triazole Derivatives As Highly Selective Cannabinoid Receptor Type 2 (Cb2) Agonists, Amer H. Tarawneh, Pankaj Pandey, Lo'ay A. Al-Momani, Anastassiya V. Gadetskaya

Faculty and Student Publications

The cannabinoid receptor 2 (CB2 receptor) has attracted considerable interest, mainly due to its potential as a target for therapeutics for treating various diseases that have a neuroinflammatory or neurodegenerative component while avoiding the adverse psychotropic effects that accompany CB1 receptor-based therapies. With the appreciation that CB2-selective ligands show marked functional selectivity, there is a renewed opportunity to explore this promising area of research from both a mechanistic as well as a therapeutic perspective. In this research, we are interested in the discovery of new chemotypes as highly selective CB2 modulators, which may serve as good starting points for further …


Dual Drug Loaded Lipid Nanocarrier Formulations For Topical Ocular Applications, Ahmed Adel Ali Youssef, Narendar Dudhipala, Soumyajit Majumdar Jan 2022

Dual Drug Loaded Lipid Nanocarrier Formulations For Topical Ocular Applications, Ahmed Adel Ali Youssef, Narendar Dudhipala, Soumyajit Majumdar

Faculty and Student Publications

Introduction: Untreated ocular infections can damage the unique fine structures of the eye with possible visual impairments and blindness. Ciprofloxacin (CIP) ophthalmic solution is prescribed as first-line therapy in ocular bacterial infections. Natamycin (NT) ophthalmic suspension is one of the progenitors in ocular antifungal therapy. Nanostructured lipid carriers (NLCs) have been widely examined for ocular penetration enhancement and distribution to deeper ocular tissues. The objective of the current study was to prepare NLCs loaded with a combination of CIP and NT (CIP-NT-NLCs) and embed them in an in-situ gelling system (CIP-NT-NLCs-IG). This novel formulation will target the co-delivery of CIP …


The Influence Of An Acute Bout Of Aerobic Exercise On Vascular Endothelial Function In Moderate Stages Of Chronic Kidney Disease, Jeffrey S. Forsse, Zacharias Papadakis, Matthew N. Peterson, James Kyle Taylor, Burritt W. Hess, Nicholas Schwedock, Dale C. Allison, Jackson O. Griggs, Ronald L. Wilson, Peter W. Grandjean Jan 2022

The Influence Of An Acute Bout Of Aerobic Exercise On Vascular Endothelial Function In Moderate Stages Of Chronic Kidney Disease, Jeffrey S. Forsse, Zacharias Papadakis, Matthew N. Peterson, James Kyle Taylor, Burritt W. Hess, Nicholas Schwedock, Dale C. Allison, Jackson O. Griggs, Ronald L. Wilson, Peter W. Grandjean

Faculty and Student Publications

Chronic kidney disease (CKD) is directly influenced by the deleterious effects of systemic inflammation and oxidative stress. The vascular endothelium may transiently respond to aerobic exercise and improve post-exercise vascular renal function in moderate stages of CKD. Brachial artery flow-mediated dilation (FMD) is a nitric-oxide-dependent measure of endothelial function that is transiently potentiated by exercise. The purpose of the study was to determine the acute influence of a single bout of high-intensity interval exercise (HIIE) or steady-state moderate-intensity exercise (SSE) on endothelial dysfunction in moderate stages of CKD. Twenty participants (n = 6 men; n = 14 women) completed 30 …


Preparation, Evaluation, And Pharmacokinetics In Beagle Dogs Of A Taste-Masked Flunixin Meglumine Orally Disintegrating Tablet Prepared Using Hot-Melt Extrusion Technology And D-Optimal Mixture Design, Yangfeng Xu, Guoqing Yan, Xuemei Wen, Liqin Wu Jan 2022

Preparation, Evaluation, And Pharmacokinetics In Beagle Dogs Of A Taste-Masked Flunixin Meglumine Orally Disintegrating Tablet Prepared Using Hot-Melt Extrusion Technology And D-Optimal Mixture Design, Yangfeng Xu, Guoqing Yan, Xuemei Wen, Liqin Wu

Faculty and Student Publications

Flunixin meglumine (FM) is a nonsteroidal anti-inflammatory drug limited by irritation of the respiratory tract and mucosa in veterinary tissue. This study aimed to develop a taste-masked FM solid dispersion (SD) by hot-melt extrusion (HME) and formulate an orally disintegrating tablet (ODT) with selected excipients by direct compression. Eudragit® E PO was chosen as the matrix, and HME parameters were optimized: extrusion temperature, 135℃; screw speed, 100 rpm; and drug loading, 20%. Characterization techniques proved that FM was rendered amorphous in the HME extrudate. In vitro dissolution studies showed that FM SD released significantly slower than the corresponding physical mixture …


Research News, Publications, 2022, Volume 4, Soumyajit Majumdar Jan 2022

Research News, Publications, 2022, Volume 4, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of October 1 through December 31, 2022


Integrating Machine Learning Algorithms With Quantum Annealing Solvers For Online Fraud Detection, Haibo Wang, Wendy Wang, Yi Liu, Bahram Alidaee Jan 2022

Integrating Machine Learning Algorithms With Quantum Annealing Solvers For Online Fraud Detection, Haibo Wang, Wendy Wang, Yi Liu, Bahram Alidaee

Faculty and Student Publications

Machine learning has been increasingly applied in identification of fraudulent transactions. However, most application systems detect duplicitous activities after they have already occurred, not at or near real time. Since spurious transactions are far fewer than the normal ones, the highly imbalanced data makes fraud detection very challenging and calls for ways to address it beyond the traditional machine learning approach. This study has proposed a detection framework, and implemented it using quantum machine learning (QML) approach by applying Support Vector Machine (SVM) enhanced with quantum annealing solvers. To evaluate its detection performance, we have further implemented twelve machine learning …


Association Between Electronic Media Use, Development Milestones And Language In Infants, Maian Stamati, Lucas G. Gago-Galvagno, Stephanie E. Miller, Angel M. Elgier, Rocío A. Hauché, Susana C. Azzollini Jan 2022

Association Between Electronic Media Use, Development Milestones And Language In Infants, Maian Stamati, Lucas G. Gago-Galvagno, Stephanie E. Miller, Angel M. Elgier, Rocío A. Hauché, Susana C. Azzollini

Faculty and Student Publications

The use of electronic media has increased in early childhood. During early childhood, language and motor skills are important for the development of other cognitive skills. Therefore, it becomes essential to study how the use of screens is associated with these important skills in the first years of life. The objective of the following research was to describe the use of electronic media (i. e., TV, cellphone and tablet) and its association with language and developmental milestones in the first years of life. Participants were 253 primary caregivers of infants between 2 to 48 months (M = 30.17 months, SD …


School Of Pharmacy Intellectual Property Report, Fy22, Third Quarter Report, Soumyajit Majumdar Jan 2022

School Of Pharmacy Intellectual Property Report, Fy22, Third Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

No abstract provided.


Uv Exposure Causes Energy Trade-Offs Leading To Increased Chytrid Fungus Susceptibility In Green Tree Frog Larvae, Rebecca L. Cramp, Michel E. B. Ohmer, Craig E. Franklin Jan 2022

Uv Exposure Causes Energy Trade-Offs Leading To Increased Chytrid Fungus Susceptibility In Green Tree Frog Larvae, Rebecca L. Cramp, Michel E. B. Ohmer, Craig E. Franklin

Faculty and Student Publications

Levels of ultraviolet (UV) radiation have increased in many parts of the world due to the anthropogenic destruction of the ozone layer. UV radiation is a potent immunosuppressant and can increase the susceptibility of animal hosts to pathogens. UV radiation can directly alter immune function via immunosuppression and photoimmunotolerance; however, UV may also influence pathogen defences by affecting the distribution of energy resources among competing physiological processes. Both defence against UV damage and repair of incurred damage, as well as the maintenance of immune defences and responding to an immune challenge, are energetically expensive. These competing demands for finite energy …


Use Of Real-Time Cadence To Prescribe Aerobic Physical Activity Intensity And Its Comparison With Existing Methods, Heontae Kim, Wei Sun, Mary Malaska, Bridget Miller, Ho Han Jan 2022

Use Of Real-Time Cadence To Prescribe Aerobic Physical Activity Intensity And Its Comparison With Existing Methods, Heontae Kim, Wei Sun, Mary Malaska, Bridget Miller, Ho Han

Faculty and Student Publications

The purpose of this study was to determine the effectiveness of physical activity intensity prescription using real-time cadence on achieving the required intensities for health benefits. Forty adults (18–65 years) participated in the study. The intensity prescriptions included Rating of Perceived Exertion, Talk Test, Heart Rate, and Real-Time Cadence. The participants performed a2-min trial for both moderate- and vigorous-intensity according to each prescription. Atri-axial accelerometer was used as acriterion measure. After completion of the trials, participant’s preference for the prescriptions was assessed by three domains (e.g., understanding, performing, maintaining). The compliance and achievement rates of RC were calculated and compared …


The Spur Adherence Profiling Tool: Preliminary Results Of Algorithm Development, Elodie De Bock, Kevin Dolgin, Benoit Arnould, Guillaume Hubert, Aaron Lee, John D. Piette Jan 2022

The Spur Adherence Profiling Tool: Preliminary Results Of Algorithm Development, Elodie De Bock, Kevin Dolgin, Benoit Arnould, Guillaume Hubert, Aaron Lee, John D. Piette

Faculty and Student Publications

Objective: The SPUR (Social, Psychological, Usage, and Rational) Adherence Profiling Tool is a recently developed adaptive instrument for measuring key patient-level risk factors for adherence problems. This study describes the SPUR questionnaire’s psychometric refinement and evaluation. Methods: Data were collected through an online survey among individuals with type 2 diabetes in the United States. 501 participants completed multiple questionnaires, including SPUR and several validated adherence measures. A Partial Credit Model (PCM) analysis was performed to evaluate the structure of the SPUR tool and verify the assumption of a single underlying latent variable reflecting adherence. Partial least-squares discriminant analyses (PLS-DA) were …


The Criticality Of Financial Development And Energy Consumption For Environmental Sustainability In Oecd Countries: Evidence From Dynamic Panel Analysis, Olatunji Abdul Shobande, Lawrence Ogbeifun Jan 2022

The Criticality Of Financial Development And Energy Consumption For Environmental Sustainability In Oecd Countries: Evidence From Dynamic Panel Analysis, Olatunji Abdul Shobande, Lawrence Ogbeifun

Faculty and Student Publications

This study explored whether financial development and energy consumption affect environmental sustainability in Organization for Economic Cooperation and Development (OECD) countries. The empirical evidence used in this study was based on the standard fixed effects and the Arellano-Bover/Bundell Bond dynamic panel approach. Our empirical results demonstrated the importance of a financial development index and energy efficiency for reducing carbon emissions and promoting sustainability in the OECD. The mechanism through which financial development affects carbon emissions has been identified as energy consumption and foreign direct investment. Our study recommends that financial development be prioritised alongside investments in energy efficiency to promote …


Optimal Frequency Intensity Of Physical Activity To Reduce The Risk Of Hypertension In The Korean Population, Jang Won Son, Sukho Lee, Minsoo Kang, Yun A. Shin, Jae Hyun Kim Jan 2022

Optimal Frequency Intensity Of Physical Activity To Reduce The Risk Of Hypertension In The Korean Population, Jang Won Son, Sukho Lee, Minsoo Kang, Yun A. Shin, Jae Hyun Kim

Faculty and Student Publications

PURPOSE: Regular physical activity (PA) is an effective lifestyle modification for preventing hypertension. This study aimed to analyze the optimal frequency of PA required to reduce the incidence of hypertension in the Korean population. Most Korean studies have included only small samples and limited age ranges. METHODS: The present study analyzed 16,299,865 participants aged ≥20 years (44.25±12.74 years) from the 2009 to 2012 Korean National Health Insurance Corporation Survey database. The International Physical Activity Questionnaire was used to assess the frequency and intensity of physical activity. Hazard ratios for incident hypertension were analyzed by physical activity participation, age, and sex …


Pharmacy Matters - December 2021/January 2022, University Of Mississippi. School Of Pharmacy Jan 2022

Pharmacy Matters - December 2021/January 2022, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "School of Pharmacy Joins Effort to Change Medicine and Vaccine Delivery," "School of Pharmacy Partners with Takeda Pharmaceuticals on Fellowship," "Two Student Pharmacists Named AACP Walmart Scholars"


Southern Register. 2022.1 (Winter 2022), University Of Mississippi. Center For The Study Of Southern Culture Jan 2022

Southern Register. 2022.1 (Winter 2022), University Of Mississippi. Center For The Study Of Southern Culture

Southern Register

No abstract provided.


Discovery Of New 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives As Anticancer Agents Targeting EgfrWt And EgfrT790m, Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab Jan 2022

Discovery Of New 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives As Anticancer Agents Targeting EgfrWt And EgfrT790m, Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab

Faculty and Student Publications

New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds 8, 10, 12a, and 12b showed potent anti-proliferative activities. Compound 12b was the most promising member with IC50 values of 8.21 and 19.56 µM against A549 and HCT-116, respectively. Compounds 8, 10, 12a, and 12b were evaluated for their kinase inhibitory activities against wild EGFR (EGFRWT). Compound 12b was the most potent member showing an IC50 value of 0.016 µM. In addition, compound 12b showed noticeable …


Research News, Grants, 2022, Volume 1, Soumyajit Majumdar Jan 2022

Research News, Grants, 2022, Volume 1, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during January - March 2022.


Research News, Grants, 2022, Volume 4, Soumyajit Majumdar Jan 2022

Research News, Grants, 2022, Volume 4, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during October - December 2022


Newsletter Winter 2022, Annette Kluck, Margaret Savoie Jan 2022

Newsletter Winter 2022, Annette Kluck, Margaret Savoie

Newsletters of the Graduate School

No abstract provided.


Does The Contraction History Of The Muscle Dictate Changes In Strength Following Resistance Training?, Zachary William Bell Jan 2022

Does The Contraction History Of The Muscle Dictate Changes In Strength Following Resistance Training?, Zachary William Bell

Electronic Theses and Dissertations

Within-subject training models, whereby researchers apply an exercise condition to one limb, and a separate exercise condition to the opposing limb, have become routine amongst the exercise literature. However, no study has directly tested whether exercising one limb with a high-load condition will influence strength adaptations within the opposing limb, even when the opposite limb is training. Furthermore, muscle post-activation performance enhancement (PAPE) is representing local level changes, however, more research is warranted to understand if this can be differentially impacted with different types (e.g. low load vs. high load) of resistance training. The purpose of this study was to …