Digital Commons Network^™

Application Of Hot-Melt Extrusion Technology For The Preparation Of Carbamazepine Extended-Release Tablets, Chamundeswara Srinivasa Akash Kalla

Electronic Theses and Dissertations

Carbamazepine (CBZ) is an anti-convulsant and specific analgesic for trigeminal neuralgia that reduces polysynaptic responses and blocks post titanic potentiation. Moreover, CBZ is effective in partial and generalized convulsions and mixed types. It is not effective in petit mal seizures. Carbamazepine extended-release tablets are used to treat episodes of mania (or) mixed episodes i.e., symptoms of mania and depression that happen at the same time, in patients with bipolar disorder. The present study was designed to develop CBZ extended-release tablets with acrylic acid-based polymer (Eudragit® RL PO) using a melt granulation and to match the USP dissolution test specification. Thermal …

Title Character: A Novel, Di Bei

Electronic Theses and Dissertations

Inspired by true events, Title Character: A Novel tells the intimate and fraught relationships of Asian female artists during a pandemic in Idaho: Jade, a rebellious girl born amid the one-child policy in Beijing, writes her love story into a script; Pearl, an ambitious actress raised in rural China, stars in Jade’s film and dates the method actor who plays her lover. Strung together by one film, young women of the Asian diaspora mirror and maneuver each other, while playing out their performances of self with art as their arena.

More Than A Feeling: Materializing Sympathy In Nineteenth-Century American Literature, Kathleen Downes

Electronic Theses and Dissertations

“More than a Feeling: Materializing Sympathy in Nineteenth-Century American Literature” breaks from a long tradition of criticism that only considers the nineteenth-century belief that sympathy was a benevolent, voluntary, imaginative act of feeling that maintains moral rectitude through the identification of suffering with others. In this context, sympathy is primarily defined as identificatory sympathy. “More than a Feeling” expands the definition of sympathy in the nineteenth century as also something that could be atmospherically communicated, transmitting good or bad feeling, and thus affecting and infecting those around them. This other form of sympathy, which for this project I term “effluvial …

Mississippi's America: Late Southern Writing On National Themes, Jacob Fennell

Electronic Theses and Dissertations

This project examines three texts each from three Mississippi authors working today: Kiese Laymon, Jesmyn Ward, and Mary Miller. These authors’ literary constructions of their home state and the South as a whole serve as critical, political frames for the United States. As a result, their work is well-served by the questions and methodology of New Southern Studies, a field actively invested in conceptions of the U.S. South as nonexceptional and lodged within greater geopolitical contexts. Indeed, the original call for New Southern Studies from Houston A. Baker, Jr. and Dana Nelson speaks to a problem of a false national …

Development Of Fenofibrate Solid Dispersion Via Hot Melt Extrusion And 3d Printing Technologies, Janhavi Santosh Deshmukh

Electronic Theses and Dissertations

The aim of this study was to develop an amorphous solid dispersion (ASD) of fenofibrate using Hot Melt Extrusion (HME) and 3D printing. By using HME, 3D printable filaments were prepared. Fenofibrate (10% w/w), Soluplus®, and Polyethylene oxide-N80 were used to prepare the HME filaments. The filaments were divided into two parts, the first part was used as a feedstock for the Fused disposition modeling 3D printing (FDM 3D printing) to print fenofibrate tablets with different percent infill densities, 90%, 70% and 50%. The second part was milled and filled into gelatin capsules to compare the dissolution release profile of …

Exploring The Habits And Perceptions Of True Crime Podcast Listeners, Remy Heinen

Electronic Theses and Dissertations

Although podcasts as a whole are growing in popularity, the true crime genre of podcasts continues to be especially popular, particularly with female listeners. The unique intersection of informational and entertainment goals associated with true crime podcasts raises ethical questions about how these priorities should be balanced. This study focused on learning more about listeners’ motivations, habits, and perceptions via an online survey. Additionally, it explored the gendered nature of true crime podcast consumption. A total of N = 657 participants completed the survey providing information about why they listen to true crime podcasts, how often they listen, and how …

Formulation Development And Characterization Of Isoniazid-Pyridoxine Combination Gummies Using An Extrusion-Based 3d Printer, Aditi Rajendra Holkunde

Electronic Theses and Dissertations

This study aimed to formulate and evaluate Isoniazid-Pyridoxine-loaded gummies for use in a population ranging from pediatric to geriatric and to study the applicability of BIO X 3D printer in printing gummy formulations. Semisolid extrusion (SSE) 3D printing is an emerging technology in personalized medicine. To address clinical multi-dose requirements, SSE has been explored to manufacture new preparations. In this study, Isoniazid (INH) and Pyridoxine Hydrochloride (PDX) were used to make gummy formulations for use in the treatment of Tuberculosis. A suitable semisolid mixture for SSE was prepared and incorporated into the BIO X 3D printer for extrusion-based 3D printing …

Mapping In/Exclusion: Queer Identity In Oxford, Mississippi, Julia Kraus

Electronic Theses and Dissertations

This thesis employs a mixed methods approach to investigate LGBTQ communities in Oxford, Mississippi, within the unique context of the Bible Belt panopticon. Through an examination of the Unitarian Universalist Congregation of Oxford (UUCO) and Oxford Pride, the study delves into the themes of visibility and surveillance, resistance and subversion, community and identity, and institutional interactions and impacts. The research is grounded in seven original interviews with UUCO members, providing nuanced insights into the functioning of LGBTQ communities within a conservative environment. Additionally, the creation of a podcast episode titled “Queering Oxford: the Long Path to Pride” offers an innovative …

Moderation In Online Incel Forums: A Comparison Of Warning Behaviors, Katherine Elizabeth Norris

Electronic Theses and Dissertations

Incels constitute an online community characterized by shared negative perspectives concerning masculinity, women, and societal norms. Platforms such as Twitter and Reddit have implemented content moderation measures aimed at curtailing the dissemination of incels' ideologies, which often promote violence and suicidal ideation. To observe the influence of content moderation on incel discourse, this study examined posts from two distinct incel forums: one subject to moderation and another without such restrictions. Employing thematic analysis, common themes within the posts were identified, and the occurrence of negative language was quantitatively assessed. Findings revealed that the moderated forum exhibited a higher prevalence of …

From Likes To Looks: The Relationship Between Tiktok Use And Body Satisfaction In A Young Adult Population, Madeline Pruett

Electronic Theses and Dissertations

Body dissatisfaction is becoming an increasingly pervasive problem among young adults, presenting severe implications including the onset of eating disorders and related behaviors. This alarming trend can be attributed, at least in part, to the ubiquity and influence of social media platforms, which serve as a modern catalyst for appearance pressures. While there is a substantial body of research establishing the connection between body dissatisfaction and traditional social media, the examination of newer platforms like TikTok, which have become highly popular among young adults, remains limited. As such, the present study aimed to bridge this gap by investigating the relationship …

Listening To The Voices Of Educators In The Implementation Of The Mississippi Seal Of Biliteracy, Rosalynn Vásquez Rutland

Electronic Theses and Dissertations

The Mississippi Department of Education adopted the Mississippi Seal of Biliteracy in 2019 changing our state’s educational language policy from English-only to English-plus another world language, elevating Spanish and other world languages to a status closer to English in the districts that the seal has been adopted. This study documents the perspectives held by Mississippi educators on the benefits, new practices, challenges, and policy perception of the Mississippi Seal of Biliteracy at a high school that has adopted the seal and one that has not. Due to the difference in sample sizes between schools, this study is a generalization of …

Does Unilateral High-Load Training Augment Strength Change In The Contralateral Arm Undergoing The Same High-Load Training Via The Cross-Education Effect?, Jun Seob Song

Electronic Theses and Dissertations

Purpose: To 1) investigate whether the cross-education effect from high-load training can augment the strength changes in the opposite arm undergoing the same training; 2) examine if the cross education of strength depends on limb dominance; and 3) examine if the cross-education of strength can be translated to increases in muscular endurance.

Methods: 160 participants were randomized into high-load training on both the dominant and non-dominant arm (D+ND), training on the dominant arm only (D-Only), training on the non-dominant arm only (ND-Only), and non-exercise control (CON). All training groups completed 18 sessions of high-load resistance exercise, with pre- and post-testing …

Development Of Multiple Dosage Forms Using Fused Deposition Modeling 3d Printing Coupled With Hot-Melt Extrusion Dissertation, Peilun Zhang

Electronic Theses and Dissertations

This dissertation explores the integration of Hot Melt Extrusion (HME) and Fused Deposition Modeling (FDM) 3D printing as a novel continuous manufacturing process for pharmaceutical dosage forms. Emphasizing the creation of personalized and complex drug delivery systems, this work highlights the potential of 3D printing technology in revolutionizing pharmaceutical manufacturing by offering customized dosage, precise API distribution, and efficient production with minimal waste. The first chapter delves into the fabrication of bilayer tablets utilizing HME in conjunction with dual-nozzle FDM 3D printing, examining the mechanical properties of HME filaments and the printing quality through a novel 3D printed tablet retention …

Molecular Modeling Of Inhibitors Of Severe Acute Respiratory Syndrome Coronavirus 2 And Urinary Tract Infections, Priyanka Samanta

Electronic Theses and Dissertations

Infectious diseases are the leading cause of disability-adjusted life years worldwide. Glycans initiate host–pathogen interactions in two particular infectious diseases, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and urinary tract infections (UTIs). In this work, recent advances of computational tools in drug design are utilized to target these glycanspecific host–pathogen interactions for the potential prevention of SARS-CoV-2 or UTIs.

SARS-CoV-2 viral entry into the host cell is mediated by the viral S-protein. Carbohydrate molecules bind to the receptor-binding domain (RBD) of the S-protein which interacts with angiotensin-converting enzyme 2 and leads to host cell invasion. Here we report computational studies …

English Language Teachers’ Perspective On The Applicability Of The Language Assessment Frameworks Used In Saudi Arabian Universities, Asmahan Ghazi Alqahtani

Electronic Theses and Dissertations

This study investigates English language assessment practices in Saudi Arabian universities from the perspectives of English language teachers. It explores how ESL teachers perceive the applicability of assessment frameworks provided by policymakers in higher education. Guided by concepts of Language Assessment Literacy, the study examines the roles and practices of various stakeholders in language assessment, the principles and concepts guiding these practices, and the awareness of the social contexts in which language assessment takes place. In Saudi Arabia, research on language assessment is needed due to the limited attention given to assessment and testing issues, and the minimal involvement of …

Impact Of Graphene Nanoplatelets On The Fresh, Static, And Dynamic Properties Of Cement Paste, Bassil Bataineh

Electronic Theses and Dissertations

The construction industry is constantly in pursuit of innovative materials and methods to boost the performance and sustainability of concrete. This thesis examines the impact of graphene nanoplatelets (GNPs) on the fresh, static, and dynamic properties of cement paste, positioning GNPs as a potential groundbreaking material. Systematic experiments were conducted to evaluate various concentrations of GNPs and their combinations with polycarboxylate ether (PCE SP) surfactant, analyzing their effects on workability, setting time, and mechanical strength. The research methodology was robust, integrating experimental design, comprehensive data analysis, and a thorough review of the relevant literature.

Creating A Caring, Accountable, Respectable, And Engaging Environment (2care2): An Applied Research Study To Address Chronic Absenteeism, Eula Anderson

Electronic Theses and Dissertations

In this study, I will explore some of the root causes behind middle school students' failure to attend class. Data shows that students are labeled chronically absent when they miss more than 10% of a school year, regardless of the absences- expelled, unexcused, or suspended. According to the U.S. Department of Education, about seven million students were labeled chronically absent in the 2015-16 school year, equating to roughly one out of every six students across the United States being absent for 15 or more days. The problem exists nationwide; however, it is more prominent in urban areas with low socioeconomic …

A Case For Digital Coaches, Elise Brown

Electronic Theses and Dissertations

In response to COVID-19, the Mississippi Department of Education (MDE) invested approximately $295 million to support digital learning efforts. This investment, referred to as the Mississippi Connects Initiative, funded state level infrastructure improvement, bulk device purchasing, digital subscription purchasing, telehealth and teletherapy resources, and professional learning for educators. Focusing on professional learning, this study aimed to determine if differences existed between schools that did and did not receive professional learning via the digital learning coaching program.

The data used in this study was collected in the spring of the 2021-2022 and 2022-2023 school years, using the BrightBytes® Technology and Learning …

North Ms Foodrx Farm-To-Farmacy: A Home Delivery Local Food Prescription Model, Cameron De'cal Brown

Electronic Theses and Dissertations

This portfolio presents a comprehensive overview of my contributions and involvement in the Farm-to-Farmacy (FTF) program model. Farm-to-Farmacy is an extension of the FoodRx program which aims to address food insecurity in rural parts of North Mississippi. This program was inspired by the 2019 FoodRx program in the Mississippi Delta that assisted in delivering fresh produce to the doorsteps of the elderly and homebound. Farm-to-Farmacy incorporates a unique approach by soliciting the support of local farmers which assists in sustainability for a program of this stature but also supports community engagement and involvement. The Farm-to-Farmacy program relies on local farmers …

Vascular Adaptations To Single Sprint Training, Matthew Alexander Chatlaong

Electronic Theses and Dissertations

Background: Recent sprint interval training studies suggest cardiorespiratory fitness improves after training with 2 x 20s but not 1 x 20s. While insufficient for improving whole-body cardiorespiratory fitness, vascular function or other components of cardiorespiratory fitness may improve. It is unknown if brief intense exercise bouts are sufficient for improvements in these outcomes. This initial exploratory work investigated these outcomes to facilitate future research in this area. Purpose: Investigate changes in micro- and macro-vascular function in young, untrained adults following 4-weeks of single sprint training. Methods: 46 healthy, untrained participants ages 18-35 were allocated to either a training or time-matched …

Advancing Diversity, Equity, And Inclusion: A Graduate Portfolio On Lebonheur Children's Hospital Initiatives, James Lee Hawkins

Electronic Theses and Dissertations

In every facet of life, diversity finds a way to play a role. By advocating for, acknowledging, and drawing attention to the disparities that emerge within the various spaces people may encounter, we consciously strive to bridge the gap, aiming for a future that is more equitable and inclusive. Diversity, equity, and inclusion (DEI) have not only become personal moral imperatives but also essential pillars at the forefront for companies, healthcare, educational institutions, and businesses alike.

A Quantitative Study Of The Effectiveness Of The University Of Mississippi's Biology Bootcamp, Nicole Lewis

Electronic Theses and Dissertations

There is a growing demand for a Science, Technology, Engineering, and Mathematics (STEM) trained workforce in the United States. In order to remain globally competitive, the US needs to increase the STEM workforce not only in numbers but also diversity. Colleges and universities throughout the US need to not only gain STEM majors but retain them through graduation. Research has shown that the majority of STEM students struggle their first year in college for a variety of reasons. Many academics agree that incoming freshman need to integrate both socially and academically to prevent attrition. This has led to the creation …

The Effects Of High School Scheduling Models On Student Achievement In Mississippi, Dustin Ryan Payne

Electronic Theses and Dissertations

This study investigates the effects of different high school scheduling practices on student achievement in Mississippi, considering school economic status as a covariate. Using a robust factorial ANOVA design, the research analyzes reading proficiency, math proficiency, and Mississippi Statewide Accountability System school performance scores across 149 public high schools, excluding those with grades other than 9 through 12, private schools, and charter schools. The primary goal was to determine whether schedule type significantly influences academic performance, independent of economic status. Results indicate that while economic status consistently affects student and school performance, schedule type alone does not show a statistically …

Synchronous, Asynchronous, Or Neither: Examining The Effects Of A Single-Session Prevention Program On Student Mental Health, Katelyn M. Sharpe

Electronic Theses and Dissertations

Young adults (aged 18-25) were identified as the most stressed age group due to internal and external factors that are relatively unique to their group. High stress levels are alarming as they coincide with a multitude of adverse effects on psychological health, including difficulty falling and staying asleep, reduction in overall sleep quality, and exacerbated depression and anxiety symptomatology. Young adults attending post-secondary education institutions are at particular risk for developing and maintaining these adverse psychological effects of stress, especially considering the low rate in which they seek treatment for psychiatric difficulties. Limited literature exists to date regarding condensing a …

Combatting Suicidality In The Military: Harnessing Forgiveness And Self-Regulation Against The Harrowing Effects Of Moral Injury And Suicidality, Mikaela J. Raley

Electronic Theses and Dissertations

Individuals with military backgrounds are significantly more likely to experience mental health concerns, including suicidal ideation. Moral injury, which is associated with suicidality, is the feeling of shame, grief, and guilt associated with perpetrating, failing to prevent, or witnessing morally transgressive acts. According to the Moral Injury Model, when one acts or witnesses an act that transgresses their moral beliefs, they experience dissonance and internal conflict. A topic that has not yet been studied in terms of moral injury is the positive psychology construct of character strengths, including forgiveness and self-regulation. This study hypothesized ratings of suicide would be positively …

Evolving To Abstraction - Seclusion Of Efik And Ibibio Women From The Precolonial Era To The Present, Itunuoluwa Williams

Electronic Theses and Dissertations

Female seclusion was an important cultural practice to the Efik and Ibibio peoples in southernmost Nigeria. Before the advent of Western education in the precolonial and colonial eras, it was particularly essential to the development of the girl child as she received a first-rate education and preparation for maturity, marriage, and motherhood. However, despite its crucial role in both cultural societies, studies on the Efik and Ibibio female seclusion cultures are far and in-between. Furthermore, the nkuho and mbopo – as they are called in Efik and Ibibio respectively – are often analyzed and presented as one singular entity, in …

Dunc13 Isoforms, Rim, And Rab3 Differentially Modulate Ethanol Sedation Sensitivity In Drosophila Melanogaster., Gaurav Shrestha

Electronic Theses and Dissertations

Dunc13 is a Drosophila active zone protein homologous to the mammalian Munc13that interacts with RIM and Rab3 as a heterotrimer. Alcohol binds to the C1 domain of Dunc13/Munc13 and inhibits its ability to bind to Diacylglycerol, inhibiting neuronal signaling. The genetic reduction of Dunc13 activity in the Dunc13P84200/+ heterozygotes induces a state in flies that mimics alcohol tolerance, evidenced by increased self-administration, and behavioral, physiological, and molecular resistance. This includes changes in the expression of key synaptic proteins, such as decreased expression of Dunc13 and Syb mRNA, and increased expression of Rim and Rab3 4hrs after ethanol exposure. Dunc13 has …

Mental Health In Rural Mississippi Counties: Experiences And Beliefs Of African American Pastors, Angela R. Adams

Electronic Theses and Dissertations

African Americans seek formal mental health treatment services at lower rates than white Americans (Substance Abuse and Mental Health Services Administration [SAMHSA], 2024) and higher risk of mental illness exists among rural African Americans (Haynes et al., 2017). Religiousness and spirituality have emerged as widely utilized coping methods among African Americans, therefore it is important to understand pastoral perspectives on mental health. In addition to the type of services being sought, the decision to seek help plays an important role in treatment utilization. Along these lines, two theoretical frameworks were used to formulate this study, the Theory of Planned Behavior …

3d-Printed Clay Composites For Lunar Habitats: Graphene And Simulant Integration, Omar Algharibeh

Electronic Theses and Dissertations

Developing sustainable construction materials for lunar habitats is critical for advancing extraterrestrial exploration, supporting a long-term human presence on the Moon, and advancing earth-based, resilient, locally available resources. Our primary goal is to utilize indigenous resource-based construction materials and 3D printing technology to reduce payloads and streamline the materials processing procedures. Additionally, enhancing the performance of native binding materials, such as those formed from local rocks and sand, may require the integration of low-cost nano-additives. These nano-additives can significantly improve the fresh and hardened properties of 3D-printed construction materials. This research focused on optimizing the mechanical performance of a clay …

Linguistic Gender Differences In English Among Saudi Medical Students In Online Courses, Ala Mohammed Alshahrani

Electronic Theses and Dissertations

This qualitative research explores gender differences in language use among Saudi medical students in online courses. Employing purposive sampling, the study, aims to comprehend the influence of gender on language patterns and communication styles in online education. Data collection involves online interviews with five teachers and survey questionnaires administered to twenty actively enrolled Saudi medical students. The interviews provide insights into language use patterns in the online learning environment, while surveys offer a broader perspective on student language use. Thematic analysis unveils recurring themes: “courses developed,” “reasons for online courses,” “interaction among male and female students in online courses,” “comfort …