Digital Commons Network^™

An Education Beyond Campus, Bill Dabney

University of Mississippi News

Gift helps students study abroad, supports national, international internships

After 100 Years: Still Making A Joyful Noise, Edwin B. Smith

University of Mississippi News

UM Jazz Ensemble celebrating centennial anniversary with Dec. 8 concert in Natchez

After 100 Years: Still Making A Joyful Noise, Edwin B. Smith

University of Mississippi News

UM Jazz Ensemble celebrating centennial anniversary with Dec. 8 concert in Natchez

Bioassay-Guided Fractionation With Antimalarial And Antimicrobial Activities Of Paeonia Officinalis, Mamdouh Nabil Samy, Basma Khalaf Mahmoud, Nourhan Hisham Shady, Usama Ramadan Abdelmohsen

Faculty and Student Publications

Bioassay-guided fractionation technique of roots of Paeonia officinalis led to isolation and structure elucidation of seven known compounds, including four monoterpene glycosides: lactiflorin (1), paeoniflorin (4), galloyl paeoniflorin (5), and (Z)-(1S,5R)-β-pinen-10-yl β-vicianoside (7); two phenolics: benzoic acid (2) and methyl gallate (3); and one sterol glycoside: β-sitosterol 3-O-β-D-glucopyranoside (6). The different fractions and the isolated compounds were evaluated for their antimicrobial and antimalarial activities. Fraction II and III showed antifungal activity against Candida neoformans with IC50 values of 28.11 and 74.37 µg/mL, respectively, compared with the standard fluconazole (IC50 = 4.68 µg/mL), and antibacterial potential against Pseudomonas aeruginosa (IC50 = …

Discovery Of A Lectin Domain That Regulates Enzyme Activity In Mouse N-Acetylglucosaminyltransferase-Iva (Mgat4a), Masamichi Nagae, Tetsuya Hirata, Hiroaki Tateno, Sushil K. Mishra

Faculty and Student Publications

N-Glycosylation is a common post-translational modification, and the number of GlcNAc branches in N-glycans impacts glycoprotein functions. N-Acetylglucosaminyltransferase-IVa (GnT-IVa, also designated as MGAT4A) forms a β1-4 GlcNAc branch on the α1-3 mannose arm in N-glycans. Downregulation or loss of GnT-IVa causes diabetic phenotypes by dysregulating glucose transporter-2 in pancreatic β-cells. Despite the physiological importance of GnT-IVa, its structure and catalytic mechanism are poorly understood. Here, we identify the lectin domain in mouse GnT-IVa’s C-terminal region. The crystal structure of the lectin domain shows structural similarity to a bacterial GlcNAc-binding lectin. Comprehensive glycan binding assay using 157 glycans and solution NMR …

Validated Determination Of Nrg1 Ig-Like Domain Structure By Mass Spectrometry Coupled With Computational Modeling, Niloofar Abolhasani Khaje, Alexander Eletsky, Sarah E. Biehn, Charles K. Mobley

Faculty and Student Publications

High resolution hydroxyl radical protein footprinting (HR-HRPF) is a mass spectrometry-based method that measures the solvent exposure of multiple amino acids in a single experiment, offering constraints for experimentally informed computational modeling. HR-HRPF-based modeling has previously been used to accurately model the structure of proteins of known structure, but the technique has never been used to determine the structure of a protein of unknown structure. Here, we present the use of HR-HRPF-based modeling to determine the structure of the Ig-like domain of NRG1, a protein with no close homolog of known structure. Independent determination of the protein structure by both …

A Distinct Mechanism Of C-Type Inactivation In The Kv-Like Kcsa Mutant E71v, Ahmed Rohaim, Bram J. A. Vermeulen, Jing Li, Felix Kümmerer

Faculty and Student Publications

C-type inactivation is of great physiological importance in voltage-activated K+ channels (Kv), but its structural basis remains unresolved. Knowledge about C-type inactivation has been largely deduced from the bacterial K+ channel KcsA, whose selectivity filter constricts under inactivating conditions. However, the filter is highly sensitive to its molecular environment, which is different in Kv channels than in KcsA. In particular, a glutamic acid residue at position 71 along the pore helix in KcsA is substituted by a valine conserved in most Kv channels, suggesting that this side chain is a molecular determinant of function. Here, a combination of X-ray crystallography, …

Experimental Identification Of Aminomethanol (Nh2ch2oh)—The Key Intermediate In The Strecker Synthesis, Santosh K. Singh, Cheng Zhu, Jesse La Jeunesse, Ryan C. Fortenberry, Ralf I. Kaiser

Faculty and Student Publications

The Strecker Synthesis of (a)chiral α-amino acids from simple organic compounds, such as ammonia (NH3), aldehydes (RCHO), and hydrogen cyanide (HCN) has been recognized as a viable route to amino acids on primordial earth. However, preparation and isolation of the simplest hemiaminal intermediate – the aminomethanol (NH2CH2OH)– formed in the Strecker Synthesis to even the simplest amino acid glycine (H2NCH2COOH) has been elusive. Here, we report the identification of aminomethanol prepared in low-temperature methylamine (CH3NH2) – oxygen (O2) ices upon exposure to energetic electrons. Isomer-selective photoionization time-of-flight mass spectrometry (PI-ReTOF-MS) facilitated the gas phase detection of aminomethanol during the temperature …

Shared Genomic Architectures Of Covid-19 And Antisocial Behavior, Charleen D. Adams, Jorim J. Tielbeek, Brian B. Boutwell

Faculty and Student Publications

Little is known about the genetics of norm violation and aggression in relation to coronavirus disease 2019 (COVID-19). To investigate this, we used summary statistics from genome-wide association studies and linkage disequilibrium score regression to calculate a matrix of genetic correlations (rgs) for antisocial behavior (ASB), COVID-19, and various health and behavioral traits. After false-discovery rate correction, ASB was genetically correlated with COVID-19 (rg = 0.51; P = 1.54E-02) and 19 other traits. ASB and COVID-19 were both positively genetically correlated with having a noisy workplace, doing heavy manual labor, chronic obstructive pulmonary disease, and genitourinary diseases. ASB and COVID-19 …

Issue 408: December 1-15, 2022, The Local Voice

The Local Voice

No abstract provided.

South-To-North Migration Preceded The Advent Of Intensive Farming In The Maya Region, Douglas J. Kennett, Mark Lipson, Keith M. Prufer, David Mora-Marín, Richard J. George, Nadin Rohland, Mark Robinson, Willa R. Trask, Heather H. J. Edgar, Ethan C. Hill, Erin E. Ray, Paige Lynch, Emily Moes, Lexi O’Donnell, Thomas K. Harper, Emily J. Kate, Josue Ramos, John Morris, Said M. Gutierrez

Faculty and Student Publications

The genetic prehistory of human populations in Central America is largely unexplored leaving an important gap in our knowledge of the global expansion of humans. We report genome-wide ancient DNA data for a transect of twenty individuals from two Belize rock-shelters dating between 9,600-3,700 calibrated radiocarbon years before present (cal. BP). The oldest individuals (9,600-7,300 cal. BP) descend from an Early Holocene Native American lineage with only distant relatedness to present-day Mesoamericans, including Mayan-speaking populations. After ~5,600 cal. BP a previously unknown human dispersal from the south made a major demographic impact on the region, contributing more than 50% of …

Scholarship Program Gains New Chair, Member, Jonathan Scott

University of Mississippi News

No abstract provided.

University Expands Research Integrity And Compliance Efforts, Gaye Swan

University of Mississippi News

Marta Panickar joins administration as inaugural director of research security

Pcaob Standards And Related Rules As Of December 2022, Public Company Accounting Oversight Board, American Institute Of Certified Public Accountants (Aicpa)

AICPA Professional Standards

No abstract provided.

Money Moves: An Analysis Of Chinese Foreign Direct Investment In Europe, Susan Soh

Honors Theses

In recent years, China has begun engaging in outward foreign direct investment (FDI). There is a significant amount of literature dedicated to understanding China’s FDI in developing nations. However, very little research has been conducted over Chinese FDI in advanced economies. As a result of this gap in existing literature, the question arises, what explains Chinese FDI in Europe?

As FDI is a transaction to which both the donor and recipient countries must agree, this thesis has a dual focus. One chapter of the thesis analyzes the effects of and motivations for Chinese FDI on European nations. In this chapter, …

The Next Arms Race And The Unknown Frontier Of Outer Space: The Conceptual Challenges For International Law And Space Weaponization, Rebecca Connolly, Aine Bennett

Journal of Space Law

No abstract provided.

Space Arbitration And Harmful Interference Disputes, Laura Yvonne Zielinski

Journal of Space Law

No abstract provided.

Satellite Data And Imagery As Evidence, Ronald J. Rychlak, Sean Patrick Taylor

Journal of Space Law

No abstract provided.

The Development Of Labor Law In Outer Space: A Comparison With The American Frontier And The High Seas, Connor Hogan

Journal of Space Law

No abstract provided.

Avoiding Conflict In Asteroid Resource Extraction, Gregory Radisic, Connor Haffey

Journal of Space Law

No abstract provided.

December 1, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

University Expanding Food Rx Program, Edwin B. Smith

University of Mississippi News

USDA awards $500K to assist with providing food for Quitman County residents

University Expanding Food Rx Program, Edwin B. Smith

University of Mississippi News

USDA awards $500K to assist with providing food for Quitman County residents

Professor To Advocate For Young Nutrition Professionals, Reese Colaluca

University of Mississippi News

Nadeeja Wijayatunga appointed to board of directors for the American Society of Nutrition

Museum Unveils 2022 Keepsake Ornament, Edwin B. Smith

University of Mississippi News

No abstract provided.

Reese Honored As Emerging Young Philanthropist, Jonathan Scott

University of Mississippi News

No abstract provided.

Indirectly And Directly Involved Students' Perspectives On Multi-Modal Communication Treatment In Persons With Aphasia, Emily Lewis

Honors Theses

Our study investigated the perspectives of students who were either directly or indirectly involved in the Multi-modal communication treatment (MCT) sessions for persons with aphasia. Two undergraduate and two graduate students were recruited from the University of Mississippi who participated in the MCT sessions. We collected their perspectives through semi-structured interviews and used thematic qualitative analysis to analyze our data. We reported themes from the indirectly involved students and the directly involved students and compared how the themes were similar and different between the indirectly and directly involved students. We discussed that both direct and indirect experience for clinical therapy …

Donations Sought For 25th Annual Books And Bears Program, Edwin B. Smith

University of Mississippi News

UM community asked to donate items for Facilities Management employees' children

From Old School To New School, Andy Belt

University of Mississippi News

Rivers gift goes toward state-of-the-art accountancy building

Top Croft Students Awarded Scholarships, Erin Garrett

University of Mississippi News

Institute celebrates 25 years of supporting international studies majors