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Articles 31 - 60 of 89
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Population Genetics Of The Giant Red Centipede Along The Appalachian Mountains, Kayla Elayne Ladner
Population Genetics Of The Giant Red Centipede Along The Appalachian Mountains, Kayla Elayne Ladner
Honors Theses
This study focused on population genetics of the giant red centipede, Scolopocryptops sexpinousus, in the Southern Appalachian Mountains. Two genetic markers were used—the mitochondrial COI gene, and the nuclear RNA Polymerase II gene. The goal of this study was to determine how many genetically distinct populations of this invertebrate species exist within the study area, and to understand the spatial distribution of genetic diversity within and among populations. I hypothesized several genetically distinct populations of S. sexpinosus would be detected because the complex topographic characteristics and historical climate cycles of the region are thought to limit movement of many forest …
Validation Of Integrated Coast-Ocean Model Cche2d-Coast And Development Of Wind Model, Afshin Gazerzadeh
Validation Of Integrated Coast-Ocean Model Cche2d-Coast And Development Of Wind Model, Afshin Gazerzadeh
Electronic Theses and Dissertations
The eastern and southern coastlines of the United States are two of the most cyclone-prone areas of the world. The effects of tropical cyclones vary mainly depending on wind intensity and geological features of the coast that it is crossing. Higher winds potentially generate higher storm surges and consequently larger floods occur along the coastlines. Therefore, it is critical to accurately predict winds, storm surge, and waves associated with a hurricane. In the present study, an integrated coastal and ocean process model, CCHE2D-Coast, is validated by assessing the model’s capabilities in simulating coast-ocean circulations driven by the astronomical tides on …
Optimizing Rna Extraction From Fungal-Algal Tissues For Transcriptomic Gene Expression Analysis, Michael J. Hohl
Optimizing Rna Extraction From Fungal-Algal Tissues For Transcriptomic Gene Expression Analysis, Michael J. Hohl
Honors Theses
Extracting high-quality RNA is critical for downstream applications such a qRT-PCR and RNA-Seq based transcriptomics. Single-stranded RNA is readily susceptible to degradation by environmental RNases, necessitating rapid and sterile homogenization techniques; freezing at -80°C, lysis buffer addition, and short bursts of beadbeating have been shown to increase yields and quality of extracted RNA. Utilizing fungal-algal tissues from the model symbiosis between the filamentous fungi Aspergillus nidulans and the green alga Chlamydomonas reinhardtii, three different commercial homogenizers and six RNA extractions kits were assessed and an optimized extraction protocol for total RNA from fungal-algal tissues was determined. Using the protocol designed …
Terpenes And Flavonoids From Salvia Apiana And Their Affinities To Cannabinoid And Opioid Receptors, Taylor Hayes
Terpenes And Flavonoids From Salvia Apiana And Their Affinities To Cannabinoid And Opioid Receptors, Taylor Hayes
Honors Theses
Salvia apiana (white sage, Lamiacae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper respiratory infections, and poison oak rashes. Native Americans widely used this plant in traditional Chumash healing. Infusion of the leaves is used as a diaphoretic and diuretic. The aqueous ethanolic extract of S. apiana showed moderate activity towards the CB1 receptor (58.3% displacement). The extract was fractionated on …
Sarah Liljegren Honored With Nsf Career Award, Edwin Smith
Sarah Liljegren Honored With Nsf Career Award, Edwin Smith
University of Mississippi News
Associate professor of biology is sixth faculty member to receive the prestigious funding
Research News. Publications, 2015. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Research News. Publications, 2015. Volume 1, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period January 1 through June 30, 2015
The Dimerization Kinetics Of Ncad12 With A Mutated Cis-X-Pro Bond, Victoria Mcclearn
The Dimerization Kinetics Of Ncad12 With A Mutated Cis-X-Pro Bond, Victoria Mcclearn
Honors Theses
VICTORIA RAE McCLEARN: DIMERIZATION KINECTICS OF NCAD12 P16A (Under the direction Dr. Susan Pedigo) Calcium binding causes a conformational change into a strand swapped dimer for the cadherins. However, regardless of the sequence similarity for Epithelial Cadherin (ECAD) and Neural Cadherin (NCAD), they respond to the presence of calcium differently. For NCAD, the rate of assembly and disassembly depends upon the presence of calcium, whereas for ECAD the rate of exchange is independent of calcium. Studies into a kinetic model to explain the differences between the rates have been recently conducted. It is believed that ECAD uses an X-dimer intermediate …
Mercury Methylation Potentials In Sediments An Ancient Cypress Wetland Using Species-Specific Isotope Dilution-Gc-Icp-Ms: Analytical Method Development And The Effect Of Sorbent Amendments, Derek Davin Bussan
Electronic Theses and Dissertations
A novel method was developed to measure mercury (Hg) directly in environmental solids using inductively coupled plasma mass spectrometry (ICP-MS) with online sample ashing. The method combines a direct mercury analyzer (DMA) that is based on sample combustion, Hg pre-concentration by amalgamation with gold, and atomic absorption spectrometry (AAS), with a high resolution ICP-MS. Unlike AAS, the ICP-MS is capable of individual isotope measurements allowing for accurate quantitation by isotope dilution mass spectrometry (IDMS) and for isotope tracer experiments. The method was validated using certified reference materials including sediment (NIST 2709), leaves (NIST 1547), and fish-muscle (DORM-3), with recoveries within …
Cranberry Metabolites With Urinary Anti-Adhesion Activity, Christina M. Coleman
Cranberry Metabolites With Urinary Anti-Adhesion Activity, Christina M. Coleman
Electronic Theses and Dissertations
The fruit of the American cranberry (Vaccinium macrocarpon Aiton, Ericaceae) is a comfood and a top selling dietary supplement in the U.S. Cranberry juice is traditionally used for the prevention of urinary tract infections (UTIs), many of which are caused by P-fimbriated Escherichia coli. Human urine produced after cranberry juice consumption can prevent E. coli adhesion, but the urinary metabolites responsible for this activity are currently not known. High-molecular weight components of cranberry juice, specifically proanthocyanidin oligomers (PACs), are currently believed to be responsible for the ability of cranberry juice to prevent UTIs. Cranberry PACs can prevent the adherence of …
Structure, Synthesis And Biological Activity Of Harmful Algal Bloom Toxins From Karlodinium Sp. And Exploration Of Microbial Derived Natural Products, Amanda Leigh Waters
Structure, Synthesis And Biological Activity Of Harmful Algal Bloom Toxins From Karlodinium Sp. And Exploration Of Microbial Derived Natural Products, Amanda Leigh Waters
Electronic Theses and Dissertations
This work features natural products isolated from both the marine and microbial environments. Part I focuses on the elucidation of toxins from harmful algal blooms (HAB). The HAB dinoflagellate Karlodinium veneficum produces a harmful suite of molecules identified as the karlotoxins (KmTx) that have been implicated in massive fish kills pan-globally. Nine new karlotoxin congeners were isolated from various Karlodinium blooms around the world and utilizing the structure of KmTx2 were characterized using overlaid 2D NMR techniques. Due to the contrasting conformational differences between KmTx and the closely related amphidinols, the absolute configuration of KmTx was further evaluated by extensive …
Geostatistical Analysis Of Arsenic In Soils At The University Of Mississippi Field Station., Elsie Ekene Okoye
Geostatistical Analysis Of Arsenic In Soils At The University Of Mississippi Field Station., Elsie Ekene Okoye
Honors Theses
Arsenic is pervasive throughout North Mississippi’s soils (Pettry and Switzer, 2001; Fordham and Norrish, 1983 and; Kaiser and Guggenberger, 2003). This is largely due to the use of pesticides and herbicides in past and present years, as arsenic is a fundamental component in chemicals used for agricultural purposes. Soils contaminated with arsenic present a serious hazard to human health due to the possibility of contaminating surface and groundwater, as well as food through plant uptake of arsenic. Consequently, it is important to understand the process and effects of arsenic absorption in soil. The focus of this research is on the …
Method Development Using Laser Ablation And Solution Icpms And Their Application In Environmental Science And Forensic Provenance Studies, Kaixuan Bu
Electronic Theses and Dissertations
Inductively coupled plasma mass spectrometry (ICPMS) is an analytical technique that can be used to determine multiple elements and isotope ratios in a wide variety of samples. In this work, four projects are described that involve the method development using laser ablation (LA) and solution-based ICPMS and their application in environmental science and forensic (provenance) investigations. In the first project, plutonium (Pu) concentrations and 240Pu/ 239Pu atom ratios were measured in kelp, lichen, aquatic moss, and horse mussel collected on or near Amchitka Island, a former nuclear test in Alaska, and at a background site. The Pu in terrestrial and …
Phytochemical Studies On The Medicinal Plant Sutherlandia Frutescens, Xiang Fu
Phytochemical Studies On The Medicinal Plant Sutherlandia Frutescens, Xiang Fu
Electronic Theses and Dissertations
Sutherlandia frutescens (L.) R. Br (Fabaceae) is a multipurpose medicinal plant with diverse biological activities, and has been widely used for the treatment of cancer, AIDS, diabetes, and infectious diseases in southern Africa. The primary goal of this study was to investigate the chemical constituents of S. frutescens and develop an analytical method to analyze this plant and the dietary supplements derived from this plant. The dissertation is composed of six chapters. Chapter 1 introduces the general background of S. frutescens, including traditional uses and chemical and biological studies on the plant. Chapter 2 describes the phytochemical studies that have …
Isolation, Structure Elucidation And Biological Evaluation Of Natural Products From Plants And Fungi, Xiaoning Wang
Isolation, Structure Elucidation And Biological Evaluation Of Natural Products From Plants And Fungi, Xiaoning Wang
Electronic Theses and Dissertations
Natural products have provided considerable value for drug discovery over the past half-century. Nearly four fifth of drugs were natural products or inspired by natural compounds. Bioactive secondary metabolites isolated from natural source, either fungal or terrestrial, are relatively safer for human health and the environment and can serve as drug or as drug leads for the development of synthetic or semi-synthetic analogs. Natural products have also been successfully used in agriculture as plant growth regulators, signal transductions, fungicides, herbicides and tranquilizers. In our continued efforts to identify bioactive compounds, seventy-seven plant and fungal extracts were evaluated using a direct-bioautography …
Discovery Of Novel Glycogen Synthase Kinase-3beta Inhibitors: Molecular Modeling, Virtual Screening, And Biological Evaluation, Gang Fu
Electronic Theses and Dissertations
Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine protein kinase which is engaged in a variety of signaling pathways, regulating a wide range of cellular processes. Due to its distinct regulation mechanism and unique substrate specificity in the molecular pathogenesis of human diseases, GSK-3 is one of the most attractive therapeutic targets for the unmet treatment of pathologies, including type-II diabetes, cancers, inflammation, and neurodegenerative disease. Recent advances in drug discovery targeting GSK-3 involved extensive computational modeling techniques. Both ligand/structure-based approaches have been well explored to design ATP-competitive inhibitors. Molecular modeling plus dynamics simulations can provide insight into the protein-substrate …
Design, Synthesis, Biological Evaluation And Metabolic Stability Studies Of Sigma Receptor Ligands, Rohit Bhat
Design, Synthesis, Biological Evaluation And Metabolic Stability Studies Of Sigma Receptor Ligands, Rohit Bhat
Electronic Theses and Dissertations
Sigma receptors represent a unique family of proteins that includes two subtypes: sigma-1 and sigma-2. Sigma-1 receptors have been implicated in the behavioral and motivational effects of psychostimulants as well as in the pathophysiology of depression and Alzheimer's disease. Sigma-2 receptors are widely expressed on many tumor cells and they are believed to play an important role in tumor cell proliferation. Therefore, sigma receptors are attractive targets for developing pharmaceutical agents directed to the treatment of psychostimulant abuse, cancer, Alzheimer's disease as well as diagnostic agents for cancer and brain imaging. A derivatized 2(3H)-benzothiazolone, (3-(2-(azepan-1-yl)ethyl)-6-propylbenzo[ d]thiazol-2(3H)-one) was reported to have …
Molecular Details Of The Catalytic Activity Of Carboxylesterases, Xiaozhen Yu
Molecular Details Of The Catalytic Activity Of Carboxylesterases, Xiaozhen Yu
Electronic Theses and Dissertations
Carboxylesterases (CEs; EC 3.1.1.1) are ubiquitous enzymes responsible for the detoxification of xenobiotics. CEs hydrolyze carboxyl esters into their corresponding alcohol and carboxylic acid. Because of their biological functions, especially their roles in converting inactive prodrugs, such as the anti-cancer drug CPT-11, to their active metabolites, a good understanding of the mechanism of the hydrolysis reaction will give us a better direction for drug design. In this study, we used a multidisciplinary approach (computational simulation, molecular biology techniques and enzyme kinetic methods) to study the dynamic motions of CEs and the potential role of these motions in the catalytic mechanism …
Hydrogeologic Analyses For An Earthen Dam Proposal At The University Field Station, Maria Theresa Brown
Hydrogeologic Analyses For An Earthen Dam Proposal At The University Field Station, Maria Theresa Brown
Honors Theses
In response to a request for a new dam at the University of Mississippi Field Station (UMFS), BTJM Engineering prepared an initial feasibility assessment and continued investigations until a full construction plan was completed. This report details the hydrogeologic analyses involed in this process. Initial site investigations included mapping surficial geology, creating a generalized stratigraphic column, mapping the potentiometric surface, and developing a conceptual and quantitative understanding of the local hydrolgic budget. This data informed decisions regarding the location of a new dam, which was finally designed with full considerations of the local hydrogeology. After the dam was designed, analysis …
Science Based Authentication Of Dietary Supplements: Studies On The Chemical Constituents, Analytical Method And Biological Activities Of Scutellaria Spp And Pfaffia Paniculata, Jing Li
Electronic Theses and Dissertations
During the last decade, the use of herbal medicine has expanded globally and gained popularity. With the tremendous expansion in the use of herbal medicine worldwide, safety and efficacy as well as quality control of herbal medicines have become more and more issues of concern for both health authorities and the public. Although herbal medicine has been in use for hundreds to thousands years, very limited science-based data exist to explicit its chemical constituents, pharmacological activities and toxicity. Therefore, lack of scientific evidence for herbal medicine usage elicits the need for systematic studies of herbal medicine, including phytochemical, analytical, and …
A Fractal Analysis Of The Binding And Dissociation Kinetics Of Analyte-Receptor Systems On Biosensor Surfaces, Ifejesu Eni-Olorunda
A Fractal Analysis Of The Binding And Dissociation Kinetics Of Analyte-Receptor Systems On Biosensor Surfaces, Ifejesu Eni-Olorunda
Electronic Theses and Dissertations
No abstract provided.
Research News: 2008, No. 2, University Of Mississippi. School Of Pharmacy
Research News: 2008, No. 2, University Of Mississippi. School Of Pharmacy
Research News: Grants and Publications (2000-2014)
Grants, publications, technology transfer, special announcements
Cocoa Farming In Ghana: Emic Experience, Etic Interpretation, Francis Danquah, Stephen K. Miller
Cocoa Farming In Ghana: Emic Experience, Etic Interpretation, Francis Danquah, Stephen K. Miller
Journal of Rural Social Sciences
This paper develops the tension between emic and etic analysis, recounting the experience of life on a cocoa farm in Ghana, from the perspective of an urban youth with familial connections to the rural community. The dual perspective of living in the city along with frequent visits to and summer sojourns on the farm provided an “outsider’s” perceptions of the rural culture. Yet even these dual emic perspectives were insufficient to bring recognition of the underlying economic realities of cocoa bean production that depended partly on migrant labor. That etic insight came later in the United Kingdom, when studying similar …
Anti-Infective Agents From The Terrestrial Plants Zanthoxylum Monophyllum (Lam.) P. Wilson And Sorocea Muriculata Miq. Against Pathogenic Fungi, Methicillin-Resistant Staphylococcus Aureus And Plasmodium Falciparum, Raquel Rodr├¡Guez Guzm├Ín
Anti-Infective Agents From The Terrestrial Plants Zanthoxylum Monophyllum (Lam.) P. Wilson And Sorocea Muriculata Miq. Against Pathogenic Fungi, Methicillin-Resistant Staphylococcus Aureus And Plasmodium Falciparum, Raquel Rodr├¡Guez Guzm├Ín
Electronic Theses and Dissertations
No abstract provided.
Research News: 2005, No. 3, University Of Mississippi. School Of Pharmacy
Research News: 2005, No. 3, University Of Mississippi. School Of Pharmacy
Research News: Grants and Publications (2000-2014)
Grants, publications, technology transfer, special announcements
Research News: 2005, No. 2, University Of Mississippi. School Of Pharmacy
Research News: 2005, No. 2, University Of Mississippi. School Of Pharmacy
Research News: Grants and Publications (2000-2014)
Grants, publications, technology transfer, special announcements
Engineering Genetic Networks To Measure Real Time Repression By Λ Cro In Vivo, Zachary Louis Leblanc
Engineering Genetic Networks To Measure Real Time Repression By Λ Cro In Vivo, Zachary Louis Leblanc
Honors Theses
The field of systems biology seeks to engineer systems in order to explore specific dynamic properties as they act in vivo. Cellular activities have been proven to be regulated by a range of DNA binding proteins that bind to specific sequences that activate or repress transcription. Certain phage and bacterial repressor proteins were among the first of these DNA binding proteins to be characterized structurally and functionally. The demand for study of key steps in regulation of protein expression, folding, and repression has created multiple studies into systems of varying complexity. The data in this report explores the lambda system, …
Fire Ant War Rages At Field Station, Jennifer Southall
Fire Ant War Rages At Field Station, Jennifer Southall
University of Mississippi News
OXFORD, Miss. - University of Mississippi entomologist James Anderson likes to quote famed biologist E.O. Wilson on the topic of fire ants. Wilson once said that fire ants are the "Vietnam of entomology." He was referring specifically to the U.S. Department of Agriculture's 20-year, $200 million failed campaign to eradicate the South American invaders through the use of insecticides.
Phytochemical And Biological Investigation Of Zanthoxylum Monophyllum (Lam) P. Wilson (Rutaceae), Laura C. Johansmann
Phytochemical And Biological Investigation Of Zanthoxylum Monophyllum (Lam) P. Wilson (Rutaceae), Laura C. Johansmann
Electronic Theses and Dissertations
No abstract provided.
Biochemist Searches For Anti-Cancer 'Key', Mitchell Diggs
Biochemist Searches For Anti-Cancer 'Key', Mitchell Diggs
University of Mississippi News
UNIVERSITY, Miss. -- Armed with knowledge of how locks work and the alignment of a particular set of tumblers, a good locksmith can fashion a key to open virtually any bolt. Although Dr. David Graves is no locksmith, his work may spur development of one of the world's most important keys.
September 21, 2000, The Daily Mississippian
September 21, 2000, The Daily Mississippian
Daily Mississippian (all digitized issues)
No abstract provided.