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Re Magazine And The Politics Of The Little Magazine, Jesse Webb Jan 2017

Re Magazine And The Politics Of The Little Magazine, Jesse Webb

Honors Theses

The little magazine played a widely significant role in the political and cultural history of Western civilization. Literary and ephemeral in nature, the little magazine gave birth to Modernism in the early 20th century by publishing the works of little known authors such as William Carlos Williams, Ezra Pound, and T.S. Eliot to name a few. Later, the Central Intelligence Agency of the United States of America recognized the influential role of the little magazine and began funding magazines that spoke to the anti- communist left in Europe and in the Americas at the beginning of the Cold War. While …

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Egg Laying Bird With Male Plumage Demonstrates The Puzzling Nature Of Sexual Differentiation And Selective Mate Preferences In Zebra Finches, John Aaron Howell Jan 2017

Egg Laying Bird With Male Plumage Demonstrates The Puzzling Nature Of Sexual Differentiation And Selective Mate Preferences In Zebra Finches, John Aaron Howell

Honors Theses

Zebra finches (Taeniopygia guttata) are oscine Passerine songbirds that are native to Australia. Zebra finches have sexually dimorphic plumage, song nuclei, and behavior. The role of chromosomes, hormones, and genes on sexual differentiation are not completely understood. A gynandromorph in our aviary had male plumage, a male partner, and produced viable offspring. Mate preference tests revealed lower preference for the gynandromorph and its progeny than controls, suggesting that they had some traits that made them unattractive to other birds. Gynandromorph lineage males had greater same-sex preferences than control males. Chromosomes in birds are different than those in humans. Males are …

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Population Genetics Of The Giant Red Centipede Along The Appalachian Mountains, Kayla Elayne Ladner Jan 2017

Population Genetics Of The Giant Red Centipede Along The Appalachian Mountains, Kayla Elayne Ladner

Honors Theses

This study focused on population genetics of the giant red centipede, Scolopocryptops sexpinousus, in the Southern Appalachian Mountains. Two genetic markers were used—the mitochondrial COI gene, and the nuclear RNA Polymerase II gene. The goal of this study was to determine how many genetically distinct populations of this invertebrate species exist within the study area, and to understand the spatial distribution of genetic diversity within and among populations. I hypothesized several genetically distinct populations of S. sexpinosus would be detected because the complex topographic characteristics and historical climate cycles of the region are thought to limit movement of many forest …

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Action Understanding Via Mirror Neuron Systems: A Proposed Model For The Science And Treatment Of Stuttering, Madison Jones Jan 2017

Action Understanding Via Mirror Neuron Systems: A Proposed Model For The Science And Treatment Of Stuttering, Madison Jones

Honors Theses

Persistent developmental stuttering is generally considered to be a speech disorder characterized by repetitions, prolongations and postural fixations, and is relatively resistant to therapy. While mainstream stuttering therapy continues to rely on behavioral speech targets, recent research suggests that mirror neuron systems can be activated to temporarily induce natural sounding fluent speech in those who stutter via exposure to second speech signals. Despite the prevalence of speech-motor based stuttering treatments, a unified account of how and why fluency is enhanced through endogenous methods remains elusive. The purpose of these two exploratory studies is to further test the validity of the …

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Little Philosophers: Assessing And Prompting Philosophical Reasoning With Children, Makensey Sanders Jan 2017

Little Philosophers: Assessing And Prompting Philosophical Reasoning With Children, Makensey Sanders

Honors Theses

There is a debate in academic philosophy and psychology of whether or not children can or should do philosophy. Robert Kitchener asserts that due to cognitive limitations, children under the age of 10 cannot think philosophically (Kitchener, 1990). Murris (2000) challenges Kitchener's arguments and concludes that more research is needed. Further, this is a period during which children show individual differences and development in cognitive capacity, specifically within executive function relating to conscious control that may influence abstract thought (Zelazo et al., 1997). The present study assessed 7- to 9-year-olds' and adults' ability to answer philosophical questions in relation to …

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Synthesis And Biological Evaluation Of Cannabinoid Receptor Ligands, Mariah Leigh Cole Jan 2017

Synthesis And Biological Evaluation Of Cannabinoid Receptor Ligands, Mariah Leigh Cole

Honors Theses

The cannabinoid receptors, members of the G-protein coupled receptor (GPCR) superfamily, have been implicated in numerous human physiological functions and diseases. These receptors, cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2), are most concentrated in the central nervous system and immune cells, respectively, and have each become a target of therapeutic interest. Dual CB1/CB2 agonists such as delta-9-tetrahydrocannbinol (THC) have demonstrated efficacy in the treatment of nausea, pain, and glaucoma, but suffer from psychotropic effects mediated by CB1, motivating the search for CB2 selective therapeutic agents. Selective modulation of the CB2 receptor has therapeutic potential in human health disorders …

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Madness In The Middle Ages: An Examination Of The Treatment Of The Mentally Ill In The Medieval Era Based On Order And Gender, Bailey Grace Elkin Jan 2017

Madness In The Middle Ages: An Examination Of The Treatment Of The Mentally Ill In The Medieval Era Based On Order And Gender, Bailey Grace Elkin

Honors Theses

This thesis investigates the treatment of the mad in Europe during the Middle Ages. I read various primary and secondary sources in the course of my investigation. Several of the secondary sources used quotes from primary sources, so I used some of that evidence as well. My conclusions were that the treatment of the mad varied based on gender and estate. When someone from the third estate went mad, family members tried mostly religious cures, since those were the only resources available to them. When members of the second estate went mad, relatives, other members of the nobility, and the …

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Modeling Migraine Chronification And Its Relief; The Effects Of Thc On Recurrent Ntg-Induced Migraine Endpoints In Rats, Blake Sowers Jan 2017

Modeling Migraine Chronification And Its Relief; The Effects Of Thc On Recurrent Ntg-Induced Migraine Endpoints In Rats, Blake Sowers

Honors Theses

This study investigated the analgesic effects of a THC pro-drug in a rodent model of recurrent migraine. Rats received 4 nitroglycerin-induced (NTG: 10mg/kg/2ml) migraine episodes every third day for 12 days; saline, cremaphor-vehicle, propranolol (10mg/kg/ml), or THC-VAL-HS (0.5, 1.0, and 2.0 mg/kg/ml) were given IP 30 minutes before NTG. Behavioral endpoints of photosensitivity, activity, orbital tightening, and tactile allodynia were assessed 110 m after NTG. Migraine severity increased over the course of the four episodes, pointing toward chronification and an important step in model validation. However, neither propranolol nor THC-VAL-HS significantly attenuated any of the migraine-related endpoints. These data are …

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The Effect Of Road Crossings On Stream-Associated Salamanders Within Holly Springs National Forest, Caleb Ashton Aldridge Jan 2017

The Effect Of Road Crossings On Stream-Associated Salamanders Within Holly Springs National Forest, Caleb Ashton Aldridge

Electronic Theses and Dissertations

Road crossings have significant effects on wildlife, but there is limited information on how road crossings affect stream-associated salamanders. Stream-associated salamanders are vital to their ecological communities and are likely to experience the effect of roads more readily than other species due to their physiological characteristics. To test the effects of road crossings on stream-associated salamanders, I surveyed 12 pairs of confluent streams – one stream crossed by a road and the other not in each pair – within Holly Springs National Forest, Mississippi. Surveys in the summer of 2015 were used to measure abundance and species richness of stream-associated …

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The Grounding Of Effective Aristotelian Law, Kyra Kinnaman Jan 2017

The Grounding Of Effective Aristotelian Law, Kyra Kinnaman

Electronic Theses and Dissertations

This paper aims to contribute meaningfully to Aristotelian scholarship by articulating the grounding of effective law. The grounding of law is the reason for which law’s efficacy can be explained. Two popular contenders for this explanation are natural law theory and legal positivism; however, this paper will build off the work of Donald Schroeder to show that neither theory is a tenable explanation for the grounding of Aristotelian law. Although Schroeder rejects natural law and positivism as appropriate interpretations of Aristotle, he fails to articulate what ultimately is the grounding of efficacious law. The final section of this paper will …

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Molecular Characterization Of The Opioid Receptors: Design, Development, And Preclinical Evaluation Of Salvinorin A-Based Molecular Probes., Adam Keasling Jan 2017

Molecular Characterization Of The Opioid Receptors: Design, Development, And Preclinical Evaluation Of Salvinorin A-Based Molecular Probes., Adam Keasling

Electronic Theses and Dissertations

The field of salvinorin chemistry represents a novel and emerging field of opioid research. The novelty is derived from the lead pharmacophore: salvinorin A — a neoclerodane diterpenoid natural product isolated from Salvia divinorum. Salvinorin A represents a pharmacologically unique compound in that it is the first known non-nitrogenous KOR subtype-selective agonist, exhibits a comparatively safe physiological profile with no reports of toxicological effects in clinical trials, and, most importantly, has a steadily growing body of literature indicating potentially useful clinical applications (e.g. antinociceptive, anti-addictive, antipruritic, neuroprotective, etc.). This has encouraged the development of analogues as essential molecular probes to …

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Development Of Phenotypic Drug Discovery Models For Tropical Parasitic Diseases, Surendra Kumar Jain Jan 2017

Development Of Phenotypic Drug Discovery Models For Tropical Parasitic Diseases, Surendra Kumar Jain

Electronic Theses and Dissertations

Malaria and visceral leishmaniasis are major killer parasitic diseases. These diseases though occur primarily in tropical countries; economic burden and overall health impacts of malaria and leishmaniasis are global. The emergence of drug-resistant and more-virulent strains of the pathogens has further amplified the problems. New drug discovery approaches primarily rely on in vitro and in vivo models of the disease. The pathogens causing leishmaniasis and malaria are intracellular. Leishmania parasite grows as amastigotes in macrophages cells, and malaria parasite grows within the hepatocytes or erythrocytes. The intracellular forms of the pathogens are responsible for the pathophysiology of the diseases. New …

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Characterizing The Developmental And Reproductive Toxicities Of Cannabidiol And Δ9-Tetrahydrocannabinol, Dennis Ray Carty Jan 2017

Characterizing The Developmental And Reproductive Toxicities Of Cannabidiol And Δ9-Tetrahydrocannabinol, Dennis Ray Carty

Electronic Theses and Dissertations

Medical marijuana is legal in twenty-nine of the United States and an additional nineteen states have passed legislation for cannabidiol (CBD) treatment of drug-resistant epilepsy, such as Dravet Syndrome (DS) which is diagnosed in children as young as two months. While CBD has shown anecdotal and recently clinical trial efficacy in reducing seizure frequency in DS patients, little is known about the potential adverse side-effects on child physiology, brain development, adult disease, or subsequent generations. Moreover, CBD is rarely administered without including low concentrations of Δ9-tetrahydrocannabinol (THC). The goal of this project is to characterize the relative morphological, behavioral, reproductive, …

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Phytochemical Investigation Of Psychoactive Medicinal Plants For The Treatment Of Neurological Disorders, Vedanjali Gogineni Jan 2017

Phytochemical Investigation Of Psychoactive Medicinal Plants For The Treatment Of Neurological Disorders, Vedanjali Gogineni

Electronic Theses and Dissertations

Neurological disorders include disorders such as migraine, tension-type headaches, Parkinson’s disease (PD), epilepsy, dementia, and Alzheimer’s disease (AD). Globally, PD is the second most comneurodegenerative disorder following AD. In developed countries, PD affects 1% of all population over 60 years of age. The prevalence of PD is increasing over the years and is expected to double by 2030. It is proposed that combination of dopaminergic drugs with monoamine oxidase B (MAO-B) inhibitors, anticholinergics, catechol-O-methyl transferase inhibitors, and other non-dopaminergic drugs can better alleviate levodopa-induced motor complications along with better control of motor symptoms. MAO-B inhibitors play a significant role in …

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Dose-Response Association Between Acute Exercise Duration, Exercise Recovery And Cognitive Function, Elizabeth Ann Crush Jan 2017

Dose-Response Association Between Acute Exercise Duration, Exercise Recovery And Cognitive Function, Elizabeth Ann Crush

Electronic Theses and Dissertations

Previous studies have shown moderate intensity exercise to be a desired intensity level to optimize cognitive function, however, this research has mostly been conducted among older adults despite the claim that cognitive function may start to decline in the early years (i.e., 20s). Another research gap within this population is our limited understanding of the effects of different exercise durations and recovery periods on cognitive function. Thus, the purpose of this study was to examine the effects of different exercise durations and recovery periods on cognition using a treadmill-based protocol. In a counterbalanced, cross-over randomized controlled design, 352 participants, ages …

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Factors Associated With Medication-Overuse Headache In Patients Seeking Treatment For Primary Headache, Kelly Reed Peck Jan 2017

Factors Associated With Medication-Overuse Headache In Patients Seeking Treatment For Primary Headache, Kelly Reed Peck

Electronic Theses and Dissertations

Although a number of risk factors for medication-overuse headache (MOH) have been identified within the general population, limited research exists examining clinical samples of headache sufferers. Further, prior studies have not assessed the relative influence of risk factors or their utility in combination. As part of an online survey, 164 headache patients completed a demographic questionnaire, a diagnostic interview for headache, a measure of headache-related disability, measures of psychiatric symptoms, and measures of medication use and substance use. Standardized mean differences were used to quantify differences between patients who met diagnostic criteria for MOH and those who did not across …

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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs, Mohamed Elsideiq Jihan Jan 2017

Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs, Mohamed Elsideiq Jihan

Electronic Theses and Dissertations

The prevention and cure of malaria is difficult as it thrives under poor socio- and pharmacoeconomic conditions in third world, tropical and subtropical regions. It is a parasitic disease spread through the bite of an infected Anopheles mosquito. In humans, malaria can be caused by several Plasmodium species that include: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae and Plasmodium knowlesi. The natural product artemisinin is a sesquiterpene lactone with an endoperoxide bridge isolated from the Chinese annual herb qinghao (Artemisia annua L or sweet wormwood). The relatively stable endoperoxide bridge is essential for their antimalarial activity. The synthesis of …

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Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye, Sai Prachetan Balguri Jan 2017

Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye, Sai Prachetan Balguri

Electronic Theses and Dissertations

Lipid based systems and topical ocular inserts of various drugs were developed for the intervention/treatment of posterior segment ocular complications. Indomethacin (IN) was developed into solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Effect of surface functionalization using chitosan (CS) on lipid nanocarriers was tested to evaluate corneal penetration. Surface modification of SLNs with CS increased ocular penetration of IN. NLCs maintained significantly higher IN concentrations in all ocular tissues tested, compared to the other formulations evaluated in vivo. Effect of surface poly (ethylene) glycol (PEG) functionalization of the NLCs on ocular disposition was studied using Ciprofloxacin (CIP) as …

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Stereotypes And The Self-Perceptions Of Black Women: How Places And Identity Strategies Matter, Brieann Avery Jan 2017

Stereotypes And The Self-Perceptions Of Black Women: How Places And Identity Strategies Matter, Brieann Avery

Electronic Theses and Dissertations

Black women are one of the most oppressed groups in America because they possess two qualities of being a minority in terms of race and gender. Whether it is magazines, television shows, or music videos, controlling images are established in the preservation of hegemonic power and to condone the remaining marginalization of black women. Black women are seen mostly sexually exploited in hip-hop. Black women are continuously being oppressed through hip-hop’s constructions created to reinforce ideals about race and gender positioning and inferiority in a hegemonic masculine world, Hip-hop promotes negative images of black women as sexual objects and the …

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Evidence Of Chemical Camouflage In Pirate Perch (Aphredoderus Sayanus); Avoiding Detection By Colonizing/Ovipositing Prey Through Chemical Crypsis, Tyler Breech Jan 2017

Evidence Of Chemical Camouflage In Pirate Perch (Aphredoderus Sayanus); Avoiding Detection By Colonizing/Ovipositing Prey Through Chemical Crypsis, Tyler Breech

Electronic Theses and Dissertations

No abstract provided.

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Whore Or Hero?: Helen Of Troy's Agency And Responsibility From Antiquity To Modern Young Adult Fiction, Alicia Dixon Jan 2017

Whore Or Hero?: Helen Of Troy's Agency And Responsibility From Antiquity To Modern Young Adult Fiction, Alicia Dixon

Honors Theses

The purpose of this research is to explore the use of Helen of Troy spanning literature from Homer to the modern Starcrossed series by Josephine Angelini, and to discuss how Helen's agency is both stripped from her and granted to her through the use of desire, death, and the connotations associated with her face and name. Specifically, the differences between ancient works and Angelini's novels in how these three categories are treated concerning Helen are used to show how a Helen with very similar characteristics to those Helens in ancient literature, who generally possess little or no agency, can go …

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Biochemical Variation In Caribbean Sponges Of The Genus Aplysina, Sarah L. Criddle Jan 2017

Biochemical Variation In Caribbean Sponges Of The Genus Aplysina, Sarah L. Criddle

Honors Theses

Sponges are among the simplest multicellular organisms, consisting of groupings of cells with similar functions rather than true tissues. Nonetheless, sponges are ecologically significant in many marine environments, including coral reefs. They are sedentary organisms that feed by filtration from the water column, which contributes to the numerous roles they play on coral reefs, including upkeep of the reef, production of usable energy, and recycling of nutrients. Like all multicellular organisms, sponges are made up of biologically significant macromolecules. These macromolecules provide the energy for the sponge, and their relative concentrations determine how sponges can store and access the energy …

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The Evaluation Of Az66, A Highly Selective Sigma-1 And Sigma-2 Receptor Antagonist, For Its Anti-Convulsive Effects In C57bl/6 Mice, Jamie Stone Jan 2017

The Evaluation Of Az66, A Highly Selective Sigma-1 And Sigma-2 Receptor Antagonist, For Its Anti-Convulsive Effects In C57bl/6 Mice, Jamie Stone

Honors Theses

The Evaluation of AZ66, A Highly Selective Sigma-1 and Sigma-2 Antagonist, for Anticonvulsive Effects in C57Bl/6 Mice (Under the direction of Lisa Wilson and Dr. Christopher McCurdy) Sigma receptors have become a popular subject for research the past few decades, but there is still much mystery behind these receptors and how they work. Researchers have found that sigma receptor antagonists can attenuate cocaine induced convulsions, however, limited research has been conducted on the effects of these antagonists on convulsions that mimic the types of seizures associated with epilepsy. Therefore, the aim of the current study was to evaluate AZ66 (20 …

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The Effect Of Golf Shoe Characteristics On Static Balance Over An Extended Duration, Jordan Colbert Jan 2017

The Effect Of Golf Shoe Characteristics On Static Balance Over An Extended Duration, Jordan Colbert

Honors Theses

Golf performance is greatly impacted by balance ability, specifically during a golfer's swinging and putting motion. Previous studies have found that certain shoe characteristics can affect balance; however, no such study has been conducted for golf shoes. This study's objective was to compare balance scores between three different golf shoe styles and determine which style or characteristics serve golfers best in improving balance under quiet standing conditions over time. Twelve adults (age: 23.4 ± 2.2 years; height: 181.5 ± 9.0 cm; mass: 95.8 ± 18.6 kg) participated in this study. Each participant made four visits, one for each footwear condition: …

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The Metaphysics Of Transubstantiation: The Problem Of Individuation In The Seventeenth Century, Conrad J. Collins Jan 2017

The Metaphysics Of Transubstantiation: The Problem Of Individuation In The Seventeenth Century, Conrad J. Collins

Honors Theses

The purpose of this thesis is to look at the recurring question of the relationship between theology and philosophy by investigating the 17th century debate on the Eucharist as it revolved around Descartes and Leibniz. The Jesuit explanation of transubstantiation involves the philosophical problem of individuation, which asks what makes an individual substance what it is. Therefore, the study focuses specifically on the problem of individuation as it is treated by the philosophers Descartes and Leibniz as they try to answer the previous question. Descartes's mechanical philosophy runs against the notion of what constitutes a body, while Leibniz's monadology finds …

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Taking Things At Face Value: Typeface And Its Influence On Reading, Memory, Judgment And Time Perception, Danielle Hollingsworth Jan 2017

Taking Things At Face Value: Typeface And Its Influence On Reading, Memory, Judgment And Time Perception, Danielle Hollingsworth

Honors Theses

Differing typefaces, such as serif, sans serif, or script, offer varying physical characteristics and can aid or inhibit legibility. These distinctions between typefaces lead to fonts being deemed as either perceptually fluent or disfluent. As fluency of a text is altered, the notion is offered that processing changes occur, which can influence factors of reading a text. Altering fonts have previously been shown to influence reading speeds, memory, and time estimation judgment. This thesis tests the relationship of font type with these aspects, with the addition of another judgment portion regarding perception of text quality. Determining the aspects which can …

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Effects Of Dioscin On Dna Methyltransferase 1 Protein Expression In Human Breast Cancer Cell Lines, David Andrew Means Jan 2017

Effects Of Dioscin On Dna Methyltransferase 1 Protein Expression In Human Breast Cancer Cell Lines, David Andrew Means

Honors Theses

In previous experiments, the steroidal saponin, dioscin, which was extracted from the roots of the wild yam (Dioscorea villosa), was observed to have potent anti-proliferative effects on the human breast cancer cell lines MCF-7 and MDA-MB-231. Dioscin was also able to activate the transcription of tumor suppressor genes GATA3 and CDH1 in these cell lines. We hypothesize that the anti-proliferative effect of dioscin on human breast cancer cells could be mediated through the epigenome. Consequently, in order to explore this hypothesis, we have analyzed the expression of DNA methyltransferase 1 (DNMT1) protein in these cells. MCF-7 and MDA-MB-231 cells were …

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Pretty Things Around The Sun, Alaina G. Newby Jan 2017

Pretty Things Around The Sun, Alaina G. Newby

Honors Theses

The following thesis contains six short stories written from July 2016 to March 2017 in Tupelo, Mississippi and Oxford, Mississippi.

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Hot-Fire Testing Of An Af-M315e 1-Newton Thruster, Alex Mcgee Jan 2017

Hot-Fire Testing Of An Af-M315e 1-Newton Thruster, Alex Mcgee

Honors Theses

AF-M315E is a green monopropellant currently being investigated for use as a potential replacement for hydrazine in low-thrust spacecraft propulsion applications. To support devel- opment e↵orts, a series of hot-fire tests were conducted to assess the performance of AF-M315E in a 1N thruster. Preliminary design and analysis shows an increase in performance versus a comparable hydrazine system. Testing was conducted with a 1N TZM (titanium, zinc, and molybdenum alloy) thruster in late July 2016 in collaboration with the Spacecraft Propulsion Systems o ce (ER23) at Marshall Space Flight Center (MSFC). Testing focused on character- izing the transient behavior of the …

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The Effect On Postural Balance As A Result Of Different Types Of Golf-Specific Footwear Over An Extended Duration, Alice Mcgee Jan 2017

The Effect On Postural Balance As A Result Of Different Types Of Golf-Specific Footwear Over An Extended Duration, Alice Mcgee

Honors Theses

The sport of golf is increasingly popular within the United States, with an estimated 35 million participants worldwide. To be successful, the golf swing, regarded as a difficult biomechanical motion to accomplish, needs to be accurate and powerful. A proper swing incorporates a weight shift from the rear foot to the leading foot, which indicates that balance is crucial to maintain. The purpose of this study was to examine the effect of golf-specific footwear on static balance over an extended duration in order to relate it to golf performance. Twelve recreationally trained males (age: 23.4±2.2 years; height: 181.5±9.0cm; mass 95.8±18.6 …

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