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Influence Of Rage Signaling On Cellular Communication In Diabetes-Mediated Vascular Calcification, Amber Michelle Kennon Jan 2021

Influence Of Rage Signaling On Cellular Communication In Diabetes-Mediated Vascular Calcification, Amber Michelle Kennon

Electronic Theses and Dissertations

Chronic hyperglycemia is one of the main characteristics of type 2 diabetes mellitus (T2DM). With the increased prevalence of T2DM, the risk of cardiovascular complications, including heart attack or stroke, is increased. Complications linked to the vasculature are increased vascular calcification (VC) or mineral deposition within the medial layer of conducting arteries. Under calcification conditions, vascular smooth muscle cells (VSMCs) undergo an osteogenic switch to an osteoblast-like cell and begin producing bone proteins. Chronic hyperglycemia can also result in increased extracellular matrix (ECM) synthesis, accumulation, and crosslinking. One of the cell types responsible for increased ECM synthesis are ‘activated’ fibroblasts …

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Describing The Gut Microbiome Of Amblema Plicata, Lauren Lawson Jan 2021

Describing The Gut Microbiome Of Amblema Plicata, Lauren Lawson

Electronic Theses and Dissertations

Freshwater mussels are important for nutrient cycling and ecosystem health, as they filter feed on their surrounding water column. This form of feeding makes these bivalves especially sensitive to conditions in their environment. Gut microbial communities (microbiomes) have been recognized as important to both host organism and ecosystem health; however, how microbiomes are organized and influenced is still unclear. In this study, the gut microbiomes of 58 individuals of the freshwater mussel Amblema plicata were compared across two river basins, five rivers, and nine sites in the southeastern USA. Planctomycetes, Firmicutes, and Cyanobacteria were the most common phyla within all …

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Group Sandtray Therapy With Adult Survivors Of Childhood Sexual Assault: A Single-Case Research Design, Jana Elaine Scott Jan 2021

Group Sandtray Therapy With Adult Survivors Of Childhood Sexual Assault: A Single-Case Research Design, Jana Elaine Scott

Electronic Theses and Dissertations

Childhood sexual assault (CSA) is a growing problem in our society. A child who experiences a sexual assault not only deals with the immediate trauma surrounding this event, but also the aftermath of this event as they progress into adulthood. Trauma and sexual trauma is an umbrella term that incorporates all of the various implications of experiencing a negative event. In the instance of trauma, neurobiological implications have been well researched and established. This knowledge highlights the need for counseling techniques to be developed and studied that target those who have experienced CSA. The aim of this single-case research design …

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Enzyme-Initiated Admicellar Polymerization, Elaheh Shakeri Jan 2021

Enzyme-Initiated Admicellar Polymerization, Elaheh Shakeri

Electronic Theses and Dissertations

Admicellar polymerization was developed in the 1980s as an economical method for modifying various surfaces. In admicellar polymerization, a low monomer to initiator (M/I) ratio was traditionally required to overcome this limitation and achieve high polymer conversion when oxygen was present in the headspace and dissolved in the reaction medium. To develop an environmentally friendly, cost-efficient, and feasible deoxygenation and initiation technique, we studied the use of glucose oxidase (GOx) in admicellar polymerization. In this method, GOx acts as the catalyst in the oxidation of ?-D-glucose, while consuming oxygen and generating hydrogen peroxide and D-glucono-?-lactone. There are many advantages of …

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Blood Money: 12th Century Trade Wars And The Fourth Crusade, Alexander Evgeniy Stalowski Jan 2021

Blood Money: 12th Century Trade Wars And The Fourth Crusade, Alexander Evgeniy Stalowski

Electronic Theses and Dissertations

The historiography of the Fourth Crusade has neglected long-term macroeconomic developments and its influence on the Fourth Crusade within the Byzantine Empire and the Italian states of Venice, Pisa, and Genoa. It is well-established that the Venetians rerouted the crusading forces to Constantinople which caused political, religious, and economic challenges that altered the Mediterranean world. Yet, the trend of writing on political events and short-term microeconomics and macroeconomics from 1180 to 1204, has done great disservice to the larger trans-regional disputes that engulfed the Mediterranean during the eleventh and twelfth centuries. This thesis will attempt to fill the void of …

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The Current Treatment Of English Phrasal Verbs In Mext-Authorized Textbooks For Japanese Junior High School Students, Natsuko Yamada Jan 2021

The Current Treatment Of English Phrasal Verbs In Mext-Authorized Textbooks For Japanese Junior High School Students, Natsuko Yamada

Electronic Theses and Dissertations

This comparative analysis, focusing on the 150 highest-frequency phrasal verbs in the phrasal verb pedagogical list (Garnier and Schmitt, 2015), highlights the limited occurrence across English language textbooks for Japanese junior high school. The spoken and written data of Japanese learners of English (i.e., NICT-JLE and NICE) shows considerable differences in the usage patterns of phrasal verbs compared to native English speakers. These results indicated that Japanese learners’ underdeveloped productive knowledge of phrasal verbs could cause intelligibility problems with native speakers especially in oral communication. In order to overcome the semantic and phonological complexity of phrasal verbs, and to break …

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Just Southern Food: Food Justice For The Mississippi Delta, Christian Tabor Owen Jan 2021

Just Southern Food: Food Justice For The Mississippi Delta, Christian Tabor Owen

Electronic Theses and Dissertations

The primary objective of this research is to promote food justice for the Mississippi Delta by investigating facts about the intersections of extreme poverty, food insecurity, and chronic illness in the Mississippi Delta. By exploring relevant literature and highlighting current initiatives, this work looks at the semantics of food justice and related terms, discusses challenges unique to the Mississippi Delta, and broadly characterizes public health models with the greatest potential for food justice advancement in this region. Pivotal to interpreting food justice not only for the Mississippi Delta or the Global South, but for any community, is a clear understanding …

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Full Issue, Journal Editors Jan 2021

Full Issue, Journal Editors

Yalobusha Review

No abstract provided.

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Rap1a Overlaps The Age/Rage Signaling Cascade In Type 2 Diabetes Mellitus, Stephanie Burr Jan 2021

Rap1a Overlaps The Age/Rage Signaling Cascade In Type 2 Diabetes Mellitus, Stephanie Burr

Electronic Theses and Dissertations

Diabetic individuals have an increased risk for developing cardiovascular disease due to stiffening of the left ventricle, which is thought to occur, in part, by increased AGE/RAGE signaling. Advanced glycation end products (AGEs) accumulate within the body over time, and under hyperglycemic conditions, the formation and accumulation of AGEs is accelerated. AGEs exert their effect by binding to their receptor (RAGE) and can induce myofibroblast differentiation, oxidative stress, cell-extracellular matrix contraction, and cell migration. Previous findings from our lab have demonstrated that preventing the production of Rap1a, a Ras-like GTPase signaling protein, in cardiac fibroblasts will decrease type 2 diabetes …

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Subcutaneous Delivery Of Albumin, Vy Nguyen Jan 2021

Subcutaneous Delivery Of Albumin, Vy Nguyen

Electronic Theses and Dissertations

An increasing number of protein drugs are used in the clinic to treat a broad range of diseases. However, because of their large molecular sizes and high hydrophilicity, protein drugs are not orally bioavailable, which commonly require intravenous, intramuscular or subcutaneous injection. Thermosensitive polymers have been widely investigated as in situ depots for sustained drug release delivered through subcutaneous route.Albumin is the most abundant proteins in bloodstream. It has long half-life (19 days in human) and plays important roles such as acting as carrier for fatty acids, amino acids, waste products and medical compounds. Albumin has been studied for decades …

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Effects Of Nonnative Phonotactic Constraints On The Perception Of Nasal-Initial Consonant Clusters, Msafiri Otonya Jan 2021

Effects Of Nonnative Phonotactic Constraints On The Perception Of Nasal-Initial Consonant Clusters, Msafiri Otonya

Electronic Theses and Dissertations

This study examines the effects of non-native phonotactic constraints on the perception of nasal-initial consonant clusters (NICC), specifically whether native English speakers can perceive NICC as accurately as native Swahili speakers. The ABX task was conducted over Zoom to test L1 English speakers (N=12) and L1 Swahili speakers (N=12). Stimuli with four conditions were used: 1) The stimuli had one of the three nasal sounds (/m/, /n/, and /?/) in word-initial consonant clusters; 2) The stimuli had NICC composed of a nasal sound followed by either a voiced or voiceless consonant; 3) The consonant clusters were composed of sounds that …

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This Garden: Oysters And Place Along Florida's Forgotten Coast, Annemarie Anderson Jan 2021

This Garden: Oysters And Place Along Florida's Forgotten Coast, Annemarie Anderson

Electronic Theses and Dissertations

THIS GARDEN is an audiovisual installation that tells the story of oyster farmers and place in Spring Creek, Florida. I use the oral history interviews and documentary photography I made there to explore aquaculturists’ deep relationship with the surrounding environment. To these farmers, the bay is a garden. They work within those often-unpredictable waters to cultivate new life. This accompanying thesis builds a chronological narrative of oyster aquaculture industry along Florida’s Forgotten Coast. It connects Florida’s burgeoning aquaculture industry to the long history of human involvement along the Gulf Coast in commercial fishing and wild harvest oyster operations. Lastly, I …

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Computational Modeling Of Climate Attributes And Condition Deterioration Of Concrete Highway Pavements, Salma Sultana Jan 2021

Computational Modeling Of Climate Attributes And Condition Deterioration Of Concrete Highway Pavements, Salma Sultana

Electronic Theses and Dissertations

An efficient and safe road network secures the nation’s economy and prosperity by providing public mobility and freight transport. Maintenance and rehabilitation of the road network cost billions of dollars annually. Road and highway infrastructures performance in any country is impacted by load repetitions and it is further compromised by climate attributes and extreme weather events. Damages to roads and bridges are among the infrastructure failures that have occurred during these extreme events. If maintenance and rehabilitation are not done promptly, the damages to the road caused by heavy traffic and extreme climate may lead to life-threatening conditions for road …

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The Role Of Acetylcholine In Attention And Lapses In Attention In Rats Using The Mode And Deviation From Mode Of Reaction Time Latency, Scott Lee Mitchell Jan 2021

The Role Of Acetylcholine In Attention And Lapses In Attention In Rats Using The Mode And Deviation From Mode Of Reaction Time Latency, Scott Lee Mitchell

Electronic Theses and Dissertations

Attention Deficit-Hyperactivity Disorder (ADHD) is currently the neurodevelopmental disorder most commonly diagnosed in children in the United States, and one of the defining characteristics of ADHD is inattention. Inattention is marked by increased lapses in attention, and when assessed clinically, it has been highly correlated with reaction-time variability (RTV). Evidence from the human/clinical literature has shown an inherently higher RTV to be the primary quantitative indicator of an ADHD diagnosis. Reaction-time distributions are characterized by an asymmetrical rightward skew, and because of the prevalence of this presentation, it has been theorized that the distribution peak and skew represent separate phenomena, …

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Pharmacological Manipulation Of Nmda Receptor Activation And Synaptic Norepinephrine Levels: Effects On Sustained Attention In Male Rats, Zach V. Redding Jan 2021

Pharmacological Manipulation Of Nmda Receptor Activation And Synaptic Norepinephrine Levels: Effects On Sustained Attention In Male Rats, Zach V. Redding

Electronic Theses and Dissertations

Impaired attention is common in many neurological disorders. Normal attention promotes the selective processing of important sensory information. This selective processing relies on neurotransmitters, like glutamate, and neuromodulators, like norepinephrine, acting in frontal, parietal, and visual cortices. We tested treatments targeting the glutamatergic and noradrenergic systems using a rat model of attentional lapses.Rats were trained to respond quickly to stimuli in a two-choice reaction time task (2CRTT). Response times were split into initiation time (IT) and movement time (MT). Performance measures were derived from IT and MT distributions. IT mode represents sensorimotor processing speed when rats are attentive. IT deviation …

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Absurdity Is A Distinct Aesthetic Category, Sarah Jean Szopinski Jan 2021

Absurdity Is A Distinct Aesthetic Category, Sarah Jean Szopinski

Electronic Theses and Dissertations

Absurdity is the sudden discomfort caused by direct awareness of your being consciousand your relation to reality. Camus’ absurdist philosophy refers to the conflict between the human desire for inherent meaning in reality and the incomprehensible and irrational nature of the universe. Facing absurdity requires confronting the absurd feeling through introspective awareness of this tension. Otherwise, you are overcome by it, succumbing to a lack of mindfulness and avoidance of the confrontation. Absurdity, especially in its aesthetic dimension, has not received the sustained attention it deserves. In this paper, I argue that due to the sustained relevance of the absurd …

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The Perception And Strategies Of Building Rapport With Children With Autism Spectrum Disorder Via Telepractice, Anna Cathryn Wall Jan 2021

The Perception And Strategies Of Building Rapport With Children With Autism Spectrum Disorder Via Telepractice, Anna Cathryn Wall

Electronic Theses and Dissertations

Telepractice is a growing method in providing services in the profession of Speech-Language Pathology. One question with this growing method is, how do we build rapport when using telepractice? In this study, we intended to find what pediatric SLPs' perceptions and strategies of building rapport via telepractice is with children with autism spectrum disorder (ASD) ages 5-12, and children’s age was considered as an influential factor. While previous studies have focused on perceptions, we wanted to know what SLPs are doing in order to build rapport with their clients when using telepractice. We reached out to 223 SLPs and there …

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An American Pilgrimage: The 1968 Poor People's Campaign Mule Train As Prophetic Social Performance, Cheston M. Bush Jan 2021

An American Pilgrimage: The 1968 Poor People's Campaign Mule Train As Prophetic Social Performance, Cheston M. Bush

Electronic Theses and Dissertations

In late spring of 1968, the Southern Christian Leadership Conference (SCLC) launched a nationwide demonstration known as the Poor People’s Campaign in an effort to overcome poverty. Nine caravans representing people from around the country converged in the Capitol to petition Congress for programs that would broaden opportunities for poor Americans. This work examines the Mississippi contingent of the campaign, the Mule Train caravan, that consisted of roughly 150 people who traveled in 15 covered wagons pulled by about 40 mules. The Mule Train left Marks, Mississippi on May 13 and arrived in Washington, D.C. in time for a June …

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The Meat Of The Gothic: Animality And Social Justice In United States Fiction And Film Of The Twenty-First Century, Amber Hodge Jan 2021

The Meat Of The Gothic: Animality And Social Justice In United States Fiction And Film Of The Twenty-First Century, Amber Hodge

Electronic Theses and Dissertations

The Meat of the Gothic: Animality and Social Justice in United States Fiction and Film of the Twenty-First Century— situates twenty-first century US gothic narratives in relation to animal studies, even as it illuminates how these narratives interrogate the effects of historic and ongoing global systems of human oppression: slavery, imperialism, and capitalism. Instead of reacting to bias by asserting a claim to a humanity perpetually imbricated in divisions of class, race, and gender, present-day authors and filmmakers create characters who form communities that include nonhuman actors as a means of generating empowerment and critique. My approach to these narratives …

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Time And Place At Prospect Hill: A Phase-One Survey Of A Historic Plantation, William Bryce Krumcke Jan 2021

Time And Place At Prospect Hill: A Phase-One Survey Of A Historic Plantation, William Bryce Krumcke

Electronic Theses and Dissertations

The goal for this thesis was to conduct the first archaeological research at Prospect Hill plantation and to create a baseline that can be used to understand the spatial layout of the plantation and provide archaeological evidence of the enslaved people who lived there. Prospect Hill is located in southwest Mississippi and was founded in 1808 by Captain Isaac Ross. The archaeological work done at Prospect Hill was a survey of approximately 10 acres that surrounds the main house. After this survey, the artifacts were classified into two categories: chronological and functional. From this analysis, a series of patterns were …

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Do Bears Prefer The Weak And The Downtrodden? The Effects Of The 52-Week Low And Financial Strength On Short-Seller Behavior, Christopher Alan Miller Jan 2021

Do Bears Prefer The Weak And The Downtrodden? The Effects Of The 52-Week Low And Financial Strength On Short-Seller Behavior, Christopher Alan Miller

Electronic Theses and Dissertations

This dissertation investigates the effects of a company’s financial strength on short-seller behavior around a non-information-producing event. The distance of a stock price to its 52-week high or low does not provide fundamental information, but the price extremes serve as salient price points upon which investors anchor their expectations of future stock performance. Using a large sample of daily short sales data, I investigated the effects of both the proximity to the 52-week low and the financial strength of the underlying company on short-seller behavior. I found that short-selling volume increases as the price nears its 52-week low and that …

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Dragon On A Dog Chain, Stephen M. Hundley Jan 2021

Dragon On A Dog Chain, Stephen M. Hundley

Electronic Theses and Dissertations

Fish lives on a barrier island of Georgia made locally famous by the atomic bomb that was dropped there by accident. He is in the care of two men, Reef and Nutzo, and the matriarch of the group, Whistle, who leads glass-bottom boat tours of the bomb and has also raised a tiger, Sugar.

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Implementation Of The Michael Heggerty Model To Increase Student Achievement Of At-Risk Readers In Kindergarten, Michelle White Nowell Jan 2021

Implementation Of The Michael Heggerty Model To Increase Student Achievement Of At-Risk Readers In Kindergarten, Michelle White Nowell

Electronic Theses and Dissertations

This applied research study seeks to help at-risk readers improve phonemic awareness in kindergarten at Mayberry Elementary by implementing the Michael Heggerty Phonemic Awareness Model so the students can become successful readers. Using three elements in this study, professional development, teacher PLCs, and data talk meetings with peer teachers in kindergarten throughout the year, the researcher sought to build teacher capacity in the implementation of the Michael Heggerty Phonemic Awareness Model to improve student achievement. Surveys, observations, focus groups, and interviews were used in the study. Additionally, the goal of this study aimed to improve the educator's capacity to address …

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The Validity Of Transracialism, Samantha Nichole Priest Jan 2021

The Validity Of Transracialism, Samantha Nichole Priest

Electronic Theses and Dissertations

In this article, the idea that transracialism could be a valid identity is considered. Standpoint epistemology presents the strongest case against transracialism as a valid identity because, according to Collin’s, racial groups have a special sense of a shared history. However, arguments for race as a social construction show how transracialism could function the same way we ordinarily feel like gender functions in our society. The violent disapproval of transracialism highlights both that ordinary usage is being challenged and that it is changing. Ultimately, narrative views of personal identity, like those suggested by Aslidair MacIntyre, and the ordinary function of …

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Development Or Detriment? The World Bank And Economic Disincentives To Water Conservation: Jordan In The 1960s And 1970s, William Chase Young Jan 2021

Development Or Detriment? The World Bank And Economic Disincentives To Water Conservation: Jordan In The 1960s And 1970s, William Chase Young

Electronic Theses and Dissertations

This thesis examines the impact of World Bank development policies on water shortagesin the Middle East and North Africa. Analyzing primary sources from the World Bank Group Archives, I contend that in funding water development projects in the 1960s and 1970s the World Bank and its subsidiaries, the International Bank for Reconstruction and Development and the International Development Association, created economic disincentives to water conservation. These disincentives likely made authorities unable to effectively respond to water shortages that developed in the latter half of the 20th century. The Hashemite Kingdom of Jordan is used as a case study, which I …

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Design And Synthesis Of Salvinorin-Based Compounds For The Opioid Receptors., Nicholas S. Akins Jan 2021

Design And Synthesis Of Salvinorin-Based Compounds For The Opioid Receptors., Nicholas S. Akins

Electronic Theses and Dissertations

Opioid receptors (OR) are expressed throughout both the peripheral and central nervous system and play crucial roles in the modulation of antinociception, addiction, anxiety, and depression. Salvinorin A, the main isolate of the hallucinogenic plant Salvia divinorum, is one of the most potent naturally occurring kappa opioid receptor agonists. Salvinorin A possesses beneficial effects as a therapeutic in a variety of CNS disorders, but due to its strong hallucinating, anxiogenic effects, and short half-life(t1/2), it has never advanced to clinical trials. Instead, salvinorin A has been used as an important prototype for the development of related drug candidates. Our initial …

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The Black Petromodernism Of Zora Neale Hurston: Energy, Race, And Mobility, Stuart Mullet Jan 2021

The Black Petromodernism Of Zora Neale Hurston: Energy, Race, And Mobility, Stuart Mullet

Electronic Theses and Dissertations

This thesis situates Zora Neale Hurston and the folk communities in her oeuvre within the context of modernity’s dependencies on fossil fuels. Such a disciplinary context provides an energy footing for our understandings of African American migrations in the twentieth century—which radically transformed the nation on multiple levels—and it illuminates the communal values that undergird Black approaches to petromodern forms of mobility. Furthermore, by engaging the Black spaces of the South, my argument begins filling a gap in the energy humanities. Few scholars in this field engage deeply those populations and regions that disproportionately experience the underbelly of petromodernity and …

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An In-Depth Approach For Functional Oligosaccharide Analysis, Hao Liu Jan 2021

An In-Depth Approach For Functional Oligosaccharide Analysis, Hao Liu

Electronic Theses and Dissertations

Heparin and heparan sulfate (Hp/HS) are linear complex glycosaminoglycans (GAGs), which are involved in diverse biological processes. Although Hp/HS GAGs influence numerous physiological and pathophysiological processes, their high degree of size polydispersity and sequence microheterogeneity make structure-function characterization challenging. In addition, it is hard to understand the structures that underlie any of the various functions with MS, because of the lability of the sulfate group during tandem mass spectrometry (MS/MS) analysis. The work presented here describes an in-depth approach for functional oligosaccharide characterization including chemical derivatization of Hp to inhibit COVID-19 infection, multi-dimensional liquid chromatography (LC) fractionation method, chemical derivatization …

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Midwifery And Medicine In Britain: A Comparative View Of Midwifery And Childbearing In Scotland And England, 1650-1780, Summer Smith Jan 2021

Midwifery And Medicine In Britain: A Comparative View Of Midwifery And Childbearing In Scotland And England, 1650-1780, Summer Smith

Electronic Theses and Dissertations

In this dissertation I contend the female midwives and childbearing women did not passively accept the alteration of the experience of birth and the ideology surrounding it in eighteenth-century Britain. While the imposition of the man-midwife and the reframing of birth as a disease to be cured in some ways forced childbearing to shift to a medicalized event, many practices persisted from the seventeenth through the nineteenth centuries, illustrating a vein of consistency in a seemingly tumultuous period. Furthermore, the changes that did take root were not solely the purview of the male medical community, but were influenced by women …

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Development And Characterization Of Albuterol Sulfate Loaded Transdermal Patches With Hme Coupled Fdm 3d Printing, Bhavana Chivukula Jan 2021

Development And Characterization Of Albuterol Sulfate Loaded Transdermal Patches With Hme Coupled Fdm 3d Printing, Bhavana Chivukula

Electronic Theses and Dissertations

Albuterol sulfate is a short-acting selective Beta 2 Adrenergic agonist. It is used to treat and prevent bronchospasm associated with asthma, bronchitis, and other breathing disorders. It is known to show extensive first pass metabolism and it requires frequent dosing which makes it difficult for patients to comply. To avoid these problems, transdermal route of delivery of Salbutamol was explored. Traditional methods of preparation of transdermal drug delivery systems involve the use of solvents and have multiple processing steps. To avoid the usage of solvents and decrease the processing steps, HME Coupled FDM 3D printing can be used. Different polymers …

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