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Fluctuations In Alcohol Impairment Of Working Memory Across The Menstrual Cycle, William Mcgarrigle

Theses and Dissertations--Psychology

Behavioral endocrinology studies in women suggest that higher circulating levels of the ovarian sex hormone estradiol (E2) may be linked to better working memory performance, especially under conditions of cognitive impairment (e.g., age-related cognitive decline). Phases of the menstrual cycle characterized by different levels of E2 may therefore influence the degree to which women are vulnerable to alcohol impairment of working memory. The current thesis used a within-subjects design to test the hypothesis that women are less sensitive to acute alcohol-induced impairment of working memory when E2 is elevated during the menstrual cycle. A sample of 75 premenopausal women completed …

Disinhibition And Bac Estimation As Predictors Of Risky Driving Behavior While Intoxicated, Sarah Heymsfeld

Theses and Dissertations--Psychology

Alcohol-related driving fatalities persist as a public health problem in the United States. Recent studies have begun focusing on driver risk-taking as a factor in DUI occurrences and consequent driving fatalities. Key factors that could contribute to risky intoxicated driving are a lack of self-awareness concerning intoxication levels and consequent risk in addition to alcohol-induced increases in the driver’s impulsivity. Fifty young adult drivers received 0.65 g/kg of alcohol (target BAC = 80 mg/dl) or a placebo in a counterbalanced order on two different days and performed a simulated driving test that measured driver risk-taking as reduced distance to other …

Power Of Perception: The Role Of Perceived Caregiver Mindset Beliefs On Undergraduate Student Academic Engagement, Katherine R. Tanaka

Theses and Dissertations--Psychology

Promoting academic engagement is vital for college student success. Researchers have explored factors like growth mindset, the belief that intelligence can improve with effort, as a driver of academic engagement. Beyond personal mindset, students’ perceptions of key social influences, such as caregivers, also play a role. This study examined how undergraduate students’ own mindsets and perceptions of their caregivers’ mindsets relate to four components of academic engagement: behavioral and emotional engagement, and behavioral and emotional disaffection. Data from undergraduates (N = 1417) were analyzed using surveys, descriptive statistics, hierarchical regression, and exploratory moderation. Students generally reported both a personal …

Cognitive-Behavioral Effects And Sex Differences In Alcohol Use, Mia Radevski

Theses and Dissertations--Psychology

Addiction models (e.g., iRISA model) suggest that excessive substance use can result in behavioral consequences such as decreased response inhibition and increased salience attribution toward alcohol cues. The primary goal of this project was to explore potential sex differences in these characteristics of addiction. This dissertation is comprised of two separate but related studies. Study 1 investigated sex differences in inhibitory control and attentional bias. The central hypotheses are 1) women who reported heavy-drinking would display greater disruptions in behavioral inhibitory control following alcohol-related cues, 2) men who reported heavy-drinking would display greater attentional bias toward alcohol-related cues, and 3) …

Establishing The Feasibility Of Crowdsourcing To Study Value-Based Decision-Making In Substance Use Disorders, Thomas Shellenberg

Theses and Dissertations--Psychology

Substance use disorders (SUDs) are characterized by repeated choices to use drugs despite adverse consequences. Value-based decision-making theory posits that choices are guided by predicted values of available options which are updated based on outcomes. Computational modeling of reinforcement learning (RL) during choice tasks has shown promise for uncovering latent mechanisms of decision-making. Recruiting people with SUD is difficult, but crowdsourcing offers an alternative for accelerating data collection. However, the validity of computational modeling using online choice task data has not been well-established. This thesis aimed to use the online crowdsourcing platform Prolific to 1) compare online and in-person choice …

Menstrual Cycle Phase And Hormonal Effects On Emotional Eating In Females With Attention-Deficit/Hyperactivity Disorder, Urveesha Nirjar

Theses and Dissertations--Psychology

Previous research has shown that cyclical fluctuations in ovarian hormones can predict changes in ADHD symptoms as well as eating behaviors, particularly emotional eating across the menstrual cycle. Previous studies have so far only examined the effects of estrogen (E2), progesterone (P4) and cycle phase in predicting individual symptoms or disorders such as ADHD or eating disorders or related behaviors separately. The aim of this study is to examine how emotional eating is influenced by naturally occurring hormonal and cycle changes in a sample overrecruited for ADHD. Seventy-eight individuals (assigned female at birth) with menstrual cycles overrecruited for ADHD provided …

Complexity, Entanglement And Codes In Quantum Field Theory, Nikolaos Angelinos

Theses and Dissertations--Physics and Astronomy

In recent decades many deep connections between quantum information theory and quantum field theory have been unearthed. In this dissertation we study topics in high-energy physics through the lens of quantum information: 1) We develop connections between error-correcting codes and Narain conformal field theories. 2) We study the entanglement entropy of one-dimensional fermionic chains with long-range interactions. 3) We study the temperature dependence of Lanczos coefficients and Krylov complexity.

Topics In Quantum Information, Complexity And Chaos, Debarghya Chakraborty

Theses and Dissertations--Physics and Astronomy

This dissertation explores quantum information, the use of codes to describe quantum field theories, and introduces new concepts to characterize the dynamics of quantum many-body systems. The contributions of this dissertation are the following: 1) We constructed Narain Conformal Field Theories (CFTs) using additive codes, where the modular bootstrap constraints translate into algebraic conditions on the codes, extending previous approaches. This helps express key CFT data, including the torus partition function, in terms of codewords. We constructed optimal Narain CFTs for small central charges, and described CFT ensembles for asymptotically large central charge with large spectral gap. 2) We studied …

Magnetic Spin Transport Coils For The N2edm Experiment, David C. Bowles

Theses and Dissertations--Physics and Astronomy

The n2EDM experiment is being construct at Paul Scherrer Institute to measure the electric dipole moment of the neutron (nEDM), in a search for new physics which could help explain the baryon asymmetry of the universe. To reach the experimental sensitivity goal of $d_n \sim 10^{-27}$, over an order of magnitude improvement from the current world limit, a spin polarization transfer efficiency of 99\% for ultracold neutrons entering or exiting the precession chamber is required, placing a stringent requirement on the adiabaticity of the magnetic field taper in the neutron guide system. The spin transport fields transition from 5~T (longitudinal) …

Qcd Analysis Of Flavor-Nonchanging Hadronic Weak Processes Through Next-To-Leading Order, Girish Lingadahalli Muralidhara

Theses and Dissertations--Physics and Astronomy

Studies in quantum chromodynamics (QCD), the fundamental theory of the strong interactions, of low-energy hadronic weak processes utilize an effective Hamiltonian framework. Below the weak-mass scale, an effective Hamiltonian contains a series of Wilson coefficients and four-quark operators that come from the operator product expansion in the Standard Model. The effective hadronic Hamiltonian pertinent to a weak process is then obtained via a renormalization group analysis in QCD from the weak-mass scale to the low-energy scale of O(2 GeV). In this thesis, the construction and phenomenological implications of such an effective Hamiltonian for flavor-conserving, parity-violating quark processes in the Standard …

Exploring The Hot And Gaseous Universe From Infrared To X-Ray, Chamani Gunasekera

Theses and Dissertations--Physics and Astronomy

Over 90% of baryonic matter in the universe exists as astrophysical plasmas. The gas
is often far from thermodynamic equilibrium, so numerical non-equilibrium spectral
synthesis simulations are used to understand observations. cloudy simulates vari-
ous physical conditions, providing spectra predictions. This thesis aims to meet the
challenge of new observatories like the JWST (James Webb Space Telescope) and
XRISM (X-Ray Imaging Spectroscopy Mission). These simulations are no better
than the underlying atomic and molecular database and the fourth chapter details
a long-needed update to an evolving database. The predicted spectra are strongly
affected by the composition of the gas, which …

Techniques For Optimizing Neutron Beta Decay Particle Detection, Austin W. Nelsen

Theses and Dissertations--Physics and Astronomy

Over the last couple decades, use of free neutron beta decay (n → p + e^- + ν_e) to extract the up-down quark transition element V_ud has become competitive with more conventional Fermi decays. Extraction of V_ud requires measurements of the vector to axial-vector coupling constant ratio λ and the free neutron lifetime τ_n. With a precise determination of V_ud, the 2.8σ departure from CKM unitarity can be addressed.

Nab, located at the Spallation Neutron Source at ORNL, will measure the electron-neutrino momentum correlation coefficient a (which couples quadratically …

Spinning Spheroidal Components Of Disk Galaxies: Resonant Interactions With Stellar Bars, Xingchen Li

Theses and Dissertations--Physics and Astronomy

The majority of disk galaxies possess stellar bars, which are the main driver in the internal evolution of barred galaxies. Bars represent non-axisymmetric perturbations in the galactic disks, producing strong gravitational torques that facilitate angular momentum transfer from the disk to the spheroidal components, such as central stellar bulges and host dark matter (DM) halos. The redistribution of angular momentum in barred galaxies proceeds mainly via resonant interactions between the bar and orbits in the spheroids. The amount of angular momentum emitted or absorbed at each resonance depends on the mass distribution, density and spin in the spheroidal components. Thus, …

Development Of A Source To Detector Simulation Of The Los Alamos National Lab Neutron Electric Dipole Moment Experiment, Dillon Buskirk

Theses and Dissertations--Physics and Astronomy

The Los Alamos National Laboratory (LANL) neutron electric dipole moment (nEDM) experiment is planning an increased precision measurement of the neutron’s permanent electric dipole moment. LANL nEDM expects to lower the statistical uncertainty to δd_LANL = 2 × 10−27 e cm after a year of live-time, which puts a more stringent upper bound on the nEDM. This statistical uncertainty is an order of magnitude less than the current best measurement set by nEDM at PSI. To reach this goal, the LANL nEDM collaboration requires a simulation tool that can tackle optimization problems, investigate systematic effects, and provide mock data …

Development Of A Novel Beam-Type Neutron Lifetime Experiment Using Ultracold Neutrons, Nicholas Floyd

Theses and Dissertations--Physics and Astronomy

Precision measurements of the neutron lifetime are critical to tests of the Standard Model. The CKM quark mixing matrix has recently been shown to deviate from unitarity in the top row, motivating the development of alternative extractions of the first element. Complementary measurements of the neutron’s lifetime and decay correlations can be used to accomplish this.

While the reported neutron lifetime by the Particle Data Group is taken from ultracold neutron (UCN) measurements, a separate class of experiments suggest a value in four sigma disagreement, meriting further study. The goal of the UCNProBe experiment at Los Alamos National Laboratory is …

The Application Of Novel Machine Learning Algorithms To Study Multi-Dimensional Fragmentation Functions Of Hadrons In Jets At Star, Hannah A. Harrison-Smith

Theses and Dissertations--Physics and Astronomy

Hadronization, the process by which colored quarks and gluons shower from high energy collisions and recombine to form stable, experimentally-observable particles, is a fundamental aspect of Quantum Chromodynamics (QCD) that is not yet fully understood. Fragmentation functions, typically measured in electron-positron collisions, encapsulate this hadronization process well for quarks. Studying proton-proton collisions offers direct access to gluon fragmentation that other channels like electron-positron do not. Recent theoretical developments have proposed the study of hadronic showers in groupings called jets, introducing the concept of multi-dimensional jet fragmentation functions. This thesis presents the extraction of collinear and transverse momentum-dependent fragmentation functions for …

Precision Neutrino Interactions In And Beyond The Standard Model, Kaushik Borah

Theses and Dissertations--Physics and Astronomy

This dissertation investigates precision measurements of neutrino interactions within the framework of the Standard Model and explores potential extensions beyond it. Neutrinos, often referred to as ghostly particles due to their weak interactions and elusive nature, have long been a frontier in particle physics. Through detailed theoretical modeling and comparison with experimental data, this work focuses on improving our understanding of neutrino-nucleon cross-sections, nucleon form factors, and generalized neutrino interactions. The study begins with a comprehensive examination of the role of vector and axial-vector form factors in neutrino-nucleon scattering and their impact on the interpretation of neutrino oscillation data from …

Mediation By Fatalism Of The Association Between Symptom Burden And Self-Care Management In Patients With Heart Failure, Ashmita Thapa, Misook L. Chung, Jia-Rong Wu, Abigail Latimer, Terry A. Lennie, Gia Mudd-Martin, Chin-Yen Lin, Jessica Harman Thompson, Junghee Kang, Debra K. Moser

UK CARES Faculty Publications

Background: Clinicians and researchers often assume that symptom burden is associated with self-care management (SCM) in patients with heart failure (HF). However, that association is often not borne out in simple regression analyses and may be because another variable mediates the association. Fatalism is an appropriate candidate for mediation and is the belief that circumstances are predetermined without opportunity for control by individuals.

Objective: Our objective was to determine whether fatalism mediated the relationship of symptom burden with SCM among adults with HF.

Methods: We conducted a secondary analysis (N = 95) from a clinical trial. We used Self-care of …

Bundle For Quantifying Vaginal Blood Loss After Childbirth, Mariana Torreglosa Ruiz, Nayara Freitas Azevedo, Cynthya Viana De Resende, Maria Paula Custódio Silva, Divanice Contim, Luciano Marques Dos Santos, Monika Wernet, Ana Linares

UK CARES Faculty Publications

Objective: To construct and validate the content of a bundle to quantify vaginal blood loss after childbirth.

Methods: This is a methodological study developed from February to August 2022, divided into bibliographic survey, instrument construction and content validity, by 14 experts. The instrument for validity consisted of 11 items selected from a systematic review. For each item in the bundle, a Likert scale was applied, and to check agreement among experts, the Concordance Index was calculated. Items with agreement above 80% were considered valid. Content validity was carried out in a single round of assessment.

Results: The final version of …

Mediators Of The Association Between Cognitive Function And Self-Care Behaviors In Patients Hospitalized With An Exacerbation Of Heart Failure, Jia-Rong Wu, Chin-Yen Lin, Abigail Latimer, Muna Hassan Hammash, Debra K. Moser

UK CARES Faculty Publications

Background: Patients with heart failure (HF) must engage in self-care, yet their self-care is often poor. Cognitive function commonly is impaired in HF and is associated with poor self-care. Heart failure knowledge and self-care confidence also are needed to preform self-care. Few investigators have examined mediators of the association of cognitive function with self-care.

Objectives: The aim of this study was to determine whether HF knowledge and self-care confidence mediated the association of cognitive function with self-care maintenance and management among patients with HF.

Methods: This was a cross-sectional observational study of 164 patients with HF. Cognitive function was assessed …

Primary Care Providers’ Experiences Treating Opioid Use Disorder Using Telehealth In The Height Of The Covid-19 Pandemic, Sarah Alexandra Marshall, Lachan E. Siebenmorgen, Katherine Youngen, Tyrone F. Borders, Nickolas Zaller

Nursing Faculty Publications

Background: The COVID-19 pandemic catalyzed a rapid shift in healthcare delivery towards telehealth services, impacting patient care, including opioid use disorder (OUD) treatment. Regulatory changes eliminated the in-person evaluation requirement for buprenorphine treatment, encouraging adoption of telehealth. This study focused on understanding experiences of primary care providers in predominantly rural areas who used telehealth for OUD treatment during the pandemic. Methods: Semi-structured interviews were conducted with 22 primary care providers. Participants practiced in 13 rural and 9 urban counties in Kentucky and Arkansas. Data were analyzed using conventional content analysis. Results: The pandemic significantly impacted healthcare delivery. While telehealth was …

Champions To Enhance Implementation Of Clinical And Community-Based Interventions In Cancer: A Scoping Review, Joseph Astorino Nicola, M. Muska Nataliansyah, Maria A. Lopez‑Olivo, Adebola Adegboyega, Kelly A. Hirko, Lou‑Anne R. Chichester, Nora L. Nock, Pamela Ginex, Shannon M. Christy, Paul Levett

Nursing Faculty Publications

Background Champions are integral across research in cancer, yet studies exploring their roles are limited and have produced mixed results. The current review examines and synthesizes descriptions of how champions emerged and the types of activities they most often performed. By examining evidence from across the translational research continuum, this scoping review aims to characterize the role of champions and strategies that facilitate their involvement in the implementation of cancer care interventions in both clinical and community‑based settings.

Methods This scoping review was designed and implemented in compliance with PRISMA‑ScR. The review focused on peer‑reviewed articles in English‑language journals. We …

High-Risk Individuals And Naloxone Use: Implications For Thn Programs In Rural Appalachian Communities, Victor Garcia, Lisa Mccann, Erick Lauber, Christian Vaccaro, Melissa Swauger, Alex Daniel Heckert

Journal of Appalachian Health

Introduction: Take-home naloxone (THN) is being made available across rural Appalachia to curb opioid overdose fatalities. Despite this initiative, some opioid users do not possess naloxone, and if they do, do not administer it to others.

Purpose: Research findings on risk factors that contribute to opioid overdose are presented. These factors, identified in a sample of 16 overdose cases, are (1) early onset age of opioid use; (2) progressive opioid use; (3) a transition from pain medication to heroin and fentanyl; (4) fears of being arrested at a naloxone intervention if first responders are contacted, and (5) limited knowledge of …

Assessing And Addressing The Determinants Of Appalachian Population Health: A Scoping Review, David L. Driscoll, Hannah O'Donnell, Maitri Patel, David C. Cattell-Gordon

Journal of Appalachian Health

Introduction: Residents of Appalachia experience elevated rates of morbidity and mortality compared to national averages, and these disparities are associated with inequitable exposures to various determinants of population health. Social and environmental determinants of health are a useful lens through which to develop and evaluate programs to mitigate regional health disparities.

Methods: This 2023 scoping review was conducted of studies linking determinants of Appalachian health with leading causes of regional mortality and morbidity. The search strategy employed a keyword search that included geographic terms for the Appalachian Region and the primary adverse health outcomes in that region. Studies meeting the …

Review Of: Coal, Cages, Crisis: The Rise Of The Prison Economy In Central Appalachia, Ted Olson Phd

Journal of Appalachian Health

Ted Olson, PhD, is a professor of both Appalachian Studies and Bluegrass, Old-Time and Roots Music Studies at East Tennessee State University. In this piece, he reviews Professor Judah Schept's Coal, Cages, Crisis: The Rise of the Prison Economy in Central Appalachia and discusses the impacts of incarceration on the health of Appalachia and on its residents more broadly.

Factors Associated With Covid-19 Vaccine Hesitancy In South Central Appalachia, Florence M. Weierbach, Rebecca Adkins Fletcher, Ingrid E. Luffman, Cynthia Meyer, Janet M. Keener, Manik Ahuja, Hadii M. Mamudu

Journal of Appalachian Health

Introduction: The newly emergent COVID-19 virus reached pandemic levels in March 2020. By the middle of August 2020, there were over 1 million deaths attributed to COVID-19 in the U.S., with those in rural areas outpacing urban counterparts. Prior to emergency approval of the Pfizer, Moderna and Johnson & Johnson vaccine formulations, mitigation efforts addressing individual behavior were challenging. However, even with the entrance of these three new vaccines, herd immunity was not achieved in rural areas, as vaccine uptake remained low there. Although there has since been an abundance of COVID-19-related research addressing health literacy, vaccine hesitancy and overall …

Disparities In Mortality Between Appalachian And Non-Appalachian Regions Of Kentucky, Sonali S. Salunkhe, Sahal Alzahrani, Beatrice Ugiliweneza

Journal of Appalachian Health

Introduction: In the opioid epidemic, the U.S. faces a significant public health crisis, with some areas of the country, such as rural and Appalachian regions, suffering more than others. The differential regional impact of the crisis in Kentucky—a state with both non-metropolitan/metropolitan and Appalachian/Non-Appalachian statuses—has not yet been documented despite such knowledge being essential to the success of overdose prevention efforts.

Purpose: This study compares all-cause, drug- and opioid-related mortality between counties in different regions of Kentucky: Appalachian non-metropolitan, Appalachian metropolitan, non-Appalachian non-metropolitan, and non-Appalachian metropolitan.

Methods: Age-adjusted mortality data from the Centers for Disease Control and Prevention’s Wide-ranging Online …

Carbapenem-Resistant Enterobacterales—Kentucky, 2013–2020: Challenges And Successes, Mary Issac, Andrea Flinchum, Kevin Spicer

Journal of Appalachian Health

Introduction: Carbapenem-resistant Enterobacterales (CRE) are considered urgent, antibiotic-resistant threats in the U.S. and are of global concern. Active collaboration between public health authorities and healthcare facilities and providers will be necessary to prevent and contain these organisms.

Purpose: To describe the epidemiology of CRE in Kentucky and to discuss challenges and successes with building and sustaining an effective prevention and containment program.

Methods: Retrospective descriptive summary of CRE isolates reported by healthcare providers, facilities, and laboratories in Kentucky from 2013 through 2020. Data available from case reporting forms and laboratory testing are summarized.

Results: From 2013 through 2020, 1805 CRE …

Changes In Perceptions Of First Responders After Witnessing A Drug Overdose: Individual And Contextual Variations Among People Who Use Opioids In West Virginia, Kathleen L. Egan, Kelly Gurka, Alexandria Macmadu, Herb Linn

Journal of Appalachian Health

Introduction: Success of opioid overdose interventions involving first responders is dependent on the comfort level that bystanders have with first responders and their willingness to call for assistance. Positive or negative experiences with first responders following witnessing an overdose may influence a person’s willingness to call a first responder for assistance in the future.

Purpose: The objective of this study was to examine changes in bystanders’ perceptions of first responders following witnessing an overdose attended by emergency medical services or a law enforcement official. It specifically explored perception changes among a sample of individuals residing in Appalachia who use prescription …

Reimagining A Caregiver-Friendly Society, Jodi L. Southerland

Journal of Appalachian Health

Demographic aging is accelerating in the Appalachian Region, resulting in a growing proportion of caregivers living in areas that lack services to support their needs. Strategies are urgently needed in Appalachia to address deficiencies in the region’s long-term supports and services for older adults and their caregivers. Strengthening equitable access to care and community supports for family caregivers is a policy priority for state and community leaders in Appalachia.